Temuterkib_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Temuterkib perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Temuterkib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.081511
GRAMD1B GRAM domain containing 1B 0.0650446
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0525074
THSD4 thrombospondin, type I, domain containing 4 0.0455687
AKAP12 A kinase (PRKA) anchor protein 12 0.0426214
SAMD4A sterile alpha motif domain containing 4A 0.0422236
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0413641
FAM107B family with sequence similarity 107, member B 0.0412277
SMOC1 SPARC related modular calcium binding 1 0.0366353
MCL1 myeloid cell leukemia 1 0.0343171
DOCK4 dedicator of cytokinesis 4 0.0342073
ASPH aspartate beta-hydroxylase 0.0313398
IGFBP3 insulin-like growth factor binding protein 3 0.0310164
PM20D1 peptidase M20 domain containing 1 0.0299082
SOD2 superoxide dismutase 2, mitochondrial 0.029828
DOCK5 dedicator of cytokinesis 5 0.0285687
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0283621
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0267054
ARHGAP26 Rho GTPase activating protein 26 0.0263921
KYNU kynureninase 0.0260545
DST dystonin 0.0252595
HSPA8 heat shock 70kDa protein 8 0.0252573
SVIL supervillin 0.0251359
MACF1 microtubule-actin crosslinking factor 1 0.024844
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0242954
WWOX WW domain containing oxidoreductase 0.0237012
LDHA lactate dehydrogenase A 0.0233648
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0224997
FNDC3B fibronectin type III domain containing 3B 0.0223182
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0217919
TPM3 tropomyosin 3 0.0215773
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0212452
MYH9 myosin, heavy chain 9, non-muscle 0.0210307
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0207508
ZSWIM6 zinc finger, SWIM-type containing 6 0.0201234
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0196128
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0189474
MAML3 mastermind-like 3 (Drosophila) 0.0189251
AHNAK AHNAK nucleoprotein 0.0189071
ATXN1 ataxin 1 0.0188221
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0185154
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.018161
RAD51B RAD51 paralog B 0.0180556
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0178971
GOLGB1 golgin B1 0.0175297
PDE10A phosphodiesterase 10A 0.0174951
EGFR epidermal growth factor receptor 0.0172235
APP amyloid beta (A4) precursor protein 0.017045
PTPRM protein tyrosine phosphatase, receptor type, M 0.0158545
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0157522
CFLAR CASP8 and FADD-like apoptosis regulator 0.0156448
BRD2 bromodomain containing 2 0.0152478
EXT1 exostosin glycosyltransferase 1 0.0151024
BASP1 brain abundant, membrane attached signal protein 1 0.0145416
INTS6 integrator complex subunit 6 0.0144395
LAMC2 laminin, gamma 2 0.0141132
CYTH1 cytohesin 1 0.0140944
FOS FBJ murine osteosarcoma viral oncogene homolog 0.014067
EXOC6B exocyst complex component 6B 0.0140373
LPP LIM domain containing preferred translocation partner in lipoma 0.0139764
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0139761
GLIS3 GLIS family zinc finger 3 0.0137823
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0134366
HLA-B major histocompatibility complex, class I, B 0.0133938
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0133757
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0131573
MYO1E myosin IE 0.0130245
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0128511
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0127161
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0126891
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0126531
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0126335
VCL vinculin 0.0125381
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0124883
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0123771
UBASH3B ubiquitin associated and SH3 domain containing B 0.0122056
LRMDA leucine rich melanocyte differentiation associated 0.0120795
APLP2 amyloid beta (A4) precursor-like protein 2 0.0120005
TTC28 tetratricopeptide repeat domain 28 0.0118198
UTRN utrophin 0.011729
MBD5 methyl-CpG binding domain protein 5 0.011637
BCAR3 breast cancer anti-estrogen resistance 3 0.0113321
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0113079
EFNA5 ephrin-A5 0.0110384
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0109845
FHIT fragile histidine triad 0.0109816
EEF2 eukaryotic translation elongation factor 2 0.0108585
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0108141
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0107797
CMIP c-Maf inducing protein 0.0107076
PLEC plectin 0.0105938
RNF213 ring finger protein 213 0.0105593
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0104976
RABGAP1L RAB GTPase activating protein 1-like 0.0103875
