Tazarotene_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tazarotene perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tazarotene_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0683711
STS steroid sulfatase (microsomal), isozyme S 0.0526842
VCL vinculin 0.0450926
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.040943
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0368742
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0351053
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0327604
PLSCR2 phospholipid scramblase 2 0.0321506
EGR1 early growth response 1 0.0301448
INTS6 integrator complex subunit 6 0.0296385
RNF213 ring finger protein 213 0.0287804
BCL2L1 BCL2-like 1 0.0276883
TM4SF19 transmembrane 4 L six family member 19 0.0259442
VMP1 vacuole membrane protein 1 0.0259057
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0253447
AKAP13 A kinase (PRKA) anchor protein 13 0.0249743
DIAPH1 diaphanous-related formin 1 0.0242853
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0230866
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0217635
AREG amphiregulin 0.0215193
PADI1 peptidyl arginine deiminase, type I 0.020938
SMAD3 SMAD family member 3 0.0209306
SHB Src homology 2 domain containing adaptor protein B 0.0199329
TNS4 tensin 4 0.0195137
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0190267
ZSWIM6 zinc finger, SWIM-type containing 6 0.0181241
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0177418
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0176086
TSHZ2 teashirt zinc finger homeobox 2 0.017389
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0169247
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0164722
LPP LIM domain containing preferred translocation partner in lipoma 0.0164681
TJP1 tight junction protein 1 0.0159783
SAMD12 sterile alpha motif domain containing 12 0.0157716
CCNL1 cyclin L1 0.0145655
RIGI RNA sensor RIG-I 0.0144486
POF1B premature ovarian failure, 1B 0.0140865
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0139618
DSCAML1 Down syndrome cell adhesion molecule like 1 0.0139107
LIMA1 LIM domain and actin binding 1 0.0134768
ERBIN erbb2 interacting protein 0.0130044
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0129005
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0127955
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0127266
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0125309
PRSS22 protease, serine, 22 0.0123276
VIM vimentin 0.0123059
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.0122826
AKAP12 A kinase (PRKA) anchor protein 12 0.012269
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0120135
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0116281
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.0115229
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0114823
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0113794
RSAD2 radical S-adenosyl methionine domain containing 2 0.0112417
MT2A metallothionein 2A 0.0112345
NABP1 nucleic acid binding protein 1 0.0111676
MYO5B myosin VB 0.0111616
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0111123
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0109653
RCOR1 REST corepressor 1 0.0108905
MYO10 myosin X 0.0108844
DGKH diacylglycerol kinase, eta 0.0108046
MRTFA myocardin related transcription factor A 0.0107884
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.0107475
ARHGAP27 Rho GTPase activating protein 27 0.0107253
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1 0.0106613
KTN1 kinectin 1 (kinesin receptor) 0.0106177
ATP10B ATPase, class V, type 10B 0.0105707
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0104491
MCTP1 multiple C2 domains, transmembrane 1 0.0101023
ARHGAP26 Rho GTPase activating protein 26 0.010065
YAP1 Yes-associated protein 1 0.00995235
MPRIP myosin phosphatase Rho interacting protein 0.00990299
PDLIM5 PDZ and LIM domain 5 0.00979956
EPHA2 EPH receptor A2 0.00965007
KDM6A lysine (K)-specific demethylase 6A 0.00958093
NCOR2 nuclear receptor corepressor 2 0.00955112
ACSL5 acyl-CoA synthetase long-chain family member 5 0.00948102
CATSPERB catsper channel auxiliary subunit beta 0.00942276
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.00941759
SP100 SP100 nuclear antigen 0.00931042
HPCAL1 hippocalcin-like 1 0.00929519
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.00927473
HDGF hepatoma-derived growth factor 0.00917829
HOMER1 homer scaffolding protein 1 0.00914965
MMP7 matrix metallopeptidase 7 0.00913741
NAV1 neuron navigator 1 0.00908562
ZHX2 zinc fingers and homeoboxes 2 0.00903286
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.00881973
IGF2 insulin-like growth factor 2 0.00880769
PCDH1 protocadherin 1 0.00880071
DYNLT2B dynein light chain Tctex-type 2B 0.0086656
CD68 CD68 molecule 0.00865265
TRIM25 tripartite motif containing 25 0.0086251
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.00862456
CTTN cortactin 0.0085983
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.00854691
