Temsirolimus_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Temsirolimus perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Temsirolimus_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.0552534
RPL3 ribosomal protein L3 0.0520202
VMP1 vacuole membrane protein 1 0.0460737
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0420847
GOLGA4 golgin A4 0.0420204
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0374304
KMT2E lysine (K)-specific methyltransferase 2E 0.0358615
CCNL1 cyclin L1 0.0351209
AKAP9 A kinase (PRKA) anchor protein 9 0.0345051
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0319778
KMT2C lysine (K)-specific methyltransferase 2C 0.0302634
PCBP2 poly(rC) binding protein 2 0.0302124
ZNF292 zinc finger protein 292 0.0299951
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0298555
QKI QKI, KH domain containing, RNA binding 0.0293926
POTEF POTE ankyrin domain family, member F 0.0283657
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0283444
HELZ helicase with zinc finger 0.0271312
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.026098
JMJD1C jumonji domain containing 1C 0.0257092
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0255376
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0252232
BCAS3 breast carcinoma amplified sequence 3 0.0245868
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0243939
PTBP2 polypyrimidine tract binding protein 2 0.0238811
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0238009
YAP1 Yes-associated protein 1 0.0232386
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0229097
ELOVL5 ELOVL fatty acid elongase 5 0.0222609
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0222571
BRD2 bromodomain containing 2 0.0221744
AKAP12 A kinase (PRKA) anchor protein 12 0.0220906
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0218775
TBK1 TANK-binding kinase 1 0.0218057
YTHDC1 YTH domain containing 1 0.0217529
WNK1 WNK lysine deficient protein kinase 1 0.0216445
FAM13A family with sequence similarity 13, member A 0.0216353
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0215901
ZBTB20 zinc finger and BTB domain containing 20 0.0212415
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0210129
COG5 component of oligomeric golgi complex 5 0.0208649
KTN1 kinectin 1 (kinesin receptor) 0.0206563
UBA6 ubiquitin-like modifier activating enzyme 6 0.0205575
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 0.0203253
NBAS neuroblastoma amplified sequence 0.0202669
ZCCHC8 zinc finger, CCHC domain containing 8 0.0200769
TSC22D2 TSC22 domain family, member 2 0.0198966
ANK2 ankyrin 2, neuronal 0.0197174
GSK3B glycogen synthase kinase 3 beta 0.0196792
TRIO trio Rho guanine nucleotide exchange factor 0.0196124
KDM4C lysine (K)-specific demethylase 4C 0.0191179
TTC3 tetratricopeptide repeat domain 3 0.0190164
TXNIP thioredoxin interacting protein 0.0188893
KDM6A lysine (K)-specific demethylase 6A 0.0187206
MYH9 myosin, heavy chain 9, non-muscle 0.0187049
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.0184384
RNF145 ring finger protein 145 0.0184355
BRWD1 bromodomain and WD repeat domain containing 1 0.0183774
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0183328
METTL15 methyltransferase like 15 0.018254
RTN4 reticulon 4 0.0180166
GARS1 glycyl-tRNA synthetase 1 0.0180039
RPL21 ribosomal protein L21 0.0179974
PRRC2C proline-rich coiled-coil 2C 0.0179612
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0179369
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0178495
DSCAM Down syndrome cell adhesion molecule 0.0178322
SPAG9 sperm associated antigen 9 0.0173347
RBM25 RNA binding motif protein 25 0.0172932
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.017285
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0171628
PDGFC platelet derived growth factor C 0.017087
SETD5 SET domain containing 5 0.0170071
B2M beta-2-microglobulin 0.0169317
DENND4A DENN/MADD domain containing 4A 0.0169217
USP9X ubiquitin specific peptidase 9, X-linked 0.0168737
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0168065
ITSN2 intersectin 2 0.0167699
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0167502
TENT4A terminal nucleotidyltransferase 4A 0.0167207
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0165435
ADAM9 ADAM metallopeptidase domain 9 0.0165389
PICALM phosphatidylinositol binding clathrin assembly protein 0.0164632
SLTM SAFB-like, transcription modulator 0.0163764
MACF1 microtubule-actin crosslinking factor 1 0.0163705
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0163489
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0163377
NCEH1 neutral cholesterol ester hydrolase 1 0.0162876
ZBTB10 zinc finger and BTB domain containing 10 0.0161903
ARHGAP12 Rho GTPase activating protein 12 0.0161827
EIF4A2 eukaryotic translation initiation factor 4A2 0.016175
ERRFI1 ERBB receptor feedback inhibitor 1 0.0160612
ADAM17 ADAM metallopeptidase domain 17 0.0159743
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0158796
