Tazarotene_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tazarotene perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tazarotene_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0502239
IGFBP3 insulin-like growth factor binding protein 3 0.0355553
VEGFA vascular endothelial growth factor A 0.0216895
TPM3 tropomyosin 3 0.0200691
RBM25 RNA binding motif protein 25 0.0194884
RAI14 retinoic acid induced 14 0.0184229
FBXO32 F-box protein 32 0.017199
TMF1 TATA element modulatory factor 1 0.0171018
MSN moesin 0.0163309
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0152889
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0151948
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0145131
FAM13A family with sequence similarity 13, member A 0.0137483
HDGF hepatoma-derived growth factor 0.013165
ENO2 enolase 2 (gamma, neuronal) 0.0131523
HLA-B major histocompatibility complex, class I, B 0.0129131
SOX4 SRY (sex determining region Y)-box 4 0.012869
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0128065
DSPP dentin sialophosphoprotein 0.0125716
ACBD3 acyl-CoA binding domain containing 3 0.012393
AKAP12 A kinase (PRKA) anchor protein 12 0.0123471
GOLGB1 golgin B1 0.0117108
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0115076
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0112146
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0111888
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.0109077
STC2 stanniocalcin 2 0.0109044
WSB1 WD repeat and SOCS box containing 1 0.010449
IGF2 insulin-like growth factor 2 0.0101984
PCBP1 poly(rC) binding protein 1 0.00990184
MSI2 musashi RNA-binding protein 2 0.00983797
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.00970346
PRRC2C proline-rich coiled-coil 2C 0.00949596
JUP junction plakoglobin 0.00912551
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0089899
UBXN4 UBX domain protein 4 0.0088799
FLNC filamin C, gamma 0.00866448
PDLIM5 PDZ and LIM domain 5 0.00850158
RAD51B RAD51 paralog B 0.00848297
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.00840088
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.00825317
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.00825039
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 0.00819826
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.00819316
APLP2 amyloid beta (A4) precursor-like protein 2 0.00814926
ITCH itchy E3 ubiquitin protein ligase 0.00812071
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.00811985
CTSS cathepsin S 0.00803099
TMA7 translation machinery associated 7 homolog (S. cerevisiae) 0.00799993
EIF3A eukaryotic translation initiation factor 3, subunit A 0.00771015
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.00753095
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.00734354
MKRN1 makorin ring finger protein 1 0.0073008
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.00725416
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.0071979
RAB7A RAB7A, member RAS oncogene family 0.00718574
RAB5B RAB5B, member RAS oncogene family 0.00710262
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.00709199
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.00703575
EIF5 eukaryotic translation initiation factor 5 0.00698583
WARS1 tryptophanyl-tRNA synthetase 1 0.00697978
ABHD3 abhydrolase domain containing 3 0.00692841
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.00685282
USP8 ubiquitin specific peptidase 8 0.00681824
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.00677109
FOSL1 FOS-like antigen 1 0.00670668
FBXL20 F-box and leucine-rich repeat protein 20 0.00669777
FNBP4 formin binding protein 4 0.00669362
SLU7 SLU7 splicing factor homolog (S. cerevisiae) 0.00665792
PDIA3 protein disulfide isomerase family A, member 3 0.00663723
JMY junction mediating and regulatory protein, p53 cofactor 0.0065584
RPRD2 regulation of nuclear pre-mRNA domain containing 2 0.00655755
CHD3 chromodomain helicase DNA binding protein 3 0.00652516
TBC1D22A TBC1 domain family, member 22A 0.0064674
TMPRSS2 transmembrane protease, serine 2 0.00645055
ESYT2 extended synaptotagmin-like protein 2 0.00643807
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.00639793
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.00638753
EIF5B eukaryotic translation initiation factor 5B 0.00632653
DTNA dystrobrevin, alpha 0.00625085
GNPDA1 glucosamine-6-phosphate deaminase 1 0.00624887
TNRC6B trinucleotide repeat containing 6B 0.00620733
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.00618691
WEE1 WEE1 G2 checkpoint kinase 0.00614004
CLIP2 CAP-GLY domain containing linker protein 2 0.00613023
TOM1 target of myb1 (chicken) 0.00611903
SKIL SKI-like proto-oncogene 0.00606485
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.00602095
PKP3 plakophilin 3 0.00596708
AKAP9 A kinase (PRKA) anchor protein 9 0.00594081
KDM7A lysine (K)-specific demethylase 7A 0.00592883
RSF1 remodeling and spacing factor 1 0.00590212
SRRM1 serine/arginine repetitive matrix 1 0.00586758
CHD4 chromodomain helicase DNA binding protein 4 0.00584347
