Telotristat Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/25025298
Similar Terms
Downloads & Tools

Genes

198 proteins with high or low expression in Telotristat relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 1.93
TTLL4 tubulin tyrosine ligase-like family member 4 1.8
ADPRH ADP-ribosylarginine hydrolase 1.28
STARD3 StAR-related lipid transfer (START) domain containing 3 1.23
YPEL5 yippee-like 5 (Drosophila) 1.23
ZNF692 zinc finger protein 692 1.11
TRPM7 transient receptor potential cation channel, subfamily M, member 7 1.1
GDPGP1 GDP-D-glucose phosphorylase 1 1.04
ADGRG6 adhesion G protein-coupled receptor G6 0.91
PIWIL2 piwi-like RNA-mediated gene silencing 2 0.72
TACSTD2 tumor-associated calcium signal transducer 2 0.71
VGF VGF nerve growth factor inducible 0.71
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.7
MYH13 myosin, heavy chain 13, skeletal muscle 0.66
BLOC1S5 biogenesis of lysosomal organelles complex-1, subunit 5, muted 0.64
F10 coagulation factor X 0.64
PSAP prosaposin 0.64
STON2 stonin 2 0.64
RAP1B RAP1B, member of RAS oncogene family 0.62
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 0.61
ZEB1 zinc finger E-box binding homeobox 1 0.61
ELOVL6 ELOVL fatty acid elongase 6 0.6
GORASP1 golgi reassembly stacking protein 1, 65kDa 0.58
ZNF169 zinc finger protein 169 0.56
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.56
OTX1 orthodenticle homeobox 1 0.56
ZNF808 zinc finger protein 808 0.55
COL14A1 collagen, type XIV, alpha 1 0.55
ZC3H6 zinc finger CCCH-type containing 6 0.55
FTL ferritin, light polypeptide 0.54
CLDN3 claudin 3 0.53
CDK10 cyclin-dependent kinase 10 0.53
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) 0.53
MSH5 mutS homolog 5 0.53
ZGRF1 zinc finger, GRF-type containing 1 0.5
ABHD2 abhydrolase domain containing 2 0.5
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit 0.49
OASL 2'-5'-oligoadenylate synthetase-like 0.49
NT5C3B 5'-nucleotidase, cytosolic IIIB 0.49
F2 coagulation factor II (thrombin) 0.49
HMOX1 heme oxygenase 1 0.49
SERINC5 serine incorporator 5 0.48
VTN vitronectin 0.48
TMEM184A transmembrane protein 184A 0.48
FSTL1 follistatin-like 1 0.48
PHETA1 PH domain containing endocytic trafficking adaptor 1 0.47
RETREG1 reticulophagy regulator 1 0.47
SFT2D3 SFT2 domain containing 3 0.46
CDC26 cell division cycle 26 0.46
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 0.46
TPM4 tropomyosin 4 0.45
PMFBP1 polyamine modulated factor 1 binding protein 1 0.44
CASKIN1 CASK interacting protein 1 0.44
H2AFX H2A histone family, member X 0.44
HBA1 hemoglobin, alpha 1 0.43
KIAA1210 KIAA1210 0.43
MFSD8 major facilitator superfamily domain containing 8 0.43
HAS3 hyaluronan synthase 3 0.43
PRELID3B PRELI domain containing 3B 0.43
SPPL2A signal peptide peptidase like 2A 0.43
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.42
MBP myelin basic protein 0.42
ANTXR2 anthrax toxin receptor 2 0.42
C14ORF119 chromosome 14 open reading frame 119 0.42
CBY1 chibby homolog 1 (Drosophila) 0.41
IGBP1 immunoglobulin (CD79A) binding protein 1 0.41
FGA fibrinogen alpha chain 0.41
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 0.41
MSRB2 methionine sulfoxide reductase B2 0.4
HSBP1 heat shock factor binding protein 1 0.4
ZNF205 zinc finger protein 205 0.4
OTC ornithine carbamoyltransferase 0.4
ZYX zyxin 0.39
R3HDM2 R3H domain containing 2 0.39
MED4 mediator complex subunit 4 0.39
WTAP Wilms tumor 1 associated protein 0.39
AHR aryl hydrocarbon receptor 0.39
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.39
ABITRAM actin binding transcription modulator 0.39
CRELD2 cysteine-rich with EGF-like domains 2 0.39
MYBPC1 myosin binding protein C, slow type 0.39
STMN2 stathmin 2 0.38
LRP4 low density lipoprotein receptor-related protein 4 0.38
CTHRC1 collagen triple helix repeat containing 1 0.38
MARCKS myristoylated alanine-rich protein kinase C substrate 0.38
MYT1L myelin transcription factor 1-like 0.38
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 0.38
AASS aminoadipate-semialdehyde synthase 0.38
ZIC5 Zic family member 5 0.38
DSC2 desmocollin 2 0.38
MFAP3L microfibrillar-associated protein 3-like 0.38
IFIH1 interferon induced with helicase C domain 1 0.37
DES desmin 0.37
MISP3 MISP family member 3 0.37
ACTB actin, beta 0.37
HOMEZ homeobox and leucine zipper encoding 0.37
FGB fibrinogen beta chain 0.37
POLR2M polymerase (RNA) II (DNA directed) polypeptide M 0.37
ADPRHL1 ADP-ribosylhydrolase like 1 0.36

