Tazarotene_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tazarotene perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tazarotene_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.0344319
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0268506
ELL2 elongation factor, RNA polymerase II, 2 0.0210581
NRIP1 nuclear receptor interacting protein 1 0.0199014
ARRDC3 arrestin domain containing 3 0.0185496
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0149631
FNIP1 folliculin interacting protein 1 0.0148592
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0143048
SMAD3 SMAD family member 3 0.0142219
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0139175
NAV2 neuron navigator 2 0.0127165
IL1RAP interleukin 1 receptor accessory protein 0.0116359
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0115347
SDC4 syndecan 4 0.0111654
MYH9 myosin, heavy chain 9, non-muscle 0.00985779
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.009475
FAM3C family with sequence similarity 3, member C 0.0093149
OGA O-GlcNAcase 0.00891926
ESYT2 extended synaptotagmin-like protein 2 0.0087074
ANLN anillin, actin binding protein 0.00844058
ABTB3 ankyrin repeat and BTB domain containing 3 0.00838635
PPARD peroxisome proliferator-activated receptor delta 0.00803448
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.00786257
TGM2 transglutaminase 2 0.00780694
RB1CC1 RB1-inducible coiled-coil 1 0.00745458
DIAPH3 diaphanous-related formin 3 0.00734119
ITCH itchy E3 ubiquitin protein ligase 0.0072677
CLSTN2 calsyntenin 2 0.00720473
JMJD1C jumonji domain containing 1C 0.00716528
AMN1 antagonist of mitotic exit network 1 homolog (S. cerevisiae) 0.00713314
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.00712038
ANKRD36 ankyrin repeat domain 36 0.00686399
KLF7 Kruppel-like factor 7 (ubiquitous) 0.00685709
USP53 ubiquitin specific peptidase 53 0.00684342
ARFGEF3 ARFGEF family member 3 0.006749
BRWD3 bromodomain and WD repeat domain containing 3 0.00673648
ZFC3H1 zinc finger, C3H1-type containing 0.00672111
NGLY1 N-glycanase 1 0.0066161
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.00655482
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.00654801
YEATS2 YEATS domain containing 2 0.00650335
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.00649115
AMPD3 adenosine monophosphate deaminase 3 0.00644819
SERINC1 serine incorporator 1 0.00643946
MKI67 marker of proliferation Ki-67 0.00628523
TGFB2 transforming growth factor, beta 2 0.0062556
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.00621521
NUP98 nucleoporin 98kDa 0.00614525
SPTBN1 spectrin, beta, non-erythrocytic 1 0.00606256
PLPP3 phospholipid phosphatase 3 0.00604096
MIS18BP1 MIS18 binding protein 1 0.00599
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.00580866
PRELID2 PRELI domain containing 2 0.00567492
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.00555863
RASA2 RAS p21 protein activator 2 0.0055375
KLC1 kinesin light chain 1 0.00549937
WWTR1 WW domain containing transcription regulator 1 0.00548938
CEP95 centrosomal protein 95kDa 0.00542274
CKAP5 cytoskeleton associated protein 5 0.00541779
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.00540254
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.00533536
KIF4A kinesin family member 4A 0.00533406
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.00529453
HSPA8 heat shock 70kDa protein 8 0.00521154
SPAG9 sperm associated antigen 9 0.00518457
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 0.00517738
GPC6 glypican 6 0.0051731
DUSP5 dual specificity phosphatase 5 0.00514661
BCAR3 breast cancer anti-estrogen resistance 3 0.00508605
RNGTT RNA guanylyltransferase and 5'-phosphatase 0.00507912
TMEM39A transmembrane protein 39A 0.00503882
NOTCH2 notch 2 0.00499271
USP9X ubiquitin specific peptidase 9, X-linked 0.00496516
KDM3B lysine (K)-specific demethylase 3B 0.00484427
RUNX1 runt-related transcription factor 1 0.00480291
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.00479083
KDM1A lysine (K)-specific demethylase 1A 0.00472849
WASHC4 WASH complex subunit 4 0.00471651
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.00469376
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.00464416
KIF11 kinesin family member 11 0.00461812
POM121 POM121 transmembrane nucleoporin 0.00460164
DOT1L DOT1-like histone H3K79 methyltransferase 0.00460153
NUP153 nucleoporin 153kDa 0.00456983
TMF1 TATA element modulatory factor 1 0.00452448
TENT2 terminal nucleotidyltransferase 2 0.00448804
AVL9 AVL9 homolog (S. cerevisiase) 0.00444755
ATAD2 ATPase family, AAA domain containing 2 0.00441584
RARS2 arginyl-tRNA synthetase 2, mitochondrial 0.00441284
CEP152 centrosomal protein 152kDa 0.00440604
MYSM1 Myb-like, SWIRM and MPN domains 1 0.00438807
DSCAM Down syndrome cell adhesion molecule 0.00437051
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.00436017
ADAM19 ADAM metallopeptidase domain 19 0.0043284
