Talc_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Talc perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Talc_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.238826
FTH1 ferritin, heavy polypeptide 1 0.178937
PDE4D phosphodiesterase 4D, cAMP-specific 0.17264
PM20D1 peptidase M20 domain containing 1 0.148779
FTL ferritin, light polypeptide 0.0911515
RPL23 ribosomal protein L23 0.0881642
WWOX WW domain containing oxidoreductase 0.0717505
RPL19 ribosomal protein L19 0.0698515
RPS12 ribosomal protein S12 0.0662053
WDR43 WD repeat domain 43 0.0653154
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0586009
RPLP1 ribosomal protein, large, P1 0.0544672
RPL4 ribosomal protein L4 0.0518294
EIF1 eukaryotic translation initiation factor 1 0.049377
TMSB10 thymosin beta 10 0.046854
GRAMD1B GRAM domain containing 1B 0.0460082
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0447578
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0443355
RPL26 ribosomal protein L26 0.0439414
RPL36 ribosomal protein L36 0.0434285
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0432912
RPS8 ribosomal protein S8 0.042977
RPS2 ribosomal protein S2 0.0394462
PTMA prothymosin, alpha 0.0389766
ATP5F1E ATP synthase F1 subunit epsilon 0.0386648
TM4SF1 transmembrane 4 L six family member 1 0.0376572
RPL37A ribosomal protein L37a 0.0359038
RPS19 ribosomal protein S19 0.0352143
ATF4 activating transcription factor 4 0.0322888
RPL9 ribosomal protein L9 0.0318157
RPL12 ribosomal protein L12 0.0317019
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0305484
PFDN2 prefoldin subunit 2 0.0290085
RPL34 ribosomal protein L34 0.0278195
NNMT nicotinamide N-methyltransferase 0.0273816
RPS27A ribosomal protein S27a 0.0273278
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0271991
KLF6 Kruppel-like factor 6 0.0268418
RPLP2 ribosomal protein, large, P2 0.0258572
TPT1 tumor protein, translationally-controlled 1 0.0253673
VEZT vezatin, adherens junctions transmembrane protein 0.025049
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0250389
ZNF804A zinc finger protein 804A 0.0249449
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0243579
NTN4 netrin 4 0.0242913
MARCHF6 membrane associated ring-CH-type finger 6 0.0239696
C15ORF48 chromosome 15 open reading frame 48 0.0239144
OSMR oncostatin M receptor 0.0232623
RPLP0 ribosomal protein, large, P0 0.0232007
RFWD3 ring finger and WD repeat domain 3 0.022891
RACK1 receptor for activated C kinase 1 0.0227601
RPL27 ribosomal protein L27 0.022584
LGALS1 lectin, galactoside-binding, soluble, 1 0.0221375
ZSWIM6 zinc finger, SWIM-type containing 6 0.0219157
RPS21 ribosomal protein S21 0.0217584
BIRC2 baculoviral IAP repeat containing 2 0.0216935
RPS17 ribosomal protein S17 0.0212888
RPL11 ribosomal protein L11 0.0210265
CAMTA1 calmodulin binding transcription activator 1 0.0208264
RPL31 ribosomal protein L31 0.0206125
OLA1 Obg-like ATPase 1 0.0203696
RSPO3 R-spondin 3 0.020184
RPS20 ribosomal protein S20 0.0196921
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0194139
RPL18 ribosomal protein L18 0.0193954
RPS15 ribosomal protein S15 0.0193082
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0192018
RPS23 ribosomal protein S23 0.0191763
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0189551
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0189237
RTN4 reticulon 4 0.018872
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0181653
BMP6 bone morphogenetic protein 6 0.0181422
RPL37 ribosomal protein L37 0.0179913
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0178795
RPS14 ribosomal protein S14 0.0177319
KYNU kynureninase 0.0173224
ROMO1 reactive oxygen species modulator 1 0.0173108
RPS10 ribosomal protein S10 0.0170191
FOXJ3 forkhead box J3 0.017008
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.0169406
LOC102724023 ES1 protein homolog, mitochondrial 0.0169073
RPL13A ribosomal protein L13a 0.0168288
H1-4 H1.4 linker histone, cluster member 0.0167418
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0166901
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0166035
XRN2 5'-3' exoribonuclease 2 0.0164295
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 0.0163985
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0159972
RPS6 ribosomal protein S6 0.0159371
RPL10A ribosomal protein L10a 0.0159173
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.0157263
RB1CC1 RB1-inducible coiled-coil 1 0.0156762
AREG amphiregulin 0.0155854
AGO2 argonaute RISC catalytic component 2 0.0155847
RPL8 ribosomal protein L8 0.0155682
NAMPT nicotinamide phosphoribosyltransferase 0.0155163
ANKRD12 ankyrin repeat domain 12 0.015494
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.0154521
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0152661

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.146578
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.139744
