Tamibarotene Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
Description A tetralin that has formula C22H25NO3. (Chemical Entities of Biological Interest Ontology, CHEBI_32181)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/108143
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Genes

198 proteins with high or low expression in Tamibarotene relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
MYH7 myosin, heavy chain 7, cardiac muscle, beta 8.38
TTLL4 tubulin tyrosine ligase-like family member 4 1.37
MT1X metallothionein 1X 0.93
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.92
KLK6 kallikrein-related peptidase 6 0.79
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.77
CNTNAP4 contactin associated protein-like 4 0.71
PLXNA3 plexin A3 0.7
ENO3 enolase 3 (beta, muscle) 0.7
LTBP3 latent transforming growth factor beta binding protein 3 0.68
SIVA1 SIVA1, apoptosis-inducing factor 0.67
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.66
CBX3 chromobox homolog 3 0.64
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa 0.64
IGFBP6 insulin-like growth factor binding protein 6 0.64
PUDP pseudouridine 5'-phosphatase 0.61
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.55
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial 0.55
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 0.53
ANGPTL4 angiopoietin-like 4 0.52
COA5 cytochrome c oxidase assembly factor 5 0.52
CEP63 centrosomal protein 63kDa 0.52
TPM1 tropomyosin 1 (alpha) 0.51
GNPAT glyceronephosphate O-acyltransferase 0.51
SLC25A39 solute carrier family 25, member 39 0.5
MACC1 metastasis associated in colon cancer 1 0.5
SERF2 small EDRK-rich factor 2 0.5
HIST2H2AA3 histone cluster 2, H2aa3 0.49
H1-2 H1.2 linker histone, cluster member 0.47
RPS20 ribosomal protein S20 0.46
VSIR V-set immunoregulatory receptor 0.46
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.46
SMAD3 SMAD family member 3 0.45
SIRAL1 SIR2 antiphage like 1 0.45
HAS3 hyaluronan synthase 3 0.44
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.44
IL6ST interleukin 6 signal transducer 0.44
H1-4 H1.4 linker histone, cluster member 0.43
MDK midkine (neurite growth-promoting factor 2) 0.43
ENO1 enolase 1, (alpha) 0.43
AKAP6 A kinase (PRKA) anchor protein 6 0.43
PRELID3B PRELI domain containing 3B 0.42
PKLR pyruvate kinase, liver and RBC 0.42
C19ORF25 chromosome 19 open reading frame 25 0.42
ITFG2 integrin alpha FG-GAP repeat containing 2 0.41
DUSP5 dual specificity phosphatase 5 0.4
GLI4 GLI family zinc finger 4 0.4
IL17RB interleukin 17 receptor B 0.4
MAGEF1 melanoma antigen family F1 0.4
MINDY2 MINDY lysine 48 deubiquitinase 2 0.39
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.39
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.38
ZNF724 zinc finger protein 724 0.38
WSB1 WD repeat and SOCS box containing 1 0.38
FOXC1 forkhead box C1 0.38
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.37
PTGES prostaglandin E synthase 0.37
LARP6 La ribonucleoprotein domain family, member 6 0.37
AP1S2 adaptor-related protein complex 1, sigma 2 subunit 0.37
TIAM1 T-cell lymphoma invasion and metastasis 1 0.37
TMEM131L transmembrane 131 like 0.37
PMF1 polyamine-modulated factor 1 0.37
SKIL SKI-like proto-oncogene 0.37
ZNF16 zinc finger protein 16 0.36
CCDC28A coiled-coil domain containing 28A 0.36
DNAH6 dynein, axonemal, heavy chain 6 0.36
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.35
SMAD1 SMAD family member 1 0.35
WNT10B wingless-type MMTV integration site family, member 10B 0.35
LIPH lipase, member H 0.35
FADD Fas (TNFRSF6)-associated via death domain 0.34
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.34
LTBP1 latent transforming growth factor beta binding protein 1 0.34
PSEN2 presenilin 2 0.34
RPL34 ribosomal protein L34 0.34
TMEM14C transmembrane protein 14C 0.34
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 0.33
TJAP1 tight junction associated protein 1 (peripheral) 0.33
LINGO1 leucine rich repeat and Ig domain containing 1 0.33
ACTB actin, beta 0.33
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 0.33
CARD10 caspase recruitment domain family, member 10 0.33
C1ORF131 chromosome 1 open reading frame 131 0.33
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa 0.32
ADAM19 ADAM metallopeptidase domain 19 0.32
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B 0.31
SNX25 sorting nexin 25 0.31
RPL28 ribosomal protein L28 0.31
PLEKHA7 pleckstrin homology domain containing, family A member 7 0.31
ISCA2 iron-sulfur cluster assembly 2 0.31
ATP9A ATPase, class II, type 9A 0.3
HOXB9 homeobox B9 0.3
RGN regucalcin 0.3
RPS9 ribosomal protein S9 0.3
KDM3A lysine (K)-specific demethylase 3A 0.3
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) 0.3
EHF ets homologous factor 0.29
AGFG2 ArfGAP with FG repeats 2 0.29

