Temsirolimus_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Temsirolimus perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Temsirolimus_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HMGA2 high mobility group AT-hook 2 0.112109
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0975142
EHBP1 EH domain binding protein 1 0.078929
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0718856
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0690701
NHSL1 NHS-like 1 0.06133
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0562265
JMJD1C jumonji domain containing 1C 0.0553144
MACF1 microtubule-actin crosslinking factor 1 0.0542673
NLGN1 neuroligin 1 0.0538196
INTS6 integrator complex subunit 6 0.051579
RASAL2 RAS protein activator like 2 0.04973
KDM4C lysine (K)-specific demethylase 4C 0.0454877
PCBP2 poly(rC) binding protein 2 0.0436505
USP34 ubiquitin specific peptidase 34 0.0418308
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0413187
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.038577
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0383598
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0372362
DENND5A DENN/MADD domain containing 5A 0.0370278
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0365899
ANK2 ankyrin 2, neuronal 0.03581
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0352483
BABAM2 BRISC and BRCA1 A complex member 2 0.0345156
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0336809
SPATS2 spermatogenesis associated, serine-rich 2 0.033201
CUX1 cut-like homeobox 1 0.0327397
TBC1D5 TBC1 domain family, member 5 0.0326705
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0326417
PCDH9 protocadherin 9 0.031864
KDM2A lysine (K)-specific demethylase 2A 0.0318607
NEBL nebulette 0.0314595
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.030803
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0299008
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0289926
ANKRD17 ankyrin repeat domain 17 0.0285242
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0279872
EXOC4 exocyst complex component 4 0.0276404
R3HDM2 R3H domain containing 2 0.0275138
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0266311
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0264771
ASPH aspartate beta-hydroxylase 0.0264425
EGR1 early growth response 1 0.02613
ANKRD12 ankyrin repeat domain 12 0.0260477
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0260308
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.0258698
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0252535
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0252507
L3MBTL4 l(3)mbt-like 4 (Drosophila) 0.0249298
LRMDA leucine rich melanocyte differentiation associated 0.0244084
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0242276
MTCL1 microtubule crosslinking factor 1 0.0238769
RABGAP1L RAB GTPase activating protein 1-like 0.0238646
VMP1 vacuole membrane protein 1 0.0236427
KSR2 kinase suppressor of ras 2 0.0233143
SAMD4A sterile alpha motif domain containing 4A 0.0231326
MCL1 myeloid cell leukemia 1 0.0228379
PFN1 profilin 1 0.0226113
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0225744
ASXL2 additional sex combs like transcriptional regulator 2 0.0225386
TRIO trio Rho guanine nucleotide exchange factor 0.0223962
MSRB3 methionine sulfoxide reductase B3 0.0222344
SERTAD2 SERTA domain containing 2 0.022121
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0220487
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0219974
EGFR epidermal growth factor receptor 0.021983
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0219647
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0217198
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0217103
PRKCE protein kinase C, epsilon 0.0216146
LPP LIM domain containing preferred translocation partner in lipoma 0.0214276
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0213884
FADS2 fatty acid desaturase 2 0.0212905
TNRC18 trinucleotide repeat containing 18 0.021143
ATF7 activating transcription factor 7 0.0209107
HOMER1 homer scaffolding protein 1 0.0207481
DIAPH2 diaphanous-related formin 2 0.0205933
SESN2 sestrin 2 0.0204997
ZNF407 zinc finger protein 407 0.0204717
PACS1 phosphofurin acidic cluster sorting protein 1 0.0204597
ZFAND3 zinc finger, AN1-type domain 3 0.0203999
BIRC6 baculoviral IAP repeat containing 6 0.0203165
FAM193A family with sequence similarity 193, member A 0.0201628
FAM168A family with sequence similarity 168, member A 0.0199194
RNF213 ring finger protein 213 0.0195515
ZNF638 zinc finger protein 638 0.0194253
PCF11 PCF11 cleavage and polyadenylation factor subunit 0.0194097
CCN2 cellular communication network factor 2 0.0193961
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0193511
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0192729
PICALM phosphatidylinositol binding clathrin assembly protein 0.0192292
C6ORF62 chromosome 6 open reading frame 62 0.0191886
YAP1 Yes-associated protein 1 0.0191857
ZCCHC7 zinc finger, CCHC domain containing 7 0.0191857
TIMP2 TIMP metallopeptidase inhibitor 2 0.0191147
AKAP13 A kinase (PRKA) anchor protein 13 0.0190084