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.138107
IGF2 insulin-like growth factor 2 -0.132675
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.118589
TXNRD1 thioredoxin reductase 1 -0.10498
PKM pyruvate kinase, muscle -0.0936495
LDHA lactate dehydrogenase A -0.0841388
POTEF POTE ankyrin domain family, member F -0.0832795
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0781907
FMNL2 formin-like 2 -0.076795
FLNB filamin B, beta -0.0718918
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0668963
HDAC9 histone deacetylase 9 -0.0602009
KTN1 kinectin 1 (kinesin receptor) -0.05789
ERBIN erbb2 interacting protein -0.057358
IGFBP3 insulin-like growth factor binding protein 3 -0.0545503
BIRC6 baculoviral IAP repeat containing 6 -0.0531208
PYGL phosphorylase, glycogen, liver -0.0527528
UBASH3B ubiquitin associated and SH3 domain containing B -0.05185
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0510511
UTRN utrophin -0.0499939
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0492034
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0481785
CMIP c-Maf inducing protein -0.0479568
AKAP13 A kinase (PRKA) anchor protein 13 -0.0478671
EEF2 eukaryotic translation elongation factor 2 -0.0477347
TPM4 tropomyosin 4 -0.0474944
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0474046
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0456506
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0450024
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0444527
KDM5B lysine (K)-specific demethylase 5B -0.0443029
EGFR epidermal growth factor receptor -0.0440011
IQGAP1 IQ motif containing GTPase activating protein 1 -0.043765
MYOF myoferlin -0.0431981
CALR calreticulin -0.0429685
COPA coatomer protein complex, subunit alpha -0.04293
MAML3 mastermind-like 3 (Drosophila) -0.0425505
TPM3 tropomyosin 3 -0.0423665
PTK2 protein tyrosine kinase 2 -0.0423263
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0413837
KMT2E lysine (K)-specific methyltransferase 2E -0.0413019
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0408167
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0407004
ZNF207 zinc finger protein 207 -0.0406638
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0405019
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.039672
BASP1 brain abundant, membrane attached signal protein 1 -0.0394375
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0378189
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0374117
PFN1 profilin 1 -0.0372082
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.037122
RHOA ras homolog family member A -0.0371152
KIF5B kinesin family member 5B -0.0365585
TMOD3 tropomodulin 3 (ubiquitous) -0.0354217
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0349964
SLC38A2 solute carrier family 38, member 2 -0.0346773
PDIA3 protein disulfide isomerase family A, member 3 -0.0345937
DOCK4 dedicator of cytokinesis 4 -0.0343057
SVIL supervillin -0.0340566
GLG1 golgi glycoprotein 1 -0.0339176
ENO1 enolase 1, (alpha) -0.0335989
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0334296
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0331372
NDRG1 N-myc downstream regulated 1 -0.0331343
TPM1 tropomyosin 1 (alpha) -0.033096
PHF20 PHD finger protein 20 -0.03289
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0325609
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0324149
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0323506
YY1 YY1 transcription factor -0.0322296
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0319929
HMGA1 high mobility group AT-hook 1 -0.031738
RBM25 RNA binding motif protein 25 -0.0316995
FGB fibrinogen beta chain -0.0316129
FOCAD focadhesin -0.0313052
ARF4 ADP-ribosylation factor 4 -0.0304802
MYADM myeloid-associated differentiation marker -0.0304692
TAGLN2 transgelin 2 -0.029567
THSD4 thrombospondin, type I, domain containing 4 -0.0292104
EXT1 exostosin glycosyltransferase 1 -0.0290897
VDAC1 voltage-dependent anion channel 1 -0.0290688
S100A6 S100 calcium binding protein A6 -0.0285277
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0281745
KCMF1 potassium channel modulatory factor 1 -0.0280955
SAMD4A sterile alpha motif domain containing 4A -0.0280716
GGNBP2 gametogenetin binding protein 2 -0.028049
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.028027
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0278095
STRN3 striatin, calmodulin binding protein 3 -0.0276931
THBS1 thrombospondin 1 -0.0274703
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.0274132
BZW2 basic leucine zipper and W2 domains 2 -0.0274106
TBC1D19 TBC1 domain family, member 19 -0.0273068
SBF2 SET binding factor 2 -0.0269138
LPP LIM domain containing preferred translocation partner in lipoma -0.0267923
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.02669
USP34 ubiquitin specific peptidase 34 -0.0262078
SRP54 signal recognition particle 54kDa -0.0261035