low expression

Symbol Name Standardized Value
TAZ tafazzin -2.11
AZGP1 alpha-2-glycoprotein 1, zinc-binding -1.47
SYN2 synapsin II -1.38
HRH1 histamine receptor H1 -1.01
DNAH12 dynein, axonemal, heavy chain 12 -0.91
PHACTR2 phosphatase and actin regulator 2 -0.74
DEDD2 death effector domain containing 2 -0.68
CRABP2 cellular retinoic acid binding protein 2 -0.67
C1ORF50 chromosome 1 open reading frame 50 -0.59
MOSPD3 motile sperm domain containing 3 -0.59
ALPK3 alpha-kinase 3 -0.58
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.55
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 -0.53
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.52
USP27X ubiquitin specific peptidase 27, X-linked -0.51
MCL1 myeloid cell leukemia 1 -0.51
PIP prolactin-induced protein -0.49
MPV17L2 MPV17 mitochondrial membrane protein-like 2 -0.48
NLRP1 NLR family, pyrin domain containing 1 -0.47
AXL AXL receptor tyrosine kinase -0.46
FTL ferritin, light polypeptide -0.45
SH3TC2 SH3 domain and tetratricopeptide repeats 2 -0.44
FBXO31 F-box protein 31 -0.43
GPATCH3 G patch domain containing 3 -0.43
ZNF561 zinc finger protein 561 -0.43
PLEKHA6 pleckstrin homology domain containing, family A member 6 -0.41
GAS6 growth arrest-specific 6 -0.41
DNAH8 dynein, axonemal, heavy chain 8 -0.4
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C -0.4
PTPN21 protein tyrosine phosphatase, non-receptor type 21 -0.4
ALDH1L2 aldehyde dehydrogenase 1 family, member L2 -0.4
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic -0.39
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa -0.39
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.39
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) -0.39
SARDH sarcosine dehydrogenase -0.38
DOLPP1 dolichyldiphosphatase 1 -0.38
IRAK2 interleukin-1 receptor-associated kinase 2 -0.38
IGSF8 immunoglobulin superfamily, member 8 -0.38
SYNPO synaptopodin -0.38
FTH1 ferritin, heavy polypeptide 1 -0.37
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 -0.37
RASA4 RAS p21 protein activator 4 -0.37
ZNF646 zinc finger protein 646 -0.36
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 -0.36
VAMP8 vesicle-associated membrane protein 8 -0.36
NT5E 5'-nucleotidase, ecto (CD73) -0.35
IFITM3 interferon induced transmembrane protein 3 -0.35
SLC38A2 solute carrier family 38, member 2 -0.35
KIFC3 kinesin family member C3 -0.35
PTBP1 polypyrimidine tract binding protein 1 -0.34
PBX3 pre-B-cell leukemia homeobox 3 -0.34
CCDC66 coiled-coil domain containing 66 -0.33
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) -0.33
PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 -0.33
NABP2 nucleic acid binding protein 2 -0.33
SETD5 SET domain containing 5 -0.33
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.33
BORCS6 BLOC-1 related complex subunit 6 -0.32
HEBP2 heme binding protein 2 -0.32
RPGR retinitis pigmentosa GTPase regulator -0.31
NMNAT3 nicotinamide nucleotide adenylyltransferase 3 -0.31
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.31
WWC2 WW and C2 domain containing 2 -0.3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F -0.3
MED28 mediator complex subunit 28 -0.3
SAYSD1 SAYSVFN motif domain containing 1 -0.3
PHF1 PHD finger protein 1 -0.3
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 -0.3
FAM219A family with sequence similarity 219, member A -0.3
LAMB3 laminin, beta 3 -0.3
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 -0.3
HBA1 hemoglobin, alpha 1 -0.3
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 -0.29
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) -0.29
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 -0.29
PRDM4 PR domain containing 4 -0.29
XTBD1 XRN2 binding domain containing 1 -0.29
VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae) -0.28
TNS2 tensin 2 -0.28
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 -0.28
ACSM3 acyl-CoA synthetase medium-chain family member 3 -0.28
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.28
BMP4 bone morphogenetic protein 4 -0.28
TGFB1 transforming growth factor, beta 1 -0.28
RAB6D RAB6D, member RAS oncogene family -0.27
SCARB2 scavenger receptor class B, member 2 -0.27
MARCKS myristoylated alanine-rich protein kinase C substrate -0.27
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.26
DMAC2L distal membrane arm assembly component 2 like -0.26
NR2F2 nuclear receptor subfamily 2, group F, member 2 -0.26
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 -0.26
S100A14 S100 calcium binding protein A14 -0.26
GPATCH2 G patch domain containing 2 -0.26
DUSP4 dual specificity phosphatase 4 -0.26
NEB nebulin -0.26
ANKRD10 ankyrin repeat domain 10 -0.26
TBC1D13 TBC1 domain family, member 13 -0.26
RABAC1 Rab acceptor 1 (prenylated) -0.26
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.26