PRKCA protein kinase C, alpha 0.0188379
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0187559
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0187249
SSH2 slingshot protein phosphatase 2 0.0186143

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.1593
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.139826
AREG amphiregulin -0.13037
BIRC3 baculoviral IAP repeat containing 3 -0.112852
PDE4D phosphodiesterase 4D, cAMP-specific -0.0920354
TMEM41B transmembrane protein 41B -0.0824308
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0802221
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0765893
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0761406
KIF5B kinesin family member 5B -0.0624249
CELF2 CUGBP, Elav-like family member 2 -0.0616729
EIF1 eukaryotic translation initiation factor 1 -0.061454
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0577593
ADGRG6 adhesion G protein-coupled receptor G6 -0.0562561
MKI67 marker of proliferation Ki-67 -0.0540538
BIRC2 baculoviral IAP repeat containing 2 -0.0528386
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0518942
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0516105
RPLP1 ribosomal protein, large, P1 -0.0511744
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0509597
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0508788
SMC4 structural maintenance of chromosomes 4 -0.0503606
RPLP0 ribosomal protein, large, P0 -0.0488486
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0483226
NAP1L1 nucleosome assembly protein 1-like 1 -0.0474276
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0449962
NEK7 NIMA-related kinase 7 -0.0435565
CXADR coxsackie virus and adenovirus receptor -0.0435528
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0429035
RAD21 RAD21 homolog (S. pombe) -0.042519
YBX1 Y box binding protein 1 -0.0417063
KDM3A lysine (K)-specific demethylase 3A -0.0415984
TPT1 tumor protein, translationally-controlled 1 -0.0412006
RACK1 receptor for activated C kinase 1 -0.0410377
LMO7 LIM domain 7 -0.0403603
MYL12B myosin, light chain 12B, regulatory -0.0402698
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0397696
SLC38A2 solute carrier family 38, member 2 -0.0384541
RPL12 ribosomal protein L12 -0.0377122
RPL26 ribosomal protein L26 -0.0370359
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0356535
YBX3 Y box binding protein 3 -0.0355083
OXR1 oxidation resistance 1 -0.0353856
RPS8 ribosomal protein S8 -0.0352857
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0348255
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0338978
DLC1 DLC1 Rho GTPase activating protein -0.0338748
ZNF217 zinc finger protein 217 -0.0335243
CCND1 cyclin D1 -0.0334511
TPR translocated promoter region, nuclear basket protein -0.0330702
SQSTM1 sequestosome 1 -0.033009
KLF6 Kruppel-like factor 6 -0.0326808
AHNAK AHNAK nucleoprotein -0.0325491
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0324561
RPL19 ribosomal protein L19 -0.0314294
ACTG1 actin gamma 1 -0.0314265
TM4SF1 transmembrane 4 L six family member 1 -0.0313408
LDHA lactate dehydrogenase A -0.0312698
ECT2 epithelial cell transforming 2 -0.0311982
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0311977
RPS27A ribosomal protein S27a -0.031109
NCEH1 neutral cholesterol ester hydrolase 1 -0.0308986
RPL4 ribosomal protein L4 -0.0304117
RPL37 ribosomal protein L37 -0.0298456
TXNRD1 thioredoxin reductase 1 -0.0297437
RPS24 ribosomal protein S24 -0.0295906
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0293722
EDN1 endothelin 1 -0.029318
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0292839
GASK1B golgi associated kinase 1B -0.0289986
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0288969
CEP95 centrosomal protein 95kDa -0.0288091
CDK6 cyclin-dependent kinase 6 -0.028613
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.028591
RPL34 ribosomal protein L34 -0.0285879
RPS2 ribosomal protein S2 -0.0285776
CENPF centromere protein F, 350/400kDa -0.0284148
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.027905
CENPE centromere protein E, 312kDa -0.0277711
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0274356
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0273957
CHD1 chromodomain helicase DNA binding protein 1 -0.02738
RPL35A ribosomal protein L35a -0.0273175
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0273009
MATR3 matrin 3 -0.0271143
TMEM123 transmembrane protein 123 -0.0270462
ICE1 interactor of little elongation complex ELL subunit 1 -0.0269473
RAB1A RAB1A, member RAS oncogene family -0.0268003
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0267455
RB1CC1 RB1-inducible coiled-coil 1 -0.026693
RPL6 ribosomal protein L6 -0.0266895
SCLT1 sodium channel and clathrin linker 1 -0.0266158
RPL23 ribosomal protein L23 -0.0265492
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0262067
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0260589
RSL1D1 ribosomal L1 domain containing 1 -0.0259144
RPS6 ribosomal protein S6 -0.0257533
OGA O-GlcNAcase -0.0255655
WDR43 WD repeat domain 43 -0.0255109
RPL38 ribosomal protein L38 -0.0252511