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0103572
PARD3B par-3 family cell polarity regulator beta 0.0102892
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0102038
SMAD3 SMAD family member 3 0.0101842
NPAS2 neuronal PAS domain protein 2 0.0101613
ZNF638 zinc finger protein 638 0.0101591

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.194904
MT2A metallothionein 2A -0.120676
FTL ferritin, light polypeptide -0.101759
TMSB10 thymosin beta 10 -0.0915305
VIM vimentin -0.0821471
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0810611
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0678443
IGF2 insulin-like growth factor 2 -0.0522341
PFN1 profilin 1 -0.0367178
RPL19 ribosomal protein L19 -0.0357405
ACTG1 actin gamma 1 -0.0348546
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0341201
PTMA prothymosin, alpha -0.0333024
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0302656
RTN4 reticulon 4 -0.0289724
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0280128
SLC38A2 solute carrier family 38, member 2 -0.0275579
TFPI2 tissue factor pathway inhibitor 2 -0.0261172
HMGA1 high mobility group AT-hook 1 -0.0255105
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0235264
RPLP0 ribosomal protein, large, P0 -0.0227069
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.0225125
FTH1 ferritin, heavy polypeptide 1 -0.0215923
RPS21 ribosomal protein S21 -0.0214892
RPS19 ribosomal protein S19 -0.0214483
TM4SF1 transmembrane 4 L six family member 1 -0.0207607
USP3 ubiquitin specific peptidase 3 -0.0207217
RPL8 ribosomal protein L8 -0.0206416
ATP5F1B ATP synthase F1 subunit beta -0.0196275
NOP58 NOP58 ribonucleoprotein -0.0195969
WDR43 WD repeat domain 43 -0.0194801
ERBIN erbb2 interacting protein -0.0192918
RPLP1 ribosomal protein, large, P1 -0.0188301
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0182887
RPL36 ribosomal protein L36 -0.0182824
RPS8 ribosomal protein S8 -0.0176438
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0175951
S100A6 S100 calcium binding protein A6 -0.0174387
RPS5 ribosomal protein S5 -0.0170721
EIF1 eukaryotic translation initiation factor 1 -0.0167474
RPS25 ribosomal protein S25 -0.0165833
RBM39 RNA binding motif protein 39 -0.016554
RBM25 RNA binding motif protein 25 -0.0164916
FGB fibrinogen beta chain -0.0164901
RPL23 ribosomal protein L23 -0.0161234
MIS18BP1 MIS18 binding protein 1 -0.0158726
PAWR PRKC, apoptosis, WT1, regulator -0.0156588
RPS15 ribosomal protein S15 -0.0155868
ZNF207 zinc finger protein 207 -0.0154261
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0154064
RPL35A ribosomal protein L35a -0.0153658
TFG TRK-fused gene -0.0153414
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0151776
GNAS GNAS complex locus -0.015164
TAGLN2 transgelin 2 -0.0151617
RPS23 ribosomal protein S23 -0.0149357
S100A10 S100 calcium binding protein A10 -0.0148278
YY1 YY1 transcription factor -0.014789
SRGN serglycin -0.0147609
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0147382
TMEM123 transmembrane protein 123 -0.0146324
PDIA3 protein disulfide isomerase family A, member 3 -0.0145814
RPS29 ribosomal protein S29 -0.0145105
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0142932
SLC38A1 solute carrier family 38, member 1 -0.0142268
SERF2 small EDRK-rich factor 2 -0.0141024
PKM pyruvate kinase, muscle -0.0139601
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0137736
ECT2 epithelial cell transforming 2 -0.0136664
CHN1 chimerin 1 -0.013486
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.0133702
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0130669
ZNF292 zinc finger protein 292 -0.0129874
ADGRG6 adhesion G protein-coupled receptor G6 -0.0129719
YBX1 Y box binding protein 1 -0.0129578
IGFBP4 insulin-like growth factor binding protein 4 -0.0128938
CYRIB CYFIP related Rac1 interactor B -0.0128746
RPL28 ribosomal protein L28 -0.012616
DENND4A DENN/MADD domain containing 4A -0.0125391
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.012448
YBX3 Y box binding protein 3 -0.0124424
NAMPT nicotinamide phosphoribosyltransferase -0.0123533
TPD52 tumor protein D52 -0.0122598
MORF4L1 mortality factor 4 like 1 -0.0122222
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0122098
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0122012
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0120676
PFDN2 prefoldin subunit 2 -0.0120362
RPL32 ribosomal protein L32 -0.0119662
RHEB Ras homolog enriched in brain -0.011958
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0119337
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0119083
NUP58 nucleoporin 58 -0.0118995
ATP5F1E ATP synthase F1 subunit epsilon -0.0118239
KMT2E lysine (K)-specific methyltransferase 2E -0.0118189
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0118064
VEZT vezatin, adherens junctions transmembrane protein -0.0117804
SEPTIN7 septin 7 -0.011731
EGR1 early growth response 1 -0.0116227
VDAC1 voltage-dependent anion channel 1 -0.0115965