| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Temsirolimus perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Temsirolimus_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.215266 |
| DSCAM | Down syndrome cell adhesion molecule | 0.126804 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.117606 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.115401 |
| COL6A3 | collagen, type VI, alpha 3 | 0.102395 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.101452 |
| MYOF | myoferlin | 0.0950281 |
| ZNF292 | zinc finger protein 292 | 0.0933233 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0897453 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0866971 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0850435 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0842421 |
| ASPH | aspartate beta-hydroxylase | 0.0840059 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0781509 |
| USP34 | ubiquitin specific peptidase 34 | 0.0754394 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0738956 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0726281 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0724163 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0720322 |
| PARD3 | par-3 family cell polarity regulator | 0.0688916 |
| AHNAK | AHNAK nucleoprotein | 0.0678008 |
| SQSTM1 | sequestosome 1 | 0.0668797 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0655667 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.065316 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0640754 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0620042 |
| EGR1 | early growth response 1 | 0.0618575 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0607339 |
| NAV2 | neuron navigator 2 | 0.0606752 |
| GLG1 | golgi glycoprotein 1 | 0.0568712 |
| ZNF638 | zinc finger protein 638 | 0.0568327 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.056261 |
| PTK2 | protein tyrosine kinase 2 | 0.0560561 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | 0.0558566 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0542997 |
| ENO1 | enolase 1, (alpha) | 0.053865 |
| PCNX4 | pecanex 4 | 0.053309 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0529865 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0528806 |
| JMJD1C | jumonji domain containing 1C | 0.0520147 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0516182 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0510939 |
| INTS6 | integrator complex subunit 6 | 0.0501277 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.049407 |
| HMGA2 | high mobility group AT-hook 2 | 0.0489965 |
| SETD5 | SET domain containing 5 | 0.0483229 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0474379 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0472713 |
| VCL | vinculin | 0.0470495 |
| FNIP1 | folliculin interacting protein 1 | 0.0469242 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0454005 |
| GPC6 | glypican 6 | 0.0447375 |
| RORA | RAR-related orphan receptor A | 0.0444774 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0441989 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0440219 |
| COPA | coatomer protein complex, subunit alpha | 0.0438223 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0437538 |
| CMIP | c-Maf inducing protein | 0.0425111 |
| NAV1 | neuron navigator 1 | 0.041555 |
| NBAS | neuroblastoma amplified sequence | 0.0408668 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0399556 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0398347 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0396598 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0393423 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0389101 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0382648 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.038108 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0379155 |
| ERBIN | erbb2 interacting protein | 0.0374919 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0367712 |
| OSMR | oncostatin M receptor | 0.0365761 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0361419 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0361141 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0324337 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0323983 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0320116 |
| NDRG1 | N-myc downstream regulated 1 | 0.0309397 |
| GRB10 | growth factor receptor-bound protein 10 | 0.030055 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0294925 |
| WDFY3 | WD repeat and FYVE domain containing 3 | 0.0280838 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0280429 |
| TENM3 | teneurin transmembrane protein 3 | 0.0280374 |
| SBF2 | SET binding factor 2 | 0.0277894 |
| GPHN | gephyrin | 0.0274853 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0274371 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0267486 |
| RASA2 | RAS p21 protein activator 2 | 0.026676 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0264452 |
| SYT1 | synaptotagmin I | 0.0260755 |
| SLTM | SAFB-like, transcription modulator | 0.0260267 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0256745 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0251019 |
| S100A6 | S100 calcium binding protein A6 | 0.0247916 |
| SMYD3 | SET and MYND domain containing 3 | 0.0246414 |
| SRPK2 | SRSF protein kinase 2 | 0.0232663 |
| CAVIN1 | caveolae associated protein 1 | 0.0231997 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0231211 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0230787 |
| CEP170 | centrosomal protein 170kDa | 0.0216058 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0209897 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.225067 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.206061 |
| FTL | ferritin, light polypeptide | -0.140116 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.110692 |
| VIM | vimentin | -0.0872175 |
| MT2A | metallothionein 2A | -0.0848718 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0845148 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0822813 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0821673 |
| PTMA | prothymosin, alpha | -0.0814079 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0801891 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.07964 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0775561 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.075647 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0743091 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0712453 |
| RPS6 | ribosomal protein S6 | -0.0712377 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0704862 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0700142 |
| FN1 | fibronectin 1 | -0.0697857 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0690824 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0684921 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0684273 |
| FAM13A | family with sequence similarity 13, member A | -0.0673182 |
| CANX | calnexin | -0.065346 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.064595 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0634605 |
| TMSB10 | thymosin beta 10 | -0.0630587 |
| EGFR | epidermal growth factor receptor | -0.0629034 |
| ELOVL5 | ELOVL fatty acid elongase 5 | -0.0621605 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0608906 |
| PRRC2C | proline-rich coiled-coil 2C | -0.060727 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0590295 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0583706 |
| RPL35A | ribosomal protein L35a | -0.0572907 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0553493 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0551828 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0548195 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0507074 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0504315 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0489155 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0473966 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0470108 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.046249 |
| INHBA | inhibin, beta A | -0.0447427 |
| DST | dystonin | -0.0429486 |
| OGA | O-GlcNAcase | -0.0428705 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0425029 |
| RIGI | RNA sensor RIG-I | -0.0424856 |
| RPL23 | ribosomal protein L23 | -0.0422739 |
| ANXA2 | annexin A2 | -0.0420435 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0412056 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0393384 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0393301 |
| LSAMP | limbic system-associated membrane protein | -0.0379882 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0374169 |
| COG5 | component of oligomeric golgi complex 5 | -0.0371911 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0365676 |
| FNDC3A | fibronectin type III domain containing 3A | -0.036347 |
| PRKD3 | protein kinase D3 | -0.0356648 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0349598 |
| CDH13 | cadherin 13 | -0.0335841 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.032383 |
| MYO10 | myosin X | -0.0323241 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0322162 |
| TCF12 | transcription factor 12 | -0.0310564 |
| NBEAL1 | neurobeachin-like 1 | -0.0294534 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0288817 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0286973 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.0282942 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0272683 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0271155 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.027037 |
| TXNRD1 | thioredoxin reductase 1 | -0.0266898 |
| TMEM165 | transmembrane protein 165 | -0.0263538 |
| RPL26 | ribosomal protein L26 | -0.0261903 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0257514 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0255907 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0249805 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0247992 |
| RUNX1 | runt-related transcription factor 1 | -0.0242076 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0240507 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0236 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0235456 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0235095 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0225295 |
| MED13 | mediator complex subunit 13 | -0.0222261 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | -0.0214525 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0213467 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0207265 |
| B2M | beta-2-microglobulin | -0.0203715 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | -0.0202567 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0188387 |
| HDLBP | high density lipoprotein binding protein | -0.0178295 |
| EFNA5 | ephrin-A5 | -0.0176103 |
| HMGB2 | high mobility group box 2 | -0.0173248 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0171729 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0170121 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0161409 |
| SMAD3 | SMAD family member 3 | -0.0160029 |
