Tandutinib Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/3038522
Similar Terms
Downloads & Tools

Genes

200 proteins with high or low expression in Tandutinib relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
PAH phenylalanine hydroxylase 1.88
APOB apolipoprotein B 1.77
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.5
NCOA4 nuclear receptor coactivator 4 1.47
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.45
FDFT1 farnesyl-diphosphate farnesyltransferase 1 1.43
CLK1 CDC-like kinase 1 1.23
TSPAN3 tetraspanin 3 1.23
NDFIP1 Nedd4 family interacting protein 1 1.21
SQLE squalene epoxidase 1.19
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 1.13
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 1.1
IDI1 isopentenyl-diphosphate delta isomerase 1 1.09
MSMO1 methylsterol monooxygenase 1 1.08
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.08
NBR1 neighbor of BRCA1 gene 1 1.07
TMEM59 transmembrane protein 59 1.06
KLHL23 kelch-like family member 23 0.93
SLC49A4 solute carrier family 49 member 4 0.92
CD63 CD63 molecule 0.9
NDFIP2 Nedd4 family interacting protein 2 0.9
FADS1 fatty acid desaturase 1 0.88
IFITM3 interferon induced transmembrane protein 3 0.87
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 0.84
SLC38A2 solute carrier family 38, member 2 0.82
LAPTM4A lysosomal protein transmembrane 4 alpha 0.81
STARD4 StAR-related lipid transfer (START) domain containing 4 0.78
RTN4R reticulon 4 receptor 0.75
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 0.73
DHCR7 7-dehydrocholesterol reductase 0.73
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 0.71
CLK4 CDC-like kinase 4 0.71
ACSS2 acyl-CoA synthetase short-chain family member 2 0.7
DHCR24 24-dehydrocholesterol reductase 0.69
LDLR low density lipoprotein receptor 0.69
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2 0.67
CALCOCO2 calcium binding and coiled-coil domain 2 0.67
ACAT2 acetyl-CoA acetyltransferase 2 0.67
FGFBP1 fibroblast growth factor binding protein 1 0.67
TP53RK TP53 regulating kinase 0.66
GINM1 glycoprotein integral membrane 1 0.64
ANKLE1 ankyrin repeat and LEM domain containing 1 0.63
SC5D sterol-C5-desaturase 0.61
PTPRD protein tyrosine phosphatase, receptor type, D 0.59
MVD mevalonate (diphospho) decarboxylase 0.59
MVK mevalonate kinase 0.59
MSANTD4 Myb/SANT-like DNA-binding domain containing 4 with coiled-coils 0.59
ABHD2 abhydrolase domain containing 2 0.58
LARP6 La ribonucleoprotein domain family, member 6 0.56
RNF149 ring finger protein 149 0.56
LPIN1 lipin 1 0.55
ITM2B integral membrane protein 2B 0.54
APOE apolipoprotein E 0.53
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.53
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.53
BORCS6 BLOC-1 related complex subunit 6 0.53
ANKRD10 ankyrin repeat domain 10 0.52
BMERB1 bMERB domain containing 1 0.52
SREBF2 sterol regulatory element binding transcription factor 2 0.52
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.5
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.5
ITM2C integral membrane protein 2C 0.5
RNF19B ring finger protein 19B 0.49
MID1IP1 MID1 interacting protein 1 0.49
RNF126 ring finger protein 126 0.49
FTH1 ferritin, heavy polypeptide 1 0.49
HIST2H2AA3 histone cluster 2, H2aa3 0.49
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.49
SCARB1 scavenger receptor class B, member 1 0.48
PLPP2 phospholipid phosphatase 2 0.48
EFR3A EFR3 homolog A (S. cerevisiae) 0.47
MEGF9 multiple EGF-like-domains 9 0.47
SQSTM1 sequestosome 1 0.46
SPAG17 sperm associated antigen 17 0.46
PLIN2 perilipin 2 0.45
CLK3 CDC-like kinase 3 0.45
MICA MHC class I polypeptide-related sequence A 0.45
RBM18 RNA binding motif protein 18 0.45
FDPS farnesyl diphosphate synthase 0.44
SLC16A6 solute carrier family 16, member 6 0.44
FASN fatty acid synthase 0.43
ACVR1B activin A receptor, type IB 0.42
AZGP1 alpha-2-glycoprotein 1, zinc-binding 0.42
RNF167 ring finger protein 167 0.42
ALDOC aldolase C, fructose-bisphosphate 0.41
IFNGR1 interferon gamma receptor 1 0.41
SGTB small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta 0.41
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.41
ATF3 activating transcription factor 3 0.41
ZBED8 zinc finger, BED-type containing 8 0.4
BAIAP3 BAI1-associated protein 3 0.4
PEG10 paternally expressed 10 0.4
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.4
TNIP2 TNFAIP3 interacting protein 2 0.4
ACACB acetyl-CoA carboxylase beta 0.4
IL10RB interleukin 10 receptor, beta 0.4
ACTL8 actin-like 8 0.4
ERG28 ergosterol biosynthesis 28 homolog 0.39
ACACA acetyl-CoA carboxylase alpha 0.39
CUX1 cut-like homeobox 1 0.39

