Tazarotene_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tazarotene perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tazarotene_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NHSL1 NHS-like 1 0.03411
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0329427
PCBP2 poly(rC) binding protein 2 0.0269949
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0262205
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0260712
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0257203
POTEF POTE ankyrin domain family, member F 0.024228
ITCH itchy E3 ubiquitin protein ligase 0.0241304
AREG amphiregulin 0.0237482
SMC3 structural maintenance of chromosomes 3 0.0236401
HMGA1 high mobility group AT-hook 1 0.0236138
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0232533
MBD5 methyl-CpG binding domain protein 5 0.0230722
FOXM1 forkhead box M1 0.0225166
RPS23 ribosomal protein S23 0.0219982
AKAP13 A kinase (PRKA) anchor protein 13 0.0218941
ATP5F1B ATP synthase F1 subunit beta 0.0218937
KDM4C lysine (K)-specific demethylase 4C 0.0210182
HMGA2 high mobility group AT-hook 2 0.020848
VMP1 vacuole membrane protein 1 0.0206873
HDGF hepatoma-derived growth factor 0.0205172
TUBA1B tubulin, alpha 1b 0.0202615
CPOX coproporphyrinogen oxidase 0.0191614
PRELID2 PRELI domain containing 2 0.0189546
EEF1G eukaryotic translation elongation factor 1 gamma 0.0188303
RRM2 ribonucleotide reductase M2 0.0184691
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0183528
LDHB lactate dehydrogenase B 0.0180159
FOSL1 FOS-like antigen 1 0.0178636
KDM2A lysine (K)-specific demethylase 2A 0.0178045
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.0173633
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0170765
RPS26 ribosomal protein S26 0.0168461
RPL21 ribosomal protein L21 0.016464
SESN2 sestrin 2 0.0162767
TBK1 TANK-binding kinase 1 0.0162643
MSN moesin 0.0160895
SDK1 sidekick cell adhesion molecule 1 0.0158193
ADAR adenosine deaminase, RNA-specific 0.0158132
RPS29 ribosomal protein S29 0.0155046
MACF1 microtubule-actin crosslinking factor 1 0.0151732
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0149917
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.014869
ASPH aspartate beta-hydroxylase 0.0146259
TENT4A terminal nucleotidyltransferase 4A 0.0144632
SSRP1 structure specific recognition protein 1 0.0144127
ADAM17 ADAM metallopeptidase domain 17 0.0142859
BABAM2 BRISC and BRCA1 A complex member 2 0.0142744
UBA6 ubiquitin-like modifier activating enzyme 6 0.0142717
PNISR PNN-interacting serine/arginine-rich protein 0.0142052
TPM3 tropomyosin 3 0.0141641
RPL9 ribosomal protein L9 0.0141389
TTLL3 tubulin tyrosine ligase-like family member 3 0.0139794
ZNF148 zinc finger protein 148 0.0138578
RPS17 ribosomal protein S17 0.013838
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0137846
CLDND1 claudin domain containing 1 0.0137545
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0137451
ZNF652 zinc finger protein 652 0.0137057
NFIA nuclear factor I/A 0.0136872
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0135706
MCL1 myeloid cell leukemia 1 0.0135441
CAMKMT calmodulin-lysine N-methyltransferase 0.0135137
KMT2D lysine (K)-specific methyltransferase 2D 0.0133136
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0132816
MRPL3 mitochondrial ribosomal protein L3 0.0129426
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0129132
TAPBP TAP binding protein (tapasin) 0.0127817
RAD52 RAD52 homolog (S. cerevisiae) 0.0127456
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0126549
EGR1 early growth response 1 0.0126025
DENND5A DENN/MADD domain containing 5A 0.0124444
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.012429
ECPAS Ecm29 proteasome adaptor and scaffold 0.0123992
NCOR2 nuclear receptor corepressor 2 0.0123973
RNPS1 RNA binding protein S1, serine-rich domain 0.0123132
PKM pyruvate kinase, muscle 0.012276
BTBD10 BTB (POZ) domain containing 10 0.0122374
FRMD5 FERM domain containing 5 0.0122007
ZNF451 zinc finger protein 451 0.0121795
CARMIL1 capping protein regulator and myosin 1 linker 1 0.0121455
PTEN phosphatase and tensin homolog 0.0121254
RPS13 ribosomal protein S13 0.0120727
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 0.012047
SPIRE1 spire-type actin nucleation factor 1 0.0119921
RPL37A ribosomal protein L37a 0.0119479
PFN1 profilin 1 0.0117741
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 0.0117086
TMA7 translation machinery associated 7 homolog (S. cerevisiae) 0.01166
FTH1 ferritin, heavy polypeptide 1 0.0116429
ATN1 atrophin 1 0.0115681
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.01155
RPL3 ribosomal protein L3 0.0115113
KSR2 kinase suppressor of ras 2 0.0115043
INTS6 integrator complex subunit 6 0.0114571
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0114271
KCNMB4 potassium channel subfamily M regulatory beta subunit 4 0.0114089
CRYBG3 beta-gamma crystallin domain containing 3 0.0113222
TIMP2 TIMP metallopeptidase inhibitor 2 0.0113209
PRH1 proline-rich protein HaeIII subfamily 1 0.0113038

