| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tazarotene perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tazarotene_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.297256 |
| C3 | complement component 3 | 0.0937129 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.070043 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0673933 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0550634 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0485867 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0469175 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0466742 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0457086 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0425101 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0413757 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.0412006 |
| FN1 | fibronectin 1 | 0.0393979 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0346545 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0337324 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0335394 |
| ITGAV | integrin, alpha V | 0.0334298 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0330646 |
| SVIL | supervillin | 0.0318939 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0303853 |
| AFDN | afadin, adherens junction formation factor | 0.0288538 |
| OSMR | oncostatin M receptor | 0.0258947 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0246275 |
| DSPP | dentin sialophosphoprotein | 0.0244557 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0244039 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0228738 |
| VCL | vinculin | 0.0227043 |
| ARHGEF18 | Rho/Rac guanine nucleotide exchange factor (GEF) 18 | 0.02234 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0217798 |
| CRLS1 | cardiolipin synthase 1 | 0.0216205 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0215971 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0215521 |
| HLF | hepatic leukemia factor | 0.0209422 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.0204662 |
| PLAC8 | placenta-specific 8 | 0.0204397 |
| MAPK14 | mitogen-activated protein kinase 14 | 0.020363 |
| VMP1 | vacuole membrane protein 1 | 0.0199411 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | 0.0192591 |
| PDGFB | platelet-derived growth factor beta polypeptide | 0.0191711 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0185821 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.0184893 |
| SMAD3 | SMAD family member 3 | 0.0184473 |
| FOXO1 | forkhead box O1 | 0.0183433 |
| RELL1 | RELT-like 1 | 0.018201 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0177881 |
| SH3RF1 | SH3 domain containing ring finger 1 | 0.017466 |
| MRTFA | myocardin related transcription factor A | 0.0174108 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0173819 |
| ITGB5 | integrin, beta 5 | 0.0172808 |
| JAG1 | jagged 1 | 0.0172509 |
| FERMT1 | fermitin family member 1 | 0.017023 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0165977 |
| TMEM51 | transmembrane protein 51 | 0.0165417 |
| MALT1 | MALT1 paracaspase | 0.0163948 |
| RBM25 | RNA binding motif protein 25 | 0.0163675 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0162473 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0159121 |
| TRAM1 | translocation associated membrane protein 1 | 0.0159042 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0158635 |
| JMJD1C | jumonji domain containing 1C | 0.0157229 |
| RTN4 | reticulon 4 | 0.0153268 |
| FAT1 | FAT atypical cadherin 1 | 0.0152749 |
| ENKUR | enkurin, TRPC channel interacting protein | 0.0152416 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.0151143 |
| GPC6 | glypican 6 | 0.0150752 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0150284 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 0.0149266 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0147022 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0146623 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0146094 |
| LPIN2 | lipin 2 | 0.0145874 |
| SRPK1 | SRSF protein kinase 1 | 0.0144891 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0144631 |
| OPTN | optineurin | 0.0144348 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | 0.0143272 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0142716 |
| KANK1 | KN motif and ankyrin repeat domains 1 | 0.0142336 |
| RANBP9 | RAN binding protein 9 | 0.0142021 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0141605 |
| BCL2L1 | BCL2-like 1 | 0.0139519 |
| RNF38 | ring finger protein 38 | 0.0138899 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0137716 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0137232 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0137052 |
| PHYHIPL | phytanoyl-CoA 2-hydroxylase interacting protein-like | 0.0136774 |
| NEK7 | NIMA-related kinase 7 | 0.0134101 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0133972 |
| LUZP1 | leucine zipper protein 1 | 0.0133925 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0133852 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0132774 |
| FNBP1L | formin binding protein 1-like | 0.0132187 |
| IL1RAP | interleukin 1 receptor accessory protein | 0.0130667 |
| CCNY | cyclin Y | 0.0129753 |
| PALS1 | protein associated with LIN7 1, MAGUK p55 family member | 0.0129217 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.0129099 |
| RPRD2 | regulation of nuclear pre-mRNA domain containing 2 | 0.0128843 |
