Temuterkib_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Temuterkib perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Temuterkib_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.200295
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.11856
VEGFA vascular endothelial growth factor A 0.109365
B2M beta-2-microglobulin 0.100691
MAML2 mastermind-like 2 (Drosophila) 0.0937702
ASPH aspartate beta-hydroxylase 0.092444
POTEF POTE ankyrin domain family, member F 0.0807709
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0793793
EZR ezrin 0.0752099
GMDS GDP-mannose 4,6-dehydratase 0.0741828
ANXA1 annexin A1 0.0740068
APLP2 amyloid beta (A4) precursor-like protein 2 0.0722475
FAT1 FAT atypical cadherin 1 0.0701425
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0684732
CDK6 cyclin-dependent kinase 6 0.0659308
MYH9 myosin, heavy chain 9, non-muscle 0.0639338
TMC5 transmembrane channel-like 5 0.0616751
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0608813
MBNL2 muscleblind-like splicing regulator 2 0.059161
PTPRK protein tyrosine phosphatase, receptor type, K 0.058383
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0572344
DSPP dentin sialophosphoprotein 0.0564106
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0527763
MACC1 metastasis associated in colon cancer 1 0.0525465
SEPTIN9 septin 9 0.0498223
DOCK5 dedicator of cytokinesis 5 0.0497666
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0496459
LCN2 lipocalin 2 0.0488475
RNF213 ring finger protein 213 0.0488084
PKM pyruvate kinase, muscle 0.0487754
ENO1 enolase 1, (alpha) 0.0485094
AKAP13 A kinase (PRKA) anchor protein 13 0.047329
KRT18 keratin 18, type I 0.0469795
TPM3 tropomyosin 3 0.0466873
GDA guanine deaminase 0.046583
BCL2L1 BCL2-like 1 0.0462105
MYO1E myosin IE 0.0453058
HSPA8 heat shock 70kDa protein 8 0.045101
ANXA2 annexin A2 0.0442363
TNIK TRAF2 and NCK interacting kinase 0.0437811
YAP1 Yes-associated protein 1 0.0434523
ITGA6 integrin, alpha 6 0.0433552
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0433449
CEMIP cell migration inducing protein, hyaluronan binding 0.04325
KRT8 keratin 8, type II 0.0424488
ZSWIM6 zinc finger, SWIM-type containing 6 0.0424078
MYOF myoferlin 0.0420466
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0418587
MBNL1 muscleblind-like splicing regulator 1 0.0417552
PDLIM5 PDZ and LIM domain 5 0.0411669
DST dystonin 0.0411122
LPP LIM domain containing preferred translocation partner in lipoma 0.0410388
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0399927
RUNX1 runt-related transcription factor 1 0.0394911
SRRM2 serine/arginine repetitive matrix 2 0.0393403
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0392277
EFNA5 ephrin-A5 0.0386795
SIK3 SIK family kinase 3 0.0386649
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0386597
SMAD3 SMAD family member 3 0.0384774
RPS3 ribosomal protein S3 0.0383592
RPS12 ribosomal protein S12 0.0381929
RASEF RAS and EF-hand domain containing 0.0377565
VMP1 vacuole membrane protein 1 0.0368412
SLTM SAFB-like, transcription modulator 0.0367035
EIF4A2 eukaryotic translation initiation factor 4A2 0.0364921
RRM2 ribonucleotide reductase M2 0.0360595
NCEH1 neutral cholesterol ester hydrolase 1 0.0360328
LOC102724023 ES1 protein homolog, mitochondrial 0.0358166
UBASH3B ubiquitin associated and SH3 domain containing B 0.0357389
EHBP1 EH domain binding protein 1 0.0356397
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0355062
SET SET nuclear proto-oncogene 0.0353274
TJP1 tight junction protein 1 0.0343629
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0342355
KLF5 Kruppel-like factor 5 (intestinal) 0.0339838
AREG amphiregulin 0.0338115
EEF1G eukaryotic translation elongation factor 1 gamma 0.0337237
MCU mitochondrial calcium uniporter 0.0336486
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0334205
FTH1 ferritin, heavy polypeptide 1 0.0333334
RPS17 ribosomal protein S17 0.033314
LDHA lactate dehydrogenase A 0.0333057
OSBPL10 oxysterol binding protein-like 10 0.0331224
NFE2L1 nuclear factor, erythroid 2-like 1 0.0330347
EEF2 eukaryotic translation elongation factor 2 0.0329136
MTUS1 microtubule associated tumor suppressor 1 0.0326299
TXNRD1 thioredoxin reductase 1 0.0323712
MACF1 microtubule-actin crosslinking factor 1 0.0321801
GCLC glutamate-cysteine ligase, catalytic subunit 0.0320165
PLEC plectin 0.0314817
SPDYA speedy/RINGO cell cycle regulator family member A 0.0307868
COBL cordon-bleu WH2 repeat protein 0.0298899
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0298175
EDN1 endothelin 1 0.0290867
ATXN1 ataxin 1 0.0287979
SMC1A structural maintenance of chromosomes 1A 0.0285288
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0283632
CUX1 cut-like homeobox 1 0.0282311
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0279104

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.285933
H1-0 H1.0 linker histone -0.10814
