| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Temsirolimus perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Temsirolimus_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0650015 |
| TNS1 | tensin 1 | 0.0577352 |
| RPL3 | ribosomal protein L3 | 0.0558569 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0545226 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0545211 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0531246 |
| C3 | complement component 3 | 0.0438031 |
| GPC6 | glypican 6 | 0.0418843 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0404954 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0377619 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0327678 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0327417 |
| HSPA1B | heat shock 70kDa protein 1B | 0.0325784 |
| VMP1 | vacuole membrane protein 1 | 0.031857 |
| VEGFA | vascular endothelial growth factor A | 0.0309528 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0304104 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0277378 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0256899 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0256089 |
| PRKCA | protein kinase C, alpha | 0.0250704 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0248868 |
| SMAD3 | SMAD family member 3 | 0.0245942 |
| PLEC | plectin | 0.024328 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0241706 |
| SEPTIN9 | septin 9 | 0.024082 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.023385 |
| CCNY | cyclin Y | 0.0229455 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | 0.0223509 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0221953 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0218861 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0213548 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0213128 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0209035 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0208848 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0207374 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0198821 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0196233 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0186021 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0183611 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.0181623 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0181104 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0180773 |
| FKTN | fukutin | 0.0179369 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.017532 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0173034 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0172772 |
| BCL2L1 | BCL2-like 1 | 0.0172297 |
| FLNA | filamin A, alpha | 0.0171097 |
| FLNB | filamin B, beta | 0.016341 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0160931 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0158588 |
| COL27A1 | collagen, type XXVII, alpha 1 | 0.0156767 |
| NABP1 | nucleic acid binding protein 1 | 0.0155989 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0155605 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0154634 |
| TNS3 | tensin 3 | 0.0153329 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0151142 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0148286 |
| HSPG2 | heparan sulfate proteoglycan 2 | 0.0147644 |
| FAM107B | family with sequence similarity 107, member B | 0.0147059 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0144865 |
| MSI2 | musashi RNA-binding protein 2 | 0.014485 |
| JAG1 | jagged 1 | 0.014405 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0143705 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0143349 |
| TBC1D22A | TBC1 domain family, member 22A | 0.01433 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0141206 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0137378 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0137192 |
| SERTAD2 | SERTA domain containing 2 | 0.0137047 |
| MYO1B | myosin IB | 0.0136838 |
| LPCAT1 | lysophosphatidylcholine acyltransferase 1 | 0.0136836 |
| RASA2 | RAS p21 protein activator 2 | 0.0136511 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0134078 |
| TUFT1 | tuftelin 1 | 0.0133987 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.0133516 |
| KYNU | kynureninase | 0.0131898 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.012837 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0127514 |
| HPCAL1 | hippocalcin-like 1 | 0.0127353 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0125856 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | 0.0122027 |
| ANGPTL2 | angiopoietin-like 2 | 0.0121593 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0120964 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.012078 |
| JAK1 | Janus kinase 1 | 0.0119687 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.011966 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0119612 |
| PDGFC | platelet derived growth factor C | 0.0119061 |
| RASGRF2 | Ras protein-specific guanine nucleotide-releasing factor 2 | 0.0118305 |
| SKI | SKI proto-oncogene | 0.0117405 |
| PCBP2 | poly(rC) binding protein 2 | 0.0115584 |
| FAM219A | family with sequence similarity 219, member A | 0.0114562 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0113966 |
| YLPM1 | YLP motif containing 1 | 0.0113102 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0112867 |
