Temsirolimus_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Temsirolimus perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Temsirolimus_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PARD3B par-3 family cell polarity regulator beta 0.0715135
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0685713
MACF1 microtubule-actin crosslinking factor 1 0.0479197
ADGRV1 adhesion G protein-coupled receptor V1 0.0475074
FNDC3B fibronectin type III domain containing 3B 0.0422633
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 0.0390927
NHSL1 NHS-like 1 0.0336908
BRWD1 bromodomain and WD repeat domain containing 1 0.0298071
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0293649
JMJD1C jumonji domain containing 1C 0.0291108
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0260195
PRR16 proline rich 16 0.025302
MAML2 mastermind-like 2 (Drosophila) 0.0249218
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0243314
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0228231
HEATR5B HEAT repeat containing 5B 0.0225259
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0220874
MTCL1 microtubule crosslinking factor 1 0.0219643
CHD7 chromodomain helicase DNA binding protein 7 0.0219032
LMO7 LIM domain 7 0.0218577
AKAP9 A kinase (PRKA) anchor protein 9 0.0216982
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0216954
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0215339
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0213384
TCF12 transcription factor 12 0.021188
FBXL17 F-box and leucine-rich repeat protein 17 0.021036
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0209384
GRB10 growth factor receptor-bound protein 10 0.0205766
SSH2 slingshot protein phosphatase 2 0.0202233
MSI2 musashi RNA-binding protein 2 0.0200754
TAS2R14 taste receptor, type 2, member 14 0.0196492
FN1 fibronectin 1 0.0194951
BIRC6 baculoviral IAP repeat containing 6 0.0192032
SREBF2 sterol regulatory element binding transcription factor 2 0.0191737
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.018473
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0183739
SLC44A5 solute carrier family 44, member 5 0.0183644
ZBTB20 zinc finger and BTB domain containing 20 0.0183293
MED13 mediator complex subunit 13 0.0182999
RTTN rotatin 0.0180127
PDE4D phosphodiesterase 4D, cAMP-specific 0.0179823
KDM4B lysine (K)-specific demethylase 4B 0.0179807
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0178067
NTM neurotrimin 0.0176535
SBF2 SET binding factor 2 0.0175969
AGPS alkylglycerone phosphate synthase 0.0175485
FNBP1L formin binding protein 1-like 0.0174562
RBM33 RNA binding motif protein 33 0.0174033
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0171629
NEK7 NIMA-related kinase 7 0.0171313
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.0170617
EXT1 exostosin glycosyltransferase 1 0.0170481
EGFR epidermal growth factor receptor 0.0170411
NPAS2 neuronal PAS domain protein 2 0.0170383
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.0170353
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0169767
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.0169083
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0168709
AARS1 alanyl-tRNA synthetase 1 0.0168388
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0167566
SMAD2 SMAD family member 2 0.016657
DENND5A DENN/MADD domain containing 5A 0.0165634
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0163
SMG6 SMG6 nonsense mediated mRNA decay factor 0.0162685
EFNB2 ephrin-B2 0.0162276
IARS1 isoleucyl-tRNA synthetase 1 0.0161094
CTBP2 C-terminal binding protein 2 0.0159801
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0159353
DSCAM Down syndrome cell adhesion molecule 0.0158724
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0154597
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0152774
MBNL2 muscleblind-like splicing regulator 2 0.0151858
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0151513
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0150359
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0149839
PLEKHG4B pleckstrin homology domain containing, family G (with RhoGef domain) member 4B 0.0149069
RAB28 RAB28, member RAS oncogene family 0.0148794
NKD1 naked cuticle homolog 1 (Drosophila) 0.0148386
YEATS2 YEATS domain containing 2 0.0148061
NCOA2 nuclear receptor coactivator 2 0.0148017
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0147769
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0147163
PDE10A phosphodiesterase 10A 0.0146639
BBX bobby sox homolog (Drosophila) 0.0143863
FMNL2 formin-like 2 0.0143408
SPRED1 sprouty-related, EVH1 domain containing 1 0.0143243
RHBDD1 rhomboid domain containing 1 0.014303
ARHGAP26 Rho GTPase activating protein 26 0.0142918
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.014287
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0141704
MICU1 mitochondrial calcium uptake 1 0.0141593
OSBPL10 oxysterol binding protein-like 10 0.0140186
SMC5 structural maintenance of chromosomes 5 0.0139227
CEMIP cell migration inducing protein, hyaluronan binding 0.0138639
