| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Temuterkib perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Temuterkib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TPM3 | tropomyosin 3 | 0.0542565 |
| POTEF | POTE ankyrin domain family, member F | 0.0534143 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0503516 |
| B2M | beta-2-microglobulin | 0.046551 |
| VEGFA | vascular endothelial growth factor A | 0.0458303 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0423273 |
| MSN | moesin | 0.0313684 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0291489 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0287067 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0264928 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0259554 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0252888 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0248386 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0247504 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0246083 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0237009 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0229783 |
| DST | dystonin | 0.0220713 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0216469 |
| HDAC9 | histone deacetylase 9 | 0.0214401 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0204778 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0199021 |
| BRD2 | bromodomain containing 2 | 0.0194769 |
| EGR1 | early growth response 1 | 0.0183673 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0183617 |
| TXNRD1 | thioredoxin reductase 1 | 0.0183057 |
| FOSL1 | FOS-like antigen 1 | 0.0180834 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0177489 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0172295 |
| RPS6 | ribosomal protein S6 | 0.0164545 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0162899 |
| SEPTIN9 | septin 9 | 0.0162714 |
| MB21D2 | Mab-21 domain containing 2 | 0.0161363 |
| CCNL1 | cyclin L1 | 0.0160576 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0158129 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0155472 |
| GOLGA4 | golgin A4 | 0.0153937 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0153168 |
| LDHA | lactate dehydrogenase A | 0.0152008 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0151222 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.015091 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.015044 |
| RNF145 | ring finger protein 145 | 0.014883 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0148722 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0146237 |
| OPTN | optineurin | 0.0144079 |
| EZR | ezrin | 0.0142946 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0139718 |
| ERBIN | erbb2 interacting protein | 0.0139112 |
| SET | SET nuclear proto-oncogene | 0.0134588 |
| ZBTB43 | zinc finger and BTB domain containing 43 | 0.0132904 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.0132301 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0128932 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0128171 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0127167 |
| AXL | AXL receptor tyrosine kinase | 0.0126226 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0125701 |
| PNN | pinin, desmosome associated protein | 0.0124793 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 0.012372 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0123624 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.012228 |
| DSPP | dentin sialophosphoprotein | 0.0119916 |
| GLIS3 | GLIS family zinc finger 3 | 0.0119289 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0117947 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0117251 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0116078 |
| RNPS1 | RNA binding protein S1, serine-rich domain | 0.0115931 |
| YBX1 | Y box binding protein 1 | 0.0115927 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0115845 |
| RRM2 | ribonucleotide reductase M2 | 0.0115184 |
| BCL2L1 | BCL2-like 1 | 0.0115092 |
| LENG8 | leukocyte receptor cluster (LRC) member 8 | 0.0113923 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0113699 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0113386 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0112977 |
| SMC3 | structural maintenance of chromosomes 3 | 0.0112672 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0112506 |
| PTK2 | protein tyrosine kinase 2 | 0.0111804 |
| SLK | STE20-like kinase | 0.0111781 |
| ATXN1 | ataxin 1 | 0.0111669 |
| ZNF148 | zinc finger protein 148 | 0.0111519 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.011145 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0111001 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0110532 |
| ATP13A3 | ATPase type 13A3 | 0.0109635 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0109572 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0108122 |
| PLEC | plectin | 0.010805 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.010773 |
| MATR3 | matrin 3 | 0.0106993 |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.0106435 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0106424 |
| RPL13A | ribosomal protein L13a | 0.0105343 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0104819 |
| ZNF146 | zinc finger protein 146 | 0.0104438 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0103778 |
| ANXA5 | annexin A5 | 0.0103746 |
