| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Temuterkib perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Temuterkib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.31583 |
| GRAMD1B | GRAM domain containing 1B | 0.121311 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.108572 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0833364 |
| TXNRD1 | thioredoxin reductase 1 | 0.0827701 |
| YBX3 | Y box binding protein 3 | 0.0787123 |
| TPM3 | tropomyosin 3 | 0.0767631 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0692011 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0615523 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0574275 |
| MCL1 | myeloid cell leukemia 1 | 0.0571853 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0553296 |
| LDHA | lactate dehydrogenase A | 0.0527579 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0495278 |
| RRM2 | ribonucleotide reductase M2 | 0.0482105 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0477196 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.047569 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.047544 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0448418 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0436926 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.043517 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0434357 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0431948 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0428248 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0412277 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0406973 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0406859 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.040014 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0400043 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0393749 |
| VCP | valosin containing protein | 0.0389087 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0388656 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0382547 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0374248 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0367836 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0366501 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.036525 |
| KRT18 | keratin 18, type I | 0.035993 |
| ENO1 | enolase 1, (alpha) | 0.0354831 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0352997 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0352996 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0350337 |
| EFNA5 | ephrin-A5 | 0.0343553 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0342567 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0341827 |
| PDE10A | phosphodiesterase 10A | 0.0339879 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0338919 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0332703 |
| OSMR | oncostatin M receptor | 0.0330506 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0327311 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0325684 |
| WWOX | WW domain containing oxidoreductase | 0.032272 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0312552 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0311808 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0300578 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0298895 |
| DST | dystonin | 0.0290835 |
| DSPP | dentin sialophosphoprotein | 0.0282184 |
| VMP1 | vacuole membrane protein 1 | 0.0277215 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0276965 |
| YAP1 | Yes-associated protein 1 | 0.0275925 |
| VCL | vinculin | 0.0271271 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0268771 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0268258 |
| AHNAK | AHNAK nucleoprotein | 0.0267852 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0267573 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0265821 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0260432 |
| ASPH | aspartate beta-hydroxylase | 0.0258339 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0258278 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0255946 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0253849 |
| ACTG1 | actin gamma 1 | 0.0253603 |
| POTEF | POTE ankyrin domain family, member F | 0.0252397 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.0250007 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0249054 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0245802 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0245552 |
| ADAR | adenosine deaminase, RNA-specific | 0.0245535 |
| SMAD3 | SMAD family member 3 | 0.0242826 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0241211 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0240847 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0239858 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0239705 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0238338 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0237909 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0235512 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0234971 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0234772 |
| EXOC4 | exocyst complex component 4 | 0.0233289 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0231021 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0229975 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0229708 |
| CANX | calnexin | 0.0227949 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0226555 |
| HDLBP | high density lipoprotein binding protein | 0.0226046 |
| RPL4 | ribosomal protein L4 | 0.0225425 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0224619 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0224418 |
| SIK3 | SIK family kinase 3 | 0.0224039 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.100926 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0571866 |
| PFN1 | profilin 1 | -0.0415869 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0346574 |
| RSF1 | remodeling and spacing factor 1 | -0.0340293 |
| BBX | bobby sox homolog (Drosophila) | -0.0328802 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0321401 |
| RAD51B | RAD51 paralog B | -0.0282025 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.027528 |
| WASF2 | WAS protein family, member 2 | -0.0264777 |
| PHIP | pleckstrin homology domain interacting protein | -0.0256914 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0256235 |
| TMEM165 | transmembrane protein 165 | -0.0233097 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0223635 |
| IGF2 | insulin-like growth factor 2 | -0.0220349 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.021687 |
| EGR1 | early growth response 1 | -0.0216802 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0215756 |
| HMGA1 | high mobility group AT-hook 1 | -0.0211375 |
| SEPTIN7 | septin 7 | -0.0204839 |
| PCBP2 | poly(rC) binding protein 2 | -0.0199224 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0198981 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0197613 |
| TFG | TRK-fused gene | -0.0196424 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0196201 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0190773 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0184618 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0184584 |
| ZNF292 | zinc finger protein 292 | -0.01834 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0179008 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0178021 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.016115 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0159331 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0158702 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0158368 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0158199 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0157131 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0156811 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0156345 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0155984 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0155019 |
| SBF2 | SET binding factor 2 | -0.0152861 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0151747 |
| PHF21A | PHD finger protein 21A | -0.0151618 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0151516 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0151509 |
| FTL | ferritin, light polypeptide | -0.0151308 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0148303 |
| RPL35A | ribosomal protein L35a | -0.014788 |
| ADNP | activity-dependent neuroprotector homeobox | -0.014749 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0146296 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0145925 |
| SETD5 | SET domain containing 5 | -0.0145921 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0145864 |
| FOXJ3 | forkhead box J3 | -0.0143552 |
| ATXN2 | ataxin 2 | -0.0143477 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0142135 |
| H1-0 | H1.0 linker histone | -0.0141185 |
| ZFP64 | ZFP64 zinc finger protein | -0.0140585 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0138957 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0138719 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0137834 |
| PPHLN1 | periphilin 1 | -0.0136771 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0136597 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0134867 |
| COG5 | component of oligomeric golgi complex 5 | -0.0134447 |
| DCAF10 | DDB1 and CUL4 associated factor 10 | -0.0133733 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0133496 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0132557 |
| CDK19 | cyclin-dependent kinase 19 | -0.0131636 |
| ANKRD36 | ankyrin repeat domain 36 | -0.013059 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0129747 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0129347 |
| NKTR | natural killer cell triggering receptor | -0.0129322 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.012805 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0128001 |
| RNF38 | ring finger protein 38 | -0.0127426 |
| TAB2 | TGF-beta activated kinase 1/MAP3K7 binding protein 2 | -0.0126837 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0125752 |
| ATN1 | atrophin 1 | -0.0124596 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -0.0124506 |
| PTMA | prothymosin, alpha | -0.0123966 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0123298 |
| RPS15 | ribosomal protein S15 | -0.0123229 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.0123019 |
| CCNI | cyclin I | -0.0122799 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | -0.0122423 |
| FMN1 | formin 1 | -0.0121834 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0121694 |
| SRRM1 | serine/arginine repetitive matrix 1 | -0.0121393 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0120051 |
| GGNBP2 | gametogenetin binding protein 2 | -0.011931 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0119301 |
| PHF20 | PHD finger protein 20 | -0.0118021 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0117635 |
| RPS21 | ribosomal protein S21 | -0.0117463 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0117181 |
| SMAD5 | SMAD family member 5 | -0.0116087 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | -0.0116015 |
| IKBIP | IKBKB interacting protein | -0.0115783 |
