Tazarotene_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tazarotene perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tazarotene_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0281396
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0192322
EGR1 early growth response 1 0.0177412
MKI67 marker of proliferation Ki-67 0.0176914
IGF2 insulin-like growth factor 2 0.0169693
PRPF4B pre-mRNA processing factor 4B 0.0144821
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0144012
DCAF8 DDB1 and CUL4 associated factor 8 0.0131016
RPS7 ribosomal protein S7 0.0127174
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0119837
H1-4 H1.4 linker histone, cluster member 0.0110092
PLEC plectin 0.0106064
HMGB2 high mobility group box 2 0.0103013
DOT1L DOT1-like histone H3K79 methyltransferase 0.0100988
TMA7 translation machinery associated 7 homolog (S. cerevisiae) 0.00989806
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.00977183
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.00971004
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.00960693
MYPN myopalladin 0.00959478
SRP54 signal recognition particle 54kDa 0.00956004
LRRC59 leucine rich repeat containing 59 0.00939964
NFE2L1 nuclear factor, erythroid 2-like 1 0.00934081
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.00933878
SRSF4 serine/arginine-rich splicing factor 4 0.00918802
HSPA8 heat shock 70kDa protein 8 0.00913027
IPO9 importin 9 0.00912611
RAB5B RAB5B, member RAS oncogene family 0.00888198
LEMD3 LEM domain containing 3 0.00881851
PNN pinin, desmosome associated protein 0.00852665
ZNF384 zinc finger protein 384 0.00851617
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0083692
KNTC1 kinetochore associated 1 0.00830177
RAI14 retinoic acid induced 14 0.00825339
BHLHE40 basic helix-loop-helix family, member e40 0.00824781
ELL2 elongation factor, RNA polymerase II, 2 0.00793147
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.00787367
GOLGA4 golgin A4 0.00786962
DCTN1 dynactin 1 0.00786231
ERI3 ERI1 exoribonuclease family member 3 0.00781302
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit 0.00774836
KIF1A kinesin family member 1A 0.00771763
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 0.00766499
DKC1 dyskeratosis congenita 1, dyskerin 0.00762815
DHFR dihydrofolate reductase 0.0076281
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 0.00761807
KIDINS220 kinase D-interacting substrate, 220kDa 0.00761053
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.00754884
KDM6B lysine (K)-specific demethylase 6B 0.00744412
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.00743485
IQGAP3 IQ motif containing GTPase activating protein 3 0.00741834
CDCA7L cell division cycle associated 7-like 0.00740011
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 0.00732485
RSRC2 arginine/serine-rich coiled-coil 2 0.00732352
TPCN2 two pore segment channel 2 0.0072758
RPS2 ribosomal protein S2 0.00702939
TULP3 tubby like protein 3 0.00701664
BSDC1 BSD domain containing 1 0.00699347
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 0.00697362
FANCI Fanconi anemia, complementation group I 0.00697192
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.00693126
NFYA nuclear transcription factor Y, alpha 0.00685842
UBAP2L ubiquitin associated protein 2-like 0.00684167
IGFBP3 insulin-like growth factor binding protein 3 0.00681809
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.00679771
SENP5 SUMO1/sentrin specific peptidase 5 0.00678405
COPG1 coatomer protein complex, subunit gamma 1 0.00673156
IWS1 IWS1 homolog (S. cerevisiae) 0.0067205
BLCAP bladder cancer associated protein 0.00671292
TTI1 TELO2 interacting protein 1 0.00668381
USP53 ubiquitin specific peptidase 53 0.00664489
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.00664365
EEF2K eukaryotic elongation factor 2 kinase 0.00664168
TMF1 TATA element modulatory factor 1 0.00660677
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.00656614
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa 0.00656084
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.00655229
RPL6 ribosomal protein L6 0.00654765
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0065167
PTRH2 peptidyl-tRNA hydrolase 2 0.00647303
ASXL1 additional sex combs like transcriptional regulator 1 0.00641673
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.00637824
INCENP inner centromere protein antigens 135/155kDa 0.00636698
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.00635682
STC2 stanniocalcin 2 0.00635626
NAMPT nicotinamide phosphoribosyltransferase 0.00634448
SCYL2 SCY1-like 2 (S. cerevisiae) 0.00632026
RPS3A ribosomal protein S3A 0.0062905
TNIP1 TNFAIP3 interacting protein 1 0.00627562
MAT2A methionine adenosyltransferase II, alpha 0.00626198
CPNE7 copine VII 0.00625975
NARS1 asparaginyl-tRNA synthetase 1 0.00622944
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa 0.00622621
TRAPPC13 trafficking protein particle complex 13 0.00619876
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.00616148
