| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Temsirolimus perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Temsirolimus_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.300655 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.104045 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0804645 |
| EFNA5 | ephrin-A5 | 0.0768022 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0764388 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0692956 |
| TMSB10 | thymosin beta 10 | 0.0634356 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0618295 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0615765 |
| AHNAK | AHNAK nucleoprotein | 0.059006 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0582029 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0521832 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0501466 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0483411 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0476373 |
| RNF213 | ring finger protein 213 | 0.0467394 |
| INTS6 | integrator complex subunit 6 | 0.0450951 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.044088 |
| LAMB3 | laminin, beta 3 | 0.0438564 |
| PLEC | plectin | 0.0432994 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0401479 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.037689 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0348261 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0330507 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0315817 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0312615 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0307026 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0304857 |
| H1-0 | H1.0 linker histone | 0.0299916 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0296039 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0294166 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0288057 |
| SCEL | sciellin | 0.0282538 |
| HDAC9 | histone deacetylase 9 | 0.0275371 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0275027 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0273395 |
| HOMER1 | homer scaffolding protein 1 | 0.0273243 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0272153 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0271363 |
| CD163L1 | CD163 molecule-like 1 | 0.0263955 |
| ANXA1 | annexin A1 | 0.0263836 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0239158 |
| SP100 | SP100 nuclear antigen | 0.0238091 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.022998 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0227971 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0224854 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0219106 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0219059 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.021349 |
| S100P | S100 calcium binding protein P | 0.0213469 |
| CUX1 | cut-like homeobox 1 | 0.0210561 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0208843 |
| DNER | delta/notch-like EGF repeat containing | 0.0208617 |
| NABP1 | nucleic acid binding protein 1 | 0.0207008 |
| CTBP2 | C-terminal binding protein 2 | 0.0206585 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | 0.0205564 |
| CES1 | carboxylesterase 1 | 0.0204189 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0197848 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0189475 |
| S100A10 | S100 calcium binding protein A10 | 0.0188773 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0188706 |
| SLTM | SAFB-like, transcription modulator | 0.0183478 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 0.0183266 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0181547 |
| AEBP2 | AE binding protein 2 | 0.0180862 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.017706 |
| FOXP1 | forkhead box P1 | 0.0175626 |
| DOCK4 | dedicator of cytokinesis 4 | 0.017475 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0169693 |
| KRT7 | keratin 7, type II | 0.0167569 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0164642 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.0163634 |
| FLNB | filamin B, beta | 0.0161324 |
| TRIM56 | tripartite motif containing 56 | 0.0160496 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0160381 |
| RPL35A | ribosomal protein L35a | 0.015947 |
| SKI | SKI proto-oncogene | 0.0157777 |
| ACTN1 | actinin, alpha 1 | 0.0157559 |
| SVIL | supervillin | 0.0157305 |
| DISC1 | disrupted in schizophrenia 1 | 0.0152462 |
| MYO1D | myosin ID | 0.0152116 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0149921 |
| MX1 | MX dynamin-like GTPase 1 | 0.0146701 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0146178 |
| RPL3 | ribosomal protein L3 | 0.0143583 |
| CMIP | c-Maf inducing protein | 0.0141177 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.014067 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | 0.0139996 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.0139627 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0138167 |
| SQSTM1 | sequestosome 1 | 0.0137424 |
| LARP1B | La ribonucleoprotein domain family, member 1B | 0.0137044 |
| IFI44L | interferon-induced protein 44-like | 0.0136997 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0136781 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0136729 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0135688 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.013384 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0132398 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0131144 |
| RPL4 | ribosomal protein L4 | 0.0130075 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.236203 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.165927 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.151614 |
| NDRG1 | N-myc downstream regulated 1 | -0.0993716 |
| MKI67 | marker of proliferation Ki-67 | -0.0882474 |
| STC1 | stanniocalcin 1 | -0.0817096 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0765915 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0687376 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0610244 |
| ASPH | aspartate beta-hydroxylase | -0.058151 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | -0.0538866 |
| RPS3 | ribosomal protein S3 | -0.0533797 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0524487 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.052307 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.051669 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0515813 |
| ARRDC3 | arrestin domain containing 3 | -0.0509624 |
| MT2A | metallothionein 2A | -0.050434 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0481135 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0455308 |
| TOP1 | topoisomerase (DNA) I | -0.0453662 |
| USP34 | ubiquitin specific peptidase 34 | -0.045274 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0435416 |
| ZNF292 | zinc finger protein 292 | -0.0416652 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0413096 |
| JMJD1C | jumonji domain containing 1C | -0.0409302 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0408823 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.040842 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0406813 |
| LDHA | lactate dehydrogenase A | -0.0401836 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0401311 |
| CCNL1 | cyclin L1 | -0.0399153 |
| RPL37A | ribosomal protein L37a | -0.0398718 |
| RPS2 | ribosomal protein S2 | -0.0389781 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0386668 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0379305 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0378474 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0375661 |
| FAM13A | family with sequence similarity 13, member A | -0.0372615 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0369903 |
| RUNX1 | runt-related transcription factor 1 | -0.0369841 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0368378 |
| PKM | pyruvate kinase, muscle | -0.0367975 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0367947 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0362809 |
| TNRC6A | trinucleotide repeat containing 6A | -0.0361498 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0360174 |
| RBM39 | RNA binding motif protein 39 | -0.0357315 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.035128 |
| CPE | carboxypeptidase E | -0.0350775 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | -0.0349376 |
| PAPOLA | poly(A) polymerase alpha | -0.0345599 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0344956 |
| BBX | bobby sox homolog (Drosophila) | -0.0340253 |
| RTN4 | reticulon 4 | -0.034005 |
| TES | testin LIM domain protein | -0.0334516 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0333032 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0332304 |
| CEP350 | centrosomal protein 350kDa | -0.0328436 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0326907 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0323462 |
| SEC61G | Sec61 gamma subunit | -0.0321511 |
| SUCO | SUN domain containing ossification factor | -0.0320409 |
| CDCP1 | CUB domain containing protein 1 | -0.0317416 |
| TMF1 | TATA element modulatory factor 1 | -0.0309128 |
| NGLY1 | N-glycanase 1 | -0.0308055 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0307272 |
| OGA | O-GlcNAcase | -0.0302935 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0300115 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0299281 |
| BRD2 | bromodomain containing 2 | -0.0296979 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0292035 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0288177 |
| RBM26 | RNA binding motif protein 26 | -0.028354 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0283255 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0282908 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0281823 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0279066 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.027801 |
| ANO6 | anoctamin 6 | -0.0275349 |
| SPAG9 | sperm associated antigen 9 | -0.0275241 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0273678 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0271587 |
| PUM2 | pumilio RNA-binding family member 2 | -0.026921 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | -0.0268042 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0266209 |
| PGK1 | phosphoglycerate kinase 1 | -0.0262513 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0260412 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.026007 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0257734 |
| PTEN | phosphatase and tensin homolog | -0.0256799 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0256766 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.025566 |
| UBC | ubiquitin C | -0.0253968 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0253873 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0253059 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0253009 |
| RBM25 | RNA binding motif protein 25 | -0.0251127 |
| CENPF | centromere protein F, 350/400kDa | -0.0250821 |
| PNN | pinin, desmosome associated protein | -0.0249234 |
