Temsirolimus_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Temsirolimus perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Temsirolimus_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.0526371
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0491013
ZSWIM6 zinc finger, SWIM-type containing 6 0.039903
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0381702
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0362564
FAT1 FAT atypical cadherin 1 0.0290512
INTS6 integrator complex subunit 6 0.0288864
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0269951
LIMCH1 LIM and calponin homology domains 1 0.0260682
CTBP2 C-terminal binding protein 2 0.0241567
HELZ helicase with zinc finger 0.0240852
GRB10 growth factor receptor-bound protein 10 0.0235235
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0230526
FAM13A family with sequence similarity 13, member A 0.0221192
SPAG9 sperm associated antigen 9 0.0217827
NRIP1 nuclear receptor interacting protein 1 0.0215486
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0214003
FNDC3B fibronectin type III domain containing 3B 0.0211069
PLEC plectin 0.0209929
APLP2 amyloid beta (A4) precursor-like protein 2 0.0200978
RNF145 ring finger protein 145 0.0199528
COPA coatomer protein complex, subunit alpha 0.0195825
FLNB filamin B, beta 0.0186249
SHB Src homology 2 domain containing adaptor protein B 0.0182235
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0180168
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.017908
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0174151
RUNX1 runt-related transcription factor 1 0.0172621
PICALM phosphatidylinositol binding clathrin assembly protein 0.0169976
PTK2 protein tyrosine kinase 2 0.0169783
PDGFC platelet derived growth factor C 0.0165788
MYH9 myosin, heavy chain 9, non-muscle 0.0165055
EPS8 epidermal growth factor receptor pathway substrate 8 0.0164779
TUFT1 tuftelin 1 0.0161855
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0159423
IRS2 insulin receptor substrate 2 0.0158296
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0158087
MYO1B myosin IB 0.0155937
HYOU1 hypoxia up-regulated 1 0.0153549
SIRT1 sirtuin 1 0.0152844
HSPA8 heat shock 70kDa protein 8 0.0152293
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0149011
SUCO SUN domain containing ossification factor 0.0148921
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0148487
UBAP2 ubiquitin associated protein 2 0.0147793
ANKRD11 ankyrin repeat domain 11 0.0147173
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0146347
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0146197
MYOF myoferlin 0.014589
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0145454
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0141085
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.0140718
WNK1 WNK lysine deficient protein kinase 1 0.0137276
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0136588
PGM3 phosphoglucomutase 3 0.0136303
ANKRD28 ankyrin repeat domain 28 0.0135569
DOCK5 dedicator of cytokinesis 5 0.0133114
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0132482
ELL2 elongation factor, RNA polymerase II, 2 0.0132263
UGCG UDP-glucose ceramide glucosyltransferase 0.0131771
XPO1 exportin 1 0.0130949
HOOK2 hook microtubule-tethering protein 2 0.0129218
MYO6 myosin VI 0.0128991
ERO1B endoplasmic reticulum oxidoreductase 1 beta 0.012858
UBA6 ubiquitin-like modifier activating enzyme 6 0.0125923
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0124143
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0123729
PELI1 pellino E3 ubiquitin protein ligase 1 0.0123005
ESYT2 extended synaptotagmin-like protein 2 0.0122369
HSPA1B heat shock 70kDa protein 1B 0.0121502
EZR ezrin 0.0121334
CD109 CD109 molecule 0.0120492
MIDEAS mitotic deacetylase associated SANT domain protein 0.0119854
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.0119394
ABLIM1 actin binding LIM protein 1 0.0119134
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0117605
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0117478
HSPA1A heat shock 70kDa protein 1A 0.0117047
AFDN afadin, adherens junction formation factor 0.0116825
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0116742
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0116607
HILPDA hypoxia inducible lipid droplet-associated 0.0116102
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0115895
FAM193B family with sequence similarity 193, member B 0.0115892
ARHGAP26 Rho GTPase activating protein 26 0.011586
FAM107B family with sequence similarity 107, member B 0.0115831
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0115642
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0115254
USP53 ubiquitin specific peptidase 53 0.0113999
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0113818
BIRC6 baculoviral IAP repeat containing 6 0.0113388
PCF11 PCF11 cleavage and polyadenylation factor subunit 0.0113124
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0112431
