Talc_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Talc perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Talc_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRB10 growth factor receptor-bound protein 10 0.0976053
FNDC3B fibronectin type III domain containing 3B 0.0873147
SAMD4A sterile alpha motif domain containing 4A 0.0861674
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0850277
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0809683
FN1 fibronectin 1 0.0803846
ESYT2 extended synaptotagmin-like protein 2 0.0725635
PLAUR plasminogen activator, urokinase receptor 0.0715798
LAMB3 laminin, beta 3 0.070526
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.063738
ERRFI1 ERBB receptor feedback inhibitor 1 0.0633423
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0622276
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0618595
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0618238
FAM13A family with sequence similarity 13, member A 0.0615812
PTMA prothymosin, alpha 0.0545843
NDRG1 N-myc downstream regulated 1 0.0536085
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0534335
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0531522
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0520568
CEMIP cell migration inducing protein, hyaluronan binding 0.0490182
COL6A3 collagen, type VI, alpha 3 0.0474515
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0460609
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0451805
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0447177
SETD5 SET domain containing 5 0.0438618
ELL2 elongation factor, RNA polymerase II, 2 0.0436599
STC1 stanniocalcin 1 0.0435014
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0417765
RPS6 ribosomal protein S6 0.041627
MAML2 mastermind-like 2 (Drosophila) 0.041612
HLA-B major histocompatibility complex, class I, B 0.0407756
NAV1 neuron navigator 1 0.0396606
JMJD1C jumonji domain containing 1C 0.03878
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.0386617
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0385214
TNPO1 transportin 1 0.0377786
NAP1L1 nucleosome assembly protein 1-like 1 0.0373755
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0373337
ANKRD12 ankyrin repeat domain 12 0.0371484
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0371203
KRT17 keratin 17, type I 0.0362473
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0360964
SEPTIN2 septin 2 0.0358754
SSH2 slingshot protein phosphatase 2 0.0356676
SOD2 superoxide dismutase 2, mitochondrial 0.0350829
IQGAP1 IQ motif containing GTPase activating protein 1 0.0350441
ATP13A3 ATPase type 13A3 0.0349945
USP3 ubiquitin specific peptidase 3 0.0340144
NAMPT nicotinamide phosphoribosyltransferase 0.0334302
ACTG1 actin gamma 1 0.0334206
SBF2 SET binding factor 2 0.0332316
IGFBP3 insulin-like growth factor binding protein 3 0.0332129
HMGA2 high mobility group AT-hook 2 0.0328792
ARHGAP21 Rho GTPase activating protein 21 0.0328069
BACE2 beta-site APP-cleaving enzyme 2 0.0326469
YAP1 Yes-associated protein 1 0.0325745
SMAD3 SMAD family member 3 0.0323075
PARD3 par-3 family cell polarity regulator 0.0321533
PRKCA protein kinase C, alpha 0.0320781
ZBTB20 zinc finger and BTB domain containing 20 0.0320641
VIM vimentin 0.032044
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0318456
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 0.031651
INTS6 integrator complex subunit 6 0.0315202
IGF2 insulin-like growth factor 2 0.0312221
NPEPPS aminopeptidase puromycin sensitive 0.031124
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0307026
ATOSA atos homolog A 0.0304968
WAC WW domain containing adaptor with coiled-coil 0.0301775
TXNIP thioredoxin interacting protein 0.030017
TPT1 tumor protein, translationally-controlled 1 0.0299357
FTH1 ferritin, heavy polypeptide 1 0.0299062
NT5C2 5'-nucleotidase, cytosolic II 0.029857
MT2A metallothionein 2A 0.0297416
AKAP9 A kinase (PRKA) anchor protein 9 0.0297003
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0296142
RPLP1 ribosomal protein, large, P1 0.029415
BZW1 basic leucine zipper and W2 domains 1 0.0292454
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0292016
OGA O-GlcNAcase 0.0289638
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 0.0284714
STK24 serine/threonine kinase 24 0.0284116
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0283649
NGLY1 N-glycanase 1 0.0283073
WARS1 tryptophanyl-tRNA synthetase 1 0.0282861
RAB10 RAB10, member RAS oncogene family 0.0278293
MMP1 matrix metallopeptidase 1 0.0277589
ZSWIM6 zinc finger, SWIM-type containing 6 0.0272649
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.0272216
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0270849
LAMC2 laminin, gamma 2 0.0265941
NHSL1 NHS-like 1 0.026563
ANTXR2 anthrax toxin receptor 2 0.026516
RACK1 receptor for activated C kinase 1 0.0264383
FSCN1 fascin actin-bundling protein 1 0.026081
RNF24 ring finger protein 24 0.0260082
UBE2H ubiquitin-conjugating enzyme E2H 0.0259137
AHNAK AHNAK nucleoprotein 0.0257379
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0256608

decreased expression

Symbol Name Standardized Value