| NMT2 | N-myristoyltransferase 2 | 0.0127851 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0127656 |
| LAMA4 | laminin, alpha 4 | 0.0127385 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0127297 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.187782 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.186447 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.121474 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.103891 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0931094 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0758233 |
| FTL | ferritin, light polypeptide | -0.0756015 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0705917 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0672692 |
| RPS3 | ribosomal protein S3 | -0.0627706 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0597666 |
| GPC3 | glypican 3 | -0.0572335 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0560503 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0556327 |
| AHSG | alpha-2-HS-glycoprotein | -0.0527852 |
| RPL11 | ribosomal protein L11 | -0.0527333 |
| APOA1 | apolipoprotein A-I | -0.0508309 |
| INTS6 | integrator complex subunit 6 | -0.0497814 |
| RPL23 | ribosomal protein L23 | -0.0486079 |
| RPL37A | ribosomal protein L37a | -0.0485227 |
| GNAS | GNAS complex locus | -0.0476361 |
| RPL35A | ribosomal protein L35a | -0.0474542 |
| RPS6 | ribosomal protein S6 | -0.0473192 |
| EHBP1 | EH domain binding protein 1 | -0.0472166 |
| RPS8 | ribosomal protein S8 | -0.0471297 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0470016 |
| RPS19 | ribosomal protein S19 | -0.0458343 |
| RPL12 | ribosomal protein L12 | -0.0458332 |
| RPS24 | ribosomal protein S24 | -0.0457921 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0456041 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0439552 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0437136 |
| APOE | apolipoprotein E | -0.0436053 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0434521 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0431829 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0430897 |
| RRBP1 | ribosome binding protein 1 | -0.0421885 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0416022 |
| TF | transferrin | -0.0410446 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0404729 |
| CALR | calreticulin | -0.0403481 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0402613 |
| RPL34 | ribosomal protein L34 | -0.0402177 |
| RACK1 | receptor for activated C kinase 1 | -0.0395889 |
| RPL19 | ribosomal protein L19 | -0.0394678 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0391726 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0386503 |
| SQSTM1 | sequestosome 1 | -0.0384728 |
| PTMA | prothymosin, alpha | -0.0379978 |
| RPL31 | ribosomal protein L31 | -0.0377506 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.036669 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0354698 |
| APOA2 | apolipoprotein A-II | -0.0353306 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0352553 |
| RPLP1 | ribosomal protein, large, P1 | -0.0345878 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0345558 |
| H1-0 | H1.0 linker histone | -0.0344769 |
| RYBP | RING1 and YY1 binding protein | -0.0344176 |
| RPS29 | ribosomal protein S29 | -0.0341451 |
| RPS14 | ribosomal protein S14 | -0.0337922 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0326485 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0325288 |
| RPL5 | ribosomal protein L5 | -0.0325222 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0322636 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0318033 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0317668 |
| KLF6 | Kruppel-like factor 6 | -0.0316357 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0308112 |
| CP | ceruloplasmin (ferroxidase) | -0.0304389 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0301693 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | -0.029934 |
| RPL26 | ribosomal protein L26 | -0.0280097 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0278025 |
| RPLP2 | ribosomal protein, large, P2 | -0.0271922 |
| DENND1A | DENN/MADD domain containing 1A | -0.0270297 |
| DST | dystonin | -0.0267793 |
| RPL27A | ribosomal protein L27a | -0.0266963 |
| KRT18 | keratin 18, type I | -0.0266454 |
| RNF213 | ring finger protein 213 | -0.0262165 |
| NABP1 | nucleic acid binding protein 1 | -0.0258342 |
| DTNA | dystrobrevin, alpha | -0.0257208 |
| RPS12 | ribosomal protein S12 | -0.0255682 |
| RPLP0 | ribosomal protein, large, P0 | -0.0255154 |
| RPL36 | ribosomal protein L36 | -0.0254297 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0250814 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0249636 |
| RPL18 | ribosomal protein L18 | -0.0247807 |
| TRIM26 | tripartite motif containing 26 | -0.024766 |
| B2M | beta-2-microglobulin | -0.0247557 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0247035 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0246387 |
| TMSB10 | thymosin beta 10 | -0.0246023 |
| USP34 | ubiquitin specific peptidase 34 | -0.024226 |
| RPL32 | ribosomal protein L32 | -0.0240827 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0239086 |
| BRD2 | bromodomain containing 2 | -0.0237421 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0237174 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0236826 |
| RPS25 | ribosomal protein S25 | -0.0236723 |
| RPL13A | ribosomal protein L13a | -0.0236349 |
