Talc_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Talc perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Talc_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0655317
RPL3 ribosomal protein L3 0.0441775
CAMTA1 calmodulin binding transcription activator 1 0.0433895
RPS2 ribosomal protein S2 0.0427289
ANKRD12 ankyrin repeat domain 12 0.0406803
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0390501
CENPF centromere protein F, 350/400kDa 0.0370465
PRELID2 PRELI domain containing 2 0.0366743
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0360507
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0342892
GOLGA4 golgin A4 0.0335539
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0330779
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0325191
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.030734
SDK1 sidekick cell adhesion molecule 1 0.0303584
ZNF292 zinc finger protein 292 0.0293906
KTN1 kinectin 1 (kinesin receptor) 0.0290165
SOX6 SRY (sex determining region Y)-box 6 0.0286358
ANKRD36 ankyrin repeat domain 36 0.0285189
MKI67 marker of proliferation Ki-67 0.0279522
TMF1 TATA element modulatory factor 1 0.0260503
KDM4C lysine (K)-specific demethylase 4C 0.0257475
HELZ helicase with zinc finger 0.0255168
NAV2 neuron navigator 2 0.0247199
UBA6 ubiquitin-like modifier activating enzyme 6 0.0246579
TPD52 tumor protein D52 0.0245719
ZNF608 zinc finger protein 608 0.0245607
ZNF451 zinc finger protein 451 0.0244513
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0244379
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0242037
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0239432
CKAP5 cytoskeleton associated protein 5 0.0232365
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0226956
FAM13A family with sequence similarity 13, member A 0.0223724
BRD2 bromodomain containing 2 0.0222919
CABIN1 calcineurin binding protein 1 0.0220872
H1-4 H1.4 linker histone, cluster member 0.0219108
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0216942
PCBP2 poly(rC) binding protein 2 0.0216317
CSF1 colony stimulating factor 1 (macrophage) 0.0215114
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0209019
SRP54 signal recognition particle 54kDa 0.0203577
HILPDA hypoxia inducible lipid droplet-associated 0.0202471
ENO2 enolase 2 (gamma, neuronal) 0.0201549
SBF2 SET binding factor 2 0.0200775
INSIG2 insulin induced gene 2 0.0199622
MXI1 MAX interactor 1, dimerization protein 0.0198196
NBEAL1 neurobeachin-like 1 0.019677
EZR ezrin 0.019664
KIF5C kinesin family member 5C 0.0195224
NAMPT nicotinamide phosphoribosyltransferase 0.0191163
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0191042
GLS2 glutaminase 2 (liver, mitochondrial) 0.0190716
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0183754
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0182504
XPO1 exportin 1 0.0182427
ASPH aspartate beta-hydroxylase 0.0180577
DENND5A DENN/MADD domain containing 5A 0.0179118
TENT4A terminal nucleotidyltransferase 4A 0.0178461
RRM2 ribonucleotide reductase M2 0.0178215
RFC3 replication factor C (activator 1) 3, 38kDa 0.0178115
RPL21 ribosomal protein L21 0.0177268
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0177238
HJURP Holliday junction recognition protein 0.0177068
CENPE centromere protein E, 312kDa 0.0177061
APLP2 amyloid beta (A4) precursor-like protein 2 0.017313
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0173112
SMC4 structural maintenance of chromosomes 4 0.0172972
KDM6A lysine (K)-specific demethylase 6A 0.0170477
RNF24 ring finger protein 24 0.0169897
RPS12 ribosomal protein S12 0.0165973
TBC1D22A TBC1 domain family, member 22A 0.0165683
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0163602
RCOR1 REST corepressor 1 0.0163441
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0162132
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa 0.0161868
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0160321
ERRFI1 ERBB receptor feedback inhibitor 1 0.0160154
NDRG1 N-myc downstream regulated 1 0.0160013
NUP58 nucleoporin 58 0.0159866
TMEM14B transmembrane protein 14B 0.0159603
LMCD1 LIM and cysteine-rich domains 1 0.015897
QKI QKI, KH domain containing, RNA binding 0.0158672
YAP1 Yes-associated protein 1 0.0158171
PEX3 peroxisomal biogenesis factor 3 0.0157656
AKAP9 A kinase (PRKA) anchor protein 9 0.0157405
MT2A metallothionein 2A 0.0156657
ANXA1 annexin A1 0.0156248
DIPK2A divergent protein kinase domain 2A 0.0155295
BCLAF1 BCL2-associated transcription factor 1 0.015519
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0155048
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0153556
DENND4A DENN/MADD domain containing 4A 0.0153302
TSC22D2 TSC22 domain family, member 2 0.0152042
FLNB filamin B, beta 0.015171
KIF13A kinesin family member 13A 0.0151376
ENO1 enolase 1, (alpha) 0.0150414
ADAM17 ADAM metallopeptidase domain 17 0.0149797
ESYT2 extended synaptotagmin-like protein 2 0.0148584
TPX2 TPX2, microtubule-associated 0.0148125

decreased expression

