| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Temsirolimus perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Temsirolimus_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GRAMD1B | GRAM domain containing 1B | 0.10494 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0789791 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0655779 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0628786 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0618573 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.057083 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0533893 |
| PCBP2 | poly(rC) binding protein 2 | 0.0477768 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0434032 |
| RPL3 | ribosomal protein L3 | 0.0405513 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0397849 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0397156 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0381542 |
| RPL4 | ribosomal protein L4 | 0.0348672 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0346213 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0333321 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0332259 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0315377 |
| PKM | pyruvate kinase, muscle | 0.0310162 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0302441 |
| SVIL | supervillin | 0.0294656 |
| FMNL2 | formin-like 2 | 0.0286591 |
| POTEF | POTE ankyrin domain family, member F | 0.0262455 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0253756 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0251442 |
| VMP1 | vacuole membrane protein 1 | 0.0245752 |
| MAFK | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K | 0.0244323 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0243535 |
| RAD51B | RAD51 paralog B | 0.0241941 |
| FLNB | filamin B, beta | 0.0239614 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.0238198 |
| ITPK1 | inositol-tetrakisphosphate 1-kinase | 0.0232678 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | 0.0229469 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0224316 |
| TPM3 | tropomyosin 3 | 0.0222141 |
| ZNF638 | zinc finger protein 638 | 0.0220519 |
| EZR | ezrin | 0.0216804 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0216051 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0213653 |
| CENPF | centromere protein F, 350/400kDa | 0.0212453 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0211107 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0206969 |
| LSAMP | limbic system-associated membrane protein | 0.020501 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0203938 |
| HDGF | hepatoma-derived growth factor | 0.0202656 |
| PYGL | phosphorylase, glycogen, liver | 0.0199292 |
| BMP6 | bone morphogenetic protein 6 | 0.019492 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0191767 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0191748 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0190184 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0188516 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0187294 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0186807 |
| MSN | moesin | 0.0184001 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0181553 |
| KRT19 | keratin 19, type I | 0.0178917 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0178162 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.017725 |
| PFKP | phosphofructokinase, platelet | 0.0176158 |
| FAM13A | family with sequence similarity 13, member A | 0.0175897 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0169899 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0169293 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | 0.0168777 |
| WWOX | WW domain containing oxidoreductase | 0.0168465 |
| MFF | mitochondrial fission factor | 0.0167157 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0164897 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0163819 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.016042 |
| FNIP1 | folliculin interacting protein 1 | 0.0159034 |
| MKI67 | marker of proliferation Ki-67 | 0.0158708 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0157897 |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | 0.0156711 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0154676 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0154495 |
| PRELID2 | PRELI domain containing 2 | 0.0154235 |
| NHSL1 | NHS-like 1 | 0.015236 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0150158 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0149317 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.014913 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0146715 |
| RBFOX1 | RNA binding protein, fox-1 homolog (C. elegans) 1 | 0.014536 |
| GSG1L2 | GSG1 like 2 | 0.014514 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.014418 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0143716 |
| SET | SET nuclear proto-oncogene | 0.0142858 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0140386 |
| KCTD3 | potassium channel tetramerization domain containing 3 | 0.0139505 |
| GPC6 | glypican 6 | 0.0139309 |
| KIF5B | kinesin family member 5B | 0.01393 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0136714 |
| PFN1 | profilin 1 | 0.0134803 |
| FHIT | fragile histidine triad | 0.0134352 |
| APP | amyloid beta (A4) precursor protein | 0.0133913 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0131406 |
| CSRP1 | cysteine and glycine-rich protein 1 | 0.0129594 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 0.0129305 |
