Temuterkib_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Temuterkib perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Temuterkib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.105769
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0682113
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.066934
LIMCH1 LIM and calponin homology domains 1 0.0648009
ELL2 elongation factor, RNA polymerase II, 2 0.0549856
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0502636
TRIO trio Rho guanine nucleotide exchange factor 0.0455875
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0447789
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0439755
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0436279
EGFR epidermal growth factor receptor 0.0429476
MUC16 mucin 16, cell surface associated 0.0428193
VEGFA vascular endothelial growth factor A 0.0425079
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0420819
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0403362
RPS12 ribosomal protein S12 0.0388615
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0372413
SMAD3 SMAD family member 3 0.0365888
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0355479
CEP350 centrosomal protein 350kDa 0.0350649
EXT1 exostosin glycosyltransferase 1 0.0350183
VCL vinculin 0.0340598
PDLIM5 PDZ and LIM domain 5 0.0340377
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0338426
FLNB filamin B, beta 0.0336261
KDM4C lysine (K)-specific demethylase 4C 0.0333962
RASAL2 RAS protein activator like 2 0.0328241
CTBP2 C-terminal binding protein 2 0.032609
ERRFI1 ERBB receptor feedback inhibitor 1 0.0321467
MBNL1 muscleblind-like splicing regulator 1 0.0314685
MACC1 metastasis associated in colon cancer 1 0.0314283
PAPOLA poly(A) polymerase alpha 0.0312452
TTC3 tetratricopeptide repeat domain 3 0.0312298
NRG1 neuregulin 1 0.0308163
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0305853
PSD3 pleckstrin and Sec7 domain containing 3 0.0305636
FAM114A1 family with sequence similarity 114, member A1 0.0305056
ANO6 anoctamin 6 0.0304602
ADAM9 ADAM metallopeptidase domain 9 0.0303902
HMGA2 high mobility group AT-hook 2 0.0301109
HSPH1 heat shock 105kDa/110kDa protein 1 0.0299756
CXCL8 chemokine (C-X-C motif) ligand 8 0.0297672
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0297068
HSPA8 heat shock 70kDa protein 8 0.0287593
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0287295
SQSTM1 sequestosome 1 0.0275167
NKD1 naked cuticle homolog 1 (Drosophila) 0.0272793
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0272291
GLRX glutaredoxin (thioltransferase) 0.0271494
EIF4A2 eukaryotic translation initiation factor 4A2 0.0268762
TXNRD1 thioredoxin reductase 1 0.0263339
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0261785
KMT2E lysine (K)-specific methyltransferase 2E 0.0260124
APP amyloid beta (A4) precursor protein 0.0257015
WDR26 WD repeat domain 26 0.0254535
CDH13 cadherin 13 0.0253642
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0251675
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0250194
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0249847
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0248572
QKI QKI, KH domain containing, RNA binding 0.0248542
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0247441
RNMT RNA (guanine-7-) methyltransferase 0.0247216
LEPROT leptin receptor overlapping transcript 0.02462
FN1 fibronectin 1 0.0245962
AUTS2 autism susceptibility candidate 2 0.0244956
ANKRD11 ankyrin repeat domain 11 0.0243008
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0242637
BRWD1 bromodomain and WD repeat domain containing 1 0.0241922
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0239706
RPL4 ribosomal protein L4 0.0239213
MAML2 mastermind-like 2 (Drosophila) 0.0237502
LDHA lactate dehydrogenase A 0.0233374
TUT7 terminal uridylyl transferase 7 0.0231864
FAT1 FAT atypical cadherin 1 0.0231592
BRD2 bromodomain containing 2 0.0229289
EEF2 eukaryotic translation elongation factor 2 0.0229205
ADGRB3 adhesion G protein-coupled receptor B3 0.022818
JAK1 Janus kinase 1 0.0225908
DST dystonin 0.0215969
GOLGA4 golgin A4 0.021591
TSC22D1 TSC22 domain family, member 1 0.0214876
ZSWIM6 zinc finger, SWIM-type containing 6 0.0213967
ZBTB20 zinc finger and BTB domain containing 20 0.0213886
COL6A3 collagen, type VI, alpha 3 0.0212447
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0210951
HPCAL1 hippocalcin-like 1 0.0206107
FAF1 Fas (TNFRSF6) associated factor 1 0.0205902
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0205682
LIMS1 LIM and senescent cell antigen-like domains 1 0.0205152
PHF3 PHD finger protein 3 0.0204954
N4BP2L2 NEDD4 binding protein 2-like 2 0.0204229
BAIAP2L1 BAI1-associated protein 2-like 1 0.0203197
CDYL chromodomain protein, Y-like 0.0203102
ANXA5 annexin A5 0.0202343
NSD3 nuclear receptor binding SET domain protein 3 0.0200415
ARHGAP5 Rho GTPase activating protein 5 0.0199529
NCEH1 neutral cholesterol ester hydrolase 1 0.0199331
TFPI2 tissue factor pathway inhibitor 2 0.0198978
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0198317

