| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Temsirolimus perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Temsirolimus_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.107827 |
| EFNA5 | ephrin-A5 | 0.0983553 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0941452 |
| LMO7 | LIM domain 7 | 0.0822878 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.080435 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0744224 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.069664 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0675323 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0630604 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0587144 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0586164 |
| METTL15 | methyltransferase like 15 | 0.0585433 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0570545 |
| SVIL | supervillin | 0.0564848 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0535288 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0534624 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0530522 |
| AK1 | adenylate kinase 1 | 0.0530498 |
| PDLIM5 | PDZ and LIM domain 5 | 0.052918 |
| TXNRD1 | thioredoxin reductase 1 | 0.0511639 |
| PRKCA | protein kinase C, alpha | 0.0507339 |
| NAV2 | neuron navigator 2 | 0.0497467 |
| JMJD1C | jumonji domain containing 1C | 0.0492149 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0485139 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0471462 |
| FNIP1 | folliculin interacting protein 1 | 0.0459554 |
| MYOF | myoferlin | 0.0441607 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0438267 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0437696 |
| BCL2L1 | BCL2-like 1 | 0.0435891 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0435293 |
| RASA2 | RAS p21 protein activator 2 | 0.0427875 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0427225 |
| ZNF638 | zinc finger protein 638 | 0.0426272 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0424859 |
| WDR7 | WD repeat domain 7 | 0.0422718 |
| RNF213 | ring finger protein 213 | 0.0418596 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0416957 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0412991 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0396908 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0391115 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0384122 |
| EPS15 | epidermal growth factor receptor pathway substrate 15 | 0.0383149 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0380063 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0374618 |
| YOD1 | YOD1 deubiquitinase | 0.0373024 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.036871 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0368098 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0368015 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0364772 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | 0.035981 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.035915 |
| SMAD2 | SMAD family member 2 | 0.0348852 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.0346832 |
| AGO3 | argonaute RISC catalytic component 3 | 0.0344433 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0340569 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0340395 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.033998 |
| RAD51B | RAD51 paralog B | 0.0337122 |
| SMYD3 | SET and MYND domain containing 3 | 0.0336752 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0329845 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0329496 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0329361 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | 0.0326226 |
| GLIS3 | GLIS family zinc finger 3 | 0.032587 |
| KATNBL1 | katanin p80 subunit B-like 1 | 0.0323278 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0322932 |
| DTNA | dystrobrevin, alpha | 0.0322833 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0322734 |
| DSG2 | desmoglein 2 | 0.0322344 |
| CD44 | CD44 molecule (Indian blood group) | 0.0321475 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0320742 |
| CEP192 | centrosomal protein 192kDa | 0.0320503 |
| YTHDC1 | YTH domain containing 1 | 0.031766 |
| DUSP16 | dual specificity phosphatase 16 | 0.0317363 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0316963 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0314017 |
| DOCK1 | dedicator of cytokinesis 1 | 0.031367 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0313143 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0311753 |
| ZNF292 | zinc finger protein 292 | 0.0310793 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0309993 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0309901 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0307099 |
| ANGPTL4 | angiopoietin-like 4 | 0.0306438 |
| GPATCH8 | G patch domain containing 8 | 0.0306137 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.030613 |
| KIF13A | kinesin family member 13A | 0.0306096 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0303598 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0303316 |
| LMTK2 | lemur tyrosine kinase 2 | 0.030116 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0300811 |
| CCNY | cyclin Y | 0.0299483 |
| PDE10A | phosphodiesterase 10A | 0.029671 |
| RIGI | RNA sensor RIG-I | 0.0293949 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0293728 |
| TMF1 | TATA element modulatory factor 1 | 0.0293545 |
| NUMB | numb homolog (Drosophila) | 0.0292312 |
| SCFD1 | sec1 family domain containing 1 | 0.0291441 |
| DYM | dymeclin | 0.0290452 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FTL | ferritin, light polypeptide | -0.167373 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.166643 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.128627 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0988882 |
| VIM | vimentin | -0.0959933 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0929584 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0841168 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0773725 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0764433 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0758247 |
| RPS6 | ribosomal protein S6 | -0.0722352 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0709596 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0691021 |
| SRPK2 | SRSF protein kinase 2 | -0.0672864 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0665001 |
| S100A6 | S100 calcium binding protein A6 | -0.0639625 |
| KRT17 | keratin 17, type I | -0.0638499 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0635371 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0631243 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0623847 |
| GOLGA4 | golgin A4 | -0.0597316 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0592212 |
| TMSB10 | thymosin beta 10 | -0.0568456 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0566847 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0563379 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0553469 |
| PKM | pyruvate kinase, muscle | -0.054368 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0543506 |
| ANXA1 | annexin A1 | -0.0542514 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0542036 |
| PTMA | prothymosin, alpha | -0.0537082 |
| RPS19 | ribosomal protein S19 | -0.0515668 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0495599 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0482595 |
| RPL23 | ribosomal protein L23 | -0.0469747 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0467448 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0465405 |
| POTEF | POTE ankyrin domain family, member F | -0.0461212 |
| RPL12 | ribosomal protein L12 | -0.0458572 |
| RBM39 | RNA binding motif protein 39 | -0.0457735 |
| DICER1 | dicer 1, ribonuclease type III | -0.0457544 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0451289 |
| RPS24 | ribosomal protein S24 | -0.0446909 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0445838 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0441873 |
| PGK1 | phosphoglycerate kinase 1 | -0.0441383 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0438574 |
| S100A9 | S100 calcium binding protein A9 | -0.042516 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0424066 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0422759 |
| CCDC6 | coiled-coil domain containing 6 | -0.0417645 |
| MEF2A | myocyte enhancer factor 2A | -0.0406433 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0405205 |
| ANXA2 | annexin A2 | -0.0403674 |
| TXNIP | thioredoxin interacting protein | -0.0402913 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0402674 |
| RPL35A | ribosomal protein L35a | -0.039899 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.039896 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0387975 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0387179 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0380748 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0374473 |
| PHF21A | PHD finger protein 21A | -0.0373143 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0366018 |
| ASPH | aspartate beta-hydroxylase | -0.0364556 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0363883 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0363759 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0361686 |
| LAMB3 | laminin, beta 3 | -0.0356331 |
| YME1L1 | YME1-like 1 ATPase | -0.035604 |
| SPAG9 | sperm associated antigen 9 | -0.0355918 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0354413 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0334518 |
| SAR1A | secretion associated, Ras related GTPase 1A | -0.0332657 |
| SNX9 | sorting nexin 9 | -0.0331852 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0329731 |
| RPLP0 | ribosomal protein, large, P0 | -0.0328554 |
| UBC | ubiquitin C | -0.0328292 |
| TPM4 | tropomyosin 4 | -0.0326498 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0324691 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0324544 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.032231 |
| RPL31 | ribosomal protein L31 | -0.032044 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0319647 |
| CCNL1 | cyclin L1 | -0.0314684 |
| MAP1B | microtubule-associated protein 1B | -0.0314424 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0311261 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0310582 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0309937 |
| H3-3B | H3.3 histone B | -0.0308605 |
| PDS5B | PDS5 cohesin associated factor B | -0.0307745 |
| RPLP2 | ribosomal protein, large, P2 | -0.0307647 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0307046 |
| RPS13 | ribosomal protein S13 | -0.0305905 |
| GDF15 | growth differentiation factor 15 | -0.0303541 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0303455 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0300761 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0300479 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0300192 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.029935 |
