Temsirolimus_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Temsirolimus perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Temsirolimus_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.184379
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.170794
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.115815
LAMB3 laminin, beta 3 0.112862
MYH9 myosin, heavy chain 9, non-muscle 0.108145
PLEC plectin 0.0734008
CANX calnexin 0.0573083
RPL4 ribosomal protein L4 0.0569324
ASPH aspartate beta-hydroxylase 0.0568296
FNDC3B fibronectin type III domain containing 3B 0.04938
LAMC2 laminin, gamma 2 0.047604
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0446253
RPL3 ribosomal protein L3 0.0442161
HSPA8 heat shock 70kDa protein 8 0.0435334
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0424751
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0397229
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0389093
NAMPT nicotinamide phosphoribosyltransferase 0.0386837
ERRFI1 ERBB receptor feedback inhibitor 1 0.0383691
EEF2 eukaryotic translation elongation factor 2 0.037719
TRIO trio Rho guanine nucleotide exchange factor 0.037233
AHNAK AHNAK nucleoprotein 0.0362451
BHLHE40 basic helix-loop-helix family, member e40 0.0361274
IGFBP3 insulin-like growth factor binding protein 3 0.0358833
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0355856
APP amyloid beta (A4) precursor protein 0.0338683
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0324045
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0319185
DSPP dentin sialophosphoprotein 0.0316911
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.03085
ELL2 elongation factor, RNA polymerase II, 2 0.0273082
TMSB4X thymosin beta 4, X-linked 0.0269067
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0267459
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0260058
TXNRD1 thioredoxin reductase 1 0.0255861
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0251226
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0249902
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0236767
MATR3 matrin 3 0.0230331
FXR1 fragile X mental retardation, autosomal homolog 1 0.0222021
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.02151
ANXA5 annexin A5 0.021299
FTH1 ferritin, heavy polypeptide 1 0.0202674
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0198054
YBX1 Y box binding protein 1 0.0197429
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0191993
IRF6 interferon regulatory factor 6 0.0191452
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.019135
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0190848
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.018826
NAV2 neuron navigator 2 0.0182934
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0182506
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0180979
TNIP1 TNFAIP3 interacting protein 1 0.0180782
KDM3A lysine (K)-specific demethylase 3A 0.0179968
GRB10 growth factor receptor-bound protein 10 0.0178383
SNX9 sorting nexin 9 0.0172912
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0172745
ADAM9 ADAM metallopeptidase domain 9 0.0172651
TFG TRK-fused gene 0.0172358
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0172055
SDC4 syndecan 4 0.0171986
IQGAP1 IQ motif containing GTPase activating protein 1 0.0171796
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0169602
SMAD3 SMAD family member 3 0.0168852
TPM3 tropomyosin 3 0.0168145
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0167705
NCKAP1 NCK-associated protein 1 0.0165407
MACF1 microtubule-actin crosslinking factor 1 0.0161433
USP3 ubiquitin specific peptidase 3 0.0161278
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0159896
RPL14 ribosomal protein L14 0.0159294
MARCHF6 membrane associated ring-CH-type finger 6 0.0157028
PPARD peroxisome proliferator-activated receptor delta 0.0156888
PDIA4 protein disulfide isomerase family A, member 4 0.0154642
PAPOLA poly(A) polymerase alpha 0.0154624
KRT8 keratin 8, type II 0.0154324
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0151927
EIF4B eukaryotic translation initiation factor 4B 0.0150615
HOOK2 hook microtubule-tethering protein 2 0.0150342
MYO5B myosin VB 0.01503
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0148136
NUP58 nucleoporin 58 0.0146865
KRT7 keratin 7, type II 0.0146227
ANXA1 annexin A1 0.0145558
MEF2A myocyte enhancer factor 2A 0.0142736
EIF4A2 eukaryotic translation initiation factor 4A2 0.0141974
USP9X ubiquitin specific peptidase 9, X-linked 0.0141892
GARS1 glycyl-tRNA synthetase 1 0.0141387
IL6ST interleukin 6 signal transducer 0.0140967
PTK2 protein tyrosine kinase 2 0.0140836
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0140635
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.013956
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0139084
