| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Temsirolimus perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Temsirolimus_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MCL1 | myeloid cell leukemia 1 | 0.0734776 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0674343 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0654366 |
| COPA | coatomer protein complex, subunit alpha | 0.0575541 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0488593 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0471175 |
| POTEF | POTE ankyrin domain family, member F | 0.0465153 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0462392 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0458069 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0434885 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0430846 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0430492 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0400837 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0394495 |
| BRD2 | bromodomain containing 2 | 0.0387181 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0382154 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.035956 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0333082 |
| PCBP2 | poly(rC) binding protein 2 | 0.0317709 |
| CCNL1 | cyclin L1 | 0.0313999 |
| SETD5 | SET domain containing 5 | 0.0313247 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0309632 |
| FMNL2 | formin-like 2 | 0.0307934 |
| HLA-B | major histocompatibility complex, class I, B | 0.0304187 |
| IL6 | interleukin 6 | 0.0300119 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0294281 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0291846 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0278961 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0277464 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0266286 |
| PM20D1 | peptidase M20 domain containing 1 | 0.026585 |
| NTN4 | netrin 4 | 0.0265277 |
| ZNF207 | zinc finger protein 207 | 0.0263885 |
| NDRG1 | N-myc downstream regulated 1 | 0.026019 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0256862 |
| RBM39 | RNA binding motif protein 39 | 0.02433 |
| PDE10A | phosphodiesterase 10A | 0.0242017 |
| HLA-A | major histocompatibility complex, class I, A | 0.0237408 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0231827 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.023074 |
| RPS29 | ribosomal protein S29 | 0.0228625 |
| RCOR1 | REST corepressor 1 | 0.0228171 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0227724 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0225715 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0224331 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0219715 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0215597 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0213568 |
| USP36 | ubiquitin specific peptidase 36 | 0.0212599 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0207836 |
| BMP6 | bone morphogenetic protein 6 | 0.0206167 |
| RAB31 | RAB31, member RAS oncogene family | 0.0204895 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0204528 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0203717 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0200132 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0199825 |
| FBXO11 | F-box protein 11 | 0.0198008 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0197869 |
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.0195362 |
| INTS6 | integrator complex subunit 6 | 0.0194393 |
| KYNU | kynureninase | 0.0194354 |
| MT1X | metallothionein 1X | 0.0193807 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.019295 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0192306 |
| TOP1 | topoisomerase (DNA) I | 0.0191631 |
| DSCAM | Down syndrome cell adhesion molecule | 0.019094 |
| NRG1 | neuregulin 1 | 0.0190783 |
| HDAC9 | histone deacetylase 9 | 0.0188824 |
| GOLGA4 | golgin A4 | 0.0187779 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0187244 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0184932 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0183156 |
| ADM | adrenomedullin | 0.0181665 |
| ARF4 | ADP-ribosylation factor 4 | 0.0181205 |
| ZNF638 | zinc finger protein 638 | 0.0180604 |
| SRP54 | signal recognition particle 54kDa | 0.0176838 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0176053 |
| HELZ | helicase with zinc finger | 0.0175363 |
| MED13 | mediator complex subunit 13 | 0.0174551 |
| COG5 | component of oligomeric golgi complex 5 | 0.0172899 |
| NUMB | numb homolog (Drosophila) | 0.0172816 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0171823 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0171755 |
| FUS | FUS RNA binding protein | 0.0168851 |
| ATXN1 | ataxin 1 | 0.0167934 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0166977 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0165732 |
| MEF2D | myocyte enhancer factor 2D | 0.0164874 |
| MSN | moesin | 0.0164778 |
| DENND4A | DENN/MADD domain containing 4A | 0.0164002 |
| VMP1 | vacuole membrane protein 1 | 0.0163704 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0163569 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0163367 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.0162845 |
| CUL3 | cullin 3 | 0.0162807 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.015993 |
