Temuterkib_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Temuterkib perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Temuterkib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NLGN1 neuroligin 1 0.104248
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.084407
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0707386
YAP1 Yes-associated protein 1 0.0615097
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0503867
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.048504
TPM3 tropomyosin 3 0.0475163
HSPA8 heat shock 70kDa protein 8 0.0464458
RRM2 ribonucleotide reductase M2 0.0432786
TENM3 teneurin transmembrane protein 3 0.0430608
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0426515
ANXA1 annexin A1 0.0422452
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0382961
PCDH7 protocadherin 7 0.0376412
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0373592
DST dystonin 0.0368578
EEF2 eukaryotic translation elongation factor 2 0.0352143
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0345308
PDGFC platelet derived growth factor C 0.0334633
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0331649
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0326016
CCN2 cellular communication network factor 2 0.0324977
CCNL1 cyclin L1 0.0320571
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0315554
EEF1G eukaryotic translation elongation factor 1 gamma 0.0298454
POTEF POTE ankyrin domain family, member F 0.029599
EXOC6B exocyst complex component 6B 0.0295939
TRIO trio Rho guanine nucleotide exchange factor 0.0295239
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0293467
LDHA lactate dehydrogenase A 0.0293008
VMP1 vacuole membrane protein 1 0.0281604
ZFAND3 zinc finger, AN1-type domain 3 0.0277549
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0275766
EIF4A2 eukaryotic translation initiation factor 4A2 0.0274561
RPL3 ribosomal protein L3 0.0267107
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0263504
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0261401
EIF4B eukaryotic translation initiation factor 4B 0.0261303
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0259005
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0256565
SMYD3 SET and MYND domain containing 3 0.0252383
ARL15 ADP-ribosylation factor-like 15 0.0249682
NEGR1 neuronal growth regulator 1 0.0248748
MED13L mediator complex subunit 13-like 0.0248502
USP9X ubiquitin specific peptidase 9, X-linked 0.0246303
PCBP2 poly(rC) binding protein 2 0.0242653
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0236557
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0232663
RSRC1 arginine/serine-rich coiled-coil 1 0.0230623
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0216981
NRXN3 neurexin 3 0.0213691
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0213013
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0211006
SFPQ splicing factor proline/glutamine-rich 0.0209918
WWOX WW domain containing oxidoreductase 0.0206776
FXR1 fragile X mental retardation, autosomal homolog 1 0.0197614
EZR ezrin 0.0197593
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0197135
JMJD1C jumonji domain containing 1C 0.0196746
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0195954
LRMDA leucine rich melanocyte differentiation associated 0.0194837
ATP11A ATPase, class VI, type 11A 0.0193914
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0191214
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0190379
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0188926
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0186914
YBX1 Y box binding protein 1 0.0183039
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0181908
BIRC3 baculoviral IAP repeat containing 3 0.0180739
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0180226
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0178665
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0178055
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0176152
ZBTB20 zinc finger and BTB domain containing 20 0.0176086
PRKCE protein kinase C, epsilon 0.0174027
PDE4D phosphodiesterase 4D, cAMP-specific 0.0173197
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0171537
EXOC4 exocyst complex component 4 0.0171208
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0171049
ARF4 ADP-ribosylation factor 4 0.0170533
MYH9 myosin, heavy chain 9, non-muscle 0.0169575
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0167865
PCM1 pericentriolar material 1 0.0167801
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0166549
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.0165693
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0165526
CEP192 centrosomal protein 192kDa 0.0164336
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0164328
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0164121
SON SON DNA binding protein 0.016366
ASXL2 additional sex combs like transcriptional regulator 2 0.0161422
WDR43 WD repeat domain 43 0.016137
PHC3 polyhomeotic homolog 3 (Drosophila) 0.01613
RLIM ring finger protein, LIM domain interacting 0.0158794