| ANK2 | ankyrin 2, neuronal | 0.0102522 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0102493 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0100362 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.271653 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.215301 |
| TMSB10 | thymosin beta 10 | -0.204178 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.186664 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.171449 |
| AHNAK | AHNAK nucleoprotein | -0.140764 |
| UBC | ubiquitin C | -0.116925 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.116771 |
| COL5A1 | collagen, type V, alpha 1 | -0.102286 |
| LOX | lysyl oxidase | -0.0980167 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0967004 |
| S100A10 | S100 calcium binding protein A10 | -0.0935463 |
| PLAT | plasminogen activator, tissue | -0.0910016 |
| PODXL | podocalyxin-like | -0.090997 |
| CDH13 | cadherin 13 | -0.0878585 |
| COL3A1 | collagen, type III, alpha 1 | -0.0824102 |
| S100A6 | S100 calcium binding protein A6 | -0.0745236 |
| FN1 | fibronectin 1 | -0.0738749 |
| LMNA | lamin A/C | -0.0723974 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0695969 |
| CSTB | cystatin B (stefin B) | -0.0615624 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0601157 |
| PTMA | prothymosin, alpha | -0.0592209 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0575769 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0562542 |
| CD99 | CD99 molecule | -0.0558694 |
| THBS2 | thrombospondin 2 | -0.0521636 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0499141 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0481859 |
| SUCNR1 | succinate receptor 1 | -0.0469055 |
| PRSS23 | protease, serine, 23 | -0.0452697 |
| CCND1 | cyclin D1 | -0.0444357 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0443784 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0425898 |
| AUTS2 | autism susceptibility candidate 2 | -0.0418827 |
| NAV1 | neuron navigator 1 | -0.0405465 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0400228 |
| CANX | calnexin | -0.0390361 |
| RIGI | RNA sensor RIG-I | -0.0388535 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0376904 |
| S100A4 | S100 calcium binding protein A4 | -0.0374445 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0372812 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0361816 |
| EGFR | epidermal growth factor receptor | -0.0345711 |
| FRMD4A | FERM domain containing 4A | -0.0339022 |
| ANXA2 | annexin A2 | -0.0336537 |
| MSI2 | musashi RNA-binding protein 2 | -0.0335734 |
| CUX1 | cut-like homeobox 1 | -0.0331794 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0324279 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.0322308 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.032189 |
| MT2A | metallothionein 2A | -0.032111 |
| HLA-B | major histocompatibility complex, class I, B | -0.0319402 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0314296 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0312833 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0305484 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.030232 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0301167 |
| TAGLN2 | transgelin 2 | -0.029848 |
| CALR | calreticulin | -0.0296787 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0295389 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0294423 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0293845 |
| COL1A2 | collagen, type I, alpha 2 | -0.0291929 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0291725 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0290652 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0287298 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0280766 |
| DGKG | diacylglycerol kinase, gamma 90kDa | -0.0280296 |
| FSTL1 | follistatin-like 1 | -0.0279447 |
| MT1X | metallothionein 1X | -0.0279198 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0276789 |
| CYTH3 | cytohesin 3 | -0.0276099 |
| COL5A2 | collagen, type V, alpha 2 | -0.0275352 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0274738 |
| HLA-C | major histocompatibility complex, class I, C | -0.0269781 |
| RRBP1 | ribosome binding protein 1 | -0.0269249 |
| RPS24 | ribosomal protein S24 | -0.0267471 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0257807 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0254836 |
| LRRC17 | leucine rich repeat containing 17 | -0.025395 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0253461 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0250996 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.0250513 |
| GNAS | GNAS complex locus | -0.0246168 |
| ZNF217 | zinc finger protein 217 | -0.0242306 |
| KRT81 | keratin 81, type II | -0.0241177 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0239745 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0236451 |
| RPS27A | ribosomal protein S27a | -0.0233594 |
| NDRG1 | N-myc downstream regulated 1 | -0.0232744 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0230862 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0230229 |
| ACTG1 | actin gamma 1 | -0.0229171 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.022705 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0226418 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0223025 |
| TNS3 | tensin 3 | -0.0220519 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0220149 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0219379 |
