Tazarotene_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tazarotene perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tazarotene_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.165287
ERRFI1 ERBB receptor feedback inhibitor 1 0.068564
KDM3A lysine (K)-specific demethylase 3A 0.0490763
TMSB4X thymosin beta 4, X-linked 0.0396552
TXNRD1 thioredoxin reductase 1 0.0349094
TRIO trio Rho guanine nucleotide exchange factor 0.0306252
TM4SF1 transmembrane 4 L six family member 1 0.0298361
DLG1 discs, large homolog 1 (Drosophila) 0.0264865
TFRC transferrin receptor 0.0257522
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0230126
SPAG9 sperm associated antigen 9 0.0227766
BZW1 basic leucine zipper and W2 domains 1 0.0222312
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0216728
RBM39 RNA binding motif protein 39 0.0207692
ARF1 ADP-ribosylation factor 1 0.019948
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.01922
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0191589
CAVIN1 caveolae associated protein 1 0.0189607
NAMPT nicotinamide phosphoribosyltransferase 0.0186243
EIF1 eukaryotic translation initiation factor 1 0.0176398
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0175686
LOXL2 lysyl oxidase-like 2 0.0174683
RPL6 ribosomal protein L6 0.0173031
NPR2 natriuretic peptide receptor 2 0.0170346
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0168695
RSL1D1 ribosomal L1 domain containing 1 0.0163324
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0162955
MACF1 microtubule-actin crosslinking factor 1 0.0161341
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0155483
KLF6 Kruppel-like factor 6 0.0147248
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0146312
TSC22D2 TSC22 domain family, member 2 0.0143663
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.0143232
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0141476
FOXK2 forkhead box K2 0.0141452
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0141158
JUN jun proto-oncogene 0.0141027
WDR43 WD repeat domain 43 0.014063
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.013904
SQSTM1 sequestosome 1 0.0138358
ZFAND3 zinc finger, AN1-type domain 3 0.0135279
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0132115
SERINC1 serine incorporator 1 0.0131724
EIF4H eukaryotic translation initiation factor 4H 0.0130634
GARS1 glycyl-tRNA synthetase 1 0.0128519
RPS27A ribosomal protein S27a 0.0128399
GNAS GNAS complex locus 0.0126038
MDN1 MDN1, midasin homolog (yeast) 0.0124632
UBE3C ubiquitin protein ligase E3C 0.0123278
LRRC49 leucine rich repeat containing 49 0.012138
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0120828
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.0119984
RPL4 ribosomal protein L4 0.0119713
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.0118798
SGK1 serum/glucocorticoid regulated kinase 1 0.0118186
TRA2A transformer 2 alpha homolog (Drosophila) 0.0117822
RLF rearranged L-myc fusion 0.0116022
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0115604
HMGB2 high mobility group box 2 0.0114505
NAP1L1 nucleosome assembly protein 1-like 1 0.0114352
ABI1 abl-interactor 1 0.0113742
CLIP2 CAP-GLY domain containing linker protein 2 0.011334
FNBP1L formin binding protein 1-like 0.011317
MEMO1 mediator of cell motility 1 0.0112795
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0112217
RSRC2 arginine/serine-rich coiled-coil 2 0.0112026
MARCHF6 membrane associated ring-CH-type finger 6 0.0111292
FUS FUS RNA binding protein 0.0110609
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0109773
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.010905
HSPA8 heat shock 70kDa protein 8 0.0108332
ANXA2 annexin A2 0.0108176
HDLBP high density lipoprotein binding protein 0.0106588
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.0104584
HBS1L HBS1-like translational GTPase 0.0103855
LRRC23 leucine rich repeat containing 23 0.0103406
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0101992
ADARB1 adenosine deaminase, RNA-specific, B1 0.0100535
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.00998908
EREG epiregulin 0.00987908
EPHA4 EPH receptor A4 0.00982651
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.00980025
MYOF myoferlin 0.00976068
UBE2I ubiquitin-conjugating enzyme E2I 0.00962736
APP amyloid beta (A4) precursor protein 0.00962657
DOCK1 dedicator of cytokinesis 1 0.00960051
RPL37 ribosomal protein L37 0.00956771
RPL38 ribosomal protein L38 0.00956236
OGA O-GlcNAcase 0.00954093
GOLT1B golgi transport 1B 0.0095074
RPL14 ribosomal protein L14 0.0094669
IGF2R insulin-like growth factor 2 receptor 0.00938128
TARS1 threonyl-tRNA synthetase 1 0.00936199
KIF1B kinesin family member 1B 0.00931022
RGS4 regulator of G-protein signaling 4 0.00928542
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.00922649
SSB Sjogren syndrome antigen B (autoantigen La) 0.00920322
SRSF7 serine/arginine-rich splicing factor 7 0.00909492
WSB1 WD repeat and SOCS box containing 1 0.00906791
AP2A2 adaptor-related protein complex 2, alpha 2 subunit 0.00905542

