Tazarotene_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tazarotene perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tazarotene_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.104791
NRIP1 nuclear receptor interacting protein 1 0.0812865
DPH6 diphthamine biosynthesis 6 0.0534939
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0516533
CD36 CD36 molecule (thrombospondin receptor) 0.0384379
GPC5 glypican 5 0.0360449
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0329548
SH3RF1 SH3 domain containing ring finger 1 0.0320932
LIMCH1 LIM and calponin homology domains 1 0.0320816
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0263386
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0242468
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0235091
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0235081
CENPF centromere protein F, 350/400kDa 0.0227867
PRKD1 protein kinase D1 0.0227634
GLI3 GLI family zinc finger 3 0.022337
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0215275
TENT5A terminal nucleotidyltransferase 5A 0.0212399
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.0210101
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.020686
PLAT plasminogen activator, tissue 0.0197301
CEMIP cell migration inducing protein, hyaluronan binding 0.0194098
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0181607
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0171934
GDF15 growth differentiation factor 15 0.0171251
ZBTB20 zinc finger and BTB domain containing 20 0.0163125
ARHGAP26 Rho GTPase activating protein 26 0.0159119
UBA6 ubiquitin-like modifier activating enzyme 6 0.0151631
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0146258
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0142558
WNT5A wingless-type MMTV integration site family, member 5A 0.0142378
MAP1B microtubule-associated protein 1B 0.0136172
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0133828
PCTP phosphatidylcholine transfer protein 0.0132087
PTEN phosphatase and tensin homolog 0.0130611
RARA retinoic acid receptor, alpha 0.0130008
OTUD7B OTU deubiquitinase 7B 0.0129601
AOPEP aminopeptidase O (putative) 0.0127302
RARB retinoic acid receptor, beta 0.0126275
SRPK2 SRSF protein kinase 2 0.0125839
FKBP10 FK506 binding protein 10, 65 kDa 0.0125612
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0123898
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0123399
CARD16 caspase recruitment domain family, member 16 0.0122361
PKP4 plakophilin 4 0.0120685
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.012048
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0120307
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0119976
FOXP1 forkhead box P1 0.0118161
SYTL3 synaptotagmin-like 3 0.0115917
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1) 0.0114675
BMERB1 bMERB domain containing 1 0.0114075
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.011263
KATNBL1 katanin p80 subunit B-like 1 0.0112624
SNX4 sorting nexin 4 0.0112524
HOXD3 homeobox D3 0.0111649
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0110656
SPIRE1 spire-type actin nucleation factor 1 0.0110016
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.01087
TTC28 tetratricopeptide repeat domain 28 0.0108482
ZNF827 zinc finger protein 827 0.0108341
DIAPH3 diaphanous-related formin 3 0.0106711
PTPRR protein tyrosine phosphatase, receptor type, R 0.0106631
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0106492
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0106411
MMS22L MMS22-like, DNA repair protein 0.010608
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.010599
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 0.010465
ANGPT1 angiopoietin 1 0.0104245
DCP1B decapping mRNA 1B 0.0103243
USP9Y ubiquitin specific peptidase 9, Y-linked 0.0102951
PTRH2 peptidyl-tRNA hydrolase 2 0.0102045
IGFBP4 insulin-like growth factor binding protein 4 0.0101718
ILKAP integrin-linked kinase-associated serine/threonine phosphatase 0.0101659
PBX3 pre-B-cell leukemia homeobox 3 0.0101514
MAB21L1 mab-21-like 1 (C. elegans) 0.0100616
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 0.0099874
COL18A1 collagen, type XVIII, alpha 1 0.00996185
DTWD1 DTW domain containing 1 0.00993113
BDKRB2 bradykinin receptor B2 0.00988197
PDE8A phosphodiesterase 8A 0.00987889
SCUBE1 signal peptide, CUB domain, EGF-like 1 0.00983799
ZFC3H1 zinc finger, C3H1-type containing 0.00977288
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.00972184
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 0.00971726
NCOR2 nuclear receptor corepressor 2 0.00956033
ESYT2 extended synaptotagmin-like protein 2 0.00948455
CCNT2 cyclin T2 0.00938736
SMAD3 SMAD family member 3 0.0093809
ZNF791 zinc finger protein 791 0.00927556
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.00920335
TOPBP1 topoisomerase (DNA) II binding protein 1 0.00916057
AUH AU RNA binding protein/enoyl-CoA hydratase 0.00914292
TOP1 topoisomerase (DNA) I 0.00911996
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.00909775
