| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Temsirolimus perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Temsirolimus_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HLA-B | major histocompatibility complex, class I, B | 0.111727 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.111165 |
| TMSB4X | thymosin beta 4, X-linked | 0.0814303 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0617504 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0580883 |
| TRIM56 | tripartite motif containing 56 | 0.0538238 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0532671 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.049833 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0483298 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0434552 |
| VIM | vimentin | 0.0431027 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0420762 |
| ANXA1 | annexin A1 | 0.0415154 |
| APP | amyloid beta (A4) precursor protein | 0.0412003 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0411569 |
| HOMER1 | homer scaffolding protein 1 | 0.0406113 |
| EZR | ezrin | 0.0399074 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0384309 |
| EREG | epiregulin | 0.0372393 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0366412 |
| MT1E | metallothionein 1E | 0.0362307 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0359213 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0356158 |
| HLA-E | major histocompatibility complex, class I, E | 0.0352232 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0348185 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0343276 |
| RIGI | RNA sensor RIG-I | 0.0339058 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0336707 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0336198 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0313811 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0307176 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0305738 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.0296618 |
| LARP1 | La ribonucleoprotein domain family, member 1 | 0.0295075 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0291623 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.0286659 |
| CDK12 | cyclin-dependent kinase 12 | 0.0285027 |
| ARL4C | ADP-ribosylation factor-like 4C | 0.0284373 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0280041 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.027893 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.0277146 |
| RPL37 | ribosomal protein L37 | 0.0271034 |
| CAVIN1 | caveolae associated protein 1 | 0.0270912 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | 0.026616 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0263037 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0261837 |
| RPLP1 | ribosomal protein, large, P1 | 0.0259644 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0259411 |
| TEX10 | testis expressed 10 | 0.0259388 |
| ATF3 | activating transcription factor 3 | 0.0255599 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | 0.0254758 |
| B2M | beta-2-microglobulin | 0.0253429 |
| NT5DC3 | 5'-nucleotidase domain containing 3 | 0.0252646 |
| VEGFC | vascular endothelial growth factor C | 0.0252294 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | 0.0250682 |
| TPM4 | tropomyosin 4 | 0.0247024 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0245803 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0245695 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0242683 |
| GPATCH2 | G patch domain containing 2 | 0.0238788 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0237648 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0236568 |
| CALU | calumenin | 0.023646 |
| CEP250 | centrosomal protein 250kDa | 0.0234391 |
| RLF | rearranged L-myc fusion | 0.0234296 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0233214 |
| SFTPA2 | surfactant protein A2 | 0.0230653 |
| DFFA | DNA fragmentation factor, 45kDa, alpha polypeptide | 0.0230136 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | 0.0228405 |
| CAPRIN2 | caprin family member 2 | 0.0226197 |
| CDC27 | cell division cycle 27 | 0.0224843 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0223317 |
| CUL1 | cullin 1 | 0.0222961 |
| WWC2 | WW and C2 domain containing 2 | 0.0222208 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.022206 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.0220226 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0219549 |
| DOP1B | DOP1 leucine zipper like protein B | 0.0216514 |
| EIF3M | eukaryotic translation initiation factor 3, subunit M | 0.0216121 |
| RPL38 | ribosomal protein L38 | 0.0215006 |
| FN1 | fibronectin 1 | 0.0214995 |
| ZNF395 | zinc finger protein 395 | 0.0214145 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0206892 |
| MDN1 | MDN1, midasin homolog (yeast) | 0.0205148 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0204172 |
| RPLP0 | ribosomal protein, large, P0 | 0.0203766 |
| RPS25 | ribosomal protein S25 | 0.0203435 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0203014 |
| RPL7L1 | ribosomal protein L7-like 1 | 0.0202469 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0199133 |
| RCAN1 | regulator of calcineurin 1 | 0.0198907 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0198552 |
| RPL27A | ribosomal protein L27a | 0.0198524 |
| PITPNA | phosphatidylinositol transfer protein, alpha | 0.0192062 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0191734 |
| ZFR | zinc finger RNA binding protein | 0.0191285 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0190104 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | 0.0188956 |
