Tazarotene_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tazarotene perturbation in LS 180 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Tazarotene_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MUC6 mucin 6, oligomeric mucus/gel-forming 0.1124
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0567765
NDRG1 N-myc downstream regulated 1 0.0368821
FAM13A family with sequence similarity 13, member A 0.0353055
GOLGA4 golgin A4 0.0325739
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.028769
TNS4 tensin 4 0.0283089
UBA6 ubiquitin-like modifier activating enzyme 6 0.0275951
RNF145 ring finger protein 145 0.0264013
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0245179
ZNF292 zinc finger protein 292 0.0211776
FTH1 ferritin, heavy polypeptide 1 0.0203994
TMF1 TATA element modulatory factor 1 0.0198599
NUP58 nucleoporin 58 0.0198346
ESYT2 extended synaptotagmin-like protein 2 0.0188197
KMT2E lysine (K)-specific methyltransferase 2E 0.0183777
VEGFA vascular endothelial growth factor A 0.0180489
ACBD3 acyl-CoA binding domain containing 3 0.0179741
HMGA1 high mobility group AT-hook 1 0.0174242
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0169414
NAMPT nicotinamide phosphoribosyltransferase 0.0167111
SRP54 signal recognition particle 54kDa 0.0165833
DERA deoxyribose-phosphate aldolase (putative) 0.0164039
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0159101
TPM3 tropomyosin 3 0.0158285
YBX1 Y box binding protein 1 0.0151722
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0150655
PNN pinin, desmosome associated protein 0.0149924
ADAM17 ADAM metallopeptidase domain 17 0.0149582
RBM39 RNA binding motif protein 39 0.0146054
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0144157
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0137309
SRRM2 serine/arginine repetitive matrix 2 0.0134051
RPS2 ribosomal protein S2 0.013352
PSAT1 phosphoserine aminotransferase 1 0.0130702
KDM6A lysine (K)-specific demethylase 6A 0.0128693
SLC31A1 solute carrier family 31 (copper transporter), member 1 0.0126183
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0126167
TXNIP thioredoxin interacting protein 0.0125756
VIM vimentin 0.0125718
CCNL1 cyclin L1 0.0124956
BCLAF1 BCL2-associated transcription factor 1 0.0124541
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0124097
RSRC2 arginine/serine-rich coiled-coil 2 0.0123261
RAB6A RAB6A, member RAS oncogene family 0.0122799
CENPF centromere protein F, 350/400kDa 0.0121924
COPA coatomer protein complex, subunit alpha 0.012178
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0121667
EREG epiregulin 0.01197
RPL3 ribosomal protein L3 0.0117037
PRRC2C proline-rich coiled-coil 2C 0.0116713
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0113835
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.011338
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0108851
AVL9 AVL9 homolog (S. cerevisiase) 0.0108489
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0108389
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0107796
DDIT4 DNA-damage-inducible transcript 4 0.0107266
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0105681
RNMT RNA (guanine-7-) methyltransferase 0.0103829
PTCH1 patched 1 0.0103657
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0102886
PCBP2 poly(rC) binding protein 2 0.0100675
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.00997813
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.00976285
SMAD4 SMAD family member 4 0.00971437
RPL21 ribosomal protein L21 0.00958005
BTBD10 BTB (POZ) domain containing 10 0.00942862
AKAP12 A kinase (PRKA) anchor protein 12 0.0094129
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.00931272
FASN fatty acid synthase 0.00919553
ARRDC3 arrestin domain containing 3 0.00889018
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.00885357
ZNF148 zinc finger protein 148 0.00882835
SLK STE20-like kinase 0.00879667
RAB5B RAB5B, member RAS oncogene family 0.00864122
COPG1 coatomer protein complex, subunit gamma 1 0.00858893
GPA33 glycoprotein A33 (transmembrane) 0.00856804
DNM2 dynamin 2 0.00856594
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.00852371
EHF ets homologous factor 0.00852295
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.00850598
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.00847901
SREBF2 sterol regulatory element binding transcription factor 2 0.00846629
TMA7 translation machinery associated 7 homolog (S. cerevisiae) 0.00841451
SKIC3 SKI3 subunit of superkiller complex 0.00839336
RIOK3 RIO kinase 3 0.00837145
TMEM39A transmembrane protein 39A 0.00832926
CASC3 cancer susceptibility candidate 3 0.00828734
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0082616
PCBP1 poly(rC) binding protein 1 0.00816003
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.00809904
EXOC1 exocyst complex component 1 0.00799214
MXI1 MAX interactor 1, dimerization protein 0.00797893
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.00797884