IFIH1 interferon induced with helicase C domain 1 -0.206943
SPAG9 sperm associated antigen 9 -0.116538
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.110944
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.10419
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0910347
STK17A serine/threonine kinase 17a -0.087477
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0817904
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0811758
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.080919
RIGI RNA sensor RIG-I -0.0806102
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0747756
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0682547
SH3KBP1 SH3-domain kinase binding protein 1 -0.0677024
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0654727
NRG1 neuregulin 1 -0.064902
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0618931
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -0.0610768
PRRC2C proline-rich coiled-coil 2C -0.0610761
FNDC3A fibronectin type III domain containing 3A -0.0606454
PTPRD protein tyrosine phosphatase, receptor type, D -0.0598046
SMYD3 SET and MYND domain containing 3 -0.0588076
OASL 2'-5'-oligoadenylate synthetase-like -0.0584983
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0579216
PAPOLA poly(A) polymerase alpha -0.0562551
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0559311
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0558138
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0549657
RAD51B RAD51 paralog B -0.05463
PDE10A phosphodiesterase 10A -0.0539253
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0528382
AFF4 AF4/FMR2 family, member 4 -0.0515427
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) -0.0511396
THSD4 thrombospondin, type I, domain containing 4 -0.0507291
SLMAP sarcolemma associated protein -0.0493929
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0492074
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0490079
NBAS neuroblastoma amplified sequence -0.0481002
PSD3 pleckstrin and Sec7 domain containing 3 -0.0478058
CREBBP CREB binding protein -0.0476586
SYT1 synaptotagmin I -0.0466067
FOXP1 forkhead box P1 -0.0462083
VCL vinculin -0.0460176
FAT1 FAT atypical cadherin 1 -0.0459796
CUL3 cullin 3 -0.044896
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0446132
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0444847
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0436183
PDLIM5 PDZ and LIM domain 5 -0.0435713
SOX4 SRY (sex determining region Y)-box 4 -0.0430994
COPA coatomer protein complex, subunit alpha -0.042789
ARHGAP5 Rho GTPase activating protein 5 -0.0426519
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0424136
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0419024
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0417237
MRTFA myocardin related transcription factor A -0.0413069
APP amyloid beta (A4) precursor protein -0.0403057
AKAP12 A kinase (PRKA) anchor protein 12 -0.0399306
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0387868
WSB1 WD repeat and SOCS box containing 1 -0.038562
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0384628
MORC3 MORC family CW-type zinc finger 3 -0.037724
EGFR epidermal growth factor receptor -0.0377145
NF1 neurofibromin 1 -0.0373676
NALF1 NALCN channel auxiliary factor 1 -0.0371596
RTN4 reticulon 4 -0.0369784
BPTF bromodomain PHD finger transcription factor -0.0361395
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0360109
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0357832
RPL35A ribosomal protein L35a -0.0356784
SLC38A1 solute carrier family 38, member 1 -0.0347345
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -0.0343297
GPC6 glypican 6 -0.0342825
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0341475
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0337076
TRIO trio Rho guanine nucleotide exchange factor -0.0336249
MTUS1 microtubule associated tumor suppressor 1 -0.0334264
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0311283
NIPBL Nipped-B homolog (Drosophila) -0.0311214
LMO7 LIM domain 7 -0.0305901
FRMD5 FERM domain containing 5 -0.0303388
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0299651
FTO fat mass and obesity associated -0.0298426
MON2 MON2 homolog (S. cerevisiae) -0.0297468
JAK1 Janus kinase 1 -0.0293801
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0290923
TRA2A transformer 2 alpha homolog (Drosophila) -0.0288482
KDM5B lysine (K)-specific demethylase 5B -0.0271121
B2M beta-2-microglobulin -0.0270402
RNF149 ring finger protein 149 -0.0265076
COG5 component of oligomeric golgi complex 5 -0.0262595
MED13 mediator complex subunit 13 -0.0260719
RBM25 RNA binding motif protein 25 -0.025762
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0256053
TMEM165 transmembrane protein 165 -0.0255403
MARCHF6 membrane associated ring-CH-type finger 6 -0.0252788
LPP LIM domain containing preferred translocation partner in lipoma -0.0248676
DST dystonin -0.0238293
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0235759
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0229725
TJP1 tight junction protein 1 -0.022214