| KLF6 | Kruppel-like factor 6 | 0.0187012 |
| ZC3H18 | zinc finger CCCH-type containing 18 | 0.0185977 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.149652 |
| TMSB10 | thymosin beta 10 | -0.116467 |
| RAD51B | RAD51 paralog B | -0.112198 |
| MT2A | metallothionein 2A | -0.0962256 |
| NEK10 | NIMA-related kinase 10 | -0.0873815 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0855063 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0816328 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0789393 |
| PRELID2 | PRELI domain containing 2 | -0.0772085 |
| DPH6 | diphthamine biosynthesis 6 | -0.0757339 |
| TP63 | tumor protein p63 | -0.0721933 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0682581 |
| RPL23 | ribosomal protein L23 | -0.0681993 |
| TSC22D1 | TSC22 domain family, member 1 | -0.067225 |
| SBF2 | SET binding factor 2 | -0.0668943 |
| VCL | vinculin | -0.066799 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0643248 |
| RCOR1 | REST corepressor 1 | -0.0628291 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0623962 |
| EGR1 | early growth response 1 | -0.0606883 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0586354 |
| RPS12 | ribosomal protein S12 | -0.0572757 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0551735 |
| POTEF | POTE ankyrin domain family, member F | -0.0541271 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0538904 |
| CMIP | c-Maf inducing protein | -0.0533133 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0516889 |
| ZNF292 | zinc finger protein 292 | -0.0514239 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0514026 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0512427 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0500935 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | -0.0491111 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0488593 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0476847 |
| FMNL2 | formin-like 2 | -0.047163 |
| RUNX1 | runt-related transcription factor 1 | -0.0471218 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0471002 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0461116 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0459914 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0454914 |
| SRPK2 | SRSF protein kinase 2 | -0.0453155 |
| SMAD3 | SMAD family member 3 | -0.0450606 |
| MYOF | myoferlin | -0.0444801 |
| RPL12 | ribosomal protein L12 | -0.0443871 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0438276 |
| ACBD6 | acyl-CoA binding domain containing 6 | -0.0434497 |
| DIAPH3 | diaphanous-related formin 3 | -0.0432767 |
| CFAP299 | cilia and flagella associated protein 299 | -0.0428914 |
| EXOC4 | exocyst complex component 4 | -0.0427483 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0420794 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0420716 |
| AEBP2 | AE binding protein 2 | -0.0415767 |
| ATP9B | ATPase, class II, type 9B | -0.0412177 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0409519 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0405373 |
| FLNB | filamin B, beta | -0.0403927 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0400923 |
| DENND1A | DENN/MADD domain containing 1A | -0.0398581 |
| COMMD10 | COMM domain containing 10 | -0.0397846 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0396391 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0395579 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0394079 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0390944 |
| CD44 | CD44 molecule (Indian blood group) | -0.0389821 |
| PIAS2 | protein inhibitor of activated STAT, 2 | -0.038861 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.038814 |
| HPCAL1 | hippocalcin-like 1 | -0.0384299 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0378304 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0377458 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0376735 |
| ECE1 | endothelin converting enzyme 1 | -0.0374384 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | -0.0374384 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0373773 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0369997 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0367106 |
| PCNX4 | pecanex 4 | -0.0366039 |
| USP34 | ubiquitin specific peptidase 34 | -0.0365346 |
| BMERB1 | bMERB domain containing 1 | -0.0364473 |
| CENPF | centromere protein F, 350/400kDa | -0.0363352 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0361697 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0361071 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0359339 |
| POU2F1 | POU class 2 homeobox 1 | -0.0358568 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | -0.0357848 |
| PODXL | podocalyxin-like | -0.0349323 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0342681 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0339001 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0338853 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0337352 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0336676 |
| ZNF217 | zinc finger protein 217 | -0.0333787 |
| PTK2 | protein tyrosine kinase 2 | -0.0333041 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0332719 |
| SON | SON DNA binding protein | -0.0331564 |
| NF1 | neurofibromin 1 | -0.0327861 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0326899 |
| ACTN4 | actinin, alpha 4 | -0.0325944 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | -0.0323983 |
| SLC38A6 | solute carrier family 38, member 6 | -0.0322979 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0322227 |
