Temuterkib_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Temuterkib perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Temuterkib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.111
SOD2 superoxide dismutase 2, mitochondrial 0.109352
FN1 fibronectin 1 0.10489
MYH9 myosin, heavy chain 9, non-muscle 0.0945833
EEF2 eukaryotic translation elongation factor 2 0.0860678
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0782525
VEGFA vascular endothelial growth factor A 0.0738414
LDHA lactate dehydrogenase A 0.0636582
TRIO trio Rho guanine nucleotide exchange factor 0.0612498
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0593574
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0564321
B2M beta-2-microglobulin 0.0526523
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0522906
HDAC9 histone deacetylase 9 0.0463997
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0455083
APLP2 amyloid beta (A4) precursor-like protein 2 0.039025
DST dystonin 0.0371313
MSN moesin 0.0371237
EEF1G eukaryotic translation elongation factor 1 gamma 0.0368717
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0368267
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.035104
SFTPA2 surfactant protein A2 0.0350575
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0331472
LAMP2 lysosomal-associated membrane protein 2 0.0331094
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0324245
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0321249
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0320746
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0316448
USP9X ubiquitin specific peptidase 9, X-linked 0.0316145
MKI67 marker of proliferation Ki-67 0.0308891
CENPF centromere protein F, 350/400kDa 0.0308362
PCBP2 poly(rC) binding protein 2 0.0305544
TXNRD1 thioredoxin reductase 1 0.0295798
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0295337
FNDC3B fibronectin type III domain containing 3B 0.0281853
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0280335
POTEF POTE ankyrin domain family, member F 0.0274293
ENO1 enolase 1, (alpha) 0.0272707
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.027239
TNIP1 TNFAIP3 interacting protein 1 0.0271692
PRELID2 PRELI domain containing 2 0.026915
TPM3 tropomyosin 3 0.0267357
RPS6 ribosomal protein S6 0.0260268
CCNL1 cyclin L1 0.025954
GOLGA4 golgin A4 0.0257873
CALR calreticulin 0.0255087
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0254471
ATXN1 ataxin 1 0.0252992
VMP1 vacuole membrane protein 1 0.0243426
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0243052
RPS12 ribosomal protein S12 0.0239706
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0236325
YBX1 Y box binding protein 1 0.0230478
DIAPH3 diaphanous-related formin 3 0.0229296
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0229296
ARRDC3 arrestin domain containing 3 0.0227403
JMJD1C jumonji domain containing 1C 0.0225572
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0225389
HSPA8 heat shock 70kDa protein 8 0.0220902
NAV2 neuron navigator 2 0.0219064
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0215736
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.021467
DUSP10 dual specificity phosphatase 10 0.0213044
NONO non-POU domain containing, octamer-binding 0.0212614
MATR3 matrin 3 0.0211727
OGA O-GlcNAcase 0.0211031
UBA6 ubiquitin-like modifier activating enzyme 6 0.0208492
BRD2 bromodomain containing 2 0.0207535
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0207405
TENT5A terminal nucleotidyltransferase 5A 0.0206265
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0206048
FNIP1 folliculin interacting protein 1 0.0205226
OPTN optineurin 0.0201458
ANXA2 annexin A2 0.0199814
MBNL1 muscleblind-like splicing regulator 1 0.0199049
TXNIP thioredoxin interacting protein 0.0198688
RB1CC1 RB1-inducible coiled-coil 1 0.0198593
FLNA filamin A, alpha 0.0198565
TGFBI transforming growth factor, beta-induced, 68kDa 0.0197594
SMAD3 SMAD family member 3 0.0197106
RPS3 ribosomal protein S3 0.0196318
VCAN versican 0.0193682
RPL23 ribosomal protein L23 0.0192714
ANLN anillin, actin binding protein 0.0189726
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.018937
PKM pyruvate kinase, muscle 0.018447
MYOF myoferlin 0.0183634
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0183169
APP amyloid beta (A4) precursor protein 0.0182595
ANXA1 annexin A1 0.0181646
CANX calnexin 0.0181063
MCL1 myeloid cell leukemia 1 0.0180092
SPAG9 sperm associated antigen 9 0.0179527
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0179197
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0178235
DSTN destrin (actin depolymerizing factor) 0.0177628
AKAP9 A kinase (PRKA) anchor protein 9 0.0177132
AHR aryl hydrocarbon receptor 0.0175054
ASPH aspartate beta-hydroxylase 0.0174802
SMC4 structural maintenance of chromosomes 4 0.0172393

decreased expression

Symbol Name Standardized Value
IER3 immediate early response 3 -0.0614085
IGFBP3 insulin-like growth factor binding protein 3 -0.0606378