| CCN2 | cellular communication network factor 2 | 0.0112847 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | 0.0112738 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.011264 |
| ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | 0.0112618 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.204811 |
| MT2A | metallothionein 2A | -0.196056 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.176965 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.170377 |
| APOB | apolipoprotein B | -0.163157 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.143023 |
| ENO1 | enolase 1, (alpha) | -0.127184 |
| IGF2 | insulin-like growth factor 2 | -0.119714 |
| GPC3 | glypican 3 | -0.117624 |
| APOA2 | apolipoprotein A-II | -0.115227 |
| RPS6 | ribosomal protein S6 | -0.104421 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.101356 |
| FTL | ferritin, light polypeptide | -0.0997629 |
| RPS24 | ribosomal protein S24 | -0.0993567 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.097676 |
| RPS8 | ribosomal protein S8 | -0.0953609 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0938899 |
| RPLP1 | ribosomal protein, large, P1 | -0.0913629 |
| RPL11 | ribosomal protein L11 | -0.0748896 |
| RPL12 | ribosomal protein L12 | -0.0734716 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0723159 |
| RPL37A | ribosomal protein L37a | -0.0707497 |
| RPL35A | ribosomal protein L35a | -0.0701654 |
| RPLP0 | ribosomal protein, large, P0 | -0.0701302 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.0696719 |
| RPL34 | ribosomal protein L34 | -0.0683736 |
| FN1 | fibronectin 1 | -0.0679947 |
| RPS19 | ribosomal protein S19 | -0.0647085 |
| RPS27A | ribosomal protein S27a | -0.064282 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0625865 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0618395 |
| TMSB10 | thymosin beta 10 | -0.0600307 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0592183 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0566758 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0547832 |
| RPL23 | ribosomal protein L23 | -0.054114 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0516773 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0513202 |
| TMEM123 | transmembrane protein 123 | -0.0500533 |
| RPS29 | ribosomal protein S29 | -0.0496913 |
| APOE | apolipoprotein E | -0.0488679 |
| RPLP2 | ribosomal protein, large, P2 | -0.0473794 |
| AHSG | alpha-2-HS-glycoprotein | -0.0467017 |
| DSPP | dentin sialophosphoprotein | -0.0460042 |
| PEG3 | paternally expressed 3 | -0.0457727 |
| TPM4 | tropomyosin 4 | -0.045143 |
| PTMA | prothymosin, alpha | -0.045006 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0437732 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0424151 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0421457 |
| RPL31 | ribosomal protein L31 | -0.0419152 |
| PLIN2 | perilipin 2 | -0.0417191 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0413181 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0409896 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0403723 |
| RPS23 | ribosomal protein S23 | -0.040281 |
| RPS13 | ribosomal protein S13 | -0.0402221 |
| CP | ceruloplasmin (ferroxidase) | -0.0402035 |
| RPL9 | ribosomal protein L9 | -0.0399741 |
| RPS21 | ribosomal protein S21 | -0.0399065 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0397988 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0386468 |
| RPS16 | ribosomal protein S16 | -0.0386273 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0385456 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0382931 |
| RPS14 | ribosomal protein S14 | -0.0381098 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0379521 |
| TRIM26 | tripartite motif containing 26 | -0.0378553 |
| RACK1 | receptor for activated C kinase 1 | -0.0376972 |
| S100A9 | S100 calcium binding protein A9 | -0.0373203 |
| RPL32 | ribosomal protein L32 | -0.036967 |
| RPS3 | ribosomal protein S3 | -0.0369321 |
| WDR45B | WD repeat domain 45B | -0.0368968 |
| H1-0 | H1.0 linker histone | -0.0368212 |
| RPL37 | ribosomal protein L37 | -0.0360143 |
| B2M | beta-2-microglobulin | -0.0358712 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.035748 |
| RPS12 | ribosomal protein S12 | -0.0350345 |
| A2M | alpha-2-macroglobulin | -0.0347183 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0344916 |
| RPL19 | ribosomal protein L19 | -0.0341865 |
| EXT1 | exostosin glycosyltransferase 1 | -0.034044 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0334963 |
| GNAS | GNAS complex locus | -0.0331634 |
| LDHA | lactate dehydrogenase A | -0.0327262 |
| RPL38 | ribosomal protein L38 | -0.0326621 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0323737 |
| GDF15 | growth differentiation factor 15 | -0.0323338 |
| RPS10 | ribosomal protein S10 | -0.0323065 |
| PGK1 | phosphoglycerate kinase 1 | -0.0317503 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0317355 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.031669 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0315609 |
| FRMD5 | FERM domain containing 5 | -0.0311315 |
| RRBP1 | ribosome binding protein 1 | -0.0310647 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0309453 |
| RPS25 | ribosomal protein S25 | -0.0305121 |
| RPS5 | ribosomal protein S5 | -0.0303251 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0302112 |
| RPL7 | ribosomal protein L7 | -0.0300155 |
