| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Temuterkib perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Temuterkib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0938491 |
| MCL1 | myeloid cell leukemia 1 | 0.0634085 |
| DST | dystonin | 0.0625131 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0613283 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0580387 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0574483 |
| PRELID2 | PRELI domain containing 2 | 0.0535874 |
| TPM3 | tropomyosin 3 | 0.0484775 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0472642 |
| RAD51B | RAD51 paralog B | 0.0454248 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0408932 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0394801 |
| ENO1 | enolase 1, (alpha) | 0.0377013 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0368512 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0363078 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0355797 |
| LSAMP | limbic system-associated membrane protein | 0.035405 |
| INTS6 | integrator complex subunit 6 | 0.0345449 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0345379 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0343468 |
| PKM | pyruvate kinase, muscle | 0.0340162 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0334099 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0324783 |
| RPL3 | ribosomal protein L3 | 0.0319807 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.031806 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0317621 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0304036 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0293489 |
| MSN | moesin | 0.0291992 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0290321 |
| AUTS2 | autism susceptibility candidate 2 | 0.0284957 |
| SQSTM1 | sequestosome 1 | 0.0282965 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.028066 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0274807 |
| LDHA | lactate dehydrogenase A | 0.0272628 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0269425 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0269131 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0265002 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.026317 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0261328 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0255479 |
| NRXN3 | neurexin 3 | 0.0248772 |
| POTEF | POTE ankyrin domain family, member F | 0.0244201 |
| BRD2 | bromodomain containing 2 | 0.0242113 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0239773 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0238993 |
| ANXA1 | annexin A1 | 0.0234967 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0233726 |
| RPL4 | ribosomal protein L4 | 0.0233102 |
| PCDH9 | protocadherin 9 | 0.0226524 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | 0.022036 |
| B2M | beta-2-microglobulin | 0.0219352 |
| DENND1A | DENN/MADD domain containing 1A | 0.0218663 |
| XYLT1 | xylosyltransferase I | 0.0217443 |
| PCDH15 | protocadherin-related 15 | 0.0215457 |
| WWOX | WW domain containing oxidoreductase | 0.0214389 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0214383 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0213272 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0209378 |
| VEGFA | vascular endothelial growth factor A | 0.020836 |
| HYOU1 | hypoxia up-regulated 1 | 0.0205788 |
| SVIL | supervillin | 0.0205208 |
| PCBP2 | poly(rC) binding protein 2 | 0.020477 |
| ITPK1 | inositol-tetrakisphosphate 1-kinase | 0.0201979 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0201777 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0200157 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0199069 |
| RPS17 | ribosomal protein S17 | 0.0196975 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0195878 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0195278 |
| SET | SET nuclear proto-oncogene | 0.0194868 |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.0193501 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0191519 |
| EZR | ezrin | 0.018903 |
| CTBP2 | C-terminal binding protein 2 | 0.0188928 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0184243 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0183328 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0183085 |
| FAM168A | family with sequence similarity 168, member A | 0.0183046 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | 0.0182647 |
| TENM2 | teneurin transmembrane protein 2 | 0.0180353 |
| RPS2 | ribosomal protein S2 | 0.0177134 |
| RPS18 | ribosomal protein S18 | 0.0176905 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0174468 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.017293 |
| FAT1 | FAT atypical cadherin 1 | 0.0172881 |
| GRAMD1B | GRAM domain containing 1B | 0.0172307 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.0165923 |
| AEBP2 | AE binding protein 2 | 0.0165611 |
| GPC6 | glypican 6 | 0.0165518 |
| DNER | delta/notch-like EGF repeat containing | 0.0165193 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0164286 |
| MAP7 | microtubule-associated protein 7 | 0.0164236 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0163375 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0161731 |