COPA coatomer protein complex, subunit alpha 0.0138324
SLC30A8 solute carrier family 30 (zinc transporter), member 8 0.0138308
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0137827
FRMD5 FERM domain containing 5 0.0136942
FILIP1 filamin A interacting protein 1 0.0136728
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0136429

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.266599
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.124348
PTMA prothymosin, alpha -0.118328
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.110012
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.104264
TMSB10 thymosin beta 10 -0.0951941
PEG10 paternally expressed 10 -0.0886153
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0881014
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0810307
RPS16 ribosomal protein S16 -0.0784565
GPC3 glypican 3 -0.0774692
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0755002
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0747087
RPS6 ribosomal protein S6 -0.0716532
COL3A1 collagen, type III, alpha 1 -0.0713292
NAP1L1 nucleosome assembly protein 1-like 1 -0.070026
CADM2 cell adhesion molecule 2 -0.0656167
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0652418
ADGRL2 adhesion G protein-coupled receptor L2 -0.0638662
MRPS30 mitochondrial ribosomal protein S30 -0.062856
COL11A1 collagen, type XI, alpha 1 -0.0628254
MKI67 marker of proliferation Ki-67 -0.0627042
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0592705
CENPF centromere protein F, 350/400kDa -0.0579401
ACTG1 actin gamma 1 -0.0561531
RPL23 ribosomal protein L23 -0.0557186
TMSB4X thymosin beta 4, X-linked -0.052989
RAD21 RAD21 homolog (S. pombe) -0.0520243
GNAS GNAS complex locus -0.0498065
TPT1 tumor protein, translationally-controlled 1 -0.049751
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0490312
ANKRD33B ankyrin repeat domain 33B -0.0483733
RAI1 retinoic acid induced 1 -0.0477282
RPLP1 ribosomal protein, large, P1 -0.0475219
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0470391
RPL12 ribosomal protein L12 -0.0467914
RPS12 ribosomal protein S12 -0.0466744
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0464272
ENO1 enolase 1, (alpha) -0.0457744
RPL35A ribosomal protein L35a -0.0457148
RPS8 ribosomal protein S8 -0.0455694
RPS19 ribosomal protein S19 -0.0454675
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0440573
DEK DEK proto-oncogene -0.0440403
SNX6 sorting nexin 6 -0.0439011
RPL11 ribosomal protein L11 -0.0420053
RPL19 ribosomal protein L19 -0.0417698
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0405491
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0399754
RPL37 ribosomal protein L37 -0.0395555
RPS3 ribosomal protein S3 -0.0394235
EMP1 epithelial membrane protein 1 -0.0391535
CSDE1 cold shock domain containing E1, RNA-binding -0.0390124
RSL1D1 ribosomal L1 domain containing 1 -0.0387625
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0386623
B2M beta-2-microglobulin -0.0382829
RPL26 ribosomal protein L26 -0.037624
YBX1 Y box binding protein 1 -0.0372458
TPX2 TPX2, microtubule-associated -0.0371351
PRRC2C proline-rich coiled-coil 2C -0.0370827
RDX radixin -0.036892
ZFAND3 zinc finger, AN1-type domain 3 -0.0367713
KPNB1 karyopherin (importin) beta 1 -0.0366435
KIF4A kinesin family member 4A -0.0359386
LHFPL6 LHFPL tetraspan subfamily member 6 -0.0359213
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0358211
ENAH enabled homolog (Drosophila) -0.0357209
CALR calreticulin -0.0356435
MYL12B myosin, light chain 12B, regulatory -0.0355629
RPS27A ribosomal protein S27a -0.0350548
RACK1 receptor for activated C kinase 1 -0.0347354
DST dystonin -0.0345072
HMGB2 high mobility group box 2 -0.0343381
EIF1 eukaryotic translation initiation factor 1 -0.0342679
CKAP2 cytoskeleton associated protein 2 -0.0342027
RPL36A ribosomal protein L36a -0.0340816
TPR translocated promoter region, nuclear basket protein -0.0335194
PCLO piccolo presynaptic cytomatrix protein -0.0334
ATP5F1B ATP synthase F1 subunit beta -0.0332152
TENM3 teneurin transmembrane protein 3 -0.0331641
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0330777
NACA nascent polypeptide-associated complex alpha subunit -0.0330502
SMC4 structural maintenance of chromosomes 4 -0.0329869
NCOR1 nuclear receptor corepressor 1 -0.0327926
HMGB1 high mobility group box 1 -0.032078
HMGA1 high mobility group AT-hook 1 -0.0319542
RPL5 ribosomal protein L5 -0.0319151
LDHA lactate dehydrogenase A -0.031622
SRP54 signal recognition particle 54kDa -0.0313816
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0313793
RPL31 ribosomal protein L31 -0.0309453
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0307988
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0306811
PGK1 phosphoglycerate kinase 1 -0.0305335
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0303539
RPLP2 ribosomal protein, large, P2 -0.0302688
CENPE centromere protein E, 312kDa -0.029966
H1-0 H1.0 linker histone -0.0299495
SAMD4B sterile alpha motif domain containing 4B -0.0299195
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0296913