NAMPT nicotinamide phosphoribosyltransferase -0.0581118
VIM vimentin -0.0572378
ZMYND8 zinc finger, MYND-type containing 8 -0.0563177
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0542483
TPT1 tumor protein, translationally-controlled 1 -0.054178
AKAP12 A kinase (PRKA) anchor protein 12 -0.0529456
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0446633
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.043127
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0382371
BTG1 B-cell translocation gene 1, anti-proliferative -0.0358785
RAI14 retinoic acid induced 14 -0.0323036
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0310595
ADM adrenomedullin -0.0289581
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0285029
TMEM132D transmembrane protein 132D -0.0267095
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0266157
BASP1 brain abundant, membrane attached signal protein 1 -0.0257661
IFI16 interferon, gamma-inducible protein 16 -0.0253135
GLIS3 GLIS family zinc finger 3 -0.0250754
SLC38A1 solute carrier family 38, member 1 -0.02503
CDH13 cadherin 13 -0.0250231
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0249928
EGFR epidermal growth factor receptor -0.0246475
GNAS GNAS complex locus -0.0234485
FRMD4A FERM domain containing 4A -0.0226916
MMP12 matrix metallopeptidase 12 -0.0213697
FTL ferritin, light polypeptide -0.0209245
ARL4C ADP-ribosylation factor-like 4C -0.0207417
FRMPD4 FERM and PDZ domain containing 4 -0.0200051
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0198574
CLMP CXADR-like membrane protein -0.0193146
SFRP1 secreted frizzled-related protein 1 -0.0191144
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0189199
ABI3BP ABI family, member 3 (NESH) binding protein -0.0188616
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0186711
AFF3 AF4/FMR2 family, member 3 -0.0184542
CTSD cathepsin D -0.0182692
INHBA inhibin, beta A -0.0182455
NDRG1 N-myc downstream regulated 1 -0.0181949
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0180994
SAMD3 sterile alpha motif domain containing 3 -0.0173974
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0172867
WSB1 WD repeat and SOCS box containing 1 -0.0171042
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0162554
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0161566
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0158831
STC1 stanniocalcin 1 -0.0156064
COL1A1 collagen, type I, alpha 1 -0.015552
SDK1 sidekick cell adhesion molecule 1 -0.0154733
RRBP1 ribosome binding protein 1 -0.0152327
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0149682
NRN1 neuritin 1 -0.0144877
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.014452
MT1X metallothionein 1X -0.014394
COL6A2 collagen, type VI, alpha 2 -0.0141257
SCGB1D1 secretoglobin, family 1D, member 1 -0.0139799
ELL2 elongation factor, RNA polymerase II, 2 -0.0138771
CADM1 cell adhesion molecule 1 -0.0136708
KDM3A lysine (K)-specific demethylase 3A -0.0135268
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0132434
WDFY1 WD repeat and FYVE domain containing 1 -0.0131681
CP ceruloplasmin (ferroxidase) -0.0130351
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0129187
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0128781
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0128118
KPNB1 karyopherin (importin) beta 1 -0.0128081
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0127038
SOX5 SRY (sex determining region Y)-box 5 -0.012673
GREM1 gremlin 1, DAN family BMP antagonist -0.0123507
HLA-A major histocompatibility complex, class I, A -0.0123497
KLHL5 kelch-like family member 5 -0.0122966
ADAM12 ADAM metallopeptidase domain 12 -0.012253
ABTB3 ankyrin repeat and BTB domain containing 3 -0.01225
SOX4 SRY (sex determining region Y)-box 4 -0.0120468
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0119863
DENND2A DENN/MADD domain containing 2A -0.0119837
DNAAF9 dynein axonemal assembly factor 9 -0.0118832
PRKG1 protein kinase, cGMP-dependent, type I -0.0118476
LSAMP limbic system-associated membrane protein -0.0117497
CAVIN1 caveolae associated protein 1 -0.0113918
FBXO11 F-box protein 11 -0.0113679
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0113271
KRT19 keratin 19, type I -0.0113209
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0113072
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0112676
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0112025
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0111843
CFB complement factor B -0.0111515
NABP1 nucleic acid binding protein 1 -0.011076
TTC28 tetratricopeptide repeat domain 28 -0.0110664
RGS17 regulator of G-protein signaling 17 -0.010984
DIAPH2 diaphanous-related formin 2 -0.0109463
TMEM263 transmembrane protein 263 -0.0107979
WIPI1 WD repeat domain, phosphoinositide interacting 1 -0.0107694
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0106775
CNTN6 contactin 6 -0.010589
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0105498
TFPI2 tissue factor pathway inhibitor 2 -0.0104053