Temuterkib_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Temuterkib perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Temuterkib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0534863
FAT1 FAT atypical cadherin 1 0.0517239
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0481356
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0443291
HSPA8 heat shock 70kDa protein 8 0.0346858
EXT1 exostosin glycosyltransferase 1 0.0339785
VEGFA vascular endothelial growth factor A 0.0283452
NEBL nebulette 0.0272201
LMO7 LIM domain 7 0.0254459
DSPP dentin sialophosphoprotein 0.0226
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0225764
LDHA lactate dehydrogenase A 0.0216409
PARD3B par-3 family cell polarity regulator beta 0.02092
KRT8 keratin 8, type II 0.0207582
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0207515
ASPH aspartate beta-hydroxylase 0.0205633
AFF1 AF4/FMR2 family, member 1 0.0197515
SPTBN1 spectrin, beta, non-erythrocytic 1 0.019668
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0189208
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0170271
PDE4D phosphodiesterase 4D, cAMP-specific 0.0170012
GMDS GDP-mannose 4,6-dehydratase 0.0167202
TPM3 tropomyosin 3 0.0165215
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0165087
TMSB4X thymosin beta 4, X-linked 0.0163503
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0163275
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0157489
AHNAK AHNAK nucleoprotein 0.0155881
SMYD3 SET and MYND domain containing 3 0.0155801
MARCHF3 membrane associated ring-CH-type finger 3 0.0155253
PTPRK protein tyrosine phosphatase, receptor type, K 0.0154205
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0151893
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0148399
UNC13B unc-13 homolog B (C. elegans) 0.0144453
GOLGB1 golgin B1 0.0143648
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0143601
TGFBR3 transforming growth factor, beta receptor III 0.0142639
CALR calreticulin 0.0141802
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0141647
SAMD4A sterile alpha motif domain containing 4A 0.0134708
ZSWIM6 zinc finger, SWIM-type containing 6 0.0132274
TRAPPC9 trafficking protein particle complex 9 0.0131705
ATXN1 ataxin 1 0.0131223
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0129116
FHIT fragile histidine triad 0.012781
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0125399
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0123843
LPP LIM domain containing preferred translocation partner in lipoma 0.0123416
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0120728
CEMIP cell migration inducing protein, hyaluronan binding 0.0117838
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0115476
CANX calnexin 0.0114402
RAD51B RAD51 paralog B 0.0113793
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0113408
PDZD8 PDZ domain containing 8 0.0112501
EGFR epidermal growth factor receptor 0.0111328
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0111203
WHRN whirlin 0.0110495
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0108648
CRY1 cryptochrome circadian clock 1 0.0108286
EIF4B eukaryotic translation initiation factor 4B 0.0107059
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0106282
ADGRV1 adhesion G protein-coupled receptor V1 0.0103637
RPL4 ribosomal protein L4 0.0103454
SIK3 SIK family kinase 3 0.0103367
RPL3 ribosomal protein L3 0.0102862
AKAP13 A kinase (PRKA) anchor protein 13 0.010149
CCSER1 coiled-coil serine-rich protein 1 0.0100866
EXOC4 exocyst complex component 4 0.0100769
SQSTM1 sequestosome 1 0.0100677
CLCN3 chloride channel, voltage-sensitive 3 0.00999156
CADPS2 Ca++-dependent secretion activator 2 0.00995345
WNK1 WNK lysine deficient protein kinase 1 0.00987849
MBNL1 muscleblind-like splicing regulator 1 0.00982449
DST dystonin 0.00964094
INTS6 integrator complex subunit 6 0.00962648
EEF1G eukaryotic translation elongation factor 1 gamma 0.00950924
APLP2 amyloid beta (A4) precursor-like protein 2 0.00944366
WWOX WW domain containing oxidoreductase 0.00941021
PTPRG protein tyrosine phosphatase, receptor type, G 0.00939286
ONECUT3 one cut homeobox 3 0.00925231
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0091949
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.00908194
IQGAP1 IQ motif containing GTPase activating protein 1 0.00903981
EIF4A2 eukaryotic translation initiation factor 4A2 0.00898579
CEMIP2 cell migration inducing hyaluronidase 2 0.00892188
TMED2 transmembrane emp24 domain trafficking protein 2 0.00891902
RRM2 ribonucleotide reductase M2 0.00882818
LURAP1L leucine rich adaptor protein 1-like 0.00871534
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.00862782
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.00861962
TMCO3 transmembrane and coiled-coil domains 3 0.00858363
SEPTIN9 septin 9 0.00853939
MUC13 mucin 13, cell surface associated 0.00850093
FOXP1 forkhead box P1 0.00838342
