Telmisartan Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/65999
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Genes

199 proteins with high or low expression in Telmisartan relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
MSH5 mutS homolog 5 1.09
BMPR1B bone morphogenetic protein receptor, type IB 1.05
ALKBH5 AlkB family member 5, RNA demethylase 0.98
ALAS1 5'-aminolevulinate synthase 1 0.94
RPE ribulose-5-phosphate-3-epimerase 0.69
HMCES 5-hydroxymethylcytosine (hmC) binding, ES cell-specific 0.67
MYCBP MYC binding protein 0.58
ZBTB8A zinc finger and BTB domain containing 8A 0.57
C19ORF25 chromosome 19 open reading frame 25 0.53
ATL1 atlastin GTPase 1 0.51
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.51
TMEM63A transmembrane protein 63A 0.5
ZFYVE26 zinc finger, FYVE domain containing 26 0.5
PEX7 peroxisomal biogenesis factor 7 0.49
MED19 mediator complex subunit 19 0.48
C1ORF109 chromosome 1 open reading frame 109 0.48
ZNF76 zinc finger protein 76 0.45
JPT1 Jupiter microtubule associated homolog 1 0.44
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.44
MRPL50 mitochondrial ribosomal protein L50 0.44
MED7 mediator complex subunit 7 0.43
FUNDC1 FUN14 domain containing 1 0.43
COMMD8 COMM domain containing 8 0.43
ZNF251 zinc finger protein 251 0.43
ADIRF adipogenesis regulatory factor 0.42
CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4 0.42
YAE1 YAE1 maturation factor of ABCE1 0.42
TIGD1 tigger transposable element derived 1 0.42
BCLAF3 BCLAF1 and THRAP3 family member 3 0.42
NOP10 NOP10 ribonucleoprotein 0.42
FANCF Fanconi anemia, complementation group F 0.41
TTC27 tetratricopeptide repeat domain 27 0.41
RUFY3 RUN and FYVE domain containing 3 0.4
JDP2 Jun dimerization protein 2 0.4
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 0.4
PEX5 peroxisomal biogenesis factor 5 0.39
ZNF445 zinc finger protein 445 0.39
RPS26 ribosomal protein S26 0.39
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 0.39
PAQR7 progestin and adipoQ receptor family member VII 0.39
PDGFA platelet-derived growth factor alpha polypeptide 0.38
E2F7 E2F transcription factor 7 0.38
ATP5PD ATP synthase peripheral stalk subunit d 0.38
SMTN smoothelin 0.37
SLC25A39 solute carrier family 25, member 39 0.37
TCP11L1 t-complex 11, testis-specific-like 1 0.36
NBPF20 neuroblastoma breakpoint family, member 20 0.36
BANF1 barrier to autointegration factor 1 0.36
KDM5B lysine (K)-specific demethylase 5B 0.36
DNAL4 dynein, axonemal, light chain 4 0.35
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 0.34
ABHD4 abhydrolase domain containing 4 0.34
GID8 GID complex subunit 8 0.34
BBS10 Bardet-Biedl syndrome 10 0.34
CCNDBP1 cyclin D-type binding-protein 1 0.34
ZNF319 zinc finger protein 319 0.34
ATXN7L3B ataxin 7-like 3B 0.34
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.34
PLIN2 perilipin 2 0.33
EPM2AIP1 EPM2A (laforin) interacting protein 1 0.33
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.33
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa 0.33
MED8 mediator complex subunit 8 0.33
RTN1 reticulon 1 0.33
MIF4GD MIF4G domain containing 0.33
SRRD SRR1 domain containing 0.32
ALG3 ALG3, alpha-1,3- mannosyltransferase 0.32
RBAK RB-associated KRAB zinc finger 0.32
NIN ninein (GSK3B interacting protein) 0.32
ZNF791 zinc finger protein 791 0.32
ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein-like 2 0.31
LONP2 lon peptidase 2, peroxisomal 0.31
SPIN4 spindlin family, member 4 0.31
RGPD2 RANBP2-like and GRIP domain containing 2 0.31
HECA headcase homolog (Drosophila) 0.31
MARCHF6 membrane associated ring-CH-type finger 6 0.31
TLE2 transducin-like enhancer of split 2 0.31
AZIN1 antizyme inhibitor 1 0.31
C12ORF60 chromosome 12 open reading frame 60 0.31
FCHO1 FCH domain only 1 0.3
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 0.3
CENPH centromere protein H 0.3
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.3
GRTP1 growth hormone regulated TBC protein 1 0.3
C17ORF53 chromosome 17 open reading frame 53 0.3
ZNF561 zinc finger protein 561 0.3
CRYBG2 crystallin beta-gamma domain containing 2 0.29
CCDC9B coiled-coil domain containing 9B 0.29
KCTD12 potassium channel tetramerization domain containing 12 0.29
TCF3 transcription factor 3 0.29
ZNF22 zinc finger protein 22 0.29
CWC15 CWC15 spliceosome-associated protein 0.29
ONECUT2 one cut homeobox 2 0.29
SH3D19 SH3 domain containing 19 0.29
ATP5PF ATP synthase peripheral stalk subunit F6 0.28
CACUL1 CDK2-associated, cullin domain 1 0.28
CAMTA2 calmodulin binding transcription activator 2 0.28
GTSF1 gametocyte specific factor 1 0.28
ANGPTL4 angiopoietin-like 4 0.28
DESI1 desumoylating isopeptidase 1 0.28

