| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Talc perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Talc_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0997537 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0873881 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0718239 |
| PGK1 | phosphoglycerate kinase 1 | 0.0581833 |
| EFNA5 | ephrin-A5 | 0.053911 |
| RGS2 | regulator of G-protein signaling 2 | 0.0519616 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0510105 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0471879 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0464843 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.044921 |
| PCBP3 | poly(rC) binding protein 3 | 0.0438222 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0437544 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0409956 |
| NEK7 | NIMA-related kinase 7 | 0.0406555 |
| FAM13A | family with sequence similarity 13, member A | 0.0404963 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0395474 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0388407 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0384008 |
| NCKAP1 | NCK-associated protein 1 | 0.0379512 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0342694 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0334397 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0330975 |
| RAB3B | RAB3B, member RAS oncogene family | 0.0330011 |
| SRGN | serglycin | 0.0320835 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0317553 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0315034 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0314924 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0310633 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0307605 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0304221 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0290761 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0271596 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0268064 |
| ENO1 | enolase 1, (alpha) | 0.0257981 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.025683 |
| ATP13A3 | ATPase type 13A3 | 0.0256823 |
| RAI1 | retinoic acid induced 1 | 0.0256794 |
| ECT2 | epithelial cell transforming 2 | 0.025469 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0252329 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0252236 |
| SEPTIN10 | septin 10 | 0.024763 |
| OGA | O-GlcNAcase | 0.0246118 |
| MKI67 | marker of proliferation Ki-67 | 0.0237888 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.0237199 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0232494 |
| RPL4 | ribosomal protein L4 | 0.02272 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0225789 |
| RO60 | Ro60, Y RNA binding protein | 0.0224822 |
| TBXT | T-box transcription factor T | 0.0217915 |
| USP3 | ubiquitin specific peptidase 3 | 0.0217571 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0212735 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0211571 |
| SRP9 | signal recognition particle 9kDa | 0.0210533 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0208693 |
| SFXN1 | sideroflexin 1 | 0.020536 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.020203 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0201698 |
| KIAA1958 | KIAA1958 | 0.0200392 |
| NGLY1 | N-glycanase 1 | 0.0199573 |
| H1-4 | H1.4 linker histone, cluster member | 0.019698 |
| RPL6 | ribosomal protein L6 | 0.0193909 |
| STC1 | stanniocalcin 1 | 0.0192076 |
| TMEM263 | transmembrane protein 263 | 0.0187279 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0186563 |
| TM9SF2 | transmembrane 9 superfamily member 2 | 0.0182919 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0181851 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0181035 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0180059 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0179791 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0179166 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0178811 |
| RPL3 | ribosomal protein L3 | 0.0176585 |
| SUB1 | SUB1 homolog (S. cerevisiae) | 0.017212 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0170694 |
| MLKL | mixed lineage kinase domain-like | 0.0168666 |
| TIAL1 | TIA1 cytotoxic granule-associated RNA binding protein-like 1 | 0.0168341 |
| CLDN1 | claudin 1 | 0.0168284 |
| CTSC | cathepsin C | 0.0166911 |
| ZFR | zinc finger RNA binding protein | 0.0164728 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | 0.0162197 |
| FMNL2 | formin-like 2 | 0.0161477 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0161405 |
| TNPO1 | transportin 1 | 0.0160418 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0159748 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0157851 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0156726 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0155898 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0155864 |
| AFDN | afadin, adherens junction formation factor | 0.0154811 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | 0.015459 |
| IL1RAP | interleukin 1 receptor accessory protein | 0.0152972 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.015275 |
| SLC16A6 | solute carrier family 16, member 6 | 0.0152381 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.015093 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0146553 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0146147 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0145688 |