PLEC plectin 0.0083807
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.00837722
HYOU1 hypoxia up-regulated 1 0.0083534
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.00822182
ARHGAP42 Rho GTPase activating protein 42 0.00820547

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.204707
PTMA prothymosin, alpha -0.12089
TMSB10 thymosin beta 10 -0.0846625
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0795369
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0682102
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0465981
NPSR1 neuropeptide S receptor 1 -0.0461755
ANXA2 annexin A2 -0.045821
TPT1 tumor protein, translationally-controlled 1 -0.0384444
ITGA6 integrin, alpha 6 -0.0370351
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0347544
S100A6 S100 calcium binding protein A6 -0.0326936
RPL35A ribosomal protein L35a -0.0326919
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0309503
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0304484
NDRG1 N-myc downstream regulated 1 -0.0299194
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0287965
HMGA1 high mobility group AT-hook 1 -0.0285712
RPS6 ribosomal protein S6 -0.0282926
GDF15 growth differentiation factor 15 -0.0268092
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0267701
TXNIP thioredoxin interacting protein -0.0267641
NCOR1 nuclear receptor corepressor 1 -0.02658
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0265719
PNISR PNN-interacting serine/arginine-rich protein -0.0253296
RPLP1 ribosomal protein, large, P1 -0.0249608
AREG amphiregulin -0.0248972
TNS4 tensin 4 -0.024046
ACTG1 actin gamma 1 -0.0239972
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0238614
S100P S100 calcium binding protein P -0.0232453
RAB1A RAB1A, member RAS oncogene family -0.0232022
RPS23 ribosomal protein S23 -0.0228631
RNF145 ring finger protein 145 -0.0226185
WDR45B WD repeat domain 45B -0.0225729
FTH1 ferritin, heavy polypeptide 1 -0.0221807
RPL8 ribosomal protein L8 -0.0218992
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0212021
CALB1 calbindin 1, 28kDa -0.0211527
MED13L mediator complex subunit 13-like -0.0207389
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0206571
FLNB filamin B, beta -0.0205935
RPLP0 ribosomal protein, large, P0 -0.0204989
RPS24 ribosomal protein S24 -0.0202927
LOC112694756 uncharaterized LOC112694756 -0.0202206
SETD5 SET domain containing 5 -0.0202143
PKM pyruvate kinase, muscle -0.0201886
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0201084
RPL34 ribosomal protein L34 -0.0201032
ESYT2 extended synaptotagmin-like protein 2 -0.0200766
GNAS GNAS complex locus -0.0197048
H1-0 H1.0 linker histone -0.0196669
PRSS3 protease, serine, 3 -0.0195069
RPL11 ribosomal protein L11 -0.0194845
EIF1 eukaryotic translation initiation factor 1 -0.0194138
ATP5F1B ATP synthase F1 subunit beta -0.0192484
RPS25 ribosomal protein S25 -0.0191408
GCC2 GRIP and coiled-coil domain containing 2 -0.0191397
TFF3 trefoil factor 3 (intestinal) -0.0191254
S100A10 S100 calcium binding protein A10 -0.0191045
MUC17 mucin 17, cell surface associated -0.0187777
RAP1B RAP1B, member of RAS oncogene family -0.0186444
PERP PERP, TP53 apoptosis effector -0.0186365
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0185489
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0185056
EPCAM epithelial cell adhesion molecule -0.0184932
KDM3A lysine (K)-specific demethylase 3A -0.0182568
ACTN4 actinin, alpha 4 -0.018019
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.017867
ZFAND3 zinc finger, AN1-type domain 3 -0.0176347
PGK1 phosphoglycerate kinase 1 -0.0176003
DDIT4 DNA-damage-inducible transcript 4 -0.0174732
NALF1 NALCN channel auxiliary factor 1 -0.0174296
CCNI cyclin I -0.0172327
RNF43 ring finger protein 43 -0.0171015
GREB1L growth regulation by estrogen in breast cancer-like -0.017003
PIGR polymeric immunoglobulin receptor -0.016872
IER3 immediate early response 3 -0.0165564
RPL32 ribosomal protein L32 -0.0165045
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0163614
RPL9 ribosomal protein L9 -0.0159863
RPL12 ribosomal protein L12 -0.0159349
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0158818
GARS1 glycyl-tRNA synthetase 1 -0.0158365
WAC WW domain containing adaptor with coiled-coil -0.0157261
FAM13A family with sequence similarity 13, member A -0.015417
AGR2 anterior gradient 2 -0.0153413
ITGB4 integrin, beta 4 -0.015232
IGFBP4 insulin-like growth factor binding protein 4 -0.0152315
ANKRD11 ankyrin repeat domain 11 -0.0151917
RBM39 RNA binding motif protein 39 -0.0150421
RPS8 ribosomal protein S8 -0.0149215
USP3 ubiquitin specific peptidase 3 -0.0147812
EREG epiregulin -0.0147792
RPS11 ribosomal protein S11 -0.0147379
RPLP2 ribosomal protein, large, P2 -0.014586
RPS21 ribosomal protein S21 -0.014536
IARS1 isoleucyl-tRNA synthetase 1 -0.014496
GPHN gephyrin -0.014453
RRBP1 ribosome binding protein 1 -0.0143561