| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Talc perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Talc_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.181207 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.175439 |
| FN1 | fibronectin 1 | 0.171807 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.170922 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.16416 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0910608 |
| FAM13A | family with sequence similarity 13, member A | 0.0902612 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0892067 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0885047 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0838594 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0832707 |
| S100A6 | S100 calcium binding protein A6 | 0.0757322 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0750795 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0721524 |
| GOLGA4 | golgin A4 | 0.060088 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0599661 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0555833 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0550856 |
| LMO7 | LIM domain 7 | 0.0547154 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0521673 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0515688 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0508934 |
| TFG | TRK-fused gene | 0.0494798 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0451907 |
| RNF145 | ring finger protein 145 | 0.0447995 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0438796 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0433697 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0433037 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0432022 |
| NDRG1 | N-myc downstream regulated 1 | 0.0430588 |
| ARRDC3 | arrestin domain containing 3 | 0.0427394 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0420374 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0411586 |
| PGK1 | phosphoglycerate kinase 1 | 0.040761 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0404701 |
| RACK1 | receptor for activated C kinase 1 | 0.0400911 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0396809 |
| RPL4 | ribosomal protein L4 | 0.0393484 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0383573 |
| CLINT1 | clathrin interactor 1 | 0.038162 |
| DSG2 | desmoglein 2 | 0.0378728 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0377834 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0371765 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0370217 |
| CANX | calnexin | 0.036874 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0366497 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0362898 |
| ASPH | aspartate beta-hydroxylase | 0.0362098 |
| TMSB4X | thymosin beta 4, X-linked | 0.0359587 |
| CDCP1 | CUB domain containing protein 1 | 0.0357454 |
| RPLP0 | ribosomal protein, large, P0 | 0.0357398 |
| H1-0 | H1.0 linker histone | 0.0344435 |
| HMGB2 | high mobility group box 2 | 0.0335444 |
| PRRC1 | proline-rich coiled-coil 1 | 0.0334372 |
| TMEM123 | transmembrane protein 123 | 0.0333516 |
| CALU | calumenin | 0.0331872 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.03306 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0325977 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0325926 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0325011 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0317578 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0308994 |
| LDHA | lactate dehydrogenase A | 0.0307125 |
| ADAR | adenosine deaminase, RNA-specific | 0.0305495 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0299376 |
| SGMS2 | sphingomyelin synthase 2 | 0.0298867 |
| TMEM39A | transmembrane protein 39A | 0.0294851 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0289347 |
| STEAP4 | STEAP family member 4 | 0.0282134 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.028155 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0280783 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0280056 |
| COPA | coatomer protein complex, subunit alpha | 0.027858 |
| ENO1 | enolase 1, (alpha) | 0.0278097 |
| UBC | ubiquitin C | 0.0276265 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0274057 |
| ANXA2 | annexin A2 | 0.0269403 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0266293 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0265794 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.026502 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0261014 |
| AHNAK | AHNAK nucleoprotein | 0.0259771 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0259025 |
| DUSP10 | dual specificity phosphatase 10 | 0.0258263 |
| EREG | epiregulin | 0.0256691 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0254195 |
| TES | testin LIM domain protein | 0.0254095 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.0254092 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0250512 |
| HDLBP | high density lipoprotein binding protein | 0.0245326 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0238522 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0237724 |
| TKT | transketolase | 0.0234615 |
| DSPP | dentin sialophosphoprotein | 0.0233271 |
| ANXA1 | annexin A1 | 0.0231988 |
| CNN3 | calponin 3, acidic | 0.0228132 |
| PDE8A | phosphodiesterase 8A | 0.0227988 |
| TOP1 | topoisomerase (DNA) I | 0.0227099 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0226933 |
