Temuterkib_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Temuterkib perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Temuterkib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.16058
VEGFA vascular endothelial growth factor A 0.150374
ASPH aspartate beta-hydroxylase 0.135241
COL6A3 collagen, type VI, alpha 3 0.13232
MYH9 myosin, heavy chain 9, non-muscle 0.106471
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0942552
IGFBP3 insulin-like growth factor binding protein 3 0.0929384
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0920342
LOXL2 lysyl oxidase-like 2 0.0782835
CDH13 cadherin 13 0.0762448
EEF2 eukaryotic translation elongation factor 2 0.0741764
CALR calreticulin 0.0700566
ENO1 enolase 1, (alpha) 0.0681497
CALU calumenin 0.064711
PLEC plectin 0.0577482
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.056267
CANX calnexin 0.0529773
PRELID2 PRELI domain containing 2 0.0529355
RPS6 ribosomal protein S6 0.0493454
TRIO trio Rho guanine nucleotide exchange factor 0.0468516
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0433768
TPM3 tropomyosin 3 0.0403585
MAP4 microtubule-associated protein 4 0.037186
COL5A1 collagen, type V, alpha 1 0.0370507
FAT1 FAT atypical cadherin 1 0.0365112
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0352314
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0352081
PTK2 protein tyrosine kinase 2 0.0350577
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0348652
MSN moesin 0.0336768
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0330899
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0329526
LIMS1 LIM and senescent cell antigen-like domains 1 0.0326155
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0323769
KTN1 kinectin 1 (kinesin receptor) 0.0316729
TPT1 tumor protein, translationally-controlled 1 0.0311562
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0311127
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0309891
ECE1 endothelin converting enzyme 1 0.0307446
ZBTB38 zinc finger and BTB domain containing 38 0.0303706
CAMTA1 calmodulin binding transcription activator 1 0.0300838
TBC1D22A TBC1 domain family, member 22A 0.0293629
CTSB cathepsin B 0.0293472
DPYSL2 dihydropyrimidinase-like 2 0.028851
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0282688
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0280178
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0272319
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0272236
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0271227
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0268643
MACF1 microtubule-actin crosslinking factor 1 0.0267964
COL3A1 collagen, type III, alpha 1 0.0256947
VMP1 vacuole membrane protein 1 0.0256872
ERRFI1 ERBB receptor feedback inhibitor 1 0.025606
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0254354
COL1A2 collagen, type I, alpha 2 0.025429
PGM3 phosphoglucomutase 3 0.0253286
HSPA8 heat shock 70kDa protein 8 0.0245946
CSNK1A1 casein kinase 1, alpha 1 0.0241111
EEF1G eukaryotic translation elongation factor 1 gamma 0.0240479
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0239018
SERINC3 serine incorporator 3 0.0237644
TNS1 tensin 1 0.0235954
EIF4B eukaryotic translation initiation factor 4B 0.0234696
RPS8 ribosomal protein S8 0.0233514
SAMD4A sterile alpha motif domain containing 4A 0.0227857
EGFR epidermal growth factor receptor 0.0227602
APP amyloid beta (A4) precursor protein 0.0225067
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.022425
TPM4 tropomyosin 4 0.0224162
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0222342
NAV2 neuron navigator 2 0.0221795
RPL37A ribosomal protein L37a 0.0220936
IL6 interleukin 6 0.0218525
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0218346
CDK13 cyclin-dependent kinase 13 0.0218227
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0217962
SETBP1 SET binding protein 1 0.021796
YBX1 Y box binding protein 1 0.0217527
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0217035
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0215913
OGA O-GlcNAcase 0.021419
RPL38 ribosomal protein L38 0.0214024
TGFBI transforming growth factor, beta-induced, 68kDa 0.0212918
ZCCHC7 zinc finger, CCHC domain containing 7 0.0212767
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0212372
CAVIN1 caveolae associated protein 1 0.021227
AGO3 argonaute RISC catalytic component 3 0.0208595
RPL31 ribosomal protein L31 0.0207885
SDC4 syndecan 4 0.0206929
RPS16 ribosomal protein S16 0.0206592
ZNF148 zinc finger protein 148 0.0205569
EFNA5 ephrin-A5 0.0205288
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0205283
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0204252
TLN1 talin 1 0.0203927
RPS20 ribosomal protein S20 0.0202846
MTDH metadherin 0.0202528
RPS27A ribosomal protein S27a 0.0199728
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0198583

decreased expression

Symbol Name Standardized Value
DPYD dihydropyrimidine dehydrogenase -0.0937365
