Temuterkib_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Temuterkib perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

136 genes differentially expressed following the Temuterkib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.245032
LMO7 LIM domain 7 0.161629
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.135266
USP34 ubiquitin specific peptidase 34 0.133609
TXNRD1 thioredoxin reductase 1 0.133007
DSCAM Down syndrome cell adhesion molecule 0.111938
PRRC2C proline-rich coiled-coil 2C 0.105496
GOLGB1 golgin B1 0.1013
EZR ezrin 0.0989953
PGK1 phosphoglycerate kinase 1 0.0955378
CXCL8 chemokine (C-X-C motif) ligand 8 0.0919834
HMGA2 high mobility group AT-hook 2 0.0906415
PTK2 protein tyrosine kinase 2 0.0745628
CANX calnexin 0.0718475
MYH9 myosin, heavy chain 9, non-muscle 0.0715695
B2M beta-2-microglobulin 0.0676928
BPTF bromodomain PHD finger transcription factor 0.0668024
SRPK2 SRSF protein kinase 2 0.0572657
EEF2 eukaryotic translation elongation factor 2 0.0535794
NAP1L1 nucleosome assembly protein 1-like 1 0.0519215
CEP350 centrosomal protein 350kDa 0.0502938
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0498785
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0447949
FNDC3B fibronectin type III domain containing 3B 0.0441323
RPS16 ribosomal protein S16 0.0431487
VEGFA vascular endothelial growth factor A 0.0427004
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0424675
ENO1 enolase 1, (alpha) 0.0407284
CSNK1A1 casein kinase 1, alpha 1 0.0395348
NRG3 neuregulin 3 0.0390187
IGFBP3 insulin-like growth factor binding protein 3 0.0387622
ANKRD11 ankyrin repeat domain 11 0.0380493
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0375602
CALD1 caldesmon 1 0.0317462
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0309179
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.030831
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0303392
ACTN4 actinin, alpha 4 0.0294041
CCNI cyclin I 0.0292707
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.028105
RTN4 reticulon 4 0.0264107
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.02636
LDHA lactate dehydrogenase A 0.0260584
PKM pyruvate kinase, muscle 0.0243975
RLF rearranged L-myc fusion 0.0236975
EIF1 eukaryotic translation initiation factor 1 0.0235004
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0233754
GOLGA4 golgin A4 0.0230171
RPS3 ribosomal protein S3 0.0226867
PRELID2 PRELI domain containing 2 0.0222673
RPS12 ribosomal protein S12 0.0210347
RPL31 ribosomal protein L31 0.0201967
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0181671
DLG1 discs, large homolog 1 (Drosophila) 0.0153749
MYO1E myosin IE 0.0125766
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0123654
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0106558
NAMPT nicotinamide phosphoribosyltransferase 0.00915654
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.00894087
RUNX1 runt-related transcription factor 1 0.00776742
ZNF292 zinc finger protein 292 0.00689581
NDRG1 N-myc downstream regulated 1 0.00515137
STC1 stanniocalcin 1 0.00481629
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.00120911

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.200203
PDE10A phosphodiesterase 10A -0.141272
PDE4D phosphodiesterase 4D, cAMP-specific -0.138522
FN1 fibronectin 1 -0.123885
PSD3 pleckstrin and Sec7 domain containing 3 -0.115232
CDH13 cadherin 13 -0.0916239
RORA RAR-related orphan receptor A -0.0913028
SETD5 SET domain containing 5 -0.0828238
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0797355
TRIO trio Rho guanine nucleotide exchange factor -0.0785302
VIM vimentin -0.0784451
EFNA5 ephrin-A5 -0.0783491
NAV2 neuron navigator 2 -0.0781802
MT2A metallothionein 2A -0.0768456
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0743027
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0739664
PTPRM protein tyrosine phosphatase, receptor type, M -0.0712378
GPC6 glypican 6 -0.0691096
TBC1D22A TBC1 domain family, member 22A -0.065889
PTMA prothymosin, alpha -0.0590182
VCL vinculin -0.0575651
RPS19 ribosomal protein S19 -0.0562939
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0488474
PCBP3 poly(rC) binding protein 3 -0.0482479
NALF1 NALCN channel auxiliary factor 1 -0.0467068
RPL23 ribosomal protein L23 -0.0451845
TMSB10 thymosin beta 10 -0.0439407
RPS25 ribosomal protein S25 -0.0430577
EXT1 exostosin glycosyltransferase 1 -0.0426002
IGF2 insulin-like growth factor 2 -0.0382926
PARD3 par-3 family cell polarity regulator -0.038072
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0377568
FNDC3A fibronectin type III domain containing 3A -0.035191
SEC31A SEC31 homolog A (S. cerevisiae) -0.035185
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0350465
ZBTB20 zinc finger and BTB domain containing 20 -0.0344763
NHSL1 NHS-like 1 -0.0328568
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0316098
ATXN1 ataxin 1 -0.0301979
DST dystonin -0.0300523
SMYD3 SET and MYND domain containing 3 -0.0295406
ESYT2 extended synaptotagmin-like protein 2 -0.0283339
ANXA2 annexin A2 -0.0274267
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0267001
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0246757
TPT1 tumor protein, translationally-controlled 1 -0.0245038
MAML2 mastermind-like 2 (Drosophila) -0.0239224
ASPH aspartate beta-hydroxylase -0.0217966
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0208919
VMP1 vacuole membrane protein 1 -0.0200031
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0196221
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0191616
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0183179
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0178761
RAD51B RAD51 paralog B -0.0170988
NKD1 naked cuticle homolog 1 (Drosophila) -0.0152936
RPS27A ribosomal protein S27a -0.0112042
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0106768
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0105792
RPS8 ribosomal protein S8 -0.00987347
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.00942868
ADAM10 ADAM metallopeptidase domain 10 -0.00594564
MCL1 myeloid cell leukemia 1 -0.00574347
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.00547634
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.00417456
IGFBP5 insulin-like growth factor binding protein 5 -0.00376323
WAC WW domain containing adaptor with coiled-coil -0.00350924
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0027968
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.00268546
UBC ubiquitin C -0.00202695
PRKCA protein kinase C, alpha -0.0010475
SIPA1L3 signal-induced proliferation-associated 1 like 3 -7.31955E-4