| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Temsirolimus perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Temsirolimus_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0942904 |
| MCL1 | myeloid cell leukemia 1 | 0.0609347 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0577136 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0562102 |
| GRAMD1B | GRAM domain containing 1B | 0.0554812 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0531366 |
| POTEF | POTE ankyrin domain family, member F | 0.0504303 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0503824 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.049225 |
| VCL | vinculin | 0.0471488 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0464346 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0450975 |
| PDE10A | phosphodiesterase 10A | 0.0444085 |
| ATXN1 | ataxin 1 | 0.0429176 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0414375 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0413878 |
| COPA | coatomer protein complex, subunit alpha | 0.0406605 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0403868 |
| RPL3 | ribosomal protein L3 | 0.0393493 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0384813 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0383848 |
| INTS6 | integrator complex subunit 6 | 0.037522 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0374878 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0371299 |
| USP34 | ubiquitin specific peptidase 34 | 0.0370759 |
| AEBP2 | AE binding protein 2 | 0.0362965 |
| PRELID2 | PRELI domain containing 2 | 0.0359913 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.035963 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0353687 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0349503 |
| WWOX | WW domain containing oxidoreductase | 0.0336086 |
| FNIP1 | folliculin interacting protein 1 | 0.0330646 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0327489 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0325935 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | 0.0321797 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0319266 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0318611 |
| YAP1 | Yes-associated protein 1 | 0.030705 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.0298633 |
| ZNF644 | zinc finger protein 644 | 0.0294977 |
| SETD5 | SET domain containing 5 | 0.0287272 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0282328 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0277654 |
| PCBP2 | poly(rC) binding protein 2 | 0.0275692 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0271686 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.02711 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0269101 |
| HOMER1 | homer scaffolding protein 1 | 0.0268443 |
| WNT2B | wingless-type MMTV integration site family, member 2B | 0.0267058 |
| RALGAPB | Ral GTPase activating protein, beta subunit (non-catalytic) | 0.0265648 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0261776 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0258323 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0255693 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0255209 |
| ZNF207 | zinc finger protein 207 | 0.0254277 |
| PYGL | phosphorylase, glycogen, liver | 0.0252757 |
| SETX | senataxin | 0.0251058 |
| TPM2 | tropomyosin 2 (beta) | 0.0248293 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | 0.0247743 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0246093 |
| CPNE1 | copine I | 0.0245411 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0243968 |
| CCNL1 | cyclin L1 | 0.0243139 |
| HYOU1 | hypoxia up-regulated 1 | 0.0242656 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0238226 |
| ZNF407 | zinc finger protein 407 | 0.0233988 |
| NBAS | neuroblastoma amplified sequence | 0.0231645 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0231086 |
| ARMH4 | armadillo like helical domain containing 4 | 0.0228896 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0227957 |
| TRIM59 | tripartite motif containing 59 | 0.0226754 |
| EXOC4 | exocyst complex component 4 | 0.0225947 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0224635 |
| ZNF638 | zinc finger protein 638 | 0.0222454 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0221179 |
| SMAD3 | SMAD family member 3 | 0.0219041 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.0216329 |
| CMIP | c-Maf inducing protein | 0.0215831 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0215078 |
| JMJD1C | jumonji domain containing 1C | 0.0214172 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0212903 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.0210993 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0210587 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.020815 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0205373 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.0204841 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0204202 |
| ACTN1 | actinin, alpha 1 | 0.0203006 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0198647 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0197797 |
| MED13L | mediator complex subunit 13-like | 0.0196419 |
| GOSR2 | golgi SNAP receptor complex member 2 | 0.0196279 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0196123 |
| ETNK1 | ethanolamine kinase 1 | 0.019488 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0194771 |