ZFHX3 zinc finger homeobox 3 0.00584164
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) 0.00584016
EPB41 erythrocyte membrane protein band 4.1 0.00583098
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0058175
SRP54 signal recognition particle 54kDa 0.00575437
SRPK2 SRSF protein kinase 2 0.00571307

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.291066
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.251711
FN1 fibronectin 1 -0.185677
ASPH aspartate beta-hydroxylase -0.135112
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0990346
S100A6 S100 calcium binding protein A6 -0.0912562
TPT1 tumor protein, translationally-controlled 1 -0.0873642
ACTG1 actin gamma 1 -0.082096
ALCAM activated leukocyte cell adhesion molecule -0.0812408
ANXA2 annexin A2 -0.0802447
TMSB10 thymosin beta 10 -0.0785144
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0750128
FTL ferritin, light polypeptide -0.0715076
LMO7 LIM domain 7 -0.069181
TM4SF1 transmembrane 4 L six family member 1 -0.0664839
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0618056
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0617528
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0615508
S100A10 S100 calcium binding protein A10 -0.0613151
BHLHE40 basic helix-loop-helix family, member e40 -0.0587953
SLC38A1 solute carrier family 38, member 1 -0.058731
KRT7 keratin 7, type II -0.0568619
UBC ubiquitin C -0.0562642
RAD21 RAD21 homolog (S. pombe) -0.053066
TRIO trio Rho guanine nucleotide exchange factor -0.0511955
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.050689
RPL8 ribosomal protein L8 -0.0506053
NAMPT nicotinamide phosphoribosyltransferase -0.0501468
LAMC2 laminin, gamma 2 -0.0494727
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -0.0493991
RPL34 ribosomal protein L34 -0.0493457
FNDC3B fibronectin type III domain containing 3B -0.0473141
RPLP0 ribosomal protein, large, P0 -0.0468077
RPL35A ribosomal protein L35a -0.0460326
PGK1 phosphoglycerate kinase 1 -0.045462
MARCHF6 membrane associated ring-CH-type finger 6 -0.0453465
AHNAK AHNAK nucleoprotein -0.0451682
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0439974
ELL2 elongation factor, RNA polymerase II, 2 -0.0439926
RACK1 receptor for activated C kinase 1 -0.0434987
TMSB4X thymosin beta 4, X-linked -0.0423358
RPLP1 ribosomal protein, large, P1 -0.041889
PTK2 protein tyrosine kinase 2 -0.0396975
RPS24 ribosomal protein S24 -0.0388498
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0388116
RPL32 ribosomal protein L32 -0.0382019
RPL19 ribosomal protein L19 -0.037965
LAMB3 laminin, beta 3 -0.037946
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0374358
CD2AP CD2-associated protein -0.0372336
TXNRD1 thioredoxin reductase 1 -0.0366981
LOC112694756 uncharaterized LOC112694756 -0.0352366
SQSTM1 sequestosome 1 -0.0347284
CAPN2 calpain 2, (m/II) large subunit -0.0338103
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0334369
DSCAM Down syndrome cell adhesion molecule -0.0333257
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0333201
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0329844
RPS23 ribosomal protein S23 -0.0325883
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0317548
RPL23 ribosomal protein L23 -0.0317479
MBNL1 muscleblind-like splicing regulator 1 -0.0314597
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.031413
RPS8 ribosomal protein S8 -0.0310989
TFG TRK-fused gene -0.029887
RPS5 ribosomal protein S5 -0.0298555
RHEB Ras homolog enriched in brain -0.0297669
RPL12 ribosomal protein L12 -0.029645
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0295429
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.029136
RPL27A ribosomal protein L27a -0.0291275
PKM pyruvate kinase, muscle -0.0290884
RPL11 ribosomal protein L11 -0.0289517
GNAS GNAS complex locus -0.0289006
ADAM9 ADAM metallopeptidase domain 9 -0.028862
EPCAM epithelial cell adhesion molecule -0.0284471
CCNI cyclin I -0.0284408
ENO1 enolase 1, (alpha) -0.0278063
ZFAND3 zinc finger, AN1-type domain 3 -0.0277233
TMEM263 transmembrane protein 263 -0.0275118
HMGA1 high mobility group AT-hook 1 -0.0272827
TSC22D2 TSC22 domain family, member 2 -0.027142
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0269544
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0267929
PLAU plasminogen activator, urokinase -0.0267536
APP amyloid beta (A4) precursor protein -0.0267521
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0266936
HMGB2 high mobility group box 2 -0.0265725
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.026464
RUNX1 runt-related transcription factor 1 -0.0263534
RHOA ras homolog family member A -0.0262323
PTMA prothymosin, alpha -0.0261062
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0260443
SDC4 syndecan 4 -0.0259319
RPL30 ribosomal protein L30 -0.0256193
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0254914
USP3 ubiquitin specific peptidase 3 -0.0253894
CCND1 cyclin D1 -0.0253035
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0252099
DEK DEK proto-oncogene -0.0251338