| TRAF3 | TNF receptor-associated factor 3 | 0.0159435 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0158486 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.015841 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0157886 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.214434 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.198646 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.17274 |
| VIM | vimentin | -0.166949 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.118278 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.117555 |
| MT2A | metallothionein 2A | -0.111271 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.100248 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0968837 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.087765 |
| AHNAK | AHNAK nucleoprotein | -0.0857227 |
| TXNRD1 | thioredoxin reductase 1 | -0.0830481 |
| RPL23 | ribosomal protein L23 | -0.0801434 |
| RPL19 | ribosomal protein L19 | -0.0799794 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0747501 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0698904 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0679655 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0648055 |
| PTMA | prothymosin, alpha | -0.0635407 |
| S100A6 | S100 calcium binding protein A6 | -0.0622972 |
| STC1 | stanniocalcin 1 | -0.0563044 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0546476 |
| RPL26 | ribosomal protein L26 | -0.0526121 |
| KLF6 | Kruppel-like factor 6 | -0.0520061 |
| CAVIN1 | caveolae associated protein 1 | -0.0498115 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0489393 |
| ASPH | aspartate beta-hydroxylase | -0.048493 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0480528 |
| IER3 | immediate early response 3 | -0.0467867 |
| ENO1 | enolase 1, (alpha) | -0.046382 |
| RACK1 | receptor for activated C kinase 1 | -0.0444555 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0423713 |
| RPS19 | ribosomal protein S19 | -0.0417785 |
| TPD52 | tumor protein D52 | -0.0409259 |
| MKI67 | marker of proliferation Ki-67 | -0.040595 |
| RPL18 | ribosomal protein L18 | -0.0402042 |
| FTL | ferritin, light polypeptide | -0.0394461 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.0388842 |
| RPL12 | ribosomal protein L12 | -0.0385988 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0381843 |
| RPL4 | ribosomal protein L4 | -0.0371161 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0370535 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0362613 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.036206 |
| RPL3 | ribosomal protein L3 | -0.0355561 |
| DST | dystonin | -0.0352878 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0348962 |
| KIF5B | kinesin family member 5B | -0.0348193 |
| RPL8 | ribosomal protein L8 | -0.0347793 |
| CANX | calnexin | -0.034154 |
| TPI1 | triosephosphate isomerase 1 | -0.0339798 |
| RPS21 | ribosomal protein S21 | -0.0337039 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0332555 |
| PYGL | phosphorylase, glycogen, liver | -0.0329372 |
| RPS12 | ribosomal protein S12 | -0.0328938 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0327188 |
| YBX1 | Y box binding protein 1 | -0.0324759 |
| TUBB | tubulin, beta class I | -0.0314892 |
| RPLP1 | ribosomal protein, large, P1 | -0.0314236 |
| RPL32 | ribosomal protein L32 | -0.0310125 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0309852 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0307694 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.030117 |
| RPL7 | ribosomal protein L7 | -0.0300612 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0299815 |
| RPS17 | ribosomal protein S17 | -0.0297683 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0295605 |
| CENPF | centromere protein F, 350/400kDa | -0.029465 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.029424 |
| ANXA2 | annexin A2 | -0.0293712 |
| LDHA | lactate dehydrogenase A | -0.0292373 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0292272 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0290574 |
| TAGLN2 | transgelin 2 | -0.0290574 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0288409 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0288405 |
| ANLN | anillin, actin binding protein | -0.0281831 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0279738 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0279517 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0276921 |
| TMEM123 | transmembrane protein 123 | -0.0275263 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0273337 |
| RPLP0 | ribosomal protein, large, P0 | -0.0268294 |
| MATR3 | matrin 3 | -0.0267328 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.026718 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0266483 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0266433 |
| THBS1 | thrombospondin 1 | -0.0259667 |
| GNAS | GNAS complex locus | -0.0255534 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.025478 |
| H1-0 | H1.0 linker histone | -0.025477 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0254409 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0253882 |
| FGB | fibrinogen beta chain | -0.0252381 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0250073 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0249999 |
| RPS3 | ribosomal protein S3 | -0.0249936 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0249655 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0249389 |
| ACTG1 | actin gamma 1 | -0.0247558 |
