| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Temsirolimus perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Temsirolimus_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.0964314 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0867422 |
| NAV2 | neuron navigator 2 | 0.0644915 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0632492 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0584194 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0538519 |
| HMGA2 | high mobility group AT-hook 2 | 0.0460107 |
| PLEC | plectin | 0.0449611 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0446955 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0441148 |
| COL1A1 | collagen, type I, alpha 1 | 0.0380713 |
| MTSS1 | metastasis suppressor 1 | 0.0357276 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0353113 |
| CDH13 | cadherin 13 | 0.032782 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0325715 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | 0.0317961 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0315199 |
| NRP1 | neuropilin 1 | 0.0303702 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0300271 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | 0.0289123 |
| SMAD3 | SMAD family member 3 | 0.0269868 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0267181 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0259962 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.025766 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.025667 |
| VMP1 | vacuole membrane protein 1 | 0.0248555 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0247917 |
| ADAM12 | ADAM metallopeptidase domain 12 | 0.02464 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0243095 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0241694 |
| NAV1 | neuron navigator 1 | 0.0241235 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0238016 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0229254 |
| ATXN1 | ataxin 1 | 0.0228145 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.022658 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0216703 |
| PDIA5 | protein disulfide isomerase family A, member 5 | 0.0215054 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0196843 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.019586 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0190786 |
| EFNA5 | ephrin-A5 | 0.0189607 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0187569 |
| RIGI | RNA sensor RIG-I | 0.0184165 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0176586 |
| ABLIM3 | actin binding LIM protein family, member 3 | 0.0173248 |
| MAP4 | microtubule-associated protein 4 | 0.0171949 |
| FNIP1 | folliculin interacting protein 1 | 0.0169312 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0168805 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0168486 |
| VCL | vinculin | 0.0166934 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0165298 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0164383 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0162055 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0158989 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0158483 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0158475 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0157202 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0156887 |
| ZNF638 | zinc finger protein 638 | 0.0154517 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0153819 |
| PRELID2 | PRELI domain containing 2 | 0.0152817 |
| FUS | FUS RNA binding protein | 0.015021 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0147502 |
| PID1 | phosphotyrosine interaction domain containing 1 | 0.0146266 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0144955 |
| CAVIN1 | caveolae associated protein 1 | 0.0143925 |
| UTRN | utrophin | 0.0143918 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0143297 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0142619 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.014256 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0139808 |
| RND3 | Rho family GTPase 3 | 0.0139788 |
| RNF220 | ring finger protein 220 | 0.013659 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | 0.0134549 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0134434 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0134388 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.013352 |
| AGO3 | argonaute RISC catalytic component 3 | 0.0130713 |
| VEGFC | vascular endothelial growth factor C | 0.0130032 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0129909 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0128641 |
| ATXN10 | ataxin 10 | 0.0128197 |
| CALU | calumenin | 0.0127967 |
| ANKS1A | ankyrin repeat and sterile alpha motif domain containing 1A | 0.012691 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0126665 |
| JMJD1C | jumonji domain containing 1C | 0.0125916 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0124892 |
| COG6 | component of oligomeric golgi complex 6 | 0.0123783 |
| AAK1 | AP2 associated kinase 1 | 0.0123653 |
| UBE3C | ubiquitin protein ligase E3C | 0.012332 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0122752 |
| SH3PXD2B | SH3 and PX domains 2B | 0.0122223 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0121256 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0119269 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | 0.0119191 |
| DNAAF9 | dynein axonemal assembly factor 9 | 0.011684 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.01166 |
