Tazarotene_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tazarotene perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tazarotene_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0938627
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0694341
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0618767
MKI67 marker of proliferation Ki-67 0.0577356
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0491777
PTMA prothymosin, alpha 0.0482881
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0459075
WDR43 WD repeat domain 43 0.0435155
THBS1 thrombospondin 1 0.0430568
SET SET nuclear proto-oncogene 0.0428576
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0383863
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0374135
ZNF292 zinc finger protein 292 0.0370985
IQGAP1 IQ motif containing GTPase activating protein 1 0.0363206
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0361039
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0354922
KIF5B kinesin family member 5B 0.034605
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0329859
KMT2E lysine (K)-specific methyltransferase 2E 0.0325868
ARHGAP21 Rho GTPase activating protein 21 0.0325823
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0323823
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0312685
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0300794
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0296833
KDM3A lysine (K)-specific demethylase 3A 0.0292705
MEF2A myocyte enhancer factor 2A 0.0288076
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0284661
HMGB2 high mobility group box 2 0.0280882
H1-4 H1.4 linker histone, cluster member 0.0280404
OLA1 Obg-like ATPase 1 0.0279706
MB21D2 Mab-21 domain containing 2 0.0278896
KDM6A lysine (K)-specific demethylase 6A 0.0272382
RPS7 ribosomal protein S7 0.0266437
USP15 ubiquitin specific peptidase 15 0.0264898
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0264027
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0262249
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0260686
CDK6 cyclin-dependent kinase 6 0.0257172
SH3RF2 SH3 domain containing ring finger 2 0.0256975
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0251968
BZW1 basic leucine zipper and W2 domains 1 0.0251411
APP amyloid beta (A4) precursor protein 0.0251149
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.0249824
SERBP1 SERPINE1 mRNA binding protein 1 0.0248948
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0246342
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0240372
ANKRD11 ankyrin repeat domain 11 0.0238124
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0233733
LUZP2 leucine zipper protein 2 0.0233595
ZBTB35 zinc finger and BTB domain containing 35 0.023315
CANX calnexin 0.0231469
HSPA4 heat shock 70kDa protein 4 0.0231353
SRP72 signal recognition particle 72kDa 0.0231117
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0231058
NONO non-POU domain containing, octamer-binding 0.0230398
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0229968
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.0229538
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0226542
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.0225688
THRAP3 thyroid hormone receptor associated protein 3 0.0225675
RPL6 ribosomal protein L6 0.0223909
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0223274
ZFAND3 zinc finger, AN1-type domain 3 0.0222533
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0222188
PDIA4 protein disulfide isomerase family A, member 4 0.0218773
TTC17 tetratricopeptide repeat domain 17 0.0218338
PDAP1 PDGFA associated protein 1 0.0214698
FOXG1 forkhead box G1 0.02143
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0213576
VGLL3 vestigial-like family member 3 0.0212395
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.0212303
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0212038
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0211676
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0210766
ZCCHC8 zinc finger, CCHC domain containing 8 0.021075
FIP1L1 factor interacting with PAPOLA and CPSF1 0.0210591
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.020979
CRY1 cryptochrome circadian clock 1 0.020969
H2AZ2 H2A.Z variant histone 2 0.0208756
CLSPN claspin 0.0208218
USP22 ubiquitin specific peptidase 22 0.0207703
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0207637
AFF1 AF4/FMR2 family, member 1 0.0205002
ZNF608 zinc finger protein 608 0.0203174
PGPEP1L pyroglutamyl-peptidase I-like 0.0202985
PNN pinin, desmosome associated protein 0.0201242
SP3 Sp3 transcription factor 0.020004
ZNF451 zinc finger protein 451 0.0198003
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.0197898
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0196573
RPL14 ribosomal protein L14 0.0194716
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 0.0193069
YAP1 Yes-associated protein 1 0.0193007
BRCA1 breast cancer 1, early onset 0.0192518
AGO3 argonaute RISC catalytic component 3 0.0192294
BCLAF1 BCL2-associated transcription factor 1 0.0191575