low expression

Symbol Name Standardized Value
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 -2.09
UNC93B1 unc-93 homolog B1 (C. elegans) -1.44
P3H2 prolyl 3-hydroxylase 2 -1.41
DAP death-associated protein -1.4
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -1.19
SCPEP1 serine carboxypeptidase 1 -0.92
RUBCN rubicon autophagy regulator -0.89
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 -0.74
ICA1L islet cell autoantigen 1,69kDa-like -0.69
GREB1 growth regulation by estrogen in breast cancer 1 -0.69
KMT2C lysine (K)-specific methyltransferase 2C -0.66
CDK10 cyclin-dependent kinase 10 -0.63
RANBP17 RAN binding protein 17 -0.6
TET3 tet methylcytosine dioxygenase 3 -0.59
THAP3 THAP domain containing, apoptosis associated protein 3 -0.57
BMP4 bone morphogenetic protein 4 -0.56
TREX1 three prime repair exonuclease 1 -0.55
ZNF814 zinc finger protein 814 -0.52
CILP2 cartilage intermediate layer protein 2 -0.52
NIPA2 non imprinted in Prader-Willi/Angelman syndrome 2 -0.5
TRIB1 tribbles pseudokinase 1 -0.5
C2CD3 C2 calcium-dependent domain containing 3 -0.5
CEMIP cell migration inducing protein, hyaluronan binding -0.46
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa -0.46
LAMA3 laminin, alpha 3 -0.45
ADM adrenomedullin -0.45
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 -0.45
NAAA N-acylethanolamine acid amidase -0.45
MT-CO1 cytochrome c oxidase subunit I -0.43
CENPJ centromere protein J -0.43
TCEA2 transcription elongation factor A (SII), 2 -0.43
PCSK6 proprotein convertase subtilisin/kexin type 6 -0.42
SYN1 synapsin I -0.42
PLEKHA8 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 -0.42
PPT1 palmitoyl-protein thioesterase 1 -0.41
ADIPOR1 adiponectin receptor 1 -0.41
MOCS2 molybdenum cofactor synthesis 2 -0.41
TRIM62 tripartite motif containing 62 -0.39
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.39
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 -0.39
IER3IP1 immediate early response 3 interacting protein 1 -0.39
GVINP1 GTPase, very large interferon inducible pseudogene 1 -0.39
B2M beta-2-microglobulin -0.39
CDK16 cyclin-dependent kinase 16 -0.37
CCDC14 coiled-coil domain containing 14 -0.37
MIB2 mindbomb E3 ubiquitin protein ligase 2 -0.37
LRFN1 leucine rich repeat and fibronectin type III domain containing 1 -0.36
ZCCHC10 zinc finger, CCHC domain containing 10 -0.35
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 -0.35
ALKBH5 AlkB family member 5, RNA demethylase -0.35
MCOLN3 mucolipin 3 -0.35
ONECUT3 one cut homeobox 3 -0.35
NUDT14 nudix (nucleoside diphosphate linked moiety X)-type motif 14 -0.35
GMCL2 germ cell-less 2, spermatogenesis associated -0.35
TRIM9 tripartite motif containing 9 -0.35
CEP152 centrosomal protein 152kDa -0.34
VEZT vezatin, adherens junctions transmembrane protein -0.34
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -0.34
VMP1 vacuole membrane protein 1 -0.34
ZNF367 zinc finger protein 367 -0.34
RTN4IP1 reticulon 4 interacting protein 1 -0.34
FUCA2 fucosidase, alpha-L- 2, plasma -0.33
FBXL14 F-box and leucine-rich repeat protein 14 -0.33
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.33
SERF2 small EDRK-rich factor 2 -0.32
ALKBH2 alkB, alkylation repair homolog 2 (E. coli) -0.32
CBARP CACN subunit beta associated regulatory protein -0.32
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor -0.31
GBA glucosidase, beta, acid -0.31
CCNQ cyclin Q -0.31
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.31
FAM219B family with sequence similarity 219, member B -0.31
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 -0.31
ASPHD2 aspartate beta-hydroxylase domain containing 2 -0.3
IVNS1ABP influenza virus NS1A binding protein -0.3
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) -0.3
EXD2 exonuclease 3'-5' domain containing 2 -0.3
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.3
RPL36A ribosomal protein L36a -0.3
IFRD1 interferon-related developmental regulator 1 -0.3
DENND5B DENN/MADD domain containing 5B -0.3
MARCKS myristoylated alanine-rich protein kinase C substrate -0.29
GRTP1 growth hormone regulated TBC protein 1 -0.29
CKM creatine kinase, muscle -0.29
ZKSCAN4 zinc finger with KRAB and SCAN domains 4 -0.29
SON SON DNA binding protein -0.29
BPGM 2,3-bisphosphoglycerate mutase -0.29
ODC1 ornithine decarboxylase 1 -0.28
TMEM109 transmembrane protein 109 -0.28
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.28
ONECUT2 one cut homeobox 2 -0.28
CREBZF CREB/ATF bZIP transcription factor -0.28
NF1 neurofibromin 1 -0.28
ZBED6 zinc finger, BED-type containing 6 -0.28
MRPL50 mitochondrial ribosomal protein L50 -0.28
FUCA1 fucosidase, alpha-L- 1, tissue -0.28
E2F8 E2F transcription factor 8 -0.28
CCDC32 coiled-coil domain containing 32 -0.28
BPTF bromodomain PHD finger transcription factor -0.27
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 -0.27