| SVIL | supervillin | 0.019347 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0192775 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0192213 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0191384 |
| RYR3 | ryanodine receptor 3 | 0.0190992 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.184347 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.165049 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.129246 |
| PTMA | prothymosin, alpha | -0.0891272 |
| VIM | vimentin | -0.0827749 |
| TMSB10 | thymosin beta 10 | -0.0779425 |
| RPS8 | ribosomal protein S8 | -0.0768979 |
| RPL12 | ribosomal protein L12 | -0.0747525 |
| RPL37A | ribosomal protein L37a | -0.0728207 |
| RPL26 | ribosomal protein L26 | -0.0688139 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.064182 |
| RPLP1 | ribosomal protein, large, P1 | -0.0637356 |
| RPS3 | ribosomal protein S3 | -0.0633725 |
| MT2A | metallothionein 2A | -0.0632615 |
| CAVIN1 | caveolae associated protein 1 | -0.0620054 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0619313 |
| RPL37 | ribosomal protein L37 | -0.0616475 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0600748 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0594693 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0590415 |
| STC1 | stanniocalcin 1 | -0.057082 |
| RPL31 | ribosomal protein L31 | -0.0551579 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0551442 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0547121 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.053966 |
| IER3 | immediate early response 3 | -0.0531949 |
| YBX3 | Y box binding protein 3 | -0.0522329 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0507328 |
| RPL11 | ribosomal protein L11 | -0.0505911 |
| SEPTIN7 | septin 7 | -0.0498848 |
| RPS27 | ribosomal protein S27 | -0.0492457 |
| RPL9 | ribosomal protein L9 | -0.0491351 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0479308 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.047309 |
| RPL38 | ribosomal protein L38 | -0.0461755 |
| RPL35A | ribosomal protein L35a | -0.0459872 |
| RPS29 | ribosomal protein S29 | -0.0450323 |
| RACK1 | receptor for activated C kinase 1 | -0.0442938 |
| PGK1 | phosphoglycerate kinase 1 | -0.0442334 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.043353 |
| FTL | ferritin, light polypeptide | -0.0426249 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0424438 |
| RPL34 | ribosomal protein L34 | -0.0414269 |
| RTN4 | reticulon 4 | -0.0412925 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0409339 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0399679 |
| RPLP0 | ribosomal protein, large, P0 | -0.0393753 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.0385476 |
| ACTG1 | actin gamma 1 | -0.0374121 |
| RPL5 | ribosomal protein L5 | -0.0366985 |
| VDAC1 | voltage-dependent anion channel 1 | -0.036127 |
| RPS27A | ribosomal protein S27a | -0.0354404 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0353154 |
| RPL19 | ribosomal protein L19 | -0.0351963 |
| RPL36 | ribosomal protein L36 | -0.0340208 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0336339 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0335333 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0334836 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0334428 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0333282 |
| PRRC2C | proline-rich coiled-coil 2C | -0.032911 |
| TPI1 | triosephosphate isomerase 1 | -0.0320989 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0315225 |
| RPS10 | ribosomal protein S10 | -0.0314864 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.03125 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0310205 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0309429 |
| S100A11 | S100 calcium binding protein A11 | -0.0305474 |
| RPS15 | ribosomal protein S15 | -0.0301097 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0298891 |
| SRP72 | signal recognition particle 72kDa | -0.0296583 |
| RPS12 | ribosomal protein S12 | -0.0295326 |
| RPLP2 | ribosomal protein, large, P2 | -0.0293039 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0292356 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0292025 |
| LMAN1 | lectin, mannose-binding, 1 | -0.029191 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0291794 |
| S100A6 | S100 calcium binding protein A6 | -0.0290983 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0290552 |
| STK4 | serine/threonine kinase 4 | -0.0289674 |
| UBB | ubiquitin B | -0.0289479 |
| ZFR | zinc finger RNA binding protein | -0.0287006 |
| TPM4 | tropomyosin 4 | -0.0284659 |
| RPL23 | ribosomal protein L23 | -0.0282157 |
| EPN2 | epsin 2 | -0.0281231 |
| RPL8 | ribosomal protein L8 | -0.0278821 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0278146 |
| CHD4 | chromodomain helicase DNA binding protein 4 | -0.0276417 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0275979 |
| RPL35 | ribosomal protein L35 | -0.0273236 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0272014 |
| RPS19 | ribosomal protein S19 | -0.0270718 |
| RPS2 | ribosomal protein S2 | -0.0269536 |
| GNAS | GNAS complex locus | -0.0263347 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | -0.0263001 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0260195 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0260101 |
| KIF5B | kinesin family member 5B | -0.0259965 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0257852 |
| RPS25 | ribosomal protein S25 | -0.0257416 |