KIF11 kinesin family member 11 0.0191121
LIN28B lin-28 homolog B (C. elegans) 0.0190751
SRRT serrate, RNA effector molecule 0.0190732
EIF4A2 eukaryotic translation initiation factor 4A2 0.0189733

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.173999
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.12682
COL11A1 collagen, type XI, alpha 1 -0.118876
RPS6 ribosomal protein S6 -0.109602
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.102918
ITGAV integrin, alpha V -0.0811009
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0783992
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0760618
PHIP pleckstrin homology domain interacting protein -0.0760481
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0747066
RPL35A ribosomal protein L35a -0.0701244
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0694612
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0676781
RPS16 ribosomal protein S16 -0.0667916
POTEF POTE ankyrin domain family, member F -0.0659846
CDH10 cadherin 10, type 2 (T2-cadherin) -0.065374
SETD5 SET domain containing 5 -0.0651955
MED13L mediator complex subunit 13-like -0.0644907
FTL ferritin, light polypeptide -0.0638388
JMJD1C jumonji domain containing 1C -0.0635928
PCDH9 protocadherin 9 -0.0592777
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0589545
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0574382
TENM3 teneurin transmembrane protein 3 -0.0573732
MDK midkine (neurite growth-promoting factor 2) -0.0569208
DST dystonin -0.0559469
RPLP0 ribosomal protein, large, P0 -0.0548027
PCLO piccolo presynaptic cytomatrix protein -0.0531334
COL5A2 collagen, type V, alpha 2 -0.0530518
RPL23 ribosomal protein L23 -0.0521164
WSB1 WD repeat and SOCS box containing 1 -0.0509101
SYT1 synaptotagmin I -0.0503935
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0490082
FN1 fibronectin 1 -0.0473016
MRPS6 mitochondrial ribosomal protein S6 -0.0472043
ATP5F1B ATP synthase F1 subunit beta -0.0470804
MEIS2 Meis homeobox 2 -0.0470384
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.047006
B2M beta-2-microglobulin -0.046758
KPNB1 karyopherin (importin) beta 1 -0.0452027
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0442819
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0442365
PDE4D phosphodiesterase 4D, cAMP-specific -0.044198
TUBA1B tubulin, alpha 1b -0.0435838
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0435703
NTM neurotrimin -0.0432506
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0423921
MT2A metallothionein 2A -0.041741
COTL1 coactosin-like F-actin binding protein 1 -0.0406378
BPTF bromodomain PHD finger transcription factor -0.0405636
TXNRD1 thioredoxin reductase 1 -0.0397318
SOX5 SRY (sex determining region Y)-box 5 -0.0395745
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 -0.0393832
SKIL SKI-like proto-oncogene -0.0392033
KMT2C lysine (K)-specific methyltransferase 2C -0.0391444
PCBP2 poly(rC) binding protein 2 -0.0386933
CENPF centromere protein F, 350/400kDa -0.0386274
TMOD3 tropomodulin 3 (ubiquitous) -0.0384374
TPT1 tumor protein, translationally-controlled 1 -0.0382506
ZBTB20 zinc finger and BTB domain containing 20 -0.0381646
USP34 ubiquitin specific peptidase 34 -0.0381639
MAP4 microtubule-associated protein 4 -0.0379048
ADNP activity-dependent neuroprotector homeobox -0.0377387
SLC38A2 solute carrier family 38, member 2 -0.037445
PDIA3 protein disulfide isomerase family A, member 3 -0.0372281
MBD5 methyl-CpG binding domain protein 5 -0.0371961
RPS19 ribosomal protein S19 -0.0368946
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0368292
PIAS1 protein inhibitor of activated STAT, 1 -0.0364587
ADGRL2 adhesion G protein-coupled receptor L2 -0.0363543
RPLP1 ribosomal protein, large, P1 -0.0354505
RASAL2 RAS protein activator like 2 -0.0352748
ZNF638 zinc finger protein 638 -0.035153
RPL28 ribosomal protein L28 -0.0349162
RNF13 ring finger protein 13 -0.0346672
TCF12 transcription factor 12 -0.0345658
PGK1 phosphoglycerate kinase 1 -0.0341837
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0341573
WASF2 WAS protein family, member 2 -0.0339277
RPS12 ribosomal protein S12 -0.0337257
ANKRD33B ankyrin repeat domain 33B -0.0334357
RPL30 ribosomal protein L30 -0.0333526
BBX bobby sox homolog (Drosophila) -0.0332626
ADAM9 ADAM metallopeptidase domain 9 -0.0332448
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0332201
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0329643
KTN1 kinectin 1 (kinesin receptor) -0.0327733
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0326866
GNAS GNAS complex locus -0.0325805
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0322615
OGA O-GlcNAcase -0.0321969
TOX thymocyte selection-associated high mobility group box -0.0321046
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0320058
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.031769
DEK DEK proto-oncogene -0.031732
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0311963
PGAP1 post-GPI attachment to proteins 1 -0.0311012
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0310227
PARD3 par-3 family cell polarity regulator -0.0310219
SEPTIN7 septin 7 -0.0309828