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.205556
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.173813
PDE4D phosphodiesterase 4D, cAMP-specific -0.118382
NLGN1 neuroligin 1 -0.117619
CELF2 CUGBP, Elav-like family member 2 -0.103918
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.101271
PCDH7 protocadherin 7 -0.099443
AHNAK AHNAK nucleoprotein -0.0938574
NAP1L1 nucleosome assembly protein 1-like 1 -0.0935058
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0880458
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0855588
TMSB10 thymosin beta 10 -0.0840917
DST dystonin -0.0830248
MMP12 matrix metallopeptidase 12 -0.0816612
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.077514
MYL12B myosin, light chain 12B, regulatory -0.0769009
SLC38A2 solute carrier family 38, member 2 -0.0738558
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0709674
ZNF804A zinc finger protein 804A -0.0625835
RAB1A RAB1A, member RAS oncogene family -0.0589014
YBX3 Y box binding protein 3 -0.0583832
DLC1 DLC1 Rho GTPase activating protein -0.0570625
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0568139
BIRC3 baculoviral IAP repeat containing 3 -0.0567486
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0550517
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0544111
KLF6 Kruppel-like factor 6 -0.0532121
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0529786
ERBIN erbb2 interacting protein -0.0518936
SQSTM1 sequestosome 1 -0.0494411
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.049149
PGK1 phosphoglycerate kinase 1 -0.0488352
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0488331
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0486936
RAB7A RAB7A, member RAS oncogene family -0.0472202
BIRC6 baculoviral IAP repeat containing 6 -0.0470562
CANX calnexin -0.0470111
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0467828
AFF4 AF4/FMR2 family, member 4 -0.0463763
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.046301
TPI1 triosephosphate isomerase 1 -0.046095
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0455637
CXADR coxsackie virus and adenovirus receptor -0.0448794
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0442681
ADGRG6 adhesion G protein-coupled receptor G6 -0.0435766
ZNF217 zinc finger protein 217 -0.0434241
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0431747
CCND1 cyclin D1 -0.0428765
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.0427975
ARB2A ARB2 cotranscriptional regulator A -0.0426285
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0422144
FBXO11 F-box protein 11 -0.0419488
LMO7 LIM domain 7 -0.0417123
RPL26 ribosomal protein L26 -0.0416834
ADIPOR2 adiponectin receptor 2 -0.0415862
TMEM123 transmembrane protein 123 -0.040976
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0406655
GJA1 gap junction protein, alpha 1, 43kDa -0.0401923
OSBPL8 oxysterol binding protein-like 8 -0.0399799
ANKRD12 ankyrin repeat domain 12 -0.0391987
FUS FUS RNA binding protein -0.0389036
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0385192
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0384404
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0384336
EDARADD EDAR-associated death domain -0.0382293
RIMS2 regulating synaptic membrane exocytosis 2 -0.0381959
HDLBP high density lipoprotein binding protein -0.0380373
SPAG9 sperm associated antigen 9 -0.0379066
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0375405
TPT1 tumor protein, translationally-controlled 1 -0.0374367
NABP1 nucleic acid binding protein 1 -0.0373831
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0372935
EIF1 eukaryotic translation initiation factor 1 -0.0372891
KDM3A lysine (K)-specific demethylase 3A -0.0371599
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0370896
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0369439
RAD21 RAD21 homolog (S. pombe) -0.0360171
LOC112694756 uncharaterized LOC112694756 -0.0356075
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0355472
PTMA prothymosin, alpha -0.0354359
CCDC47 coiled-coil domain containing 47 -0.0351657
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0350867
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0347322
CLPTM1L CLPTM1-like -0.0346993
RASAL2 RAS protein activator like 2 -0.0343729
MYPN myopalladin -0.0343507
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0342648
CDK6 cyclin-dependent kinase 6 -0.0341593
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0338429
MARCHF6 membrane associated ring-CH-type finger 6 -0.033832
TMEM41B transmembrane protein 41B -0.0336363
CMIP c-Maf inducing protein -0.0336101
ANXA1 annexin A1 -0.0334396
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0332342
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0330753
ECT2 epithelial cell transforming 2 -0.0329395
NIPBL Nipped-B homolog (Drosophila) -0.0327592
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0327577
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.032672
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0326222