NBAS neuroblastoma amplified sequence 0.00791183
MPZL3 myelin protein zero-like 3 0.00788074
PRPF4B pre-mRNA processing factor 4B 0.00782473
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.00776396
SNX2 sorting nexin 2 0.00767699

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.221413
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.182616
NPSR1 neuropeptide S receptor 1 -0.163434
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.156825
TPT1 tumor protein, translationally-controlled 1 -0.152336
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.128972
GMDS GDP-mannose 4,6-dehydratase -0.114686
TMSB10 thymosin beta 10 -0.10836
AHNAK AHNAK nucleoprotein -0.107781
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.105168
NALF1 NALCN channel auxiliary factor 1 -0.100312
MYO1E myosin IE -0.0994312
VCL vinculin -0.0975457
ALCAM activated leukocyte cell adhesion molecule -0.0947651
PTMA prothymosin, alpha -0.089253
PTPRK protein tyrosine phosphatase, receptor type, K -0.0848179
FAT1 FAT atypical cadherin 1 -0.0786506
EXT1 exostosin glycosyltransferase 1 -0.0734501
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0730602
ITGA6 integrin, alpha 6 -0.0712503
ACTG1 actin gamma 1 -0.0697467
CEMIP cell migration inducing protein, hyaluronan binding -0.0696764
ANTXR2 anthrax toxin receptor 2 -0.0647355
PIGR polymeric immunoglobulin receptor -0.0623546
ONECUT3 one cut homeobox 3 -0.0613739
ANXA2 annexin A2 -0.0609952
GREB1L growth regulation by estrogen in breast cancer-like -0.0608716
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0602491
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0589339
TPM4 tropomyosin 4 -0.0579893
CADPS Ca++-dependent secretion activator -0.0554898
PATJ PATJ crumbs cell polarity complex component -0.0537687
GPHN gephyrin -0.053234
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0519779
FHIT fragile histidine triad -0.050646
SMYD3 SET and MYND domain containing 3 -0.0495155
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0490152
MAML3 mastermind-like 3 (Drosophila) -0.0482484
ACTN4 actinin, alpha 4 -0.0474075
PDE4D phosphodiesterase 4D, cAMP-specific -0.0473476
CCSER1 coiled-coil serine-rich protein 1 -0.0466511
KLF5 Kruppel-like factor 5 (intestinal) -0.046229
MBNL1 muscleblind-like splicing regulator 1 -0.0456749
PDLIM5 PDZ and LIM domain 5 -0.0452761
LPP LIM domain containing preferred translocation partner in lipoma -0.0446124
RPL34 ribosomal protein L34 -0.0438632
PARD3 par-3 family cell polarity regulator -0.0434432
KRT8 keratin 8, type II -0.0431411
RPS24 ribosomal protein S24 -0.0429672
KRT18 keratin 18, type I -0.0428027
RPL35A ribosomal protein L35a -0.0426052
RPLP0 ribosomal protein, large, P0 -0.0425247
PSD3 pleckstrin and Sec7 domain containing 3 -0.0419816
DIAPH2 diaphanous-related formin 2 -0.0415714
SLC35F3 solute carrier family 35, member F3 -0.0413562
RPS8 ribosomal protein S8 -0.0412124
S100A6 S100 calcium binding protein A6 -0.0409383
SLC38A2 solute carrier family 38, member 2 -0.0406472
SAMD5 sterile alpha motif domain containing 5 -0.04063
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0406057
H1-0 H1.0 linker histone -0.0404194
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0401813
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0401575
FRMD5 FERM domain containing 5 -0.0398351
ASPH aspartate beta-hydroxylase -0.0394009
POF1B premature ovarian failure, 1B -0.038938
S100A10 S100 calcium binding protein A10 -0.0384515
EZR ezrin -0.0376161
LMO7 LIM domain 7 -0.0375591
ANKRD17 ankyrin repeat domain 17 -0.0374847
RPLP1 ribosomal protein, large, P1 -0.0366105
FOXP1 forkhead box P1 -0.0358079
EPCAM epithelial cell adhesion molecule -0.0351813
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0350122
ZBTB20 zinc finger and BTB domain containing 20 -0.0348311
PALLD palladin, cytoskeletal associated protein -0.034772
LAMA4 laminin, alpha 4 -0.0347689
PGK1 phosphoglycerate kinase 1 -0.0344624
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0342356
PKM pyruvate kinase, muscle -0.0342104
MYO1D myosin ID -0.0340447
IER3 immediate early response 3 -0.0340279
PTPRB protein tyrosine phosphatase, receptor type, B -0.0334249
RPS25 ribosomal protein S25 -0.0330745
RPS6 ribosomal protein S6 -0.0328289
FLNB filamin B, beta -0.0328087
PARD3B par-3 family cell polarity regulator beta -0.0327563
RAB10 RAB10, member RAS oncogene family -0.0326962
NRXN3 neurexin 3 -0.0326951
RPL8 ribosomal protein L8 -0.0322693
DENND1A DENN/MADD domain containing 1A -0.0321947
CUX1 cut-like homeobox 1 -0.0319148
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0318503
RPL19 ribosomal protein L19 -0.0316777
EHBP1 EH domain binding protein 1 -0.0316219
SH3D19 SH3 domain containing 19 -0.0310665
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0309879
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0309371
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0308145
RPS27A ribosomal protein S27a -0.0307012