low expression

Symbol Name Standardized Value
ZFP62 ZFP62 zinc finger protein -1.35
ZNF57 zinc finger protein 57 -1.3
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 -1.0
MCOLN3 mucolipin 3 -0.98
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 -0.76
PIGX phosphatidylinositol glycan anchor biosynthesis, class X -0.74
F3 coagulation factor III (thromboplastin, tissue factor) -0.72
H3C1 H3 clustered histone 1 -0.69
SMIM19 small integral membrane protein 19 -0.67
CCN1 cellular communication network factor 1 -0.63
TP73 tumor protein p73 -0.62
ATP13A2 ATPase type 13A2 -0.61
BCOR BCL6 corepressor -0.58
MAP2K5 mitogen-activated protein kinase kinase 5 -0.56
SMIM26 small integral membrane protein 26 -0.56
DMD dystrophin -0.56
CMTM4 CKLF-like MARVEL transmembrane domain containing 4 -0.55
SIKE1 suppressor of IKBKE 1 -0.55
DNAH8 dynein, axonemal, heavy chain 8 -0.55
NMU neuromedin U -0.55
AREG amphiregulin -0.53
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3 -0.53
ZNF564 zinc finger protein 564 -0.53
NEMP1 nuclear envelope integral membrane protein 1 -0.52
FAM86B2 family with sequence similarity 86, member B2 -0.52
LCORL ligand dependent nuclear receptor corepressor-like -0.51
NEMP2 nuclear envelope integral membrane protein 2 -0.5
BCAM basal cell adhesion molecule (Lutheran blood group) -0.5
CDA cytidine deaminase -0.5
GSE1 Gse1 coiled-coil protein -0.49
MICB MHC class I polypeptide-related sequence B -0.49
UTP14C UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) -0.49
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.49
ARSK arylsulfatase family, member K -0.48
ZNF276 zinc finger protein 276 -0.48
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.48
FBXO33 F-box protein 33 -0.47
PPP1R26 protein phosphatase 1, regulatory subunit 26 -0.46
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae) -0.46
UBE2G2 ubiquitin-conjugating enzyme E2G 2 -0.46
R3HDM4 R3H domain containing 4 -0.45
PROM1 prominin 1 -0.45
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase -0.44
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 -0.44
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 -0.44
PGS1 phosphatidylglycerophosphate synthase 1 -0.44
FITM2 fat storage-inducing transmembrane protein 2 -0.44
C12ORF57 chromosome 12 open reading frame 57 -0.44
AXIN2 axin 2 -0.43
PRAME preferentially expressed antigen in melanoma -0.43
ENC1 ectodermal-neural cortex 1 (with BTB domain) -0.43
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4 -0.42
DUSP7 dual specificity phosphatase 7 -0.42
TIPE1 TNF alpha induced protein 8 like 1 -0.42
ANKS6 ankyrin repeat and sterile alpha motif domain containing 6 -0.41
GATD1 glutamine amidotransferase class 1 domain containing 1 -0.41
PHKG2 phosphorylase kinase, gamma 2 (testis) -0.41
ZNF273 zinc finger protein 273 -0.41
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 -0.41
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.41
MCOLN2 mucolipin 2 -0.4
SNRPF small nuclear ribonucleoprotein polypeptide F -0.4
FICD FIC domain containing -0.4
SCO1 SCO1 cytochrome c oxidase assembly protein -0.4
CNTRL centriolin -0.4
PRMT9 protein arginine methyltransferase 9 -0.39
FBXO31 F-box protein 31 -0.39
PHF19 PHD finger protein 19 -0.39
ZNF286A zinc finger protein 286A -0.38
BCL2L12 BCL2-like 12 (proline rich) -0.38
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.38
TLL2 tolloid-like 2 -0.38
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) -0.38
MTERF2 mitochondrial transcription termination factor 2 -0.38
KLHL23 kelch-like family member 23 -0.37
FOXO1 forkhead box O1 -0.37
FAM185A family with sequence similarity 185, member A -0.37
SELENON selenoprotein N -0.37
CILP2 cartilage intermediate layer protein 2 -0.37
CEP63 centrosomal protein 63kDa -0.37
PRSS12 protease, serine, 12 (neurotrypsin, motopsin) -0.37
PRXL2C peroxiredoxin like 2C -0.36
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 -0.36
CHSY1 chondroitin sulfate synthase 1 -0.36
CPN1 carboxypeptidase N, polypeptide 1 -0.35
TMEM131L transmembrane 131 like -0.35
ZNF142 zinc finger protein 142 -0.35
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 -0.35
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.35
SLC35B1 solute carrier family 35, member B1 -0.35
DCTPP1 dCTP pyrophosphatase 1 -0.35
TSPAN4 tetraspanin 4 -0.34
KIAA1586 KIAA1586 -0.34
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa -0.34
COL17A1 collagen, type XVII, alpha 1 -0.34
FBXO4 F-box protein 4 -0.34
CIAO2B cytosolic iron-sulfur assembly component 2B -0.34
PTPRD protein tyrosine phosphatase, receptor type, D -0.34
ANAPC11 anaphase promoting complex subunit 11 -0.33