Temsirolimus_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Temsirolimus perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Temsirolimus_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAV2 neuron navigator 2 0.0389781
SOD2 superoxide dismutase 2, mitochondrial 0.0296269
INTS6 integrator complex subunit 6 0.0271664
FTH1 ferritin, heavy polypeptide 1 0.0249984
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0249365
FNIP1 folliculin interacting protein 1 0.0242455
MYOF myoferlin 0.0208404
PLEC plectin 0.0189957
NRIP1 nuclear receptor interacting protein 1 0.0174828
MBNL2 muscleblind-like splicing regulator 2 0.0170221
SMAD3 SMAD family member 3 0.0160697
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.015547
FNDC3B fibronectin type III domain containing 3B 0.0155292
CEMIP cell migration inducing protein, hyaluronan binding 0.0144753
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0143901
HSPA8 heat shock 70kDa protein 8 0.0143411
ZNF638 zinc finger protein 638 0.013242
ITCH itchy E3 ubiquitin protein ligase 0.0130742
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0129345
KDM6A lysine (K)-specific demethylase 6A 0.0129148
SPAG9 sperm associated antigen 9 0.0128585
TMEM65 transmembrane protein 65 0.0120132
USP34 ubiquitin specific peptidase 34 0.0113147
HMGA2 high mobility group AT-hook 2 0.0112931
LCOR ligand dependent nuclear receptor corepressor 0.0111709
MEGF6 multiple EGF-like-domains 6 0.0107279
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0105777
USP9X ubiquitin specific peptidase 9, X-linked 0.0105474
ARRDC3 arrestin domain containing 3 0.0105258
FRMD6 FERM domain containing 6 0.0103687
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0102084
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0101185
ATP9A ATPase, class II, type 9A 0.0100505
ZCCHC7 zinc finger, CCHC domain containing 7 0.00993453
FMNL2 formin-like 2 0.00993102
ERBIN erbb2 interacting protein 0.00982606
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.00960063
DENND4C DENN/MADD domain containing 4C 0.00930744
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.00922299
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.00916758
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.00893377
BIRC3 baculoviral IAP repeat containing 3 0.00891402
KIAA1217 KIAA1217 0.00867928
ZSWIM6 zinc finger, SWIM-type containing 6 0.00865437
USP53 ubiquitin specific peptidase 53 0.00863819
IARS1 isoleucyl-tRNA synthetase 1 0.00856804
EPAS1 endothelial PAS domain protein 1 0.00844663
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) 0.008427
CNOT1 CCR4-NOT transcription complex, subunit 1 0.00834871
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.00828266
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.00816466
SPIRE1 spire-type actin nucleation factor 1 0.00812875
RASA3 RAS p21 protein activator 3 0.0080586
IFRD1 interferon-related developmental regulator 1 0.00804171
N4BP2L2 NEDD4 binding protein 2-like 2 0.00793398
GRB10 growth factor receptor-bound protein 10 0.00788556
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.00785062
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0077795
KLHL24 kelch-like family member 24 0.00773118
LIFR leukemia inhibitory factor receptor alpha 0.00771535
ERRFI1 ERBB receptor feedback inhibitor 1 0.00765877
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.00764208
KIF16B kinesin family member 16B 0.00761654
FAM3C family with sequence similarity 3, member C 0.00759712
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 0.00754945
ELL2 elongation factor, RNA polymerase II, 2 0.00754781
MAGT1 magnesium transporter 1 0.00754059
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 0.00749378
UBN2 ubinuclein 2 0.00748675
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0074379
FAM13A family with sequence similarity 13, member A 0.00738152
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.00737968
FAM219A family with sequence similarity 219, member A 0.00736604
HSPH1 heat shock 105kDa/110kDa protein 1 0.00734453
THRB thyroid hormone receptor, beta 0.00734046
ESYT2 extended synaptotagmin-like protein 2 0.00732524
PDIA3 protein disulfide isomerase family A, member 3 0.00730491
CAMTA1 calmodulin binding transcription activator 1 0.00722804
KDM4B lysine (K)-specific demethylase 4B 0.0071972
ATXN7L1 ataxin 7-like 1 0.00716764
RAD51B RAD51 paralog B 0.00714541
TNRC6A trinucleotide repeat containing 6A 0.00709952
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0070356
HIPK3 homeodomain interacting protein kinase 3 0.00690306
RND3 Rho family GTPase 3 0.00687044
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.00682613
IGF1R insulin-like growth factor 1 receptor 0.00681177
PCCA propionyl CoA carboxylase, alpha polypeptide 0.00679547
CDKN2A cyclin-dependent kinase inhibitor 2A 0.00679482
RREB1 ras responsive element binding protein 1 0.00670023
DMTF1 cyclin D binding myb-like transcription factor 1 0.00664592