NPSR1 neuropeptide S receptor 1 -0.0849834
PDIA4 protein disulfide isomerase family A, member 4 -0.0826899
TPT1 tumor protein, translationally-controlled 1 -0.0804371
GARS1 glycyl-tRNA synthetase 1 -0.0772702
KDM3A lysine (K)-specific demethylase 3A -0.0758943
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0749664
PDIA3 protein disulfide isomerase family A, member 3 -0.0692625
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0683105
AGR2 anterior gradient 2 -0.0655341
ANLN anillin, actin binding protein -0.0601989
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0556953
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0523474
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0434489
IARS1 isoleucyl-tRNA synthetase 1 -0.0431453
RAB1A RAB1A, member RAS oncogene family -0.0425953
RRBP1 ribosome binding protein 1 -0.041366
AHNAK AHNAK nucleoprotein -0.0409897
ZFAND3 zinc finger, AN1-type domain 3 -0.0404255
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0395211
WDR45B WD repeat domain 45B -0.0394556
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0380077
DLG1 discs, large homolog 1 (Drosophila) -0.03719
STAU1 staufen double-stranded RNA binding protein 1 -0.0366525
PTMA prothymosin, alpha -0.0362297
ZNF292 zinc finger protein 292 -0.0352513
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0350413
CD2AP CD2-associated protein -0.0349901
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0348079
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0343559
CLTC clathrin, heavy chain (Hc) -0.0340662
S100A6 S100 calcium binding protein A6 -0.0337773
RPL35A ribosomal protein L35a -0.0335603
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0328358
COG5 component of oligomeric golgi complex 5 -0.0328358
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0322596
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0322214
GOLGA4 golgin A4 -0.0315493
INSIG1 insulin induced gene 1 -0.0308943
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0302632
ESRP1 epithelial splicing regulatory protein 1 -0.0301418
NIPSNAP2 nipsnap homolog 2 -0.0297815
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0295012
MON2 MON2 homolog (S. cerevisiae) -0.0291091
FAM13A family with sequence similarity 13, member A -0.0286535
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0286403
PPARG peroxisome proliferator-activated receptor gamma -0.0285015
TMEM123 transmembrane protein 123 -0.0282886
AVL9 AVL9 homolog (S. cerevisiase) -0.0282197
GNAS GNAS complex locus -0.0275098
LCORL ligand dependent nuclear receptor corepressor-like -0.0273652
LMAN1 lectin, mannose-binding, 1 -0.0272904
RPS24 ribosomal protein S24 -0.027265
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0268204
RAD21 RAD21 homolog (S. pombe) -0.0265687
KMT2A lysine (K)-specific methyltransferase 2A -0.0264243
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0262427
SEC63 SEC63 homolog (S. cerevisiae) -0.0258878
EIF1 eukaryotic translation initiation factor 1 -0.025568
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.0254869
CEP95 centrosomal protein 95kDa -0.0254769
RLF rearranged L-myc fusion -0.0253565
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0250794
WSB1 WD repeat and SOCS box containing 1 -0.0245977
SMC4 structural maintenance of chromosomes 4 -0.0243626
HMGB2 high mobility group box 2 -0.0242773
NAMPT nicotinamide phosphoribosyltransferase -0.0242636
MYL12B myosin, light chain 12B, regulatory -0.0241623
ACACA acetyl-CoA carboxylase alpha -0.0239891
EPCAM epithelial cell adhesion molecule -0.0239254
ARCN1 archain 1 -0.023825
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0237587
XPO1 exportin 1 -0.0237058
ACBD3 acyl-CoA binding domain containing 3 -0.0236814
USP3 ubiquitin specific peptidase 3 -0.0236393
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0235217
S100A10 S100 calcium binding protein A10 -0.023425
ZMYM2 zinc finger, MYM-type 2 -0.023408
CANX calnexin -0.0233494
BIRC6 baculoviral IAP repeat containing 6 -0.0230634
SPAG9 sperm associated antigen 9 -0.0229187
TES testin LIM domain protein -0.0228803
HLA-C major histocompatibility complex, class I, C -0.0225792
CAMKMT calmodulin-lysine N-methyltransferase -0.022571
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0225039
GLG1 golgi glycoprotein 1 -0.0222715
MARCHF6 membrane associated ring-CH-type finger 6 -0.0219671
RPL32 ribosomal protein L32 -0.0219611
PIAS1 protein inhibitor of activated STAT, 1 -0.0218564
MORF4L2 mortality factor 4 like 2 -0.0218477
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0218463
RPL12 ribosomal protein L12 -0.0214259
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.021372
CCNI cyclin I -0.0213503
SLC31A1 solute carrier family 31 (copper transporter), member 1 -0.0212926
CLINT1 clathrin interactor 1 -0.0212839
KLHL24 kelch-like family member 24 -0.0212431
TRIM2 tripartite motif containing 2 -0.0211785
HMGB1 high mobility group box 1 -0.0211194