Symbol Name Standardized Value
VCL vinculin -0.159777
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.14442
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.135991
FOXP1 forkhead box P1 -0.114619
EGFR epidermal growth factor receptor -0.107194
PKM pyruvate kinase, muscle -0.0958216
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0942175
TMSB4X thymosin beta 4, X-linked -0.091898
AHNAK AHNAK nucleoprotein -0.0791478
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0785388
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.078274
LOC112694756 uncharaterized LOC112694756 -0.0732771
TPT1 tumor protein, translationally-controlled 1 -0.0718048
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0682014
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0671792
RPL35A ribosomal protein L35a -0.0640827
S100A6 S100 calcium binding protein A6 -0.0639788
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.055914
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0556017
EEF2 eukaryotic translation elongation factor 2 -0.0555211
NBEA neurobeachin -0.0541699
PTMA prothymosin, alpha -0.0528586
PDE4D phosphodiesterase 4D, cAMP-specific -0.0524452
LDHA lactate dehydrogenase A -0.0491987
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0490681
ZFAND3 zinc finger, AN1-type domain 3 -0.0490043
GLI3 GLI family zinc finger 3 -0.0465988
ACTG1 actin gamma 1 -0.04592
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0455665
ZMYND8 zinc finger, MYND-type containing 8 -0.0450839
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0450497
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0449582
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0441431
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0426892
DOCK3 dedicator of cytokinesis 3 -0.042664
HDLBP high density lipoprotein binding protein -0.0421825
RPS24 ribosomal protein S24 -0.040834
OSMR oncostatin M receptor -0.0407376
RIGI RNA sensor RIG-I -0.0406733
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0394917
NPAS2 neuronal PAS domain protein 2 -0.0391905
TXNRD1 thioredoxin reductase 1 -0.0385255
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -0.0380255
S100A4 S100 calcium binding protein A4 -0.0365927
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0361628
ZEB1 zinc finger E-box binding homeobox 1 -0.03575
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0341948
RTN4 reticulon 4 -0.0340963
HLA-B major histocompatibility complex, class I, B -0.0336727
SSBP2 single-stranded DNA binding protein 2 -0.0330923
RPL23 ribosomal protein L23 -0.0318527
SLC38A2 solute carrier family 38, member 2 -0.0317127
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0315684
TCF12 transcription factor 12 -0.0311568
ANK2 ankyrin 2, neuronal -0.0311493
DLG1 discs, large homolog 1 (Drosophila) -0.0309995
PARD3 par-3 family cell polarity regulator -0.0309973
PHF14 PHD finger protein 14 -0.0309508
KPNB1 karyopherin (importin) beta 1 -0.0304456
NF1 neurofibromin 1 -0.0300893
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0299126
RPL13A ribosomal protein L13a -0.0295381
RPLP1 ribosomal protein, large, P1 -0.0295207
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0290258
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 -0.0288242
PPP1R9A protein phosphatase 1, regulatory subunit 9A -0.0287487
IFI6 interferon, alpha-inducible protein 6 -0.0285716
MYO5C myosin VC -0.0282249
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0280034
ANKRD11 ankyrin repeat domain 11 -0.0279449
RPLP2 ribosomal protein, large, P2 -0.0277892
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0276622
LARP1 La ribonucleoprotein domain family, member 1 -0.0275997
TBCA tubulin folding cofactor A -0.0275744
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0275255
CALR calreticulin -0.0274728
ZNF438 zinc finger protein 438 -0.0273914
FHAD1 forkhead-associated (FHA) phosphopeptide binding domain 1 -0.0272406
RPLP0 ribosomal protein, large, P0 -0.0270209
ADAM10 ADAM metallopeptidase domain 10 -0.0270121
TRERF1 transcriptional regulating factor 1 -0.0265926
RPS23 ribosomal protein S23 -0.0264538
RPL11 ribosomal protein L11 -0.0264082
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0261316
GARS1 glycyl-tRNA synthetase 1 -0.0258997
RHOA ras homolog family member A -0.0257161
CAMKMT calmodulin-lysine N-methyltransferase -0.0255741
ZBTB20 zinc finger and BTB domain containing 20 -0.0255139
ACACA acetyl-CoA carboxylase alpha -0.0254779
ADNP activity-dependent neuroprotector homeobox -0.0252904
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -0.0247569
LOXL3 lysyl oxidase-like 3 -0.0246733
RPL34 ribosomal protein L34 -0.0245869
RPS21 ribosomal protein S21 -0.0245288
PTPRG protein tyrosine phosphatase, receptor type, G -0.0245235
RPL27A ribosomal protein L27a -0.0243839
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0243429
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.024121
RPS6 ribosomal protein S6 -0.0240204
ZNFX1 zinc finger, NFX1-type containing 1 -0.0237888