| TAF2 | TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa | 0.0116476 |
| MT1X | metallothionein 1X | 0.0116234 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.011616 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.248188 |
| MT2A | metallothionein 2A | -0.187529 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.155163 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.147529 |
| NDRG1 | N-myc downstream regulated 1 | -0.143387 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.140591 |
| TMSB10 | thymosin beta 10 | -0.106125 |
| PTMA | prothymosin, alpha | -0.0972919 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0833457 |
| CADM1 | cell adhesion molecule 1 | -0.0820204 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0777533 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0683986 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0596831 |
| CD44 | CD44 molecule (Indian blood group) | -0.0589819 |
| FTL | ferritin, light polypeptide | -0.0579857 |
| RPS3 | ribosomal protein S3 | -0.0579238 |
| ENO1 | enolase 1, (alpha) | -0.0564756 |
| RPL35A | ribosomal protein L35a | -0.0502963 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0484422 |
| VCAN | versican | -0.0462253 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0450122 |
| RPL11 | ribosomal protein L11 | -0.0447682 |
| B2M | beta-2-microglobulin | -0.0446325 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.042873 |
| RPS8 | ribosomal protein S8 | -0.0411029 |
| RACK1 | receptor for activated C kinase 1 | -0.0399266 |
| IER3 | immediate early response 3 | -0.0397115 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0384366 |
| RPL26 | ribosomal protein L26 | -0.0356446 |
| HMGA1 | high mobility group AT-hook 1 | -0.0353046 |
| RPL13A | ribosomal protein L13a | -0.0349827 |
| RPL37A | ribosomal protein L37a | -0.0344988 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0344779 |
| RPL23 | ribosomal protein L23 | -0.0343517 |
| PDE10A | phosphodiesterase 10A | -0.0340877 |
| RPL12 | ribosomal protein L12 | -0.0338748 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0338407 |
| RPS19 | ribosomal protein S19 | -0.033766 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0337282 |
| RPS6 | ribosomal protein S6 | -0.0337041 |
| PGK1 | phosphoglycerate kinase 1 | -0.0336723 |
| QKI | QKI, KH domain containing, RNA binding | -0.0329381 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0325674 |
| TPM4 | tropomyosin 4 | -0.0323994 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0311922 |
| RPS12 | ribosomal protein S12 | -0.0309637 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0304014 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0297117 |
| CALR | calreticulin | -0.0295178 |
| RPS14 | ribosomal protein S14 | -0.0291535 |
| RPL18 | ribosomal protein L18 | -0.0289299 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0282959 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.0277138 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0274725 |
| CALD1 | caldesmon 1 | -0.0274217 |
| HLA-A | major histocompatibility complex, class I, A | -0.027268 |
| LOX | lysyl oxidase | -0.0270313 |
| HLA-B | major histocompatibility complex, class I, B | -0.0267179 |
| USP3 | ubiquitin specific peptidase 3 | -0.0266818 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0265353 |
| INHBA | inhibin, beta A | -0.026038 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0259869 |
| RPL7 | ribosomal protein L7 | -0.0259089 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0258814 |
| RHEB | Ras homolog enriched in brain | -0.0256837 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0251924 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0250624 |
| RAB2A | RAB2A, member RAS oncogene family | -0.024873 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0246107 |
| RPL5 | ribosomal protein L5 | -0.0242687 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0242445 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0238974 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0238667 |
| YBX1 | Y box binding protein 1 | -0.0238443 |
| MATR3 | matrin 3 | -0.0237605 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0235908 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0232646 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0232084 |
| RPS25 | ribosomal protein S25 | -0.0228954 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0223879 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0222455 |
| SEPTIN7 | septin 7 | -0.0221028 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.022017 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0219947 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0219546 |
| POSTN | periostin, osteoblast specific factor | -0.0219337 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0217356 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0216827 |
| ZNF292 | zinc finger protein 292 | -0.0213952 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.0213685 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0212279 |
| CLINT1 | clathrin interactor 1 | -0.0211553 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0211378 |
| H1-0 | H1.0 linker histone | -0.0209201 |
| MAP1B | microtubule-associated protein 1B | -0.0208537 |
| LDHA | lactate dehydrogenase A | -0.0208274 |
| RPS17 | ribosomal protein S17 | -0.0203842 |
| GOLGA4 | golgin A4 | -0.0203517 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0202237 |
| TFG | TRK-fused gene | -0.0201494 |
