Temuterkib_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Temuterkib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Temuterkib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
POTEF POTE ankyrin domain family, member F 0.132308
FTL ferritin, light polypeptide 0.127727
MT2A metallothionein 2A 0.121869
DST dystonin 0.113308
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0850782
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0841568
KTN1 kinectin 1 (kinesin receptor) 0.0829813
PTMA prothymosin, alpha 0.0817435
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0808543
RPS12 ribosomal protein S12 0.0784384
B2M beta-2-microglobulin 0.0769424
HLA-B major histocompatibility complex, class I, B 0.0734311
CAPRIN2 caprin family member 2 0.0715116
ZDHHC14 zinc finger, DHHC-type containing 14 0.0629576
TP63 tumor protein p63 0.0621406
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0620087
RPL37A ribosomal protein L37a 0.0616221
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0547222
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0538652
RAB7A RAB7A, member RAS oncogene family 0.053313
ENO1 enolase 1, (alpha) 0.0524304
TXNIP thioredoxin interacting protein 0.0524288
SDC4 syndecan 4 0.0512925
ENO2 enolase 2 (gamma, neuronal) 0.0507108
INTS6 integrator complex subunit 6 0.0499006
BRD2 bromodomain containing 2 0.0495877
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.048786
RPS6 ribosomal protein S6 0.0484855
RPL31 ribosomal protein L31 0.04821
ZSWIM6 zinc finger, SWIM-type containing 6 0.0477344
RPS3 ribosomal protein S3 0.0476237
BIRC3 baculoviral IAP repeat containing 3 0.0463129
RPS8 ribosomal protein S8 0.0453699
RPS19 ribosomal protein S19 0.0452242
PKM pyruvate kinase, muscle 0.0440216
VEGFA vascular endothelial growth factor A 0.0438101
RPL36 ribosomal protein L36 0.0431221
HLA-A major histocompatibility complex, class I, A 0.0430278
APLP2 amyloid beta (A4) precursor-like protein 2 0.0430032
CFLAR CASP8 and FADD-like apoptosis regulator 0.040566
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0405125
VCL vinculin 0.0404797
ZFP36L1 ZFP36 ring finger protein-like 1 0.0402724
SP100 SP100 nuclear antigen 0.0397867
RPS17 ribosomal protein S17 0.0397218
FTH1 ferritin, heavy polypeptide 1 0.0388542
TIMP2 TIMP metallopeptidase inhibitor 2 0.0380061
LOC102724023 ES1 protein homolog, mitochondrial 0.0374748
PRELID2 PRELI domain containing 2 0.0374519
TMSB4X thymosin beta 4, X-linked 0.0372714
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.037064
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0369236
CCNL1 cyclin L1 0.0368074
IFI6 interferon, alpha-inducible protein 6 0.0349897
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.034827
LDHA lactate dehydrogenase A 0.0340104
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0339723
MT1E metallothionein 1E 0.0338407
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.033788
SQSTM1 sequestosome 1 0.0335549
EEF1G eukaryotic translation elongation factor 1 gamma 0.0335047
HOMER1 homer scaffolding protein 1 0.033422
WWTR1 WW domain containing transcription regulator 1 0.0333824
KMT2E lysine (K)-specific methyltransferase 2E 0.0328686
PSD3 pleckstrin and Sec7 domain containing 3 0.0328412
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0327872
RPL37 ribosomal protein L37 0.0317831
DNER delta/notch-like EGF repeat containing 0.0308679
RPS27 ribosomal protein S27 0.0305507
JUN jun proto-oncogene 0.0304481
CLIP2 CAP-GLY domain containing linker protein 2 0.0303382
TPI1 triosephosphate isomerase 1 0.0300209
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0297663
BCAR3 breast cancer anti-estrogen resistance 3 0.0294638
CADM2 cell adhesion molecule 2 0.0294149
TPM3 tropomyosin 3 0.0293685
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0291698
EIF4A2 eukaryotic translation initiation factor 4A2 0.0279124
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.027901
ASPH aspartate beta-hydroxylase 0.0278334
HILPDA hypoxia inducible lipid droplet-associated 0.0277044
RPLP2 ribosomal protein, large, P2 0.0276368
RPS13 ribosomal protein S13 0.0275924
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0275217
OSBPL8 oxysterol binding protein-like 8 0.0273492
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0272138
YBX1 Y box binding protein 1 0.0268093
RPL35A ribosomal protein L35a 0.0266667
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0265406
PLK2 polo-like kinase 2 0.0263882
RPL19 ribosomal protein L19 0.0261305
RPLP1 ribosomal protein, large, P1 0.0254435
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0253778
AREG amphiregulin 0.025107
IFITM1 interferon induced transmembrane protein 1 0.0249937
CALR calreticulin 0.0248579
RPS25 ribosomal protein S25 0.0248499
PCBP2 poly(rC) binding protein 2 0.0245118
HDAC9 histone deacetylase 9 0.0244991
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0244818

decreased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 -0.177626
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.123632
