Temuterkib_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Temuterkib perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Temuterkib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.159294
AKAP12 A kinase (PRKA) anchor protein 12 0.132369
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0863034
DSPP dentin sialophosphoprotein 0.0718249
ENO1 enolase 1, (alpha) 0.0586841
ASPH aspartate beta-hydroxylase 0.0535655
FN1 fibronectin 1 0.0524816
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0468761
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0430401
SVIL supervillin 0.039202
PDLIM5 PDZ and LIM domain 5 0.0389248
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0364854
FRMD5 FERM domain containing 5 0.0360337
EXT1 exostosin glycosyltransferase 1 0.0338491
LDHA lactate dehydrogenase A 0.0335221
C3 complement component 3 0.0330342
FAT1 FAT atypical cadherin 1 0.0325306
LPP LIM domain containing preferred translocation partner in lipoma 0.0323687
GRB10 growth factor receptor-bound protein 10 0.0322072
PEG3 paternally expressed 3 0.0316647
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0313234
TPM4 tropomyosin 4 0.0313142
SAMD4A sterile alpha motif domain containing 4A 0.0310821
DST dystonin 0.0309784
MYH9 myosin, heavy chain 9, non-muscle 0.0302438
FAM107B family with sequence similarity 107, member B 0.0300991
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0282457
TF transferrin 0.0262818
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0260914
CANX calnexin 0.0257857
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0253219
GCLC glutamate-cysteine ligase, catalytic subunit 0.0249908
EEF2 eukaryotic translation elongation factor 2 0.0248382
PLIN2 perilipin 2 0.0245732
MBNL2 muscleblind-like splicing regulator 2 0.0243782
FOXP1 forkhead box P1 0.0240739
KRT18 keratin 18, type I 0.024042
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0239192
KYNU kynureninase 0.0236468
VCL vinculin 0.0236093
KRT8 keratin 8, type II 0.0228753
ATXN1 ataxin 1 0.0222725
TRIO trio Rho guanine nucleotide exchange factor 0.0222492
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0222296
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0221198
TXNRD1 thioredoxin reductase 1 0.0220417
APLP2 amyloid beta (A4) precursor-like protein 2 0.0210443
POTEF POTE ankyrin domain family, member F 0.0188296
MYO1E myosin IE 0.0178466
UBC ubiquitin C 0.0177846
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0172599
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0172414
ZBTB20 zinc finger and BTB domain containing 20 0.0171016
MAML2 mastermind-like 2 (Drosophila) 0.0165562
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0163611
RNF213 ring finger protein 213 0.0163589
TMSB10 thymosin beta 10 0.0159507
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0158257
LMO7 LIM domain 7 0.0156926
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0154383
PALLD palladin, cytoskeletal associated protein 0.0151786
RPL3 ribosomal protein L3 0.0150849
SOD2 superoxide dismutase 2, mitochondrial 0.01503
TPM1 tropomyosin 1 (alpha) 0.0148162
AKAP9 A kinase (PRKA) anchor protein 9 0.0147564
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0147376
VCAN versican 0.014618
SP100 SP100 nuclear antigen 0.0145794
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0142614
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0142565
LIMS1 LIM and senescent cell antigen-like domains 1 0.0141702
ITGAV integrin, alpha V 0.0140364
AHSG alpha-2-HS-glycoprotein 0.0140053
GPC6 glypican 6 0.0139144
TNS1 tensin 1 0.0134766
PAWR PRKC, apoptosis, WT1, regulator 0.013284
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0132326
MAP1B microtubule-associated protein 1B 0.0131794
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0130615
CTSB cathepsin B 0.0130019
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0129571
VEGFA vascular endothelial growth factor A 0.0129274
ACTG1 actin gamma 1 0.012702
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0127019
MACF1 microtubule-actin crosslinking factor 1 0.0122502
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0122281
GOLGB1 golgin B1 0.0122252
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0121932
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0121809
AHNAK AHNAK nucleoprotein 0.0121517
SYNE1 spectrin repeat containing, nuclear envelope 1 0.0119839
ANXA2 annexin A2 0.0119304
STC2 stanniocalcin 2 0.0118565
RAB10 RAB10, member RAS oncogene family 0.0118387
ADAM9 ADAM metallopeptidase domain 9 0.0118357
ATF3 activating transcription factor 3 0.0118182
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.011729
EXOC6B exocyst complex component 6B 0.0115937
UTRN utrophin 0.0115253
VIM vimentin 0.0114003

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.0779176
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0640519
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0609096
APOB apolipoprotein B -0.0532934