FN1 fibronectin 1 -0.0925694
TMSB10 thymosin beta 10 -0.0778907
FNDC3B fibronectin type III domain containing 3B -0.067492
INHBA inhibin, beta A -0.0673169
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0644451
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0639188
MAP1B microtubule-associated protein 1B -0.0595966
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0567366
IFI6 interferon, alpha-inducible protein 6 -0.0556083
MBNL1 muscleblind-like splicing regulator 1 -0.0506743
DPYSL3 dihydropyrimidinase-like 3 -0.0500651
TRPS1 trichorhinophalangeal syndrome I -0.0445286
PSD3 pleckstrin and Sec7 domain containing 3 -0.0438754
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0413973
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0394478
LDHA lactate dehydrogenase A -0.0381048
MT2A metallothionein 2A -0.0380866
OSMR oncostatin M receptor -0.037572
PALLD palladin, cytoskeletal associated protein -0.036692
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0363649
ANKRD28 ankyrin repeat domain 28 -0.0348333
EGR1 early growth response 1 -0.0334421
GLIS3 GLIS family zinc finger 3 -0.0326963
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0326167
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0325456
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0317564
ZFPM2 zinc finger protein, FOG family member 2 -0.0315946
CXCL8 chemokine (C-X-C motif) ligand 8 -0.031046
SQLE squalene epoxidase -0.0301166
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0300905
MAML2 mastermind-like 2 (Drosophila) -0.0300403
IFITM3 interferon induced transmembrane protein 3 -0.0297696
MTSS1 metastasis suppressor 1 -0.0296684
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0295831
MX2 MX dynamin-like GTPase 2 -0.0295503
FTH1 ferritin, heavy polypeptide 1 -0.0292007
CALD1 caldesmon 1 -0.0277743
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0269095
FRMD5 FERM domain containing 5 -0.0262338
CFB complement factor B -0.02573
PLSCR1 phospholipid scramblase 1 -0.0255975
BBX bobby sox homolog (Drosophila) -0.0251998
CNTN5 contactin 5 -0.0250536
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0245597
PFN1 profilin 1 -0.0244311
DLG1 discs, large homolog 1 (Drosophila) -0.0243848
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0243171
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0242652
VEGFC vascular endothelial growth factor C -0.0234214
JAK2 Janus kinase 2 -0.0233887
PIEZO2 piezo-type mechanosensitive ion channel component 2 -0.0231654
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0229366
RIGI RNA sensor RIG-I -0.0225569
SIK3 SIK family kinase 3 -0.022458
SP100 SP100 nuclear antigen -0.0221946
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0220971
IFI44L interferon-induced protein 44-like -0.0219109
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0211347
FBN1 fibrillin 1 -0.0207706
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.020427
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0200758
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0200195
RPL18 ribosomal protein L18 -0.0200086
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0197296
P3H2 prolyl 3-hydroxylase 2 -0.0197031
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0196373
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -0.0195742
ANTXR2 anthrax toxin receptor 2 -0.0191001
ISG15 ISG15 ubiquitin-like modifier -0.01897
MMP3 matrix metallopeptidase 3 -0.0189471
TENM1 teneurin transmembrane protein 1 -0.0188373
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0188338
EVI5 ecotropic viral integration site 5 -0.0188248
PDE4D phosphodiesterase 4D, cAMP-specific -0.0188084
TSC22D2 TSC22 domain family, member 2 -0.0183613
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0182902
ZEB2 zinc finger E-box binding homeobox 2 -0.0182511
SON SON DNA binding protein -0.018164
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0179295
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0179014
ZBTB20 zinc finger and BTB domain containing 20 -0.0178808
KLF6 Kruppel-like factor 6 -0.0177938
MYADM myeloid-associated differentiation marker -0.0177856
CADM1 cell adhesion molecule 1 -0.0176986
HDAC9 histone deacetylase 9 -0.0175622
ICAM1 intercellular adhesion molecule 1 -0.0173554
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0171362
LIPG lipase, endothelial -0.0169158
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0168996
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0168882
SAMD9 sterile alpha motif domain containing 9 -0.0167979
FAM107B family with sequence similarity 107, member B -0.0165625
IFI16 interferon, gamma-inducible protein 16 -0.0164038
S100A6 S100 calcium binding protein A6 -0.0163533
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -0.0161996
RUNX2 runt-related transcription factor 2 -0.016199
GRB10 growth factor receptor-bound protein 10 -0.0161129
NREP neuronal regeneration related protein -0.0159802
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0158954