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.259782
VIM vimentin -0.240556
MT2A metallothionein 2A -0.121086
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.101505
POTEF POTE ankyrin domain family, member F -0.0766038
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.074051
SLC38A2 solute carrier family 38, member 2 -0.0701197
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0645114
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0630394
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0623699
TXNIP thioredoxin interacting protein -0.060564
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0599688
CD44 CD44 molecule (Indian blood group) -0.0553225
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0552119
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0539315
DST dystonin -0.0532777
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0505734
CENPF centromere protein F, 350/400kDa -0.0487381
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0483859
KTN1 kinectin 1 (kinesin receptor) -0.0482801
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0451587
SMC4 structural maintenance of chromosomes 4 -0.0425295
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0422724
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.0408534
PSD3 pleckstrin and Sec7 domain containing 3 -0.040817
RPS6 ribosomal protein S6 -0.0404646
RIGI RNA sensor RIG-I -0.0395721
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0375375
WARS1 tryptophanyl-tRNA synthetase 1 -0.0375325
PCBP2 poly(rC) binding protein 2 -0.0374972
ENO2 enolase 2 (gamma, neuronal) -0.0373902
TP63 tumor protein p63 -0.0368498
TSC22D1 TSC22 domain family, member 1 -0.0366158
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0363644
IFI6 interferon, alpha-inducible protein 6 -0.0353086
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.034837
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0346454
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0343053
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0333931
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0333568
IFITM1 interferon induced transmembrane protein 1 -0.0330338
MT1E metallothionein 1E -0.0322081
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0321273
DPYD dihydropyrimidine dehydrogenase -0.0317504
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0314642
ADGRG6 adhesion G protein-coupled receptor G6 -0.0313496
ADAR adenosine deaminase, RNA-specific -0.0311484
FOSL1 FOS-like antigen 1 -0.0309067
PLSCR1 phospholipid scramblase 1 -0.0308611
HLA-A major histocompatibility complex, class I, A -0.0304089
RNF213 ring finger protein 213 -0.0303986
PTMA prothymosin, alpha -0.0291391
CCNL1 cyclin L1 -0.0285326
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0281815
ENO1 enolase 1, (alpha) -0.0280173
B2M beta-2-microglobulin -0.0279208
HMGA1 high mobility group AT-hook 1 -0.0278978
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0274002
PDIA3 protein disulfide isomerase family A, member 3 -0.0271602
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0266785
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.026284
PKM pyruvate kinase, muscle -0.026205
CADM2 cell adhesion molecule 2 -0.0261882
GCLM glutamate-cysteine ligase, modifier subunit -0.0261539
TAPBP TAP binding protein (tapasin) -0.025873
ADAM17 ADAM metallopeptidase domain 17 -0.0251128
UBC ubiquitin C -0.0250784
RAB27B RAB27B, member RAS oncogene family -0.02472
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 -0.0246698
TPI1 triosephosphate isomerase 1 -0.0242702
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0242098
CALD1 caldesmon 1 -0.0240114
KMT2E lysine (K)-specific methyltransferase 2E -0.0239739
SON SON DNA binding protein -0.023809
VCL vinculin -0.0236079
ANKRD12 ankyrin repeat domain 12 -0.0233512
MYADM myeloid-associated differentiation marker -0.0226815
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0225496
CFAP299 cilia and flagella associated protein 299 -0.0222938
EGR1 early growth response 1 -0.0218012
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.021729
DEK DEK proto-oncogene -0.0216378
SP100 SP100 nuclear antigen -0.0216326
DARS1 aspartyl-tRNA synthetase 1 -0.02155
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0214746
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0211409
PTK2 protein tyrosine kinase 2 -0.0210133
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0209417
IFIH1 interferon induced with helicase C domain 1 -0.0208661
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -0.020785
FBXO11 F-box protein 11 -0.0206834
BIRC3 baculoviral IAP repeat containing 3 -0.0206184
EEF2 eukaryotic translation elongation factor 2 -0.0204713
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0204453
PFN1 profilin 1 -0.0202765
RAD51B RAD51 paralog B -0.0199505
AKAP9 A kinase (PRKA) anchor protein 9 -0.0197253
PGAP1 post-GPI attachment to proteins 1 -0.0196906
RTN4 reticulon 4 -0.019593
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0195845