| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Temuterkib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Temuterkib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ASPH | aspartate beta-hydroxylase | 0.135832 |
| GRAMD1B | GRAM domain containing 1B | 0.11286 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0921698 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0893395 |
| MCL1 | myeloid cell leukemia 1 | 0.0854829 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0662201 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0614649 |
| SLTM | SAFB-like, transcription modulator | 0.0609002 |
| INTS6 | integrator complex subunit 6 | 0.0576161 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0512295 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.051222 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0479916 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0472967 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0467548 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0461646 |
| TXNRD1 | thioredoxin reductase 1 | 0.0453198 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0448843 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.044458 |
| LMO7 | LIM domain 7 | 0.0423074 |
| HOMER1 | homer scaffolding protein 1 | 0.0418523 |
| MYOF | myoferlin | 0.0397516 |
| VMP1 | vacuole membrane protein 1 | 0.0391672 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0385234 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0383213 |
| NABP1 | nucleic acid binding protein 1 | 0.0376195 |
| USP53 | ubiquitin specific peptidase 53 | 0.0375666 |
| CMIP | c-Maf inducing protein | 0.0375394 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0372159 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0370709 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0370209 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0361625 |
| AREG | amphiregulin | 0.0352697 |
| ANXA2 | annexin A2 | 0.034967 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0347021 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0343378 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0330509 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0330504 |
| SCEL | sciellin | 0.03304 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.032494 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0322585 |
| SMYD3 | SET and MYND domain containing 3 | 0.0319603 |
| PTK2 | protein tyrosine kinase 2 | 0.0303786 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0301802 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0301062 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0299087 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0298563 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0294759 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0293551 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0291551 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0290617 |
| TPM4 | tropomyosin 4 | 0.0284879 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0283157 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0282863 |
| VCL | vinculin | 0.0280644 |
| MYO1E | myosin IE | 0.0276374 |
| PKM | pyruvate kinase, muscle | 0.0274526 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0267345 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0259123 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0254871 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0253586 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0253163 |
| CTBP2 | C-terminal binding protein 2 | 0.0251085 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0249321 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0246537 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0245193 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0245068 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0245045 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0244142 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0241249 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0237675 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0235886 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.02348 |
| FNDC3A | fibronectin type III domain containing 3A | 0.02338 |
| STC1 | stanniocalcin 1 | 0.0233421 |
| OXSR1 | oxidative stress responsive 1 | 0.0233339 |
| ANXA1 | annexin A1 | 0.0229445 |
| EZR | ezrin | 0.0228819 |
| NTN4 | netrin 4 | 0.02288 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.022613 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0225098 |
| RAB10 | RAB10, member RAS oncogene family | 0.0225064 |
| ACTG1 | actin gamma 1 | 0.0224219 |
| FBXO11 | F-box protein 11 | 0.0224195 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0223621 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0223592 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0222399 |
| CANX | calnexin | 0.0221862 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0221668 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0221469 |
| PTMA | prothymosin, alpha | 0.0218697 |
| DST | dystonin | 0.0218682 |
| HYOU1 | hypoxia up-regulated 1 | 0.0214198 |
| UGDH | UDP-glucose 6-dehydrogenase | 0.0211864 |
| FUS | FUS RNA binding protein | 0.0211358 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0209666 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0208498 |
| ENO1 | enolase 1, (alpha) | 0.0208176 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0207652 |
| PLS3 | plastin 3 | 0.0204598 |