GOLGA3 golgin A3 0.00613523
SIL1 SIL1 nucleotide exchange factor 0.00613386
CEP85 centrosomal protein 85kDa 0.00612788
WEE1 WEE1 G2 checkpoint kinase 0.00611739
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.00610751
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 0.00609129

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.489472
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.156517
AKAP12 A kinase (PRKA) anchor protein 12 -0.134385
VIM vimentin -0.113555
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.110551
YBX3 Y box binding protein 3 -0.0855232
TMSB10 thymosin beta 10 -0.082545
KTN1 kinectin 1 (kinesin receptor) -0.0684032
TFPI2 tissue factor pathway inhibitor 2 -0.0682759
BBX bobby sox homolog (Drosophila) -0.0642148
POTEF POTE ankyrin domain family, member F -0.0611653
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0576902
TPI1 triosephosphate isomerase 1 -0.0573537
RPLP0 ribosomal protein, large, P0 -0.0567618
MYL12B myosin, light chain 12B, regulatory -0.0546824
UBC ubiquitin C -0.0541051
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0531423
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0521295
USP34 ubiquitin specific peptidase 34 -0.0514233
CSDE1 cold shock domain containing E1, RNA-binding -0.0509865
ZCCHC7 zinc finger, CCHC domain containing 7 -0.05062
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0500125
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0497838
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0495156
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0484934
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0484514
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0457529
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0455144
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0450146
UBE2H ubiquitin-conjugating enzyme E2H -0.0449389
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0443028
KDM2A lysine (K)-specific demethylase 2A -0.0437906
RSF1 remodeling and spacing factor 1 -0.0433624
PHIP pleckstrin homology domain interacting protein -0.0423345
PCBP2 poly(rC) binding protein 2 -0.0423142
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0413739
PTMA prothymosin, alpha -0.040947
ADAR adenosine deaminase, RNA-specific -0.0408263
WSB1 WD repeat and SOCS box containing 1 -0.0406803
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0404984
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0401398
TPM2 tropomyosin 2 (beta) -0.0400504
RPL8 ribosomal protein L8 -0.0395295
RPS8 ribosomal protein S8 -0.0386714
NIPBL Nipped-B homolog (Drosophila) -0.0378731
TXNRD1 thioredoxin reductase 1 -0.0376915
RPS21 ribosomal protein S21 -0.0372553
SEPTIN7 septin 7 -0.0369243
RPS15 ribosomal protein S15 -0.0364795
MT2A metallothionein 2A -0.0361764
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0361124
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0360593
RTN4 reticulon 4 -0.0360393
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0357033
RPL37 ribosomal protein L37 -0.0356682
EML4 echinoderm microtubule associated protein like 4 -0.0354828
VDAC1 voltage-dependent anion channel 1 -0.0352022
NF1 neurofibromin 1 -0.0349893
KPNB1 karyopherin (importin) beta 1 -0.0349741
PGK1 phosphoglycerate kinase 1 -0.034859
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0347176
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0343408
CCNL1 cyclin L1 -0.0343067
RPL19 ribosomal protein L19 -0.0338764
TUBA1B tubulin, alpha 1b -0.0338734
PHF20 PHD finger protein 20 -0.033727
EXOC4 exocyst complex component 4 -0.0332909
CD2AP CD2-associated protein -0.0331453
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0330528
ENO1 enolase 1, (alpha) -0.0328362
PKM pyruvate kinase, muscle -0.0326234
FMNL2 formin-like 2 -0.0322557
HLA-B major histocompatibility complex, class I, B -0.0318624
ACTG1 actin gamma 1 -0.0318207
ZFAND3 zinc finger, AN1-type domain 3 -0.0316457
TPT1 tumor protein, translationally-controlled 1 -0.0309387
RPL12 ribosomal protein L12 -0.0306984
FBXO11 F-box protein 11 -0.0305347
XPO1 exportin 1 -0.0301601
RAD51B RAD51 paralog B -0.0301183
MTPN myotrophin -0.0300189
SLC38A2 solute carrier family 38, member 2 -0.0297807
IFI6 interferon, alpha-inducible protein 6 -0.0294785
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0288223
S100A10 S100 calcium binding protein A10 -0.0287126
MCL1 myeloid cell leukemia 1 -0.0286746
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0284722
GRAMD1B GRAM domain containing 1B -0.0284603
IGF1R insulin-like growth factor 1 receptor -0.0282763
NCOA7 nuclear receptor coactivator 7 -0.027924
DEK DEK proto-oncogene -0.0278153
RPL35A ribosomal protein L35a -0.0276433
FUS FUS RNA binding protein -0.0276134
SETD5 SET domain containing 5 -0.0275557
AHNAK AHNAK nucleoprotein -0.0274711
BIRC6 baculoviral IAP repeat containing 6 -0.0273002
THSD4 thrombospondin, type I, domain containing 4 -0.0272158
ZNF207 zinc finger protein 207 -0.027148
RPS24 ribosomal protein S24 -0.0269973
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0267363