Tamoxifen Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A stilbenoid that has formula C26H29NO. (Chemical Entities of Biological Interest Ontology, CHEBI_41774)
External Link http://ctdbase.org/detail.go?type=chem&acc=D013629
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Genes

297 genes/proteins interacting with the chemical Tamoxifen from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADD3 adducin 3 (gamma)
AGR2 anterior gradient 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
ALOX5 arachidonate 5-lipoxygenase
APCS amyloid P component, serum
APOE apolipoprotein E
AQP9 aquaporin 9
AR androgen receptor
ARTN artemin
ATF2 activating transcription factor 2
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5
BAD BCL2-associated agonist of cell death
BAG1 BCL2-associated athanogene
BAX BCL2-associated X protein
BCAR1 breast cancer anti-estrogen resistance 1
BCAR3 breast cancer anti-estrogen resistance 3
BCAR4 breast cancer anti-estrogen resistance 4 (non-protein coding)
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BID BH3 interacting domain death agonist
BIK BCL2-interacting killer (apoptosis-inducing)
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
C3 complement component 3
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CARM1 coactivator-associated arginine methyltransferase 1
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCND1 cyclin D1
CCNE1 cyclin E1
CD36 CD36 molecule (thrombospondin receptor)
CDC25B cell division cycle 25B
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFLAR CASP8 and FADD-like apoptosis regulator
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal)
CHUK conserved helix-loop-helix ubiquitous kinase
CKB creatine kinase, brain
CNOT1 CCR4-NOT transcription complex, subunit 1
COMT catechol-O-methyltransferase
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYCS cytochrome c, somatic
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A cytochrome P450, family 3, subfamily A
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DEK DEK proto-oncogene
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30
DMBT1 deleted in malignant brain tumors 1
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
E2F1 E2F transcription factor 1
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EP300 E1A binding protein p300
EPOR erythropoietin receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERCC2 excision repair cross-complementation group 2
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
ESRRA estrogen-related receptor alpha
ESRRG estrogen-related receptor gamma
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F2 coagulation factor II (thrombin)
F8 coagulation factor VIII, procoagulant component
F9 coagulation factor IX
FADD Fas (TNFRSF6)-associated via death domain
FASLG Fas ligand (TNF superfamily, member 6)
FGF2 fibroblast growth factor 2 (basic)
FGFR1 fibroblast growth factor receptor 1
FKBPL FK506 binding protein like
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXA1 forkhead box A1
FOXL2 forkhead box L2
FOXM1 forkhead box M1
FSHB follicle stimulating hormone, beta polypeptide
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
GFAP glial fibrillary acidic protein
GH1 growth hormone 1
GJB1 gap junction protein, beta 1, 32kDa
GLUD1 glutamate dehydrogenase 1
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GPER1 G protein-coupled estrogen receptor 1
GPS2 G protein pathway suppressor 2
GRB7 growth factor receptor-bound protein 7
GSK3B glycogen synthase kinase 3 beta
GSTA1 glutathione S-transferase alpha 1
GSTA2 glutathione S-transferase alpha 2
GSTA3 glutathione S-transferase alpha 3
GSTP1 glutathione S-transferase pi 1
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
H19 H19, imprinted maternally expressed transcript (non-protein coding)
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC4 histone deacetylase 4
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H')
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9)
HRG histidine-rich glycoprotein
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL1B interleukin 1, beta
IL4 interleukin 4
IL6 interleukin 6
ILK integrin-linked kinase
JUN jun proto-oncogene
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KLRC3 killer cell lectin-like receptor subfamily C, member 3
LHB luteinizing hormone beta polypeptide
LIF leukemia inhibitory factor
LIPC lipase, hepatic
LPL lipoprotein lipase
LTF lactotransferrin
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK12 mitogen-activated protein kinase 12
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MAPT microtubule-associated protein tau
MBP myelin basic protein
MCL1 myeloid cell leukemia 1
MCM6 minichromosome maintenance complex component 6
MEN1 multiple endocrine neoplasia I
MGMT O-6-methylguanine-DNA methyltransferase
MKI67 marker of proliferation Ki-67
MMP1 matrix metallopeptidase 1
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC1 mucin 1, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH10 myosin, heavy chain 10, non-muscle
MYO5A myosin VA (heavy chain 12, myoxin)
NANS N-acetylneuraminic acid synthase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NCOA1 nuclear receptor coactivator 1
NCOA2 nuclear receptor coactivator 2
NCOA3 nuclear receptor coactivator 3
NCOA6 nuclear receptor coactivator 6
NCOR1 nuclear receptor corepressor 1
NCOR2 nuclear receptor corepressor 2
NELFB negative elongation factor complex member B
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NOA1 nitric oxide associated 1
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOTCH1 notch 1
NR0B1 nuclear receptor subfamily 0, group B, member 1
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR5A1 nuclear receptor subfamily 5, group A, member 1
NRIP1 nuclear receptor interacting protein 1
OXCT1 3-oxoacid CoA transferase 1
OXTR oxytocin receptor
PA2G4 proliferation-associated 2G4, 38kDa
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
PELP1 proline, glutamate and leucine rich protein 1
PGR progesterone receptor
PHB2 prohibitin 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLG plasminogen
PLK1 polo-like kinase 1
POLB polymerase (DNA directed), beta
POU5F1 POU class 5 homeobox 1
PPARA peroxisome proliferator-activated receptor alpha
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPIA peptidylprolyl isomerase A (cyclophilin A)
PRAME preferentially expressed antigen in melanoma
PRF1 perforin 1 (pore forming protein)
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRL prolactin
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PROS1 protein S (alpha)
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTH parathyroid hormone
PTHLH parathyroid hormone-like hormone
PTPRO protein tyrosine phosphatase, receptor type, O
RAD51 RAD51 recombinase
RB1 retinoblastoma 1
RBL1 retinoblastoma-like 1
RBL2 retinoblastoma-like 2
RBM17 RNA binding motif protein 17
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RORA RAR-related orphan receptor A
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
SFPQ splicing factor proline/glutamine-rich
SHBG sex hormone-binding globulin
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SNAI1 snail family zinc finger 1
SNCG synuclein, gamma (breast cancer-specific protein 1)
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SP1 Sp1 transcription factor
SP3 Sp3 transcription factor
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SST somatostatin
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
TBX21 T-box 21
TERT telomerase reverse transcriptase
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFB1 transforming growth factor, beta 1
TLE3 transducin-like enhancer of split 3
TNF tumor necrosis factor
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TRRAP transformation/transcription domain-associated protein
TXNRD1 thioredoxin reductase 1
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VWF von Willebrand factor
WT1 Wilms tumor 1
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6