EIF5 eukaryotic translation initiation factor 5 0.0112393
ZNF451 zinc finger protein 451 0.0112368
FOSL1 FOS-like antigen 1 0.0112308
ERRFI1 ERBB receptor feedback inhibitor 1 0.0112115
ETNK1 ethanolamine kinase 1 0.0112102
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0110733
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0110531

decreased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.311648
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.298363
FN1 fibronectin 1 -0.244698
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.221988
NRG1 neuregulin 1 -0.145513
PTMA prothymosin, alpha -0.11959
SQSTM1 sequestosome 1 -0.102672
FTL ferritin, light polypeptide -0.0931224
HLA-B major histocompatibility complex, class I, B -0.0877859
TMSB10 thymosin beta 10 -0.0871373
MT2A metallothionein 2A -0.0871237
VIM vimentin -0.080439
GLIS3 GLIS family zinc finger 3 -0.0785206
NAMPT nicotinamide phosphoribosyltransferase -0.0767665
B2M beta-2-microglobulin -0.0730751
ITGA1 integrin, alpha 1 -0.0713745
TPT1 tumor protein, translationally-controlled 1 -0.0605949
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0590773
HMGA2 high mobility group AT-hook 2 -0.0581411
OSMR oncostatin M receptor -0.0579125
TMEM156 transmembrane protein 156 -0.056794
S100A6 S100 calcium binding protein A6 -0.0564249
IFI27 interferon, alpha-inducible protein 27 -0.0509614
ETV1 ets variant 1 -0.0502464
SOX4 SRY (sex determining region Y)-box 4 -0.0498222
ASPH aspartate beta-hydroxylase -0.0465172
SYT1 synaptotagmin I -0.0449121
TMSB4X thymosin beta 4, X-linked -0.0435714
ENO2 enolase 2 (gamma, neuronal) -0.0411688
LOC102724023 ES1 protein homolog, mitochondrial -0.0409494
KLHL5 kelch-like family member 5 -0.0406608
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0397041
HLA-A major histocompatibility complex, class I, A -0.0390274
ENO1 enolase 1, (alpha) -0.0386232
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0385476
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0373817
IFI16 interferon, gamma-inducible protein 16 -0.0368499
RAI14 retinoic acid induced 14 -0.0355495
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0348908
IER3 immediate early response 3 -0.0348093
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0344688
IFI6 interferon, alpha-inducible protein 6 -0.032647
PDE4D phosphodiesterase 4D, cAMP-specific -0.0324263
CENPF centromere protein F, 350/400kDa -0.0323498
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0320776
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.031649
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0316411
TPI1 triosephosphate isomerase 1 -0.0313733
RACK1 receptor for activated C kinase 1 -0.0313154
RPL31 ribosomal protein L31 -0.0311163
VCL vinculin -0.0303678
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0301284
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0301146
HMGA1 high mobility group AT-hook 1 -0.0292664
PGK1 phosphoglycerate kinase 1 -0.029239
ACTG1 actin gamma 1 -0.0289344
MBD5 methyl-CpG binding domain protein 5 -0.0287933
PLIN2 perilipin 2 -0.0287824
EIF1 eukaryotic translation initiation factor 1 -0.0287796
BZW1 basic leucine zipper and W2 domains 1 -0.0287222
BASP1 brain abundant, membrane attached signal protein 1 -0.0274444
ETV6 ets variant 6 -0.0269987
SFTPA2 surfactant protein A2 -0.0269903
LOC112694756 uncharaterized LOC112694756 -0.0266971
PKM pyruvate kinase, muscle -0.0264281
RPL26 ribosomal protein L26 -0.0263929
WSB1 WD repeat and SOCS box containing 1 -0.0262747
FOXP1 forkhead box P1 -0.0255687
RPL37A ribosomal protein L37a -0.025547
MKI67 marker of proliferation Ki-67 -0.0254408
SMOX spermine oxidase -0.0252682
RPS6 ribosomal protein S6 -0.025158
ZMYND8 zinc finger, MYND-type containing 8 -0.0251362
TPR translocated promoter region, nuclear basket protein -0.0246702
EGR1 early growth response 1 -0.0245182
RPL35A ribosomal protein L35a -0.0243838
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0239732
ZBTB20 zinc finger and BTB domain containing 20 -0.0239019
RRBP1 ribosome binding protein 1 -0.0237823
RPS29 ribosomal protein S29 -0.0237704
TXNIP thioredoxin interacting protein -0.0235272
GCC2 GRIP and coiled-coil domain containing 2 -0.0234449
CALU calumenin -0.0234291
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0232066
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.023149
RPS24 ribosomal protein S24 -0.0230662
EXT1 exostosin glycosyltransferase 1 -0.0230334
NRP1 neuropilin 1 -0.0229059
EREG epiregulin -0.0225904
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0223544
PELO pelota homolog (Drosophila) -0.0223469
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0220244
GNAS GNAS complex locus -0.0219438
CD44 CD44 molecule (Indian blood group) -0.0219401
RPL9 ribosomal protein L9 -0.0219291
SOS1 son of sevenless homolog 1 (Drosophila) -0.021695
RPS8 ribosomal protein S8 -0.0215371
TSC22D1 TSC22 domain family, member 1 -0.0213858
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0212447
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0212031