M6PR mannose-6-phosphate receptor (cation dependent) 0.0156456
FUBP1 far upstream element (FUSE) binding protein 1 0.01563
EIF5 eukaryotic translation initiation factor 5 0.0155911
YTHDC1 YTH domain containing 1 0.0155328
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.0153843
APLP2 amyloid beta (A4) precursor-like protein 2 0.015359

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.247679
VIM vimentin -0.236111
AREG amphiregulin -0.132179
PTMA prothymosin, alpha -0.0727768
TMSB10 thymosin beta 10 -0.0702157
ACTG1 actin gamma 1 -0.0549346
IFIH1 interferon induced with helicase C domain 1 -0.0475477
MYL12B myosin, light chain 12B, regulatory -0.0442483
SLC38A2 solute carrier family 38, member 2 -0.0396006
VDAC1 voltage-dependent anion channel 1 -0.0391672
GCG glucagon -0.0382111
FTL ferritin, light polypeptide -0.03613
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0357229
S100A10 S100 calcium binding protein A10 -0.035022
TMEM123 transmembrane protein 123 -0.0349898
H1-0 H1.0 linker histone -0.0346604
GNAS GNAS complex locus -0.0341759
RPL35A ribosomal protein L35a -0.0339802
TM4SF1 transmembrane 4 L six family member 1 -0.0339649
ATP5F1B ATP synthase F1 subunit beta -0.0327882
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0326765
HMGA1 high mobility group AT-hook 1 -0.0318494
HSPB1 heat shock 27kDa protein 1 -0.031271
EIF1 eukaryotic translation initiation factor 1 -0.0305052
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0304079
TUBA1B tubulin, alpha 1b -0.0302296
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0300468
RPS8 ribosomal protein S8 -0.0282822
HMGA2 high mobility group AT-hook 2 -0.0277557
RPS29 ribosomal protein S29 -0.0275388
NAP1L1 nucleosome assembly protein 1-like 1 -0.027114
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0270854
S100A6 S100 calcium binding protein A6 -0.0270801
RPS6 ribosomal protein S6 -0.0268415
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0264151
TPT1 tumor protein, translationally-controlled 1 -0.0262963
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0262455
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0261652
RPS13 ribosomal protein S13 -0.0253092
ANKRD12 ankyrin repeat domain 12 -0.0248288
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0247303
KPNB1 karyopherin (importin) beta 1 -0.0244501
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0242764
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.023959
RPS15 ribosomal protein S15 -0.0229338
RPS23 ribosomal protein S23 -0.0226022
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0225803
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0224482
WDR45B WD repeat domain 45B -0.0222348
PFN1 profilin 1 -0.0220353
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0219467
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0219211
SEPTIN7 septin 7 -0.0218536
CLDN1 claudin 1 -0.0217747
TPM4 tropomyosin 4 -0.0214702
EHBP1 EH domain binding protein 1 -0.0214235
ZNF217 zinc finger protein 217 -0.0213748
RPS24 ribosomal protein S24 -0.0208945
NABP1 nucleic acid binding protein 1 -0.0203341
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0201843
SYT1 synaptotagmin I -0.0199503
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0194371
FBXO11 F-box protein 11 -0.0191826
AKAP12 A kinase (PRKA) anchor protein 12 -0.01914
RPS27A ribosomal protein S27a -0.0190432
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0189101
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.018512
RPLP1 ribosomal protein, large, P1 -0.0184178
LRRC23 leucine rich repeat containing 23 -0.0182801
PA2G4 proliferation-associated 2G4, 38kDa -0.0181886
ADGRG6 adhesion G protein-coupled receptor G6 -0.0181292
INTS6 integrator complex subunit 6 -0.0180365
EIF5B eukaryotic translation initiation factor 5B -0.0180296
CCNI cyclin I -0.0178056
RAB10 RAB10, member RAS oncogene family -0.0176114
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0175731
RPS19 ribosomal protein S19 -0.017515
RPS5 ribosomal protein S5 -0.0174658
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0174188
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0173173
HMGB1 high mobility group box 1 -0.0171921
RPLP2 ribosomal protein, large, P2 -0.0170928
RPL37A ribosomal protein L37a -0.0170752
FGFR1 fibroblast growth factor receptor 1 -0.0168521
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0168297
RPL34 ribosomal protein L34 -0.0168239
CDK12 cyclin-dependent kinase 12 -0.0167783
RPL19 ribosomal protein L19 -0.0166503
CAVIN1 caveolae associated protein 1 -0.016583
LMAN1 lectin, mannose-binding, 1 -0.0165807
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 -0.0163562
RPL8 ribosomal protein L8 -0.0162671
STAU1 staufen double-stranded RNA binding protein 1 -0.016003
YBX3 Y box binding protein 3 -0.0159659
MYPN myopalladin -0.0155047
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0153994
WASF2 WAS protein family, member 2 -0.01514
SNX14 sorting nexin 14 -0.0150168
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0149366
MMP12 matrix metallopeptidase 12 -0.0148035