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.00664038
COPA coatomer protein complex, subunit alpha 0.00660937
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.00659519
EPS8 epidermal growth factor receptor pathway substrate 8 0.00654663
PTEN phosphatase and tensin homolog 0.00652716
RSAD2 radical S-adenosyl methionine domain containing 2 0.00650282
ZC3H12C zinc finger CCCH-type containing 12C 0.00643731
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.00643356
TNS1 tensin 1 0.00637343

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.310679
FLNB filamin B, beta -0.124102
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.119023
TPT1 tumor protein, translationally-controlled 1 -0.110622
MT2A metallothionein 2A -0.103838
NDRG1 N-myc downstream regulated 1 -0.101783
B2M beta-2-microglobulin -0.0760534
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0739075
TMSB10 thymosin beta 10 -0.0708848
ENO1 enolase 1, (alpha) -0.0692802
RPS6 ribosomal protein S6 -0.0668108
IFITM1 interferon induced transmembrane protein 1 -0.0599615
CLU clusterin -0.0578962
PGK1 phosphoglycerate kinase 1 -0.0575757
PTMA prothymosin, alpha -0.0566028
DPYD dihydropyrimidine dehydrogenase -0.0558084
CD44 CD44 molecule (Indian blood group) -0.0543348
IFITM3 interferon induced transmembrane protein 3 -0.0511905
LOC112694756 uncharaterized LOC112694756 -0.0502691
RPS3 ribosomal protein S3 -0.0498147
RPLP2 ribosomal protein, large, P2 -0.0491321
RPS12 ribosomal protein S12 -0.0477509
RPS19 ribosomal protein S19 -0.0473674
RPL37A ribosomal protein L37a -0.0463828
ANXA2 annexin A2 -0.0462514
PODXL podocalyxin-like -0.0462133
CAV1 caveolin 1, caveolae protein, 22kDa -0.0455511
LDHA lactate dehydrogenase A -0.0454039
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0448548
BCL2L1 BCL2-like 1 -0.0441862
RPL11 ribosomal protein L11 -0.0414408
ITGA6 integrin, alpha 6 -0.0395186
RPL37 ribosomal protein L37 -0.0382617
RPS24 ribosomal protein S24 -0.037774
RPS21 ribosomal protein S21 -0.0377231
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0375193
RPL35A ribosomal protein L35a -0.0373927
HLA-B major histocompatibility complex, class I, B -0.0368078
RPL12 ribosomal protein L12 -0.0360648
RPS13 ribosomal protein S13 -0.0359856
H1-0 H1.0 linker histone -0.0354404
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0351583
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0350931
RPL26 ribosomal protein L26 -0.0338981
NAP1L1 nucleosome assembly protein 1-like 1 -0.0337939
RPS8 ribosomal protein S8 -0.0332848
LMNA lamin A/C -0.032856
RPL23 ribosomal protein L23 -0.0323428
CD9 CD9 molecule -0.0314345
RPL13A ribosomal protein L13a -0.0313775
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0312507
RACK1 receptor for activated C kinase 1 -0.0310387
SULF1 sulfatase 1 -0.030694
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0298228
LMO7 LIM domain 7 -0.0292206
GNAS GNAS complex locus -0.0291948
CD59 CD59 molecule, complement regulatory protein -0.0286848
BCAR3 breast cancer anti-estrogen resistance 3 -0.0285433
AHNAK AHNAK nucleoprotein -0.0282204
PRSS23 protease, serine, 23 -0.0279602
RPL7A ribosomal protein L7a -0.0277825
NRG1 neuregulin 1 -0.0275861
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0273264
RPL30 ribosomal protein L30 -0.027287
KRT17 keratin 17, type I -0.027226
IFI6 interferon, alpha-inducible protein 6 -0.0271181
OSMR oncostatin M receptor -0.0270967
EMP1 epithelial membrane protein 1 -0.0269329
RPS27 ribosomal protein S27 -0.0268337
SAMD9 sterile alpha motif domain containing 9 -0.0265731
TMSB4X thymosin beta 4, X-linked -0.0264493
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0263926
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0263451
EXT1 exostosin glycosyltransferase 1 -0.0263193
RPL32 ribosomal protein L32 -0.026294
RPL31 ribosomal protein L31 -0.0262645
ACTN4 actinin, alpha 4 -0.0261031
RPL34 ribosomal protein L34 -0.0259115
IFI16 interferon, gamma-inducible protein 16 -0.0258207
RPLP1 ribosomal protein, large, P1 -0.02543
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0251515
RPL35 ribosomal protein L35 -0.0251464
RPS14 ribosomal protein S14 -0.0250801
TSC22D1 TSC22 domain family, member 1 -0.0244576
S100A9 S100 calcium binding protein A9 -0.0243005
FOXP1 forkhead box P1 -0.0242657
RPS25 ribosomal protein S25 -0.0240764
RPLP0 ribosomal protein, large, P0 -0.023953
MECOM MDS1 and EVI1 complex locus -0.023884
RPL5 ribosomal protein L5 -0.0236268
LIMA1 LIM domain and actin binding 1 -0.0233991
RPL19 ribosomal protein L19 -0.0233267
HSPG2 heparan sulfate proteoglycan 2 -0.0232826
MYH9 myosin, heavy chain 9, non-muscle -0.0232529
RPL36 ribosomal protein L36 -0.0231794
FTL ferritin, light polypeptide -0.0230616
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.023009
RPL8 ribosomal protein L8 -0.0229768
RPS5 ribosomal protein S5 -0.0228788
SLC35F3 solute carrier family 35, member F3 -0.0226418