TEX10 testis expressed 10 0.0043104
USP12 ubiquitin specific peptidase 12 0.00428967
H1-4 H1.4 linker histone, cluster member 0.00424511
BRCA1 breast cancer 1, early onset 0.00421081
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.00420426
EIF4B eukaryotic translation initiation factor 4B 0.00418712

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.267056
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.148187
HLA-B major histocompatibility complex, class I, B -0.102987
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0997973
FTL ferritin, light polypeptide -0.0954412
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0911662
TMSB10 thymosin beta 10 -0.0854882
IER3 immediate early response 3 -0.0818191
TPT1 tumor protein, translationally-controlled 1 -0.0651949
B2M beta-2-microglobulin -0.0646861
RPS6 ribosomal protein S6 -0.0643767
FRMD4A FERM domain containing 4A -0.0633535
CD44 CD44 molecule (Indian blood group) -0.0570058
IGFBP3 insulin-like growth factor binding protein 3 -0.054804
HLA-A major histocompatibility complex, class I, A -0.0546259
MT2A metallothionein 2A -0.0505062
LDHA lactate dehydrogenase A -0.0498966
FTH1 ferritin, heavy polypeptide 1 -0.0494603
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0492906
PGK1 phosphoglycerate kinase 1 -0.0488144
ADM adrenomedullin -0.0472586
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0471094
GLIS3 GLIS family zinc finger 3 -0.0462025
RPS8 ribosomal protein S8 -0.0431528
ENO1 enolase 1, (alpha) -0.0422385
RPS12 ribosomal protein S12 -0.0421087
PTMA prothymosin, alpha -0.04078
COL6A3 collagen, type VI, alpha 3 -0.0370109
RPS3 ribosomal protein S3 -0.0368347
HMGA2 high mobility group AT-hook 2 -0.0358035
IFITM3 interferon induced transmembrane protein 3 -0.0353575
RPL37A ribosomal protein L37a -0.0352902
RPLP2 ribosomal protein, large, P2 -0.0351759
RPL35A ribosomal protein L35a -0.0344314
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0341808
RPL23 ribosomal protein L23 -0.0338897
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0331915
RPS24 ribosomal protein S24 -0.0329874
RPLP1 ribosomal protein, large, P1 -0.032359
EGR1 early growth response 1 -0.0322515
CALR calreticulin -0.0317164
CDH13 cadherin 13 -0.0309004
PLIN2 perilipin 2 -0.0306999
NAP1L1 nucleosome assembly protein 1-like 1 -0.0299299
UGCG UDP-glucose ceramide glucosyltransferase -0.029914
CTSD cathepsin D -0.0297172
EIF1 eukaryotic translation initiation factor 1 -0.0293042
RPS13 ribosomal protein S13 -0.0290659
PKM pyruvate kinase, muscle -0.0288612
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0287236
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0286077
ZMYND8 zinc finger, MYND-type containing 8 -0.0284569
RPL12 ribosomal protein L12 -0.0282765
RPS19 ribosomal protein S19 -0.0282074
RPL19 ribosomal protein L19 -0.0275923
RACK1 receptor for activated C kinase 1 -0.0271712
BASP1 brain abundant, membrane attached signal protein 1 -0.0268143
TMSB4X thymosin beta 4, X-linked -0.026594
RPS23 ribosomal protein S23 -0.0264712
SLC38A1 solute carrier family 38, member 1 -0.0262642
GNAS GNAS complex locus -0.0262091
RPL9 ribosomal protein L9 -0.0261631
DIAPH2 diaphanous-related formin 2 -0.0259045
RPL11 ribosomal protein L11 -0.0258918
C3 complement component 3 -0.0256131
TPM4 tropomyosin 4 -0.0256086
RPS4X ribosomal protein S4, X-linked -0.0253644
EXT1 exostosin glycosyltransferase 1 -0.0252402
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0250946
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0250501
RPL26 ribosomal protein L26 -0.0249554
TGFBI transforming growth factor, beta-induced, 68kDa -0.0243203
COL1A1 collagen, type I, alpha 1 -0.0240391
UBC ubiquitin C -0.0240291
RPLP0 ribosomal protein, large, P0 -0.0237323
COL1A2 collagen, type I, alpha 2 -0.0237115
ACTG1 actin gamma 1 -0.0237058
RPL36A ribosomal protein L36a -0.0234222
SFRP1 secreted frizzled-related protein 1 -0.023413
RPS10 ribosomal protein S10 -0.0234075
VEGFA vascular endothelial growth factor A -0.0232171
RPL36 ribosomal protein L36 -0.0231381
SLC38A2 solute carrier family 38, member 2 -0.0230686
HILPDA hypoxia inducible lipid droplet-associated -0.0227452
HLA-E major histocompatibility complex, class I, E -0.0226933
LOC112694756 uncharaterized LOC112694756 -0.0225513
RPL5 ribosomal protein L5 -0.0224931
RPL27A ribosomal protein L27a -0.0220297
RPS21 ribosomal protein S21 -0.0219242
RPS14 ribosomal protein S14 -0.0218096
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.021733
RPL32 ribosomal protein L32 -0.0216922
BTG1 B-cell translocation gene 1, anti-proliferative -0.0212954
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0212807
ARL4C ADP-ribosylation factor-like 4C -0.0208336
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0207899
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0207717
IFI6 interferon, alpha-inducible protein 6 -0.0207186
SFTPA2 surfactant protein A2 -0.0206969
RPL7A ribosomal protein L7a -0.0205936