| ANXA5 | annexin A5 | 0.0126999 |
| YBX1 | Y box binding protein 1 | 0.0126214 |
| CADM2 | cell adhesion molecule 2 | 0.0125001 |
| CCNH | cyclin H | 0.012442 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.168495 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.153164 |
| VIM | vimentin | -0.150881 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.149657 |
| EFNA5 | ephrin-A5 | -0.116633 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.105731 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.105659 |
| PTMA | prothymosin, alpha | -0.105203 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.09885 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0886552 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0845778 |
| TMSB10 | thymosin beta 10 | -0.0827499 |
| SMYD3 | SET and MYND domain containing 3 | -0.0793478 |
| RPL26 | ribosomal protein L26 | -0.078286 |
| RPS24 | ribosomal protein S24 | -0.077019 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0742843 |
| RPL37A | ribosomal protein L37a | -0.0682801 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0678779 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0676175 |
| RPL12 | ribosomal protein L12 | -0.0669553 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0657439 |
| RPS3 | ribosomal protein S3 | -0.0646848 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0628417 |
| RPS12 | ribosomal protein S12 | -0.062556 |
| DST | dystonin | -0.0611714 |
| CDH13 | cadherin 13 | -0.0580072 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0578189 |
| PCBP3 | poly(rC) binding protein 3 | -0.0577848 |
| NEK7 | NIMA-related kinase 7 | -0.0563085 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0562705 |
| KYNU | kynureninase | -0.0542801 |
| GDA | guanine deaminase | -0.0541154 |
| RPL9 | ribosomal protein L9 | -0.0538057 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0529808 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0513145 |
| HLA-B | major histocompatibility complex, class I, B | -0.0507788 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0505072 |
| RPL36A | ribosomal protein L36a | -0.0504555 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0496472 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0487555 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0485813 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0480417 |
| VCL | vinculin | -0.0471166 |
| ASPH | aspartate beta-hydroxylase | -0.0446521 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0444583 |
| RPS19 | ribosomal protein S19 | -0.0432599 |
| RACK1 | receptor for activated C kinase 1 | -0.0425498 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0424856 |
| RPS8 | ribosomal protein S8 | -0.0413063 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0407399 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0406845 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0394063 |
| RPS17 | ribosomal protein S17 | -0.0391959 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0381914 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0381438 |
| RPS14 | ribosomal protein S14 | -0.0379426 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.0379105 |
| NCKAP5 | NCK-associated protein 5 | -0.0370125 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0365309 |
| RPL13A | ribosomal protein L13a | -0.0364292 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0352787 |
| CTSC | cathepsin C | -0.0351651 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.035059 |
| OSMR | oncostatin M receptor | -0.0348237 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.034432 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0343357 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0340795 |
| BMERB1 | bMERB domain containing 1 | -0.0336342 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0336309 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0335224 |
| ENAH | enabled homolog (Drosophila) | -0.033394 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.033168 |
| S100A6 | S100 calcium binding protein A6 | -0.0325796 |
| RPS6 | ribosomal protein S6 | -0.0323511 |
| STC1 | stanniocalcin 1 | -0.032326 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0322438 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0318105 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0311655 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0307649 |
| RPL23 | ribosomal protein L23 | -0.0303825 |
| COL5A2 | collagen, type V, alpha 2 | -0.0303242 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | -0.0298222 |
| RPL31 | ribosomal protein L31 | -0.0296898 |
| NF1 | neurofibromin 1 | -0.0295946 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0295747 |
| PDE10A | phosphodiesterase 10A | -0.0291558 |
| B2M | beta-2-microglobulin | -0.028899 |
| PCNX4 | pecanex 4 | -0.02886 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0279436 |
| CANX | calnexin | -0.0275909 |
| RPL35A | ribosomal protein L35a | -0.0275336 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0273609 |
| TBXT | T-box transcription factor T | -0.0272643 |
| RPS27A | ribosomal protein S27a | -0.0271531 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0271439 |
| STEAP1B | STEAP family member 1B | -0.0270173 |
| SCN3A | sodium channel, voltage gated, type III alpha subunit | -0.0268374 |
| PALLD | palladin, cytoskeletal associated protein | -0.0265813 |
| SAR1A | secretion associated, Ras related GTPase 1A | -0.0264402 |
| PLCB4 | phospholipase C, beta 4 | -0.0263871 |