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0158762
NUP58 nucleoporin 58 0.0158724
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0158271
DAPK3 death-associated protein kinase 3 0.0157278
LENG8 leukocyte receptor cluster (LRC) member 8 0.0156853
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0156385

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.417464
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.152984
TPT1 tumor protein, translationally-controlled 1 -0.125229
BMP10 bone morphogenetic protein 10 -0.1088
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.10197
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.097112
AHNAK AHNAK nucleoprotein -0.0913686
VCL vinculin -0.0833985
RPL35A ribosomal protein L35a -0.080694
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0794756
PDE4B phosphodiesterase 4B, cAMP-specific -0.0788297
RPL26 ribosomal protein L26 -0.0778925
RPS8 ribosomal protein S8 -0.0743818
RPS6 ribosomal protein S6 -0.0727679
DLG1 discs, large homolog 1 (Drosophila) -0.0710991
GLI3 GLI family zinc finger 3 -0.0706314
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0702585
RPL34 ribosomal protein L34 -0.0647359
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0633528
FOXP1 forkhead box P1 -0.0629182
RPS3 ribosomal protein S3 -0.0611884
CCND1 cyclin D1 -0.0595137
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0527203
RPS12 ribosomal protein S12 -0.0521613
RPL31 ribosomal protein L31 -0.0515644
MYL12B myosin, light chain 12B, regulatory -0.051016
ACTG1 actin gamma 1 -0.0503195
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0496512
RPL37A ribosomal protein L37a -0.0492999
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0489074
SOX6 SRY (sex determining region Y)-box 6 -0.0482032
RPLP1 ribosomal protein, large, P1 -0.0481265
TMSB4X thymosin beta 4, X-linked -0.0474652
DIAPH3 diaphanous-related formin 3 -0.0465114
PGK1 phosphoglycerate kinase 1 -0.0461487
S100A4 S100 calcium binding protein A4 -0.0458513
KPNB1 karyopherin (importin) beta 1 -0.0454565
LPP LIM domain containing preferred translocation partner in lipoma -0.04473
RPL7A ribosomal protein L7a -0.0437941
RPL9 ribosomal protein L9 -0.0425187
LDHA lactate dehydrogenase A -0.0424027
EBNA1BP2 EBNA1 binding protein 2 -0.0417739
MKI67 marker of proliferation Ki-67 -0.0411655
S100A6 S100 calcium binding protein A6 -0.0408435
ARL4C ADP-ribosylation factor-like 4C -0.0401629
RPLP2 ribosomal protein, large, P2 -0.0395329
RPS19 ribosomal protein S19 -0.0392992
RPS24 ribosomal protein S24 -0.0391007
TPM4 tropomyosin 4 -0.0385725
GLI2 GLI family zinc finger 2 -0.0376875
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0375828
ENO1 enolase 1, (alpha) -0.0374563
SMC4 structural maintenance of chromosomes 4 -0.0373951
RPS13 ribosomal protein S13 -0.0372471
RPL12 ribosomal protein L12 -0.0366684
RPS27A ribosomal protein S27a -0.0359933
RPL32 ribosomal protein L32 -0.0355781
RPS25 ribosomal protein S25 -0.0353654
RPL11 ribosomal protein L11 -0.0348097
UNC13A unc-13 homolog A (C. elegans) -0.0336874
RFC3 replication factor C (activator 1) 3, 38kDa -0.0333468
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0332694
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0330393
NAV2 neuron navigator 2 -0.032792
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0326773
NBEA neurobeachin -0.0326478
RPL13A ribosomal protein L13a -0.0324676
GNAS GNAS complex locus -0.0316344
TAS2R14 taste receptor, type 2, member 14 -0.0315382
EVI5 ecotropic viral integration site 5 -0.0312979
SSBP2 single-stranded DNA binding protein 2 -0.0311312
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.030622
RPL36 ribosomal protein L36 -0.0303062
CAMKMT calmodulin-lysine N-methyltransferase -0.0302805
RPS17 ribosomal protein S17 -0.0301248
NFIA nuclear factor I/A -0.0301042
RPS21 ribosomal protein S21 -0.0297364
RPL8 ribosomal protein L8 -0.0295718
GPATCH8 G patch domain containing 8 -0.0287235
HJURP Holliday junction recognition protein -0.0284794
CUX1 cut-like homeobox 1 -0.0283442
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -0.0281265
HSPB1 heat shock 27kDa protein 1 -0.0280236
ENO2 enolase 2 (gamma, neuronal) -0.0278731
LOC112694756 uncharaterized LOC112694756 -0.0278064
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0272933
RPL23 ribosomal protein L23 -0.0272194
NAP1L1 nucleosome assembly protein 1-like 1 -0.0268087
RPL37 ribosomal protein L37 -0.0266159
RPS29 ribosomal protein S29 -0.0265907
RSL1D1 ribosomal L1 domain containing 1 -0.0264023
TUBB tubulin, beta class I -0.0263344
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0262989
RPL7 ribosomal protein L7 -0.0262763
PRSS23 protease, serine, 23 -0.0259882
RACK1 receptor for activated C kinase 1 -0.0256166
TTC28 tetratricopeptide repeat domain 28 -0.0255439
SDK1 sidekick cell adhesion molecule 1 -0.0255438
PTPRF protein tyrosine phosphatase, receptor type, F -0.0254363
BMP2K BMP2 inducible kinase -0.0253713