low expression

Symbol Name Standardized Value
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 -0.72
C4ORF33 chromosome 4 open reading frame 33 -0.71
COL17A1 collagen, type XVII, alpha 1 -0.67
HBA1 hemoglobin, alpha 1 -0.61
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) -0.59
FOXO1 forkhead box O1 -0.58
TMEM248 transmembrane protein 248 -0.58
MRPL57 mitochondrial ribosomal protein L57 -0.57
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 -0.56
PSEN2 presenilin 2 -0.53
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 -0.53
TRIB3 tribbles pseudokinase 3 -0.51
TINAGL1 tubulointerstitial nephritis antigen-like 1 -0.5
NCOA1 nuclear receptor coactivator 1 -0.49
MICOS10 mitochondrial contact site and cristae organizing system subunit 10 -0.49
FAM185A family with sequence similarity 185, member A -0.46
COL13A1 collagen, type XIII, alpha 1 -0.46
EGR1 early growth response 1 -0.45
MKS1 Meckel syndrome, type 1 -0.45
CCDC158 coiled-coil domain containing 158 -0.45
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.44
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 -0.43
ELP5 elongator acetyltransferase complex subunit 5 -0.42
ZMYM6 zinc finger, MYM-type 6 -0.41
FAR1 fatty acyl CoA reductase 1 -0.41
MARCKS myristoylated alanine-rich protein kinase C substrate -0.4
TRMO tRNA methyltransferase O -0.4
JAG1 jagged 1 -0.39
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.39
MPDU1 mannose-P-dolichol utilization defect 1 -0.39
ABHD3 abhydrolase domain containing 3 -0.38
MLX MLX, MAX dimerization protein -0.38
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.38
PTPRB protein tyrosine phosphatase, receptor type, B -0.37
SPPL2B signal peptide peptidase like 2B -0.37
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.36
SLC38A2 solute carrier family 38, member 2 -0.36
DAD1 defender against cell death 1 -0.36
CSNK2B casein kinase 2, beta polypeptide -0.36
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) -0.36
NCKAP5L NCK-associated protein 5-like -0.35
MAP2K5 mitogen-activated protein kinase kinase 5 -0.35
CD63 CD63 molecule -0.35
SERINC1 serine incorporator 1 -0.35
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 -0.35
EMP3 epithelial membrane protein 3 -0.35
GPATCH2L G patch domain containing 2-like -0.34
VCPKMT valosin containing protein lysine (K) methyltransferase -0.34
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.34
S100A6 S100 calcium binding protein A6 -0.34
ZMAT5 zinc finger, matrin-type 5 -0.33
FGFBP1 fibroblast growth factor binding protein 1 -0.33
CCDC102A coiled-coil domain containing 102A -0.33
CYB5D2 cytochrome b5 domain containing 2 -0.32
F2RL1 coagulation factor II (thrombin) receptor-like 1 -0.32
RAB30 RAB30, member RAS oncogene family -0.32
NEBL nebulette -0.32
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 -0.32
UGCG UDP-glucose ceramide glucosyltransferase -0.32
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -0.31
DOCK3 dedicator of cytokinesis 3 -0.31
NAGS N-acetylglutamate synthase -0.31
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H -0.31
MED12L mediator complex subunit 12-like -0.31
CTDNEP1 CTD nuclear envelope phosphatase 1 -0.3
NHSL1 NHS-like 1 -0.3
GAMT guanidinoacetate N-methyltransferase -0.3
ABHD2 abhydrolase domain containing 2 -0.3
CYB561 cytochrome b561 -0.3
ZNF532 zinc finger protein 532 -0.29
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) -0.29
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase -0.29
MRPS23 mitochondrial ribosomal protein S23 -0.28
TSPAN3 tetraspanin 3 -0.28
TMEM41B transmembrane protein 41B -0.28
DMD dystrophin -0.28
DNAH5 dynein, axonemal, heavy chain 5 -0.28
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -0.28
WSB1 WD repeat and SOCS box containing 1 -0.28
GEM GTP binding protein overexpressed in skeletal muscle -0.28
JMJD8 jumonji domain containing 8 -0.28
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.28
STEAP1 six transmembrane epithelial antigen of the prostate 1 -0.28
IQCB1 IQ motif containing B1 -0.27
NT5C 5', 3'-nucleotidase, cytosolic -0.27
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.27
RNASET2 ribonuclease T2 -0.26
CIAO2B cytosolic iron-sulfur assembly component 2B -0.26
MRPS14 mitochondrial ribosomal protein S14 -0.26
TDRD9 tudor domain containing 9 -0.26
SZT2 seizure threshold 2 homolog (mouse) -0.26
HSH2D hematopoietic SH2 domain containing -0.26
STARD5 StAR-related lipid transfer (START) domain containing 5 -0.26
HCCS holocytochrome c synthase -0.25
LRP1 low density lipoprotein receptor-related protein 1 -0.25
IER3IP1 immediate early response 3 interacting protein 1 -0.25
KIAA1210 KIAA1210 -0.25
CST3 cystatin C -0.25
CKM creatine kinase, muscle -0.25