TM4SF1 transmembrane 4 L six family member 1 -0.109363
RAI1 retinoic acid induced 1 -0.0900036
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0892188
AHNAK AHNAK nucleoprotein -0.0685141
USP34 ubiquitin specific peptidase 34 -0.0647871
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0629274
DLG1 discs, large homolog 1 (Drosophila) -0.0554231
ZMYND8 zinc finger, MYND-type containing 8 -0.0541035
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0537276
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0504281
SLC38A2 solute carrier family 38, member 2 -0.0493837
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0434919
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0419193
CEP170 centrosomal protein 170kDa -0.0410548
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0408912
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0404469
ZNF217 zinc finger protein 217 -0.038747
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0376382
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.036649
NAMPT nicotinamide phosphoribosyltransferase -0.0365809
RTN4 reticulon 4 -0.0365734
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0363656
ADGRG6 adhesion G protein-coupled receptor G6 -0.0359219
WARS1 tryptophanyl-tRNA synthetase 1 -0.0355488
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0355166
MKI67 marker of proliferation Ki-67 -0.0352109
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -0.033758
TRIP12 thyroid hormone receptor interactor 12 -0.0332326
CENPF centromere protein F, 350/400kDa -0.0327348
RIGI RNA sensor RIG-I -0.0322731
EHBP1 EH domain binding protein 1 -0.0321156
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0319944
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0315089
TMEM41B transmembrane protein 41B -0.0311907
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0309993
WDR26 WD repeat domain 26 -0.0302991
ACTG1 actin gamma 1 -0.0296637
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0289881
KLF6 Kruppel-like factor 6 -0.028527
FERMT1 fermitin family member 1 -0.0282885
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0281192
EMP1 epithelial membrane protein 1 -0.0280433
TAS2R14 taste receptor, type 2, member 14 -0.0280372
OSMR oncostatin M receptor -0.0276787
YEATS2 YEATS domain containing 2 -0.0272139
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0272029
ZEB1 zinc finger E-box binding homeobox 1 -0.0271926
SRGN serglycin -0.0270112
UPP1 uridine phosphorylase 1 -0.0268721
CANX calnexin -0.0263457
PYGB phosphorylase, glycogen; brain -0.0263126
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0263116
STAT1 signal transducer and activator of transcription 1, 91kDa -0.026201
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0261709
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0260282
RAB27B RAB27B, member RAS oncogene family -0.0259885
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0258935
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0258547
KIAA1958 KIAA1958 -0.0253075
BRWD3 bromodomain and WD repeat domain containing 3 -0.0251049
MIB1 mindbomb E3 ubiquitin protein ligase 1 -0.0247954
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.024775
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.024678
TNPO1 transportin 1 -0.024405
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -0.0244015
APP amyloid beta (A4) precursor protein -0.0240895
TEX10 testis expressed 10 -0.0240073
ANLN anillin, actin binding protein -0.0238868
KDM3A lysine (K)-specific demethylase 3A -0.0238818
MYSM1 Myb-like, SWIRM and MPN domains 1 -0.0238537
UBE2E3 ubiquitin-conjugating enzyme E2E 3 -0.0238477
THSD4 thrombospondin, type I, domain containing 4 -0.0236219
XPO7 exportin 7 -0.0231693
BIRC6 baculoviral IAP repeat containing 6 -0.0231631
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0227422
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0224808
ATP13A3 ATPase type 13A3 -0.0224439
HDLBP high density lipoprotein binding protein -0.0218556
CAPRIN1 cell cycle associated protein 1 -0.021753
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.021698
RGS4 regulator of G-protein signaling 4 -0.0216529
CUL1 cullin 1 -0.0214558
KIF14 kinesin family member 14 -0.0213643
SPRY4 sprouty homolog 4 (Drosophila) -0.0212867
LOC112694756 uncharaterized LOC112694756 -0.021245
XPO1 exportin 1 -0.0212033
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0210997
ERCC6L2 excision repair cross-complementation group 6-like 2 -0.0210476
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -0.0208864
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0207684
SINHCAF SIN3-HDAC complex associated factor -0.0206758
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0205934
DPYSL2 dihydropyrimidinase-like 2 -0.0205589
BIRC2 baculoviral IAP repeat containing 2 -0.0202322
ETNK1 ethanolamine kinase 1 -0.02021
ANTXR2 anthrax toxin receptor 2 -0.0201779
ARHGAP29 Rho GTPase activating protein 29 -0.0201035
ANKRD17 ankyrin repeat domain 17 -0.0200047