GPC3 glypican 3 -0.0518804
TPT1 tumor protein, translationally-controlled 1 -0.0379811
SLC38A2 solute carrier family 38, member 2 -0.0369796
RBM25 RNA binding motif protein 25 -0.0307832
RPLP1 ribosomal protein, large, P1 -0.0293513
FNDC3B fibronectin type III domain containing 3B -0.029301
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0279571
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.0264981
EML4 echinoderm microtubule associated protein like 4 -0.0253162
RPL11 ribosomal protein L11 -0.0248664
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0243897
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0242588
RBM39 RNA binding motif protein 39 -0.0237979
EPAS1 endothelial PAS domain protein 1 -0.0236578
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.0235825
FTL ferritin, light polypeptide -0.0226726
RPS24 ribosomal protein S24 -0.0199034
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0197843
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0194401
RUNX1 runt-related transcription factor 1 -0.0193441
RPS19 ribosomal protein S19 -0.018418
RPL26 ribosomal protein L26 -0.0183588
ELL2 elongation factor, RNA polymerase II, 2 -0.0173072
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 -0.0172001
RPLP2 ribosomal protein, large, P2 -0.0170237
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0167026
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0152037
RPL37A ribosomal protein L37a -0.0151805
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0151272
RPS3 ribosomal protein S3 -0.0149557
PNISR PNN-interacting serine/arginine-rich protein -0.0147499
GNAS GNAS complex locus -0.014632
CFB complement factor B -0.0145311
ARID3A AT rich interactive domain 3A (BRIGHT-like) -0.0144191
PDGFB platelet-derived growth factor beta polypeptide -0.0143716
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0143597
PTPRF protein tyrosine phosphatase, receptor type, F -0.0138755
A2M alpha-2-macroglobulin -0.0136364
CRLS1 cardiolipin synthase 1 -0.0134172
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0132899
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0131922
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0131546
RPS6 ribosomal protein S6 -0.013093
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0128891
MT1X metallothionein 1X -0.0128267
APOC1 apolipoprotein C-I -0.0126064
RPS21 ribosomal protein S21 -0.0124995
ZMYND8 zinc finger, MYND-type containing 8 -0.0122437
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0121548
APOE apolipoprotein E -0.0118553
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0118425
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.011839
MALT1 MALT1 paracaspase -0.0116592
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.011647
MED13L mediator complex subunit 13-like -0.011594
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -0.0115906
RRBP1 ribosome binding protein 1 -0.0114944
HP1BP3 heterochromatin protein 1, binding protein 3 -0.011493
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0113906
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0112987
NF1 neurofibromin 1 -0.0112236
KIF21A kinesin family member 21A -0.0111599
KMT2E lysine (K)-specific methyltransferase 2E -0.0111172
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0109749
NT5C2 5'-nucleotidase, cytosolic II -0.0108831
IER3 immediate early response 3 -0.0108536
NIPBL Nipped-B homolog (Drosophila) -0.0108202
WSB1 WD repeat and SOCS box containing 1 -0.0107624
ZSWIM5 zinc finger, SWIM-type containing 5 -0.010518
ANKRD12 ankyrin repeat domain 12 -0.0104695
RPL12 ribosomal protein L12 -0.0103634
MIDN midnolin -0.0103225
RPL32 ribosomal protein L32 -0.0102634
KDM3A lysine (K)-specific demethylase 3A -0.0102605
LOC112694756 uncharaterized LOC112694756 -0.0101439
LRMDA leucine rich melanocyte differentiation associated -0.0100425
RPS12 ribosomal protein S12 -0.0100247
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 -0.0100227
EGR1 early growth response 1 -0.0100006
USP3 ubiquitin specific peptidase 3 -0.0099727
ASXL1 additional sex combs like transcriptional regulator 1 -0.00996124
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) -0.00985339
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.00982458
WAC WW domain containing adaptor with coiled-coil -0.0098167
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0098152
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.00968123
TMEM51 transmembrane protein 51 -0.0096012
AFDN afadin, adherens junction formation factor -0.00946486
SRRM1 serine/arginine repetitive matrix 1 -0.00941902
PHIP pleckstrin homology domain interacting protein -0.00941367
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.00941241
OGA O-GlcNAcase -0.0093863
PUM2 pumilio RNA-binding family member 2 -0.00930484
RPL19 ribosomal protein L19 -0.00923714
FGG fibrinogen gamma chain -0.00918992
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.00915066