| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Temsirolimus perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Temsirolimus_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0663862 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0616087 |
| NAV2 | neuron navigator 2 | 0.0439744 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0439588 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0435579 |
| RND3 | Rho family GTPase 3 | 0.043383 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0432982 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0394971 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0338028 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0335511 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0305291 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0300985 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0294781 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0292528 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0288678 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0287177 |
| C1D | C1D nuclear receptor corepressor | 0.0286952 |
| MYADM | myeloid-associated differentiation marker | 0.0285286 |
| PLEC | plectin | 0.0282831 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0280026 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0269858 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0256057 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0243575 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.023689 |
| APP | amyloid beta (A4) precursor protein | 0.023339 |
| ATP13A3 | ATPase type 13A3 | 0.0230589 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0228898 |
| BCL2L1 | BCL2-like 1 | 0.0227639 |
| NOTCH2 | notch 2 | 0.0221347 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0220937 |
| RPL3 | ribosomal protein L3 | 0.0208944 |
| MSN | moesin | 0.0206957 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0201717 |
| WDFY1 | WD repeat and FYVE domain containing 1 | 0.0191296 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0178781 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0178258 |
| OPTN | optineurin | 0.0174312 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0168663 |
| GOLGA4 | golgin A4 | 0.0168605 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0164943 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.016314 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.015817 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0156355 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | 0.0156087 |
| MMP12 | matrix metallopeptidase 12 | 0.0155621 |
| DOT1L | DOT1-like histone H3K79 methyltransferase | 0.0155093 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0155062 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0155057 |
| E2F7 | E2F transcription factor 7 | 0.015439 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0151959 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0149569 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0147795 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0145422 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0144085 |
| KIF3C | kinesin family member 3C | 0.0144067 |
| RPL4 | ribosomal protein L4 | 0.0144009 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0136795 |
| RNF145 | ring finger protein 145 | 0.0135381 |
| FOSL1 | FOS-like antigen 1 | 0.0134855 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0134723 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0134267 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0133992 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0133176 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0131724 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.0131684 |
| ANO6 | anoctamin 6 | 0.0131206 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0130886 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0128606 |
| WBP2 | WW domain binding protein 2 | 0.0125475 |
| FLNA | filamin A, alpha | 0.0123102 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | 0.0121641 |
| SH3GL1 | SH3-domain GRB2-like 1 | 0.0117338 |
| PTMS | parathymosin | 0.0116061 |
| TPM3 | tropomyosin 3 | 0.0115097 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0114558 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0113806 |
| VAT1 | vesicle amine transport 1 | 0.0112454 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0112354 |
| MINK1 | misshapen-like kinase 1 | 0.0111702 |
| ATL3 | atlastin GTPase 3 | 0.0111478 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0111147 |
| ZBTB43 | zinc finger and BTB domain containing 43 | 0.0110748 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0109578 |
| TM4SF19 | transmembrane 4 L six family member 19 | 0.0109373 |
| SLC35F5 | solute carrier family 35, member F5 | 0.0109221 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0109215 |
| ZBTB7C | zinc finger and BTB domain containing 7C | 0.0109134 |
| MEF2D | myocyte enhancer factor 2D | 0.0108764 |
| LYST | lysosomal trafficking regulator | 0.0106705 |
| SUCO | SUN domain containing ossification factor | 0.0106605 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0106592 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0105371 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | 0.0105208 |
| CALR | calreticulin | 0.01044 |
| HPS3 | Hermansky-Pudlak syndrome 3 | 0.0102942 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0102782 |
| NGLY1 | N-glycanase 1 | 0.0102708 |
| GPC5 | glypican 5 | 0.0102425 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0101288 |
| KLHL24 | kelch-like family member 24 | 0.0101112 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.207113 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.174742 |
| FN1 | fibronectin 1 | -0.144572 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.139408 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.129609 |
| COL5A1 | collagen, type V, alpha 1 | -0.127774 |
| VIM | vimentin | -0.126877 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.125845 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.124271 |
| RIGI | RNA sensor RIG-I | -0.115259 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.110657 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.104912 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0991167 |
| CDH13 | cadherin 13 | -0.0977266 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0947804 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0942781 |
| LOX | lysyl oxidase | -0.0913845 |
| AHNAK | AHNAK nucleoprotein | -0.0908282 |
| NAV1 | neuron navigator 1 | -0.0899891 |
| MAP1B | microtubule-associated protein 1B | -0.0826903 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0781037 |
| PRSS23 | protease, serine, 23 | -0.0758491 |
| MX2 | MX dynamin-like GTPase 2 | -0.0668944 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0630216 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0626737 |
| S100A10 | S100 calcium binding protein A10 | -0.0593092 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0584337 |
| ANXA2 | annexin A2 | -0.0579772 |
| SP100 | SP100 nuclear antigen | -0.0542122 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0534791 |
| THBS2 | thrombospondin 2 | -0.0529871 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0520928 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0515703 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0510413 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0505599 |
| TMSB10 | thymosin beta 10 | -0.0504839 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0494429 |
| LDHA | lactate dehydrogenase A | -0.0491841 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0479043 |
| MYOF | myoferlin | -0.0475235 |
| SUCNR1 | succinate receptor 1 | -0.047204 |
| PRELID2 | PRELI domain containing 2 | -0.0468019 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.046477 |
| TENM3 | teneurin transmembrane protein 3 | -0.046137 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0459996 |
| FNDC3A | fibronectin type III domain containing 3A | -0.045741 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0455388 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0452481 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0450577 |
| B2M | beta-2-microglobulin | -0.0446496 |
| VCL | vinculin | -0.0440117 |
| LRRC17 | leucine rich repeat containing 17 | -0.0431911 |
| RUNX1 | runt-related transcription factor 1 | -0.0430639 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0427039 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0426853 |
| DCLK2 | doublecortin-like kinase 2 | -0.0426758 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0425678 |
| LMNA | lamin A/C | -0.0424463 |
| HLA-B | major histocompatibility complex, class I, B | -0.041589 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0411692 |
| COL5A2 | collagen, type V, alpha 2 | -0.0407685 |
| TAGLN2 | transgelin 2 | -0.0402276 |
| MT2A | metallothionein 2A | -0.0402028 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0399844 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0393639 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0392565 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0391628 |
| IL7R | interleukin 7 receptor | -0.0388426 |
| ASPH | aspartate beta-hydroxylase | -0.0388146 |
| CUX1 | cut-like homeobox 1 | -0.0387054 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0383449 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0382836 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0375577 |
| DST | dystonin | -0.0374037 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0372933 |
| HLA-C | major histocompatibility complex, class I, C | -0.0370748 |
| PCDH7 | protocadherin 7 | -0.0368968 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0367759 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0367632 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.0364147 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0360944 |
| CDK6 | cyclin-dependent kinase 6 | -0.0354094 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | -0.0351183 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.034832 |
| EFNA5 | ephrin-A5 | -0.0347974 |
| MED13L | mediator complex subunit 13-like | -0.0342463 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0338524 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.033656 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0334747 |
| JAZF1 | JAZF zinc finger 1 | -0.0332857 |
| CAVIN1 | caveolae associated protein 1 | -0.0327385 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0326811 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0324461 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0322241 |
| RNF213 | ring finger protein 213 | -0.031705 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0316865 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.031516 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0315048 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0310917 |
| FSTL1 | follistatin-like 1 | -0.0304852 |