decreased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0899771
ATOSA atos homolog A -0.0792845
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0779439
S100A9 S100 calcium binding protein A9 -0.0715362
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0683519
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0668267
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0651622
FTH1 ferritin, heavy polypeptide 1 -0.0650892
GRB10 growth factor receptor-bound protein 10 -0.0643908
TMSB10 thymosin beta 10 -0.0623296
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0578697
TM4SF1 transmembrane 4 L six family member 1 -0.0556406
PDE4D phosphodiesterase 4D, cAMP-specific -0.0554799
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0544621
PLAUR plasminogen activator, urokinase receptor -0.0515885
LAMC2 laminin, gamma 2 -0.0475905
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0464184
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.045662
ZMYND8 zinc finger, MYND-type containing 8 -0.0442213
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0431094
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0427759
SRPK2 SRSF protein kinase 2 -0.0425621
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0417626
PKM pyruvate kinase, muscle -0.0409306
SOX4 SRY (sex determining region Y)-box 4 -0.0394566
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0387634
FTL ferritin, light polypeptide -0.0382628
S100A10 S100 calcium binding protein A10 -0.0381997
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0380261
BBX bobby sox homolog (Drosophila) -0.0378382
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0374763
H3-3B H3.3 histone B -0.0370877
CSTB cystatin B (stefin B) -0.0366153
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0365777
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0364072
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0359941
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.034986
ANXA2 annexin A2 -0.0337461
NPEPPS aminopeptidase puromycin sensitive -0.033331
ANTXR2 anthrax toxin receptor 2 -0.0330015
RAD51B RAD51 paralog B -0.0328943
SLC38A1 solute carrier family 38, member 1 -0.0323645
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0323379
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0316719
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0315201
ZNFX1 zinc finger, NFX1-type containing 1 -0.0313302
OGA O-GlcNAcase -0.03128
ABHD17C abhydrolase domain containing 17C -0.0312616
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0305085
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0293208
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0290657
RPS24 ribosomal protein S24 -0.028968
CXXC1 CXXC finger protein 1 -0.0289516
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.02894
KDM3A lysine (K)-specific demethylase 3A -0.0287079
CCNI cyclin I -0.0286727
WASF2 WAS protein family, member 2 -0.0285779
PERP PERP, TP53 apoptosis effector -0.0285768
S100A6 S100 calcium binding protein A6 -0.0284332
PTMA prothymosin, alpha -0.0284172
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0282972
RHOA ras homolog family member A -0.0279859
LOC112694756 uncharaterized LOC112694756 -0.0273098
DICER1 dicer 1, ribonuclease type III -0.0272543
CD2AP CD2-associated protein -0.0272374
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0271335
TMCC3 transmembrane and coiled-coil domain family 3 -0.0270546
KDM7A lysine (K)-specific demethylase 7A -0.0270317
CDK13 cyclin-dependent kinase 13 -0.0269391
MYO1E myosin IE -0.026939
ACTG1 actin gamma 1 -0.0268217
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0265637
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0263066
GCC2 GRIP and coiled-coil domain containing 2 -0.0260133
NFE2L2 nuclear factor, erythroid 2-like 2 -0.025911
ZEB1 zinc finger E-box binding homeobox 1 -0.0258058
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0257964
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0255273
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0251019
THOC2 THO complex 2 -0.0249769
JUP junction plakoglobin -0.0249357
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0249107
CLDN4 claudin 4 -0.0248803
TXNIP thioredoxin interacting protein -0.0248679
BPTF bromodomain PHD finger transcription factor -0.0247129
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0246103
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -0.0243926
S100A11 S100 calcium binding protein A11 -0.0243685
PRDM1 PR domain containing 1, with ZNF domain -0.0241418
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0237505
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 -0.0235508
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0234858
ANKRD12 ankyrin repeat domain 12 -0.0233156
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0232787
SSH2 slingshot protein phosphatase 2 -0.023097
TPT1 tumor protein, translationally-controlled 1 -0.0230552
BCL2L1 BCL2-like 1 -0.0229521
KMT2C lysine (K)-specific methyltransferase 2C -0.0227022
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0226036
RPS29 ribosomal protein S29 -0.0224935