| TMEM263 | transmembrane protein 263 | 0.0221767 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.169378 |
| RPL35A | ribosomal protein L35a | -0.111403 |
| FTL | ferritin, light polypeptide | -0.105841 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0916488 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0903285 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0805897 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0793428 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0775112 |
| TMSB10 | thymosin beta 10 | -0.0707884 |
| HLA-B | major histocompatibility complex, class I, B | -0.0672125 |
| RPS29 | ribosomal protein S29 | -0.0637389 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0567971 |
| RNF213 | ring finger protein 213 | -0.0547708 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.052704 |
| POTEF | POTE ankyrin domain family, member F | -0.0496605 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0488737 |
| RBM47 | RNA binding motif protein 47 | -0.0482763 |
| MCL1 | myeloid cell leukemia 1 | -0.0469845 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0448858 |
| PKM | pyruvate kinase, muscle | -0.0429132 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0428522 |
| CCND1 | cyclin D1 | -0.0416556 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0413751 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | -0.0407064 |
| NAV2 | neuron navigator 2 | -0.0402561 |
| RPL38 | ribosomal protein L38 | -0.0396415 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0389473 |
| INTS6 | integrator complex subunit 6 | -0.0389266 |
| RPS13 | ribosomal protein S13 | -0.0385975 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0379671 |
| RPL31 | ribosomal protein L31 | -0.0378396 |
| RPL9 | ribosomal protein L9 | -0.0376545 |
| ACTG1 | actin gamma 1 | -0.0372343 |
| VCL | vinculin | -0.0369848 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0365443 |
| PTK2 | protein tyrosine kinase 2 | -0.0364249 |
| ERBIN | erbb2 interacting protein | -0.0361299 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0353645 |
| RBM25 | RNA binding motif protein 25 | -0.0344634 |
| MX2 | MX dynamin-like GTPase 2 | -0.0344014 |
| RPL37A | ribosomal protein L37a | -0.0339526 |
| RAD51B | RAD51 paralog B | -0.0323698 |
| RIGI | RNA sensor RIG-I | -0.0321382 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0320183 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0319768 |
| RPS10 | ribosomal protein S10 | -0.0319147 |
| MED13 | mediator complex subunit 13 | -0.0318206 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0315182 |
| LMNA | lamin A/C | -0.0313215 |
| RPS23 | ribosomal protein S23 | -0.0305857 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0304756 |
| RPLP2 | ribosomal protein, large, P2 | -0.0303586 |
| TBCA | tubulin folding cofactor A | -0.0299752 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0298898 |
| CTBP2 | C-terminal binding protein 2 | -0.0296086 |
| VEGFA | vascular endothelial growth factor A | -0.0294325 |
| EGR1 | early growth response 1 | -0.0288541 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.028569 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | -0.0285395 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0284306 |
| CAVIN1 | caveolae associated protein 1 | -0.0282808 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0282355 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0281947 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0277387 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0276937 |
| CTSD | cathepsin D | -0.0275444 |
| ZNF207 | zinc finger protein 207 | -0.0272678 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0272154 |
| PLEC | plectin | -0.0271894 |
| NABP1 | nucleic acid binding protein 1 | -0.0264861 |
| RPS24 | ribosomal protein S24 | -0.0264515 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0261746 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | -0.026125 |
| PGBD5 | piggyBac transposable element derived 5 | -0.0261225 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0257218 |
| DST | dystonin | -0.0256977 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0253266 |
| PDXK | pyridoxal (pyridoxine, vitamin B6) kinase | -0.0252573 |
| SP100 | SP100 nuclear antigen | -0.025233 |
| FNBP4 | formin binding protein 4 | -0.0250857 |
| ZNF609 | zinc finger protein 609 | -0.0250267 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0248551 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | -0.0247514 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | -0.0247373 |
| RPS3 | ribosomal protein S3 | -0.024651 |
| AEBP2 | AE binding protein 2 | -0.0245876 |
| GOLGB1 | golgin B1 | -0.0244924 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0243977 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0241457 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | -0.024096 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0240055 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.023997 |
| RPS21 | ribosomal protein S21 | -0.0239838 |
| G0S2 | G0/G1 switch 2 | -0.0238684 |
| ATXN1 | ataxin 1 | -0.0236868 |
| HLA-E | major histocompatibility complex, class I, E | -0.0235678 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0235512 |
| BPTF | bromodomain PHD finger transcription factor | -0.0235429 |
| RPL28 | ribosomal protein L28 | -0.023542 |
| RPS25 | ribosomal protein S25 | -0.0231967 |