| MYO5B | myosin VB | 0.0203669 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | -0.0979769 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0656004 |
| TMSB10 | thymosin beta 10 | -0.0622007 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0579079 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0559841 |
| MT2A | metallothionein 2A | -0.0522659 |
| NDRG1 | N-myc downstream regulated 1 | -0.0502296 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0456535 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0437379 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.042783 |
| FAM13A | family with sequence similarity 13, member A | -0.0403908 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0403127 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0400084 |
| NGLY1 | N-glycanase 1 | -0.0393495 |
| RPS3 | ribosomal protein S3 | -0.0362017 |
| TMEM165 | transmembrane protein 165 | -0.0344413 |
| SEC61G | Sec61 gamma subunit | -0.0337506 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | -0.0326136 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0293754 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0291564 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0287956 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0282756 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0272869 |
| OSMR | oncostatin M receptor | -0.0267261 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0230386 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0226137 |
| RPS12 | ribosomal protein S12 | -0.0218148 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0216842 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0216579 |
| SON | SON DNA binding protein | -0.0212907 |
| RPL37A | ribosomal protein L37a | -0.0210321 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0209386 |
| SPTSSA | serine palmitoyltransferase, small subunit A | -0.0204723 |
| HLA-B | major histocompatibility complex, class I, B | -0.0204345 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.02031 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0202683 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0201067 |
| MGAT4C | MGAT4 family, member C | -0.0199209 |
| S100P | S100 calcium binding protein P | -0.0199116 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0194014 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | -0.0183192 |
| FRY | furry homolog (Drosophila) | -0.018195 |
| GPC6 | glypican 6 | -0.0179709 |
| MT1X | metallothionein 1X | -0.0179548 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0178193 |
| B2M | beta-2-microglobulin | -0.0176666 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0174688 |
| RPL26 | ribosomal protein L26 | -0.017403 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.017355 |
| RPS24 | ribosomal protein S24 | -0.0172776 |
| RPL19 | ribosomal protein L19 | -0.0166934 |
| RPS6 | ribosomal protein S6 | -0.0166351 |
| RPS27 | ribosomal protein S27 | -0.0163275 |
| KIAA1217 | KIAA1217 | -0.0157684 |
| IFNAR2 | interferon (alpha, beta and omega) receptor 2 | -0.0156341 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0154547 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0153978 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0151551 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0151434 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | -0.0150322 |
| S100A9 | S100 calcium binding protein A9 | -0.0148208 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0148055 |
| CAB39 | calcium binding protein 39 | -0.0145638 |
| H1-0 | H1.0 linker histone | -0.0145467 |
| ESCO1 | establishment of sister chromatid cohesion N-acetyltransferase 1 | -0.0143972 |
| CYFIP1 | cytoplasmic FMR1 interacting protein 1 | -0.0141823 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | -0.0141778 |
| RPL30 | ribosomal protein L30 | -0.0139304 |
| RPL36 | ribosomal protein L36 | -0.0137134 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | -0.013633 |
| MARF1 | meiosis regulator and mRNA stability factor 1 | -0.013576 |
| YEATS2 | YEATS domain containing 2 | -0.0135534 |
| TMEM87A | transmembrane protein 87A | -0.0135339 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0134778 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0134542 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | -0.0133212 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.0132186 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0131741 |
| RPS19 | ribosomal protein S19 | -0.0130983 |
| NDE1 | nudE neurodevelopment protein 1 | -0.0129747 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0129005 |
| PMP22 | peripheral myelin protein 22 | -0.0126565 |
| RPS21 | ribosomal protein S21 | -0.0125178 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0123917 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0123523 |
| FRMD4B | FERM domain containing 4B | -0.0122842 |
| S100A6 | S100 calcium binding protein A6 | -0.0122052 |
| RPL7 | ribosomal protein L7 | -0.0122014 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0121624 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.012157 |
| ARRDC3 | arrestin domain containing 3 | -0.0120293 |
| SP3 | Sp3 transcription factor | -0.0119728 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0119102 |
| CDCP1 | CUB domain containing protein 1 | -0.0119039 |
| MX1 | MX dynamin-like GTPase 1 | -0.0118992 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0118847 |
| RIGI | RNA sensor RIG-I | -0.0118715 |
| RPL34 | ribosomal protein L34 | -0.0118606 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0118495 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0118247 |