ITPKB inositol-trisphosphate 3-kinase B 0.00904294
MTMR10 myotubularin related protein 10 0.0090386
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.00899308
NCK1 NCK adaptor protein 1 0.00898318
WDR43 WD repeat domain 43 0.00892795

decreased expression

Symbol Name Standardized Value
VCL vinculin -0.136774
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.114039
NRG1 neuregulin 1 -0.104341
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0953766
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0936003
NALF1 NALCN channel auxiliary factor 1 -0.085674
PTMA prothymosin, alpha -0.0844267
VIM vimentin -0.0760358
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0655252
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0650959
SYT1 synaptotagmin I -0.0650381
PTPRD protein tyrosine phosphatase, receptor type, D -0.0609512
RPS6 ribosomal protein S6 -0.0608635
RPL23 ribosomal protein L23 -0.0606559
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0598243
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0581631
RPL19 ribosomal protein L19 -0.0563597
TRIO trio Rho guanine nucleotide exchange factor -0.0561547
COL1A1 collagen, type I, alpha 1 -0.054574
EXT1 exostosin glycosyltransferase 1 -0.051076
LSAMP limbic system-associated membrane protein -0.050818
HELZ helicase with zinc finger -0.0507717
FAM13A family with sequence similarity 13, member A -0.050341
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0499468
TPT1 tumor protein, translationally-controlled 1 -0.0492438
B2M beta-2-microglobulin -0.0486589
RPL38 ribosomal protein L38 -0.0483244
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0475577
ACTG1 actin gamma 1 -0.0456648
SLIT2 slit homolog 2 (Drosophila) -0.0445004
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0444846
FNDC3B fibronectin type III domain containing 3B -0.0429017
TPM1 tropomyosin 1 (alpha) -0.0424346
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0417207
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0413901
TLE4 transducin-like enhancer of split 4 -0.0412974
PRKCA protein kinase C, alpha -0.0412639
THSD4 thrombospondin, type I, domain containing 4 -0.0405983
HILPDA hypoxia inducible lipid droplet-associated -0.0399149
RPL34 ribosomal protein L34 -0.0386795
MCL1 myeloid cell leukemia 1 -0.0386661
TPM4 tropomyosin 4 -0.0381075
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0380222
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0376926
RPLP1 ribosomal protein, large, P1 -0.0372408
RPL37A ribosomal protein L37a -0.0369822
NAMPT nicotinamide phosphoribosyltransferase -0.0368065
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0367969
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0367923
COL3A1 collagen, type III, alpha 1 -0.0367537
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0366731
FNDC3A fibronectin type III domain containing 3A -0.0361457
SETD5 SET domain containing 5 -0.0360942
NAP1L1 nucleosome assembly protein 1-like 1 -0.0359054
PTPRK protein tyrosine phosphatase, receptor type, K -0.035641
MYH9 myosin, heavy chain 9, non-muscle -0.0356166
RPS12 ribosomal protein S12 -0.0353402
FMN1 formin 1 -0.0351155
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0351032
SPAG9 sperm associated antigen 9 -0.0349864
SMYD3 SET and MYND domain containing 3 -0.0344881
CSNK1A1 casein kinase 1, alpha 1 -0.0343562
RPS19 ribosomal protein S19 -0.0341574
MED13 mediator complex subunit 13 -0.0340482
KDM3A lysine (K)-specific demethylase 3A -0.0335954
FNBP1 formin binding protein 1 -0.0335574
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0329219
PKM pyruvate kinase, muscle -0.0324075
BCAS3 breast carcinoma amplified sequence 3 -0.0322327
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0317376
EIF1 eukaryotic translation initiation factor 1 -0.0317111
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0315273
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -0.0313779
RPS3 ribosomal protein S3 -0.030978
MSI2 musashi RNA-binding protein 2 -0.0306756
TMSB10 thymosin beta 10 -0.0304527
UNC5C unc-5 homolog C (C. elegans) -0.0304252
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0303675
RPL26 ribosomal protein L26 -0.0302543
ZC3H11A zinc finger CCCH-type containing 11A -0.0302466
ZMYM2 zinc finger, MYM-type 2 -0.0300108
PCBP2 poly(rC) binding protein 2 -0.0299912
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0298242
CUX1 cut-like homeobox 1 -0.0293232
RPS2 ribosomal protein S2 -0.0292101
LPIN1 lipin 1 -0.0290815
RPL12 ribosomal protein L12 -0.0288979
PDE4D phosphodiesterase 4D, cAMP-specific -0.0282106
NIPBL Nipped-B homolog (Drosophila) -0.0281169
NPAS2 neuronal PAS domain protein 2 -0.0278485
LMNA lamin A/C -0.0274573
KMT2C lysine (K)-specific methyltransferase 2C -0.0273932
RPS24 ribosomal protein S24 -0.0272261
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0270739
WSB1 WD repeat and SOCS box containing 1 -0.0269947
IER3 immediate early response 3 -0.0269257
SQSTM1 sequestosome 1 -0.026822
THBS1 thrombospondin 1 -0.0267073
AHNAK AHNAK nucleoprotein -0.0266778
RNF213 ring finger protein 213 -0.0264901