MYO10 myosin X 0.0138772
RUNX1 runt-related transcription factor 1 0.0138549
FLNA filamin A, alpha 0.0138221
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0137708
CALR calreticulin 0.0136208
CCNL1 cyclin L1 0.0135625

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.205816
PTMA prothymosin, alpha -0.148389
TMSB10 thymosin beta 10 -0.12234
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0911198
IFI6 interferon, alpha-inducible protein 6 -0.0641035
IFI27 interferon, alpha-inducible protein 27 -0.0631151
ACTG1 actin gamma 1 -0.0572038
LPP LIM domain containing preferred translocation partner in lipoma -0.0486161
RPL35A ribosomal protein L35a -0.0467378
EXT1 exostosin glycosyltransferase 1 -0.0457185
MT2A metallothionein 2A -0.0452006
EIF1 eukaryotic translation initiation factor 1 -0.0445872
IFITM3 interferon induced transmembrane protein 3 -0.0445724
ISG15 ISG15 ubiquitin-like modifier -0.0429207
IFITM1 interferon induced transmembrane protein 1 -0.042426
CSTB cystatin B (stefin B) -0.0419755
WSB1 WD repeat and SOCS box containing 1 -0.04171
RPS19 ribosomal protein S19 -0.0405639
SOX4 SRY (sex determining region Y)-box 4 -0.0398999
FBXO32 F-box protein 32 -0.0397535
TPT1 tumor protein, translationally-controlled 1 -0.0388678
LIMCH1 LIM and calponin homology domains 1 -0.0379272
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0376
ENO2 enolase 2 (gamma, neuronal) -0.0367815
HLA-B major histocompatibility complex, class I, B -0.0354217
RPS29 ribosomal protein S29 -0.0329236
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0328653
RPL9 ribosomal protein L9 -0.0326871
RPLP2 ribosomal protein, large, P2 -0.0319625
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0316661
RPS13 ribosomal protein S13 -0.0316047
RPS8 ribosomal protein S8 -0.0310223
RPLP1 ribosomal protein, large, P1 -0.0310066
RPL37A ribosomal protein L37a -0.030663
RPS3 ribosomal protein S3 -0.0296338
S100A9 S100 calcium binding protein A9 -0.0294888
ARID4B AT rich interactive domain 4B (RBP1-like) -0.029345
VIM vimentin -0.0289776
S100A6 S100 calcium binding protein A6 -0.0281995
RPS14 ribosomal protein S14 -0.0279188
IFI16 interferon, gamma-inducible protein 16 -0.0275042
MX2 MX dynamin-like GTPase 2 -0.0262885
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.026011
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0254364
MYO1E myosin IE -0.0253134
BASP1 brain abundant, membrane attached signal protein 1 -0.0252824
RPS23 ribosomal protein S23 -0.0252189
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0250856
TMEM165 transmembrane protein 165 -0.0245328
TPM4 tropomyosin 4 -0.0242549
HSPB1 heat shock 27kDa protein 1 -0.0240754
RPS25 ribosomal protein S25 -0.0236816
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0236704
VCL vinculin -0.0233609
LY6E lymphocyte antigen 6 complex, locus E -0.0230626
TPI1 triosephosphate isomerase 1 -0.0228555
YY1 YY1 transcription factor -0.0228281
RPL34 ribosomal protein L34 -0.0228042
HLA-A major histocompatibility complex, class I, A -0.0223626
ARHGAP20 Rho GTPase activating protein 20 -0.0216978
RPL31 ribosomal protein L31 -0.0216447
WASF2 WAS protein family, member 2 -0.0213522
H3-3B H3.3 histone B -0.0212489
RCOR1 REST corepressor 1 -0.0211865
C15ORF48 chromosome 15 open reading frame 48 -0.0211345
PDLIM5 PDZ and LIM domain 5 -0.0210884
RPS27 ribosomal protein S27 -0.0210557
RNF213 ring finger protein 213 -0.0209325
TXNIP thioredoxin interacting protein -0.0205726
RAB7A RAB7A, member RAS oncogene family -0.0203894
RPL36 ribosomal protein L36 -0.0202919
RPS17 ribosomal protein S17 -0.0200864
RBM25 RNA binding motif protein 25 -0.0199795
RPL15 ribosomal protein L15 -0.0196209
ARF4 ADP-ribosylation factor 4 -0.0194436
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0194365
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0191038
MDK midkine (neurite growth-promoting factor 2) -0.0188373
RPL32 ribosomal protein L32 -0.0187586
ETV6 ets variant 6 -0.0187128
RPS16 ribosomal protein S16 -0.0185643
WFDC2 WAP four-disulfide core domain 2 -0.0185384
GNAS GNAS complex locus -0.0183232
RPL37 ribosomal protein L37 -0.0181849
RPS24 ribosomal protein S24 -0.0178494
ANKRD17 ankyrin repeat domain 17 -0.0177678
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.017699
F3 coagulation factor III (thromboplastin, tissue factor) -0.0174164
RPL12 ribosomal protein L12 -0.0171118
RPL36A ribosomal protein L36a -0.0170599
RPS6 ribosomal protein S6 -0.0170318
NPC2 Niemann-Pick disease, type C2 -0.0170127
RPL23 ribosomal protein L23 -0.0169324
RPS21 ribosomal protein S21 -0.0169308
B2M beta-2-microglobulin -0.0169061
UBE2H ubiquitin-conjugating enzyme E2H -0.0167028
WARS1 tryptophanyl-tRNA synthetase 1 -0.016676
FRMD5 FERM domain containing 5 -0.0165499
LDHA lactate dehydrogenase A -0.0165393
RBM47 RNA binding motif protein 47 -0.0163039