| FAM107B | family with sequence similarity 107, member B | 0.0161464 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0158189 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0157642 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0157521 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0155418 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.175931 |
| GDA | guanine deaminase | -0.170634 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.166356 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.155783 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.140745 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.137732 |
| TMSB10 | thymosin beta 10 | -0.107156 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.106275 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.102377 |
| EFNA5 | ephrin-A5 | -0.0926098 |
| FN1 | fibronectin 1 | -0.0899106 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0831981 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0808736 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0807043 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0780032 |
| SMYD3 | SET and MYND domain containing 3 | -0.0745409 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0739148 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0736051 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0714807 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0712416 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0698558 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0695784 |
| NRCAM | neuronal cell adhesion molecule | -0.0633641 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0585471 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0567608 |
| NEK7 | NIMA-related kinase 7 | -0.0559538 |
| VIM | vimentin | -0.0542032 |
| OSMR | oncostatin M receptor | -0.0536625 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0532161 |
| BMERB1 | bMERB domain containing 1 | -0.0500026 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0485151 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0471472 |
| RPS24 | ribosomal protein S24 | -0.0471299 |
| TXNRD1 | thioredoxin reductase 1 | -0.0469072 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0463465 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0460444 |
| FTL | ferritin, light polypeptide | -0.0459395 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0457033 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0451323 |
| MYOF | myoferlin | -0.0437754 |
| RPL12 | ribosomal protein L12 | -0.0434859 |
| STC1 | stanniocalcin 1 | -0.0432817 |
| PTMA | prothymosin, alpha | -0.0423358 |
| RPLP1 | ribosomal protein, large, P1 | -0.0420969 |
| KYNU | kynureninase | -0.0414267 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0406114 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0405403 |
| GNAS | GNAS complex locus | -0.0403435 |
| CTSC | cathepsin C | -0.0400889 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0398439 |
| ENAH | enabled homolog (Drosophila) | -0.0394689 |
| RPL19 | ribosomal protein L19 | -0.0393815 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0392912 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0386167 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0384619 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0379583 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0372173 |
| PCBP3 | poly(rC) binding protein 3 | -0.0371553 |
| ATAD1 | ATPase family, AAA domain containing 1 | -0.036664 |
| INHBA | inhibin, beta A | -0.0360726 |
| PHF20 | PHD finger protein 20 | -0.0357622 |
| S100A6 | S100 calcium binding protein A6 | -0.0356869 |
| CD109 | CD109 molecule | -0.0350575 |
| RTN4 | reticulon 4 | -0.0342184 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.033964 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0330088 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0326357 |
| TNPO1 | transportin 1 | -0.0324989 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0324468 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0319383 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0317018 |
| RPL26 | ribosomal protein L26 | -0.0316198 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0315588 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0298149 |
| MFF | mitochondrial fission factor | -0.0297272 |
| RTN1 | reticulon 1 | -0.0295863 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0295065 |
| RPS19 | ribosomal protein S19 | -0.0293132 |
| NF1 | neurofibromin 1 | -0.0292382 |
| LAMA1 | laminin, alpha 1 | -0.0292217 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0292205 |
| RPL34 | ribosomal protein L34 | -0.0291625 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0284387 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0284165 |
| ASPH | aspartate beta-hydroxylase | -0.0283469 |
| AOPEP | aminopeptidase O (putative) | -0.0281424 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0280709 |
| RBM39 | RNA binding motif protein 39 | -0.0280415 |
| RPL35A | ribosomal protein L35a | -0.0279896 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0276241 |
| PRKD3 | protein kinase D3 | -0.0274165 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0270853 |
| RPL36 | ribosomal protein L36 | -0.027055 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0269869 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0265012 |
| SRGN | serglycin | -0.0263178 |
| PDE10A | phosphodiesterase 10A | -0.0262845 |
| JMJD1C | jumonji domain containing 1C | -0.0260296 |
| RPS21 | ribosomal protein S21 | -0.0260117 |
| RPL32 | ribosomal protein L32 | -0.0259325 |