| KLF6 | Kruppel-like factor 6 | 0.014528 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0144498 |
| CORO1C | coronin, actin binding protein, 1C | 0.0143809 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.268835 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.258526 |
| FN1 | fibronectin 1 | -0.129588 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.116597 |
| VIM | vimentin | -0.106113 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0852108 |
| RPS6 | ribosomal protein S6 | -0.0850917 |
| TMSB10 | thymosin beta 10 | -0.0836173 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0835061 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0807238 |
| RPLP1 | ribosomal protein, large, P1 | -0.0806716 |
| RPL35A | ribosomal protein L35a | -0.0792134 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0707412 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0643699 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.06032 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.060308 |
| PKM | pyruvate kinase, muscle | -0.0589028 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0569907 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0565768 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0564597 |
| S100A6 | S100 calcium binding protein A6 | -0.0554505 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0541109 |
| EGR1 | early growth response 1 | -0.0539936 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.053923 |
| COL5A2 | collagen, type V, alpha 2 | -0.0537884 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0536421 |
| RPS24 | ribosomal protein S24 | -0.0532979 |
| CALR | calreticulin | -0.0528195 |
| RPL23 | ribosomal protein L23 | -0.0522956 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0514891 |
| FTL | ferritin, light polypeptide | -0.0514864 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0514484 |
| MCL1 | myeloid cell leukemia 1 | -0.0508743 |
| PDE10A | phosphodiesterase 10A | -0.0502244 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0470973 |
| LDHA | lactate dehydrogenase A | -0.0464246 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0453642 |
| RPLP0 | ribosomal protein, large, P0 | -0.0443584 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | -0.0439726 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0438845 |
| NDRG1 | N-myc downstream regulated 1 | -0.0435424 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0428234 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0426495 |
| RPS19 | ribosomal protein S19 | -0.0422939 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0418785 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.041477 |
| UBC | ubiquitin C | -0.0413485 |
| RPS4X | ribosomal protein S4, X-linked | -0.0400327 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0399335 |
| POTEF | POTE ankyrin domain family, member F | -0.0393726 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0387264 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0386808 |
| RPS23 | ribosomal protein S23 | -0.0384377 |
| RPL28 | ribosomal protein L28 | -0.0380722 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0373381 |
| RPS8 | ribosomal protein S8 | -0.0365388 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0365156 |
| RPL39 | ribosomal protein L39 | -0.0363523 |
| ZNF207 | zinc finger protein 207 | -0.0361581 |
| RTN1 | reticulon 1 | -0.0360132 |
| YBX1 | Y box binding protein 1 | -0.0356316 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0355974 |
| PCBP2 | poly(rC) binding protein 2 | -0.0355259 |
| RPL9 | ribosomal protein L9 | -0.0350339 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0347947 |
| RPLP2 | ribosomal protein, large, P2 | -0.0345814 |
| RPS21 | ribosomal protein S21 | -0.0345305 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0344037 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0342005 |
| LAMA5 | laminin, alpha 5 | -0.033969 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0338933 |
| HLA-B | major histocompatibility complex, class I, B | -0.0336339 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0334413 |
| GLRX | glutaredoxin (thioltransferase) | -0.0330481 |
| RPL34 | ribosomal protein L34 | -0.03278 |
| TXNRD1 | thioredoxin reductase 1 | -0.0327431 |
| RPL31 | ribosomal protein L31 | -0.0322724 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0319529 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0318616 |
| RPS16 | ribosomal protein S16 | -0.0317577 |
| RPS28 | ribosomal protein S28 | -0.0317438 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0315836 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0315703 |
| GRB10 | growth factor receptor-bound protein 10 | -0.030899 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0304946 |
| RPL27A | ribosomal protein L27a | -0.0300433 |
| RPL11 | ribosomal protein L11 | -0.0296186 |
| RPL38 | ribosomal protein L38 | -0.0296083 |
| PFN1 | profilin 1 | -0.0295727 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0294381 |
| RPS14 | ribosomal protein S14 | -0.0291438 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0289706 |
| EXT1 | exostosin glycosyltransferase 1 | -0.028624 |
| GNAS | GNAS complex locus | -0.0282668 |
| TOB1 | transducer of ERBB2, 1 | -0.0280972 |
| RPS20 | ribosomal protein S20 | -0.0280958 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0276694 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0276148 |
| S100A10 | S100 calcium binding protein A10 | -0.0273419 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0273124 |