ZEB1 zinc finger E-box binding homeobox 1 0.00847861
SAMD9 sterile alpha motif domain containing 9 0.00839784

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.190737
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.169235
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.144769
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.13533
MBNL2 muscleblind-like splicing regulator 2 -0.100919
B2M beta-2-microglobulin -0.0880766
AHI1 Abelson helper integration site 1 -0.0804788
SQSTM1 sequestosome 1 -0.0769125
CANX calnexin -0.075737
LMO7 LIM domain 7 -0.0723443
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0650423
ZMYND8 zinc finger, MYND-type containing 8 -0.0646357
EIF1 eukaryotic translation initiation factor 1 -0.063189
UBC ubiquitin C -0.0620627
HLA-B major histocompatibility complex, class I, B -0.0612967
EZR ezrin -0.058935
H1-0 H1.0 linker histone -0.0585222
BTBD9 BTB (POZ) domain containing 9 -0.0576777
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0568343
HDLBP high density lipoprotein binding protein -0.0539393
RRBP1 ribosome binding protein 1 -0.0528073
GCLC glutamate-cysteine ligase, catalytic subunit -0.0525037
PTMA prothymosin, alpha -0.0515898
RHOBTB3 Rho-related BTB domain containing 3 -0.050924
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0503805
IRF1 interferon regulatory factor 1 -0.0478953
SEC31A SEC31 homolog A (S. cerevisiae) -0.0469662
GOLGB1 golgin B1 -0.0464726
PERP PERP, TP53 apoptosis effector -0.0463193
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0461255
RAB1A RAB1A, member RAS oncogene family -0.0461206
AHNAK AHNAK nucleoprotein -0.0453694
DSCAM Down syndrome cell adhesion molecule -0.0445572
LCN2 lipocalin 2 -0.0435985
FNDC3A fibronectin type III domain containing 3A -0.0433077
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0429825
MORF4L2 mortality factor 4 like 2 -0.0422199
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0409631
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0404238
PDIA3 protein disulfide isomerase family A, member 3 -0.0403616
PKM pyruvate kinase, muscle -0.040293
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0398827
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0397228
CALR calreticulin -0.0396239
TSC22D1 TSC22 domain family, member 1 -0.0393673
RPL34 ribosomal protein L34 -0.0388687
UGDH UDP-glucose 6-dehydrogenase -0.0386473
HLA-C major histocompatibility complex, class I, C -0.0370817
RPS6 ribosomal protein S6 -0.0370106
SPATA13 spermatogenesis associated 13 -0.0366661
RPLP1 ribosomal protein, large, P1 -0.0365848
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0365321
KDM3A lysine (K)-specific demethylase 3A -0.0360324
EPCAM epithelial cell adhesion molecule -0.0358246
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0352887
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0343518
MYO1E myosin IE -0.0339305
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0333309
LOC112694756 uncharaterized LOC112694756 -0.0330886
RUNX1 runt-related transcription factor 1 -0.0328331
RPL35A ribosomal protein L35a -0.0326995
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.032521
JUN jun proto-oncogene -0.03193
PHF3 PHD finger protein 3 -0.0318039
RPL19 ribosomal protein L19 -0.0316106
VDAC1 voltage-dependent anion channel 1 -0.0311721
AGR2 anterior gradient 2 -0.0311626
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0307793
PATJ PATJ crumbs cell polarity complex component -0.0307725
RPL7L1 ribosomal protein L7-like 1 -0.0305196
NF1 neurofibromin 1 -0.0304954
GOLPH3L golgi phosphoprotein 3-like -0.0304746
SREBF2 sterol regulatory element binding transcription factor 2 -0.0304039
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0294215
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0291875
PIBF1 progesterone immunomodulatory binding factor 1 -0.0291778
FTL ferritin, light polypeptide -0.0288661
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0286824
RPL12 ribosomal protein L12 -0.0285609
HLA-A major histocompatibility complex, class I, A -0.028526
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.028477
ZMYM2 zinc finger, MYM-type 2 -0.0283524
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0282533
PGK1 phosphoglycerate kinase 1 -0.0281683
HLA-E major histocompatibility complex, class I, E -0.0280971
FUS FUS RNA binding protein -0.0278458
TM9SF2 transmembrane 9 superfamily member 2 -0.0276075
LOC102724023 ES1 protein homolog, mitochondrial -0.0275987
SBF2 SET binding factor 2 -0.0275229
WDR45B WD repeat domain 45B -0.0273038
LMAN1 lectin, mannose-binding, 1 -0.027282
UBL3 ubiquitin-like 3 -0.0271634
ABLIM1 actin binding LIM protein 1 -0.0269811
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0268998
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0263584
TMEM263 transmembrane protein 263 -0.0263213
EPHB2 EPH receptor B2 -0.0263174
CLTC clathrin, heavy chain (Hc) -0.0262218
SEC24D SEC24 family member D -0.0260005
S100A10 S100 calcium binding protein A10 -0.0260004